JP2016519065A5 - - Google Patents
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- JP2016519065A5 JP2016519065A5 JP2016502113A JP2016502113A JP2016519065A5 JP 2016519065 A5 JP2016519065 A5 JP 2016519065A5 JP 2016502113 A JP2016502113 A JP 2016502113A JP 2016502113 A JP2016502113 A JP 2016502113A JP 2016519065 A5 JP2016519065 A5 JP 2016519065A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- acid sequence
- amino acid
- seq
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 132
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 90
- 229920001184 polypeptide Polymers 0.000 claims description 88
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 81
- 230000003993 interaction Effects 0.000 claims description 24
- 230000004927 fusion Effects 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 17
- 150000007523 nucleic acids Chemical group 0.000 claims description 15
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 12
- 230000003834 intracellular effect Effects 0.000 claims description 9
- 238000005415 bioluminescence Methods 0.000 claims description 8
- 230000029918 bioluminescence Effects 0.000 claims description 8
- 238000004020 luminiscence type Methods 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims 1
- 239000012634 fragment Substances 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 102000037865 fusion proteins Human genes 0.000 description 7
- 108020001507 fusion proteins Proteins 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108091035707 Consensus sequence Proteins 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791549P | 2013-03-15 | 2013-03-15 | |
| US61/791,549 | 2013-03-15 | ||
| PCT/US2014/026354 WO2014151736A1 (en) | 2013-03-15 | 2014-03-13 | Activation of bioluminescence by structural complementation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013133A Division JP7280842B2 (ja) | 2013-03-15 | 2020-01-30 | 構造的相補性による生物発光の活性化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519065A JP2016519065A (ja) | 2016-06-30 |
| JP2016519065A5 true JP2016519065A5 (cg-RX-API-DMAC7.html) | 2017-04-13 |
| JP6654557B2 JP6654557B2 (ja) | 2020-02-26 |
Family
ID=51581027
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502113A Active JP6654557B2 (ja) | 2013-03-15 | 2014-03-13 | 構造的相補性による生物発光の活性化 |
| JP2020013133A Active JP7280842B2 (ja) | 2013-03-15 | 2020-01-30 | 構造的相補性による生物発光の活性化 |
| JP2023004036A Active JP7532562B2 (ja) | 2013-03-15 | 2023-01-13 | 構造的相補性による生物発光の活性化 |
| JP2024124929A Pending JP2024167207A (ja) | 2013-03-15 | 2024-07-31 | 構造的相補性による生物発光の活性化 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013133A Active JP7280842B2 (ja) | 2013-03-15 | 2020-01-30 | 構造的相補性による生物発光の活性化 |
| JP2023004036A Active JP7532562B2 (ja) | 2013-03-15 | 2023-01-13 | 構造的相補性による生物発光の活性化 |
| JP2024124929A Pending JP2024167207A (ja) | 2013-03-15 | 2024-07-31 | 構造的相補性による生物発光の活性化 |
Country Status (15)
| Country | Link |
|---|---|
| US (11) | US9797890B2 (cg-RX-API-DMAC7.html) |
| EP (4) | EP4177261A1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6654557B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20230079494A (cg-RX-API-DMAC7.html) |
| CN (2) | CN117024548A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2014236949C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015023394B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2906063C (cg-RX-API-DMAC7.html) |
| DK (2) | DK2970412T5 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2926463T3 (cg-RX-API-DMAC7.html) |
| IL (3) | IL286816B (cg-RX-API-DMAC7.html) |
| PL (2) | PL2970412T3 (cg-RX-API-DMAC7.html) |
| PT (2) | PT3783011T (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201601929YA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014151736A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4177261A1 (en) | 2013-03-15 | 2023-05-10 | Promega Corporation | Activation of bioluminescence by structural complementation |
| US11365402B2 (en) | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
| JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 内部タンパク質タグ |
| EP3254113B1 (en) * | 2015-02-05 | 2024-10-09 | Promega Corporation | Luciferase-based thermal shift assays |
| US10634680B2 (en) | 2016-04-26 | 2020-04-28 | University Of Utah Research Foundation | Target-binding activated split reporter systems for analyte detection and related components and methods |
| CA3040507A1 (en) | 2016-10-20 | 2018-04-26 | President And Fellows Of Harvard College | In vitro and cell based assays for measuring the activity of botulinum neurotoxins |
| CA3022981C (en) * | 2017-11-01 | 2025-05-06 | Queen's University At Kingston | HIPPO BIOLUMINOUS TRAIL BIOSENSOR |
| JP7248693B2 (ja) * | 2018-02-26 | 2023-03-29 | テクニーシェ・ユニバーシタイト・アイントホーベン | 溶液中の生物分子またはリガンドを検出し、定量化する生物発光バイオセンサー |
| EP4140991B1 (en) | 2018-06-01 | 2024-05-15 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| EP3807419A4 (en) * | 2018-06-12 | 2022-09-07 | Promega Corporation | MULTIPLE LUCIFERASE |
| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| CN119955899A (zh) | 2018-10-03 | 2025-05-09 | 普洛麦格公司 | 用于稳定腔肠素及其类似物和衍生物的组合物、方法和试剂盒 |
| WO2020113036A2 (en) | 2018-11-28 | 2020-06-04 | Promega Corporation | Reactive peptide labeling |
| US20200200765A1 (en) | 2018-12-04 | 2020-06-25 | Promega Corporation | Broad spectrum gpcr binding agents |
| US11913944B2 (en) | 2019-03-20 | 2024-02-27 | Promega Corporation | Photoaffinity probes |
| EP3953374A4 (en) * | 2019-04-10 | 2023-06-07 | Promega Corporation | COMPOSITIONS AND METHODS FOR DETECTION OF ANALYTES USING BIOLUMINESCENCE |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| US20200399660A1 (en) | 2019-06-24 | 2020-12-24 | Promega Corporation | Modified polyamine polymers for delivery of biomolecules into cells |
| DE102019127894B4 (de) * | 2019-10-16 | 2022-05-12 | Sensor-Instruments Entwicklungs- Und Vertriebs-Gmbh | Produktkennzeichnungssystem und verfahren zur kennzeichnung eines produkts |
| CA3155743A1 (en) * | 2019-11-22 | 2021-05-27 | The Regents Of The University Of California | Split-enzyme system to detect specific dna in living cells |
| KR20220121816A (ko) | 2019-11-27 | 2022-09-01 | 프로메가 코포레이션 | 다분할 루시퍼라제 펩타이드 및 폴리펩타이드 |
| WO2021119149A1 (en) | 2019-12-10 | 2021-06-17 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
| WO2021194343A1 (en) | 2020-03-25 | 2021-09-30 | Erasmus University Medical Center Rotterdam | Reporter system for radionuclide imaging |
| US20230176057A1 (en) * | 2020-05-11 | 2023-06-08 | Chan Zuckerberg Biohub, Inc. | Detection assay for sars-cov-2 virus |
| WO2021237118A2 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
| EP4204808A1 (en) | 2020-08-28 | 2023-07-05 | Promega Corporation | Target engagement assay for ras proteins |
| WO2022245922A1 (en) * | 2021-05-18 | 2022-11-24 | The Board Of Regents Of The University Of Texas System | Poly-adp ribose (par) tracker optimized split-protein reassembly par detection reagents |
| WO2023215497A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Photoactivatable compounds and uses thereof |
| US20240060059A1 (en) | 2022-05-04 | 2024-02-22 | Promega Corporation | Circularly permuted dehalogenase variants |
| US20240174992A1 (en) | 2022-05-04 | 2024-05-30 | Promega Corporation | Split modified dehalogenase variants |
| US20240132859A1 (en) | 2022-05-04 | 2024-04-25 | Promega Corporation | Modified dehalogenase with extended surface loop regions |
| WO2024151471A1 (en) * | 2023-01-09 | 2024-07-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High-throughput assay based on ligand-biased structural dynamics response |
| WO2024217577A1 (zh) * | 2023-04-21 | 2024-10-24 | 深圳琅技生命科技有限公司 | 一种肽以及含有该肽的发光复合物 |
| AU2024265176A1 (en) * | 2023-05-04 | 2025-12-11 | Promega Corporation | Complementation-based tags and reporters for dual-modality labeling |
| WO2025064581A1 (en) * | 2023-09-18 | 2025-03-27 | The Brigham And Women’S Hospital, Inc. | Biosensor platform for the rapid detection of analytes |
| WO2025158412A1 (en) | 2024-01-26 | 2025-07-31 | Biohaven Therapeutics Ltd. | BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS |
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| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5756688A (en) | 1992-10-14 | 1998-05-26 | Sterling Winthrop Inc. | MR imaging compositions and methods |
| ES2105332T3 (es) | 1992-10-14 | 1997-10-16 | Nycomed Imaging As | Polimeros quelantes. |
| GB9503969D0 (en) | 1995-02-28 | 1995-04-19 | Sams Bernard | Incrementing mechanism |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US5879739A (en) | 1997-02-20 | 1999-03-09 | Tower Semiconductor Ltd. | Batch process for forming metal plugs in a dielectric layer of a semiconductor wafer |
| EP1156103B1 (en) * | 2000-04-26 | 2010-08-11 | Chisso Corporation | Oplophorus luciferase |
| JP4613441B2 (ja) * | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
| US20040181830A1 (en) | 2001-05-07 | 2004-09-16 | Kovalic David K. | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US7008642B1 (en) | 2001-02-12 | 2006-03-07 | Advanced Cardiovascular Systems, Inc. | Compositions for achieving a therapeutic effect in an anatomical structure and methods of using the same |
| US7195884B2 (en) | 2002-07-19 | 2007-03-27 | Promega Corp. | Methods and kits for transferases |
| AU2003283995A1 (en) * | 2002-09-30 | 2004-04-19 | Protein Design Labs, Inc. | Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes |
| US7237811B1 (en) * | 2005-04-20 | 2007-07-03 | Lawrence Barry G | Casement window latch assembly |
| WO2007041251A2 (en) | 2005-09-30 | 2007-04-12 | Montana State University | System for detecting protein-protein interactions |
| US7601517B2 (en) | 2006-01-10 | 2009-10-13 | Stanford University | Split protein self complementing fragments, systems, and methods of use thereof |
| WO2007132461A2 (en) | 2006-05-11 | 2007-11-22 | Ramot At Tel Aviv University Ltd. | Classification of protein sequences and uses of classified proteins |
| US20090075313A1 (en) | 2007-05-04 | 2009-03-19 | Stanford University | Split protein fragments, split protein systems, methods of making split protein systems, and methods of using split protein systems |
| WO2009058364A1 (en) | 2007-11-01 | 2009-05-07 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Cell-free methods for detecting protein-ligand interctions |
| EP2222328A4 (en) * | 2007-11-15 | 2013-06-05 | Endocyte Inc | PROCESS FOR THE ADMINISTRATION OF CONJUGATES |
| JP5582505B2 (ja) | 2009-02-09 | 2014-09-03 | Ｊｎｃ株式会社 | セレンテラジン類縁体及びその製造方法 |
| WO2010119721A1 (ja) | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
| EP3181687B1 (en) | 2009-05-01 | 2018-08-08 | Promega Corporation | Synthetic oplophorus luciferases with enhanced light output |
| EP2550529B1 (en) * | 2010-03-23 | 2021-11-17 | Iogenetics, LLC. | Bioinformatic processes for determination of peptide binding |
| EP3498709B1 (en) | 2010-11-02 | 2025-12-31 | Promega Corporation | Luciferases from Oplophorus: Novel Coelenterazine Substrates and Their Methods of Use |
| US20150125438A1 (en) * | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
| KR102150479B1 (ko) * | 2012-12-12 | 2020-09-01 | 프로메가 코포레이션 | 세포내 생물발광 공명 에너지 전이를 이용하여 생물활성제에 의한 세포 표적 결합의 인식 |
| EP4177261A1 (en) * | 2013-03-15 | 2023-05-10 | Promega Corporation | Activation of bioluminescence by structural complementation |
| JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 内部タンパク質タグ |
-
2014
- 2014-03-13 EP EP22182344.6A patent/EP4177261A1/en active Pending
- 2014-03-13 PL PL14769752.8T patent/PL2970412T3/pl unknown
- 2014-03-13 CA CA2906063A patent/CA2906063C/en active Active
- 2014-03-13 US US14/209,610 patent/US9797890B2/en active Active
- 2014-03-13 KR KR1020237017712A patent/KR20230079494A/ko active Pending
- 2014-03-13 PL PL20197758.4T patent/PL3783011T3/pl unknown
- 2014-03-13 SG SG10201601929YA patent/SG10201601929YA/en unknown
- 2014-03-13 DK DK14769752.8T patent/DK2970412T5/da active
- 2014-03-13 EP EP20197758.4A patent/EP3783011B1/en active Active
- 2014-03-13 JP JP2016502113A patent/JP6654557B2/ja active Active
- 2014-03-13 EP EP22196592.4A patent/EP4169935A1/en active Pending
- 2014-03-13 PT PT201977584T patent/PT3783011T/pt unknown
- 2014-03-13 SG SG11201507306VA patent/SG11201507306VA/en unknown
- 2014-03-13 PT PT147697528T patent/PT2970412T/pt unknown
- 2014-03-13 EP EP14769752.8A patent/EP2970412B1/en active Active
- 2014-03-13 CN CN202310649630.0A patent/CN117024548A/zh active Pending
- 2014-03-13 ES ES14769752T patent/ES2926463T3/es active Active
- 2014-03-13 IL IL286816A patent/IL286816B/en unknown
- 2014-03-13 KR KR1020157024687A patent/KR20150129721A/ko not_active Ceased
- 2014-03-13 US US14/209,546 patent/US9797889B2/en active Active
- 2014-03-13 CN CN201480015213.XA patent/CN105143249A/zh active Pending
- 2014-03-13 ES ES20197758T patent/ES2929362T3/es active Active
- 2014-03-13 KR KR1020217008951A patent/KR102675860B1/ko active Active
- 2014-03-13 BR BR112015023394A patent/BR112015023394B8/pt active IP Right Grant
- 2014-03-13 DK DK20197758.4T patent/DK3783011T5/da active
- 2014-03-13 AU AU2014236949A patent/AU2014236949C1/en active Active
- 2014-03-13 WO PCT/US2014/026354 patent/WO2014151736A1/en not_active Ceased
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2015
- 2015-09-01 IL IL240985A patent/IL240985B/en active IP Right Grant
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2016
- 2016-03-17 US US15/073,249 patent/US9869670B2/en active Active
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2017
- 2017-09-27 US US15/717,534 patent/US10107800B2/en active Active
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2018
- 2018-02-19 US US15/899,219 patent/US10184936B2/en active Active
- 2018-06-29 US US16/023,972 patent/US10288605B2/en active Active
- 2018-07-13 US US16/035,117 patent/US10648971B2/en active Active
- 2018-10-31 AU AU2018256548A patent/AU2018256548B2/en active Active
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2020
- 2020-01-30 JP JP2020013133A patent/JP7280842B2/ja active Active
- 2020-04-16 IL IL273989A patent/IL273989B/en unknown
- 2020-04-17 US US16/851,841 patent/US11493504B2/en active Active
- 2020-08-04 AU AU2020213288A patent/AU2020213288B2/en active Active
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2022
- 2022-11-07 US US18/053,273 patent/US12367513B2/en active Active
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2023
- 2023-01-13 JP JP2023004036A patent/JP7532562B2/ja active Active
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2024
- 2024-07-31 JP JP2024124929A patent/JP2024167207A/ja active Pending
- 2024-09-19 US US18/890,453 patent/US12366572B2/en active Active
- 2024-09-23 US US18/893,549 patent/US20250045806A1/en active Pending
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