ES2105332T3 - Polimeros quelantes. - Google Patents
Polimeros quelantes.Info
- Publication number
- ES2105332T3 ES2105332T3 ES93923302T ES93923302T ES2105332T3 ES 2105332 T3 ES2105332 T3 ES 2105332T3 ES 93923302 T ES93923302 T ES 93923302T ES 93923302 T ES93923302 T ES 93923302T ES 2105332 T3 ES2105332 T3 ES 2105332T3
- Authority
- ES
- Spain
- Prior art keywords
- polymer
- chelating polymers
- diagnostic
- pursuant
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyamides (AREA)
- Polyethers (AREA)
Abstract
SEGUN ESTA INVENCION, SE PRESENTA UN POLIMERO QUE CONTIENE UNIDADES QUE CONTIENEN EL RESIDUO DE UN AGENTE QUELANTE ENLAZADO A UNA UNIDAD DE POLI(OXIDO DE ALQUILENO) Y UN METODO PARA LA PREPARACION DEL MISMO. EL POLIMERO ES PARTICULARMENTE UTIL PARA COMPOSICIONES FORMADORAS DE IMAGENES TERAPEUTICAS Y DE DIAGNOSTICO Y COMO AGENTE ANTIESTATICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96114692A | 1992-10-14 | 1992-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2105332T3 true ES2105332T3 (es) | 1997-10-16 |
Family
ID=25504123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93923302T Expired - Lifetime ES2105332T3 (es) | 1992-10-14 | 1993-10-07 | Polimeros quelantes. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5583206A (es) |
EP (1) | EP0664819B1 (es) |
JP (1) | JPH08502528A (es) |
KR (1) | KR950703582A (es) |
AU (1) | AU5323794A (es) |
CA (1) | CA2146990A1 (es) |
DE (1) | DE69312951T2 (es) |
ES (1) | ES2105332T3 (es) |
HK (1) | HK1001498A1 (es) |
WO (1) | WO1994009056A1 (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5559214A (en) * | 1993-05-28 | 1996-09-24 | Sterling Winthrop Inc. | Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods |
US5730968A (en) * | 1994-03-31 | 1998-03-24 | Sterling Winthrop Inc. | Segmented chelating polymers as imaging and therapeutic agents |
US5801228A (en) * | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
US5859215A (en) * | 1995-10-25 | 1999-01-12 | Wallac Oy | Biospecific binding reactants labelled with luminescent lanthanide chelates and their use |
WO1998010797A2 (en) * | 1996-09-12 | 1998-03-19 | Nycomed Imaging As | Marker compositions |
US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
US6896874B2 (en) * | 1998-05-26 | 2005-05-24 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
US6361759B1 (en) * | 1998-05-26 | 2002-03-26 | Wisconsin Alumni Research Foundation | MR signal-emitting coatings |
EP1063254A1 (de) * | 1999-06-25 | 2000-12-27 | Technische Uni München, Klinikum rechts der Isar, Inst. für Experiment. Onkoligie und Therapieforschung | Copolymere für den Transport von Nukleinsäuren in die Zelle |
AU776715B2 (en) * | 1999-06-25 | 2004-09-16 | Christian Plank | Combinations for introducing nucleic acids into cells |
US6756037B2 (en) | 2000-03-31 | 2004-06-29 | Enzon, Inc. | Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups |
US6777387B2 (en) | 2000-03-31 | 2004-08-17 | Enzon Pharmaceuticals, Inc. | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same |
US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
DE60223499T2 (de) * | 2001-02-20 | 2008-10-16 | Enzon, Inc. | Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate |
US20040253292A1 (en) * | 2003-04-23 | 2004-12-16 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
KR101419056B1 (ko) | 2005-04-29 | 2014-07-11 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 다층 폴리우레탄 보호 필름 |
JP5192384B2 (ja) | 2005-09-22 | 2013-05-08 | メディバス エルエルシー | ビス−(α−アミノ)−ジオール−ジエステル含有ポリ(エステルアミド)およびポリ(エステルウレタン)組成物および使用の方法 |
JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
US20070156042A1 (en) * | 2005-12-30 | 2007-07-05 | Orhan Unal | Medical device system and method for tracking and visualizing a medical device system under MR guidance |
US8457712B2 (en) * | 2005-12-30 | 2013-06-04 | Wisconsin Alumni Research Foundation | Multi-mode medical device system and methods of manufacturing and using same |
DOP2007000020A (es) | 2006-01-31 | 2007-09-15 | Bayer Schering Pharma Ag | Modulación de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias |
US8532742B2 (en) * | 2006-11-15 | 2013-09-10 | Wisconsin Alumni Research Foundation | System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions |
CN101541857B (zh) * | 2006-11-27 | 2012-12-12 | 阿克塔马克斯手术器材有限责任公司 | 多官能聚环氧烷、水凝胶和组织粘合剂 |
US20080183070A1 (en) * | 2007-01-29 | 2008-07-31 | Wisconsin Alumni Research Foundation | Multi-mode medical device system with thermal ablation capability and methods of using same |
US20080208039A1 (en) * | 2007-02-28 | 2008-08-28 | Wisconsin Alumni Research Foundation | System and method of performing therapeutic endovascular interventions |
EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
EP2072060A1 (en) | 2007-12-18 | 2009-06-24 | Institut Curie | Methods and compositions for the preparation and use of toxin conjugates. |
US20100004313A1 (en) * | 2008-02-29 | 2010-01-07 | Tbd | Modified Poloxamers for Gene Expression and Associated Methods |
WO2009137711A1 (en) * | 2008-05-07 | 2009-11-12 | Medivas, Llc | Biodegradable metal-chelating polymers and vaccines |
EP2161020A1 (en) * | 2008-09-09 | 2010-03-10 | Koninklijke Philips Electronics N.V. | Chelating amphiphilic polymers |
US20120027859A1 (en) * | 2008-10-15 | 2012-02-02 | Turnell William G | Biodegradable Proline-Based Polymers |
US8524457B2 (en) | 2009-09-22 | 2013-09-03 | William Patterson | Method for the selection of specific affinity binders by homogeneous noncompetitive assay |
US9125942B2 (en) | 2010-01-19 | 2015-09-08 | Northwestern University | Paramagnetic metal-nanodiamond conjugates |
US20120277517A1 (en) * | 2011-04-08 | 2012-11-01 | The Johns Hopkins University | Formulation and Methods for Enhanced Interventional Image-Guided Therapy of Cancer |
US20120271100A1 (en) | 2011-04-14 | 2012-10-25 | Northwestern University | Compositions and methods for the detection of zinc |
US9963549B2 (en) | 2011-06-23 | 2018-05-08 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
EP2823270B1 (en) | 2012-03-09 | 2022-05-04 | Promega Corporation | pH SENSORS |
US20140134665A1 (en) | 2012-11-15 | 2014-05-15 | Northwestern University | Compositions and methods for the detection of zinc |
US9551705B2 (en) | 2012-12-12 | 2017-01-24 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
DK3783011T5 (da) | 2013-03-15 | 2024-08-19 | Promega Corp | Aktivering af bioluminescens via strukturel komplementering |
CN106062565B (zh) | 2014-02-27 | 2018-06-08 | 宝洁公司 | 用于评估生物可利用的锌的方法 |
AU2015258962B2 (en) | 2014-05-15 | 2020-07-02 | Cleveland Heartlab, Inc. | Compositions and methods for purification and detection of HDL and ApoA1 |
EP3164507B1 (en) | 2014-07-02 | 2020-02-12 | Promega Corporation | Reversible metal ion chelators |
US9969991B2 (en) | 2014-09-12 | 2018-05-15 | Promega Corporation | Internal protein tags |
EP3233067B1 (en) | 2014-12-18 | 2019-11-06 | DSM IP Assets B.V. | Drug delivery system for delivery of acid sensitive drugs |
RU2602502C2 (ru) * | 2015-03-05 | 2016-11-20 | Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук | Способ получения радиофармпрепаратов класса поли-n-виниламидов с металлами группы марганца |
JP2018517793A (ja) | 2015-04-28 | 2018-07-05 | ローム アンド ハース エレクトロニック マテリアルズ エルエルシーRohm and Haas Electronic Materials LLC | 電気めっき浴用の添加剤としてのビス無水物及びジアミンの反応生成物 |
WO2016210290A1 (en) | 2015-06-26 | 2016-12-29 | Northwestern University | Gd(III)-DITHIOLANE GOLD NANOPARTICLE CONJUGATES |
NL2020578B1 (en) * | 2018-03-13 | 2019-09-20 | Xeikon Mfg Nv | A metal compound, use of the metal compound as a charge control agent composition and a chargeable toner composition |
EP3941195A4 (en) | 2019-03-20 | 2023-03-22 | Promega Corporation | PHOTOAFFINITY PROBES |
US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
AU2020392245A1 (en) | 2019-11-27 | 2022-06-23 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
US20230357266A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Photoactivatable compounds and uses thereof |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3562161A (en) * | 1968-10-08 | 1971-02-09 | Atlantic Richfield Co | Polyalkylene glycol esters of ethylene-diaminetetraacetic acid as lubricant dispersants |
US3859337A (en) * | 1969-06-11 | 1975-01-07 | Stauffer Chemical Co | Ethylenediaminetetraacetic acid anhydride derivatives |
USRE30885E (en) * | 1981-03-13 | 1982-03-23 | Cincinnati Milacron Inc. | Novel diamide and lubricants containing same |
US4859777A (en) * | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
CS226911B1 (en) * | 1981-10-28 | 1984-04-16 | Jaroslav Kahovec | Polymere polydonor komplexons and method of their manufacture polymere polydonor |
US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
US4972837A (en) * | 1983-04-26 | 1990-11-27 | Regents Of The University Of California | Contrast agents for nuclear magnetic resonance imaging |
JPS59215321A (ja) * | 1983-05-23 | 1984-12-05 | Sumitomo Chem Co Ltd | 二官能性配位子化合物を結合した反応性高分子 |
FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
US4943523A (en) * | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4602097A (en) * | 1984-06-11 | 1986-07-22 | Ulano Corporation | Water soluble photoinitiator benzophenone and thioxanthenone ethoxy-ether derivatives |
US4687659A (en) * | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
US4859451A (en) * | 1984-10-04 | 1989-08-22 | Salutar, Inc. | Paramagnetic contrast agents for MR imaging |
US4687658A (en) * | 1984-10-04 | 1987-08-18 | Salutar, Inc. | Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging |
EP0184899B1 (en) * | 1984-11-01 | 1990-04-18 | Nycomed As | Paramagnetic contrast agents for use in "in vivo" diagnostic methods using nmr, and their preparation |
SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
US4826673A (en) * | 1985-01-09 | 1989-05-02 | Mallinckrodt, Inc. | Methods and compositions for enhancing magnetic resonance imaging |
US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
US4746507A (en) * | 1985-04-02 | 1988-05-24 | Salutar, Inc. | EDHPA based contrast agents for MR imaging, apparatus and methods |
JPH084504B2 (ja) * | 1985-04-26 | 1996-01-24 | 味の素株式会社 | 安定化ス−パ−オキサイドジスムタ−ゼ |
SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
US4909257A (en) * | 1986-05-01 | 1990-03-20 | The Regents Of The University Of California | Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging |
US4814098A (en) * | 1986-09-06 | 1989-03-21 | Bellex Corporation | Magnetic material-physiologically active substance conjugate |
JPS63112622A (ja) * | 1986-10-30 | 1988-05-17 | Agency Of Ind Science & Technol | 多塩基酸ポリエ−テル誘導体及びそれからなる界面活性剤 |
US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
US4933441A (en) * | 1987-01-27 | 1990-06-12 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
DE3855239T2 (de) * | 1987-07-16 | 1996-10-31 | Nycomed Imaging As | Aminocarbonsäure und Derivate |
US5202423A (en) * | 1988-07-08 | 1993-04-13 | Wallac Oy | Terpyridine derivatives |
US5137711A (en) * | 1988-07-19 | 1992-08-11 | Mallickrodt Medical, Inc. | Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents |
GB8824593D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
SE465155B (sv) * | 1989-12-19 | 1991-08-05 | Exploaterings Ab Tbf | Metallkelatbildande hydrofil polymer foer adsorption etc samt ett saett foer framstaellning av polymeren |
DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
ATE153860T1 (de) * | 1990-04-10 | 1997-06-15 | Imarx Pharmaceutical Corp | Polymere und ihre verwendung als kontrastmittel bei der bilderzeugung mit magnetischer resonanz |
ES2068587T3 (es) * | 1990-05-30 | 1995-04-16 | Deutsches Krebsforsch | Medicamentos tumorales sustituidos con polieter. |
US5077037A (en) * | 1990-08-03 | 1991-12-31 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US5285719A (en) * | 1992-09-11 | 1994-02-15 | Gas Research Institute | Rapid frozen food thawing system |
US5407657A (en) * | 1992-09-22 | 1995-04-18 | Unger; Evan C. | Hybrid magnetic resonance contrast agents |
-
1993
- 1993-10-07 KR KR1019950701430A patent/KR950703582A/ko not_active Application Discontinuation
- 1993-10-07 EP EP93923302A patent/EP0664819B1/en not_active Expired - Lifetime
- 1993-10-07 DE DE69312951T patent/DE69312951T2/de not_active Expired - Fee Related
- 1993-10-07 CA CA002146990A patent/CA2146990A1/en not_active Abandoned
- 1993-10-07 AU AU53237/94A patent/AU5323794A/en not_active Abandoned
- 1993-10-07 JP JP6510122A patent/JPH08502528A/ja active Pending
- 1993-10-07 ES ES93923302T patent/ES2105332T3/es not_active Expired - Lifetime
- 1993-10-07 WO PCT/US1993/009587 patent/WO1994009056A1/en active IP Right Grant
-
1994
- 1994-11-28 US US08/348,197 patent/US5583206A/en not_active Expired - Fee Related
-
1998
- 1998-01-19 HK HK98100427A patent/HK1001498A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH08502528A (ja) | 1996-03-19 |
AU5323794A (en) | 1994-05-09 |
CA2146990A1 (en) | 1994-04-28 |
EP0664819B1 (en) | 1997-08-06 |
DE69312951T2 (de) | 1997-12-11 |
HK1001498A1 (en) | 1998-06-19 |
DE69312951D1 (de) | 1997-09-11 |
EP0664819A1 (en) | 1995-08-02 |
KR950703582A (ko) | 1995-09-20 |
US5583206A (en) | 1996-12-10 |
WO1994009056A1 (en) | 1994-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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