JP2016519051A5 - - Google Patents
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- Publication number
- JP2016519051A5 JP2016519051A5 JP2015562159A JP2015562159A JP2016519051A5 JP 2016519051 A5 JP2016519051 A5 JP 2016519051A5 JP 2015562159 A JP2015562159 A JP 2015562159A JP 2015562159 A JP2015562159 A JP 2015562159A JP 2016519051 A5 JP2016519051 A5 JP 2016519051A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- pcsk9
- mutein
- tear lipocalin
- human tear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781511P | 2013-03-14 | 2013-03-14 | |
| US61/781,511 | 2013-03-14 | ||
| EP13175023 | 2013-07-04 | ||
| EP13175023.4 | 2013-07-04 | ||
| PCT/EP2014/055013 WO2014140210A1 (en) | 2013-03-14 | 2014-03-13 | Novel binding proteins for pcsk9 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519051A JP2016519051A (ja) | 2016-06-30 |
| JP2016519051A5 true JP2016519051A5 (https=) | 2017-04-13 |
| JP6619650B2 JP6619650B2 (ja) | 2019-12-11 |
Family
ID=48703321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562159A Expired - Fee Related JP6619650B2 (ja) | 2013-03-14 | 2014-03-13 | 新規のｐｃｓｋ９結合タンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9150629B2 (https=) |
| EP (1) | EP2968490A1 (https=) |
| JP (1) | JP6619650B2 (https=) |
| KR (1) | KR20150131151A (https=) |
| CN (1) | CN105246503A (https=) |
| AU (1) | AU2014230460B2 (https=) |
| BR (1) | BR112015021681A2 (https=) |
| CA (1) | CA2905186A1 (https=) |
| HK (1) | HK1213194A1 (https=) |
| IL (1) | IL241329A0 (https=) |
| MX (1) | MX2015012420A (https=) |
| PH (1) | PH12015501687A1 (https=) |
| RU (1) | RU2015142437A (https=) |
| SG (1) | SG11201505856TA (https=) |
| WO (1) | WO2014140210A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| HK1213194A1 (zh) | 2013-03-14 | 2016-06-30 | Daiichi Sankyo Co., Ltd. | 用於新型的结合蛋白质pcsk9 |
| WO2015095553A1 (en) * | 2013-12-20 | 2015-06-25 | Nephrogenesis, Llc | Methods and apparatus for kidney dialysis |
| US9398085B2 (en) | 2014-11-07 | 2016-07-19 | Ringcentral, Inc. | Systems and methods for initiating a peer-to-peer communication session |
| CN114573680A (zh) | 2015-05-04 | 2022-06-03 | 皮里斯制药有限公司 | Cd137特异性的蛋白 |
| EA202092778A1 (ru) | 2018-05-16 | 2021-05-27 | ЛИБ ТЕРАПЬЮТИКС, ЭлЭлСи | Композиции, содержащие pcsk9-связывающие молекулы, и способы применения |
| EP3810177B1 (en) | 2018-06-21 | 2024-12-04 | Ra Pharmaceuticals, Inc. | Cyclic polypeptides for pcsk9 inhibition |
| WO2019246386A1 (en) | 2018-06-21 | 2019-12-26 | Ra Pharmaceuticals Inc. | Cyclic polypeptides for pcsk9 inhibition |
| IL279363B2 (en) | 2018-06-21 | 2025-12-01 | Merck Sharp & Dohme | Pcsk9 antagonist compounds |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| EP3946417A1 (en) * | 2019-03-29 | 2022-02-09 | Pieris Pharmaceuticals GmbH | Inhaled administration of lipocalin muteins |
| EP4076492A4 (en) | 2019-12-20 | 2024-01-17 | Merck Sharp & Dohme LLC | PCSK9 ANTAGONIST COMPOUNDS |
| WO2022021000A1 (zh) * | 2020-07-27 | 2022-02-03 | 深圳华大生命科学研究院 | 一种抗体结合的特征性表位及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| DK1087778T3 (da) | 1998-06-08 | 2005-12-19 | Hoffmann La Roche | Anvendelse af PEG-IFN-alfa og Ribavirin til behandling af kronisk hepatitis C |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| AU2002335930B2 (en) | 2001-03-09 | 2005-07-28 | Morphosys Ag | Serum albumin binding moieties |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| WO2003029471A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of apolipoprotein d |
| AT411852B (de) | 2002-02-12 | 2004-06-25 | Didosyan Yuri S Dr | Verfahren und vorrichtung zur änderung des polarisationszustandes von licht mit einem magnetisch einachsigen kristall |
| AU2003264100A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| US7892827B2 (en) | 2004-11-26 | 2011-02-22 | Pieris Ag | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
| JP2009509535A (ja) | 2005-09-27 | 2009-03-12 | アムニクス， インコーポレイテッド | タンパク様薬剤およびその使用 |
| US8598317B2 (en) * | 2006-03-20 | 2013-12-03 | Technische Universitaet Muenchen | Muteins of tear lipocalin with affinity for the T-cell coreceptor CD4 |
| EP2046820B1 (en) | 2006-08-01 | 2010-10-20 | Pieris AG | Muteins of tear lipocalin and methods for obtaining the same |
| US20100040611A1 (en) * | 2006-11-07 | 2010-02-18 | Sparrow Carl P | Antagonists of pcsk9 |
| WO2008057459A2 (en) * | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| EA200901376A1 (ru) * | 2007-04-13 | 2010-12-30 | Новартис Аг | Молекулы и способы модуляции пропротеинконвертазы субтилизинового/кексинового типа 9(pcsk9) |
| EP2190863B1 (en) | 2007-07-31 | 2015-09-02 | Affibody AB | New albumin binding compositions, methods and uses |
| PL2580236T3 (pl) * | 2010-06-08 | 2019-09-30 | Pieris Pharmaceuticals Gmbh | Muteiny lipokaliny łez wiążące IL-4 R alfa |
| CN103003296A (zh) | 2010-07-09 | 2013-03-27 | 阿菲博迪公司 | 多肽 |
| MY175188A (en) * | 2012-01-09 | 2020-06-13 | Pieris Ag | Methods for preventing, treating or diagnosing disorders |
| HK1213194A1 (zh) | 2013-03-14 | 2016-06-30 | Daiichi Sankyo Co., Ltd. | 用於新型的结合蛋白质pcsk9 |
-
2014
- 2014-03-13 HK HK16101229.3A patent/HK1213194A1/zh unknown
- 2014-03-13 EP EP14716250.7A patent/EP2968490A1/en not_active Withdrawn
- 2014-03-13 US US14/208,629 patent/US9150629B2/en active Active
- 2014-03-13 CA CA2905186A patent/CA2905186A1/en not_active Abandoned
- 2014-03-13 KR KR1020157028381A patent/KR20150131151A/ko not_active Ceased
- 2014-03-13 MX MX2015012420A patent/MX2015012420A/es unknown
- 2014-03-13 AU AU2014230460A patent/AU2014230460B2/en not_active Ceased
- 2014-03-13 JP JP2015562159A patent/JP6619650B2/ja not_active Expired - Fee Related
- 2014-03-13 BR BR112015021681A patent/BR112015021681A2/pt not_active Application Discontinuation
- 2014-03-13 WO PCT/EP2014/055013 patent/WO2014140210A1/en not_active Ceased
- 2014-03-13 CN CN201480012827.2A patent/CN105246503A/zh active Pending
- 2014-03-13 RU RU2015142437A patent/RU2015142437A/ru not_active Application Discontinuation
- 2014-03-13 SG SG11201505856TA patent/SG11201505856TA/en unknown
-
2015
- 2015-07-30 PH PH12015501687A patent/PH12015501687A1/en unknown
- 2015-08-28 US US14/839,222 patent/US9598476B2/en not_active Expired - Fee Related
- 2015-09-08 IL IL241329A patent/IL241329A0/en unknown
-
2017
- 2017-02-28 US US15/445,066 patent/US20170173112A1/en not_active Abandoned
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