JP2016520327A5 - - Google Patents

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JP2016520327A5
JP2016520327A5 JP2016518043A JP2016518043A JP2016520327A5 JP 2016520327 A5 JP2016520327 A5 JP 2016520327A5 JP 2016518043 A JP2016518043 A JP 2016518043A JP 2016518043 A JP2016518043 A JP 2016518043A JP 2016520327 A5 JP2016520327 A5 JP 2016520327A5
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detectable marker
enzyme
biological sample
biomarker
sensitive
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JP6847660B2 (ja
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Priority claimed from PCT/US2014/041370 external-priority patent/WO2014197840A1/en
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JP2016518043A 2013-06-07 2014-06-06 リガンドをコードする合成バイオマーカーのアフィニティベースの検出 Expired - Fee Related JP6847660B2 (ja)

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US201361832766P 2013-06-07 2013-06-07
US61/832,766 2013-06-07
PCT/US2014/041370 WO2014197840A1 (en) 2013-06-07 2014-06-06 Affinity-based detection of ligand-encoded synthetic biomarkers

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JP2019164018A Division JP7017544B2 (ja) 2013-06-07 2019-09-09 リガンドをコードする合成バイオマーカーのアフィニティベースの検出

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JP2016520327A JP2016520327A (ja) 2016-07-14
JP2016520327A5 true JP2016520327A5 (https=) 2017-07-20
JP6847660B2 JP6847660B2 (ja) 2021-03-24

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JP2016518043A Expired - Fee Related JP6847660B2 (ja) 2013-06-07 2014-06-06 リガンドをコードする合成バイオマーカーのアフィニティベースの検出
JP2019164018A Active JP7017544B2 (ja) 2013-06-07 2019-09-09 リガンドをコードする合成バイオマーカーのアフィニティベースの検出
JP2022010714A Active JP7368868B2 (ja) 2013-06-07 2022-01-27 リガンドをコードする合成バイオマーカーのアフィニティベースの検出

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JP2019164018A Active JP7017544B2 (ja) 2013-06-07 2019-09-09 リガンドをコードする合成バイオマーカーのアフィニティベースの検出
JP2022010714A Active JP7368868B2 (ja) 2013-06-07 2022-01-27 リガンドをコードする合成バイオマーカーのアフィニティベースの検出

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US (2) US10527619B2 (https=)
EP (1) EP3004374B1 (https=)
JP (3) JP6847660B2 (https=)
CN (2) CN105452481A (https=)
CA (1) CA2914754A1 (https=)
ES (1) ES2828985T3 (https=)
WO (1) WO2014197840A1 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2890501T3 (es) 2009-03-02 2022-01-20 Massachusetts Inst Technology Métodos y productos para la creación de perfiles enzimáticos in vivo
CA2830235C (en) 2011-03-15 2023-10-24 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
KR102104539B1 (ko) 2013-02-28 2020-04-27 삼성전자주식회사 탄산수 제조 장치를 갖춘 냉장고
JP6847660B2 (ja) * 2013-06-07 2021-03-24 マサチューセッツ インスティテュート オブ テクノロジー リガンドをコードする合成バイオマーカーのアフィニティベースの検出
WO2015148622A1 (en) * 2014-03-26 2015-10-01 Virginia Commonwealth University Nanosensor for assessing thrombin inhibitors
WO2016090471A1 (en) * 2014-12-08 2016-06-16 University Health Network System and method for enhanced mass spectrometry imaging
JP6752231B2 (ja) 2015-06-01 2020-09-09 カリフォルニア インスティテュート オブ テクノロジー 抗原を用いて特異的集団に関してt細胞をスクリーニングするための組成物および方法
WO2017049403A1 (en) 2015-09-22 2017-03-30 University Health Network System and method for optimized mass spectrometry analysis
PT3364189T (pt) * 2015-10-16 2021-03-17 Toyo Boseki Produto para teste imunocromatográfico
WO2017177115A1 (en) 2016-04-08 2017-10-12 Massachusetts Institute Of Technology Methods to specifically profile protease activity at lymph nodes
US11428689B2 (en) 2016-05-05 2022-08-30 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
WO2018064383A1 (en) * 2016-09-28 2018-04-05 Georgia Tech Research Corporation Methods and compositions for noninvasive detection of organ transplant rejection
US10191040B2 (en) * 2016-09-30 2019-01-29 Chin-Yih Hong Method of multiplex immunoassays utilizing differential affinity and methods for synthesizing aptamer-based reagents for multiplex immunoassays
CN110268054A (zh) * 2016-11-16 2019-09-20 通用生物传感器有限公司 切割事件转导方法和产品
EP3574340B1 (en) * 2017-01-27 2024-06-26 Massachusetts Institute of Technology Method and system for localization of a vehicle using surface penetrating radar
WO2018165475A1 (en) 2017-03-08 2018-09-13 California Institute Of Technology Pairing antigen specificity of a t cell with t cell receptor sequences
CA3059358A1 (en) 2017-04-07 2018-10-11 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
US11331019B2 (en) 2017-08-07 2022-05-17 The Research Foundation For The State University Of New York Nanoparticle sensor having a nanofibrous membrane scaffold
EP3756010A4 (en) 2018-02-20 2021-11-03 Pavonis Diagnostics Inc. ALUMINUM OXIDE SURFACES AND INTERFACE MOLECULES
US11054428B2 (en) * 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
KR102034381B1 (ko) * 2018-05-04 2019-10-18 고려대학교 산학협력단 다층 나노선 복합체 및 그 제조방법
US11028425B2 (en) 2018-06-08 2021-06-08 Glympse Bio, Inc. Diagnosis and monitoring of liver disease
US11732009B2 (en) 2018-06-08 2023-08-22 Glympse Bio, Inc. Activity sensor with tunable analyte
WO2020023899A1 (en) * 2018-07-27 2020-01-30 Veravas, Inc. Methods for depletion and enrichment
EP3856921B1 (en) 2018-09-25 2026-04-29 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
US20200245926A1 (en) * 2019-02-01 2020-08-06 Glympse Bio, Inc. Compositions and methods for monitoring progression and regression of disease in patients in response to therapy
JP7740987B2 (ja) 2019-02-28 2025-09-17 ジョージア・テック・リサーチ・コーポレーション 生物学的活性の論理ゲート化プロファイリングのための組成物および方法
US20210262025A1 (en) 2020-02-18 2021-08-26 Massachusetts Institute Of Technology Multiplexed in vivo disease sensing with nucleic acid-barcoded reporters
US20220049283A1 (en) * 2020-08-14 2022-02-17 Weiwei Li Li Method of detecting SARS-CoV-2 cleavage targeted proprotein convertase and facilitated protease activity
CN115989390B (zh) * 2020-08-20 2024-10-25 豪夫迈·罗氏有限公司 冻干物保持器、其制造方法以及干燥底物的过程
EP4211468A4 (en) * 2020-09-11 2024-10-09 Glympse Bio, Inc. DETECTION OF EX VIVO PROTEASE ACTIVITY FOR DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT OF DISEASES
JP7813807B2 (ja) * 2021-03-10 2026-02-13 アヴィタイド エルエルシー 親和剤
CN116029977B (zh) * 2022-11-08 2024-03-15 安徽萍聚德医疗科技股份有限公司 测定胃肠动力标记物在结直肠传输时间的鉴定分析方法

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217344A (en) 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4186183A (en) 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
US4261975A (en) 1979-09-19 1981-04-14 Merck & Co., Inc. Viral liposome particle
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4774085A (en) 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
WO1991017424A1 (en) 1990-05-03 1991-11-14 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
ATE427493T1 (de) 1992-05-29 2009-04-15 Univ Rockefeller Verfahren zur bestimmung der folge von peptiden unter verwendung eines massenspektrometers
US5500161A (en) 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
JPH0856665A (ja) 1994-07-07 1996-03-05 Nederland Centr Org Toegepast Natuur Onder タンパク質分解酵素用の基質としての修飾された酵素前駆体
US5885775A (en) 1996-10-04 1999-03-23 Perseptive Biosystems, Inc. Methods for determining sequences information in polynucleotides using mass spectrometry
US6339069B1 (en) 1996-10-15 2002-01-15 Elan Pharmaceuticalstechnologies, Inc. Peptide-lipid conjugates, liposomes and lipsomal drug delivery
US6037137A (en) 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US5996586A (en) 1997-03-26 1999-12-07 Phillips; Michael Breath test for detection of lung cancer
AU738237B2 (en) 1997-07-22 2001-09-13 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
DE69912444T3 (de) 1998-08-25 2010-05-06 University Of Washington, Seattle Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
AU2005227364A1 (en) 1999-06-29 2005-11-24 Transave, Inc. Peptide-lipid conjugates, liposomes and liposomal drug delivery
US20040014652A1 (en) 2000-06-01 2004-01-22 Andre Trouet Tumor activated prodrug compounds and methods of making and using the same
WO2002014867A2 (en) 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US20020164649A1 (en) 2000-10-25 2002-11-07 Rajendra Singh Mass tags for quantitative analysis
US20020119490A1 (en) 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
ATE476654T1 (de) 2001-03-02 2010-08-15 Activx Biosciences Inc Plattform für protein-profiling
US7045296B2 (en) 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
DK3031910T3 (en) * 2002-02-21 2017-10-23 Inst Virology MN / CA IX-SPECIFIC MONOCLONAL ANTIBODIES GENERATED BY MN / CA IX-DEFICIENT MOUSE AND METHODS OF USE
US20070010433A1 (en) 2002-07-11 2007-01-11 Sema Aps Use of compounds capable of inhibiting the proteolytic processing of semaphorins for prevention, treatment, diagnosis and prognosis of an invasive disease
US7041453B2 (en) 2002-08-22 2006-05-09 Bioarray Solutions Ltd. Molecular constructs and methods of use for detection of biochemical reactions
US7169892B2 (en) 2003-01-10 2007-01-30 Astellas Pharma Inc. Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems
US20050260695A1 (en) * 2003-09-23 2005-11-24 Genprime, Inc. Methods, compositions, devices, and kits for detecting mastitis
SE0302559D0 (sv) 2003-09-25 2003-09-25 Astrazeneca Ab Method
US9695251B2 (en) 2003-10-31 2017-07-04 The Regents Of The University Of California Activatable cell penetrating peptides with quenched fluorophores
US7985401B2 (en) 2003-10-31 2011-07-26 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US7431915B2 (en) 2003-10-31 2008-10-07 The Regents Of The University Of California Peptides whose uptake by cells is controllable
EP1718662A4 (en) 2004-02-27 2008-12-31 Hitachi Chemical Res Ct Inc Multiplex detection probes
US20080253960A1 (en) 2004-04-01 2008-10-16 The Trustees Of The University Of Pennsylvania Center For Technology Transfer Lipoprotein-Based Nanoplatforms
JP2005315688A (ja) 2004-04-28 2005-11-10 Japan Science & Technology Agency 酸化傷害タンパク質解析用タグ、及び該タグを用いる酸化傷害タンパク質の検出方法
US20070054345A1 (en) 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US7618780B2 (en) 2004-05-20 2009-11-17 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
DE602005019600D1 (de) 2004-09-20 2010-04-08 Univ Florida Systeme und verfahren zur auswertung der wirksamkeit von enzymen
US7329506B2 (en) 2004-12-03 2008-02-12 Rutgers, The State University Apparatuses and methods for determining protease activity
AU2005318097A1 (en) 2004-12-22 2006-06-29 Kuros Biosurgery Ag Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors
US20070207555A1 (en) 2005-02-03 2007-09-06 Cesar Guerra Ultra-sensitive detection systems using multidimension signals
US20060257883A1 (en) 2005-05-10 2006-11-16 Bjoraker David G Detection and measurement of hematological parameters characterizing cellular blood components
JP2007024631A (ja) 2005-07-14 2007-02-01 Human Science Shinko Zaidan 同位体標識法
EP1999150A1 (en) 2005-11-08 2008-12-10 Oxford Genome Sciences (UK) Limited New protein isoforms and uses thereof
CA2630559A1 (en) 2005-11-21 2007-05-24 Protox Therapeutics Incorporated Modified pore-forming protein toxins and use thereof
EP1957983A4 (en) 2005-11-21 2010-03-24 Univ Columbia DIGITAL MULTIPLEX IMMUNE PRESENCE USING A LIBRARY OF PHOTOSPARABLE MASS DAYS
GB0524313D0 (en) 2005-11-29 2006-01-04 Imp College Innovations Ltd Particles
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
EP1808187A1 (en) 2006-01-11 2007-07-18 Straumann Holding AG Cell selective implant surface with controlled release of bioactive agents
US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
US20080026480A1 (en) 2006-02-14 2008-01-31 Perkinelmer Las, Inc. Detection systems for mass labels
US7468258B2 (en) 2006-03-07 2008-12-23 Wake Forest University Health Sciences Self-quenching homofluorophore compositions for detecting enzyme activity
CA2644694C (en) 2006-03-10 2014-05-13 Sangeeta N. Bhatia Triggered self-assembly conjugates and nanosystems
US7906341B2 (en) 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US20080113875A1 (en) 2006-09-08 2008-05-15 Pierre Chaurand Molecular detection by matrix free desorption ionization mass spectrometry
US7696309B2 (en) 2006-10-23 2010-04-13 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
EP2099496A2 (en) 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
JPWO2008072676A1 (ja) 2006-12-12 2010-04-02 国立大学法人 鹿児島大学 新規疾患マーカーおよびそれを用いた診断
GB0701821D0 (en) 2007-02-01 2007-03-14 Pentapharm Ag Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid
KR20090113908A (ko) 2007-02-23 2009-11-02 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 금속단백질 활성 억제용 항체 및 이를 함유하는 약학적 조성물
KR100857770B1 (ko) * 2007-04-11 2008-09-09 한국과학기술연구원 단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도
US8278057B2 (en) 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
JP5604782B2 (ja) * 2007-09-28 2014-10-15 独立行政法人農業・食品産業技術総合研究機構 受容体再構築物、ならびにこれを用いる疾病検査法
WO2009054913A1 (en) 2007-10-19 2009-04-30 The Charles Stark Draper Laboratory, Inc. Rapid detection of volatile organic compounds for identification of bacteria in a sample
US20090286286A1 (en) 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
EP2229147A2 (en) 2007-12-03 2010-09-22 The Johns Hopkins University Methods of synthesis and use of chemospheres
JP2011517934A (ja) 2008-03-03 2011-06-23 カンザス ステイト ユニバーシティ リサーチ ファウンデーション プロテアーゼアッセイ
WO2009124265A1 (en) 2008-04-03 2009-10-08 The Board Of Trustees Of The Leland Stanford Junior University Probes for in vivo targeting of active cysteine proteases
KR101103548B1 (ko) 2008-08-29 2012-01-09 한국과학기술연구원 단백질분해효소 활성 측정용 나노입자 센서 및 그 제조방법
ES2890501T3 (es) 2009-03-02 2022-01-20 Massachusetts Inst Technology Métodos y productos para la creación de perfiles enzimáticos in vivo
EP2435096A1 (en) 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
JP2012533560A (ja) 2009-07-15 2012-12-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞における取り込みが制御可能なペプチド
WO2011127210A1 (en) 2010-04-06 2011-10-13 Massachusetts Institute Of Technology Targeted delivery of nucleic acids
EP2603231B1 (en) 2010-07-13 2021-12-29 Rhode Island Board Of Governors For Higher Education Compositions comprising a pH-sensitive membrane insertion polipeptide.
EP2603201B1 (en) 2010-08-13 2020-03-11 Rhode Island Board of Governors for Higher Education Liposome compositions and methods of use thereof
US20120055055A1 (en) 2010-09-02 2012-03-08 Illumin8 Outdoor Media, LLC Systems and Method for Outdoor Media Signage
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
IT1403720B1 (it) 2010-12-22 2013-10-31 Univ Padova Metodo di rilevamento di un enzima proteolitico mediante amplificazione di un segnale catalizzata da nanoparticelle di oro
CA2830235C (en) 2011-03-15 2023-10-24 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
CA2841238C (en) 2011-07-08 2019-10-01 Biosynthema Inc. Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors
EP2788496B1 (en) 2011-12-06 2017-09-27 Meon Medical Solutions GmbH & Co. KG Method of diagnosing pneumonia by detecting a volatile organic compound
CN102558362A (zh) 2012-02-17 2012-07-11 东莞金朗生物科技有限公司 一种用于治疗糖尿病的融合蛋白及其制备方法
JP6375289B2 (ja) 2012-04-05 2018-08-15 マサチューセッツ インスティテュート オブ テクノロジー 免疫刺激組成物およびその使用方法
CN104540518A (zh) 2012-04-27 2015-04-22 西托姆克斯治疗公司 结合表皮生长因子受体的可活化的抗体其使用方法
US9731029B2 (en) 2012-05-21 2017-08-15 Massachusetts Institute Of Technology Protein retrosplicing enabled by a double ligation reaction
CN103012595B (zh) 2012-12-17 2014-05-21 同昕生物技术(北京)有限公司 稳定的NT-proBNP校准品及应用
CA2896282C (en) 2013-01-04 2021-07-20 Cytomx Therapeutics, Inc. Compositions and methods for detecting protease activity in biological systems
CA2899170C (en) 2013-01-30 2022-08-02 Ngm Biopharmaceuticals, Inc. Compositions and methods of use in treating metabolic disorders
AU2014212308B2 (en) 2013-01-30 2018-08-09 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US10791937B2 (en) 2013-03-14 2020-10-06 Lumicell, Inc. Medical imaging device and methods of use
WO2014176284A1 (en) 2013-04-22 2014-10-30 Avelas Biosciences, Inc. Selective drug delivery compositions and methods of use
WO2014197816A1 (en) 2013-06-06 2014-12-11 Massachusetts Institute Of Technology Stimulus responsive nanocomplexes and methods of use thereof
JP6847660B2 (ja) 2013-06-07 2021-03-24 マサチューセッツ インスティテュート オブ テクノロジー リガンドをコードする合成バイオマーカーのアフィニティベースの検出
US20160184459A1 (en) 2013-08-09 2016-06-30 The Research Foundation For The State University Of New York Cancer cell specific imaging probes and methods of use
EP3046572B1 (en) 2013-09-17 2025-07-30 Blaze Bioscience, Inc. Chlorotoxin conjugates and methods of use thereof
US20150080721A1 (en) 2013-09-17 2015-03-19 Blaze Bioscience, Inc. Detection of tumor microenvironment with chlorotoxin conjugates
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
CN114533898B (zh) 2015-07-09 2025-07-01 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
US11090358B2 (en) 2015-09-09 2021-08-17 Fred Hutchinson Cancer Research Center Cartilage-homing peptides
EP3400299B1 (en) 2016-01-08 2020-11-11 University of Georgia Research Foundation, Inc. Methods for cleaving dna and rna molecules
US20170267727A1 (en) 2016-03-04 2017-09-21 Lehigh University Conjugates of pH Low Insertion Peptide and Monomethyl Auristatins in the Treatment of Solid Tumors
WO2017177115A1 (en) 2016-04-08 2017-10-12 Massachusetts Institute Of Technology Methods to specifically profile protease activity at lymph nodes
US20190161523A1 (en) 2016-04-12 2019-05-30 Blaze Bioscience, Inc. Methods of treatment using chlorotoxin conjugates
WO2017181149A1 (en) 2016-04-15 2017-10-19 Blaze Bioscience, Inc. Methods of treating breast cancer
US11428689B2 (en) 2016-05-05 2022-08-30 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
US20190375786A1 (en) 2016-09-09 2019-12-12 Fred Hutchinson Cancer Research Center Stable peptides and methods of use thereof
WO2018064383A1 (en) 2016-09-28 2018-04-05 Georgia Tech Research Corporation Methods and compositions for noninvasive detection of organ transplant rejection
CA3059358A1 (en) 2017-04-07 2018-10-11 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
WO2018227132A1 (en) 2017-06-09 2018-12-13 Rhode Island Council On Postsecondary Education Linked and other ph-triggered compounds
US20190076081A1 (en) 2017-09-12 2019-03-14 Elwha Llc Systems, compositions, and methods for targeted challenge and identification of gut microbiota
EP3692146A4 (en) 2017-10-04 2021-06-30 The Broad Institute, Inc. DIAGNOSTICS BASED ON CRISPR EFFECTOR SYSTEM
WO2019075292A1 (en) 2017-10-12 2019-04-18 Massachusetts Institute Of Technology PROSTATE CANCER PROTEIN NANOCATORS AND USES THEREOF
JP2021503278A (ja) 2017-11-01 2021-02-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア CasZ組成物及び使用方法
WO2019089804A1 (en) 2017-11-01 2019-05-09 The Regents Of The University Of California Casy compositions and methods of use
US10253365B1 (en) 2017-11-22 2019-04-09 The Regents Of The University Of California Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs
CN111836903A (zh) 2017-12-22 2020-10-27 博德研究所 基于crispr效应系统的多重诊断
WO2019126762A2 (en) 2017-12-22 2019-06-27 The Broad Institute, Inc. Cas12a systems, methods, and compositions for targeted rna base editing
EP3728576A4 (en) 2017-12-22 2021-11-24 The Broad Institute, Inc. CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF RNA BASES
BR112020015093A2 (pt) 2018-01-29 2020-12-08 The Broad Institute, Inc. Diagnóstico baseado no sistema de efetor crispr
CN108484847A (zh) 2018-02-27 2018-09-04 同济大学 一种含金纳米粒子的多重响应性嵌段共聚物纳米材料的制备方法
US11054428B2 (en) 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
US11732009B2 (en) 2018-06-08 2023-08-22 Glympse Bio, Inc. Activity sensor with tunable analyte
EP3856921B1 (en) 2018-09-25 2026-04-29 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
US20200116725A1 (en) 2018-10-16 2020-04-16 Massachusetts Institute Of Technology Renal clearable nanocatalysts for disease monitoring
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
US20210262025A1 (en) 2020-02-18 2021-08-26 Massachusetts Institute Of Technology Multiplexed in vivo disease sensing with nucleic acid-barcoded reporters

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