CN105452481A - 基于亲和力检测配体编码的合成性生物标记物 - Google Patents

基于亲和力检测配体编码的合成性生物标记物 Download PDF

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Publication number
CN105452481A
CN105452481A CN201480044141.1A CN201480044141A CN105452481A CN 105452481 A CN105452481 A CN 105452481A CN 201480044141 A CN201480044141 A CN 201480044141A CN 105452481 A CN105452481 A CN 105452481A
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Prior art keywords
enzyme
detectable
methods according
responsive
biomarker
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CN201480044141.1A
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English (en)
Chinese (zh)
Inventor
S·N·巴哈蒂亚
D·K·伍德
G·A·黄
A·D·瓦尔林
K·Y·林
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Priority to CN202311329945.3A priority Critical patent/CN118010994A/zh
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Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201480044141.1A 2013-06-07 2014-06-06 基于亲和力检测配体编码的合成性生物标记物 Pending CN105452481A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311329945.3A CN118010994A (zh) 2013-06-07 2014-06-06 基于亲和力检测配体编码的合成性生物标记物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361832766P 2013-06-07 2013-06-07
US61/832,766 2013-06-07
PCT/US2014/041370 WO2014197840A1 (en) 2013-06-07 2014-06-06 Affinity-based detection of ligand-encoded synthetic biomarkers

Related Child Applications (1)

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CN202311329945.3A Division CN118010994A (zh) 2013-06-07 2014-06-06 基于亲和力检测配体编码的合成性生物标记物

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CN105452481A true CN105452481A (zh) 2016-03-30

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CN201480044141.1A Pending CN105452481A (zh) 2013-06-07 2014-06-06 基于亲和力检测配体编码的合成性生物标记物
CN202311329945.3A Pending CN118010994A (zh) 2013-06-07 2014-06-06 基于亲和力检测配体编码的合成性生物标记物

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Country Link
US (2) US10527619B2 (https=)
EP (1) EP3004374B1 (https=)
JP (3) JP6847660B2 (https=)
CN (2) CN105452481A (https=)
CA (1) CA2914754A1 (https=)
ES (1) ES2828985T3 (https=)
WO (1) WO2014197840A1 (https=)

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CN110268054A (zh) * 2016-11-16 2019-09-20 通用生物传感器有限公司 切割事件转导方法和产品
CN110494714A (zh) * 2017-01-27 2019-11-22 麻省理工学院 确定表面特征
CN115989390A (zh) * 2020-08-20 2023-04-18 豪夫迈·罗氏有限公司 冻干物保持器、其制造方法以及干燥底物的过程
CN116029977A (zh) * 2022-11-08 2023-04-28 安徽萍聚德医疗科技股份有限公司 测定胃肠动力标记物在结直肠传输时间的鉴定分析方法
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JP6752231B2 (ja) 2015-06-01 2020-09-09 カリフォルニア インスティテュート オブ テクノロジー 抗原を用いて特異的集団に関してｔ細胞をスクリーニングするための組成物および方法
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JP7740987B2 (ja) 2019-02-28 2025-09-17 ジョージア・テック・リサーチ・コーポレーション 生物学的活性の論理ゲート化プロファイリングのための組成物および方法
US20210262025A1 (en) 2020-02-18 2021-08-26 Massachusetts Institute Of Technology Multiplexed in vivo disease sensing with nucleic acid-barcoded reporters
US20220049283A1 (en) * 2020-08-14 2022-02-17 Weiwei Li Li Method of detecting SARS-CoV-2 cleavage targeted proprotein convertase and facilitated protease activity
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