JP2016517431A5 - - Google Patents
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- Publication number
- JP2016517431A5 JP2016517431A5 JP2016502761A JP2016502761A JP2016517431A5 JP 2016517431 A5 JP2016517431 A5 JP 2016517431A5 JP 2016502761 A JP2016502761 A JP 2016502761A JP 2016502761 A JP2016502761 A JP 2016502761A JP 2016517431 A5 JP2016517431 A5 JP 2016517431A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydroxyacetoxy
- cyclopentyl
- phenyl
- methylpyrrolidinium bromide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 63
- 238000004519 manufacturing process Methods 0.000 claims description 42
- 210000004243 sweat Anatomy 0.000 claims description 41
- 150000001875 compounds Chemical class 0.000 claims description 36
- 229940015042 glycopyrrolate Drugs 0.000 claims description 12
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000000699 topical effect Effects 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 37
- FIAFMTCUJCWADZ-UHFFFAOYSA-M [1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OCC)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 FIAFMTCUJCWADZ-UHFFFAOYSA-M 0.000 claims 18
- BYLYKBTVPVGVIU-UHFFFAOYSA-M [1-(2-methoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OC)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 BYLYKBTVPVGVIU-UHFFFAOYSA-M 0.000 claims 18
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 239000007787 solid Substances 0.000 claims 8
- 208000008454 Hyperhidrosis Diseases 0.000 claims 6
- 230000037315 hyperhidrosis Effects 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- FIAFMTCUJCWADZ-NRQRHMLOSA-M [1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OCC)(C)CCC1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 FIAFMTCUJCWADZ-NRQRHMLOSA-M 0.000 claims 4
- BYLYKBTVPVGVIU-MZXPGCLASA-M [1-(2-methoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OC)(C)CCC1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 BYLYKBTVPVGVIU-MZXPGCLASA-M 0.000 claims 4
- 239000006071 cream Substances 0.000 claims 4
- 239000000839 emulsion Substances 0.000 claims 4
- 239000006260 foam Substances 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- 239000006210 lotion Substances 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 239000000725 suspension Substances 0.000 claims 4
- 238000011200 topical administration Methods 0.000 claims 4
- 230000001815 facial effect Effects 0.000 claims 2
- 210000001099 axilla Anatomy 0.000 description 6
- 230000001078 anti-cholinergic effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 0 CCC*(CC)OC([C@@](C1CCCC1)c1ccccc1)=O Chemical compound CCC*(CC)OC([C@@](C1CCCC1)c1ccccc1)=O 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- -1 glycopyrrolate compound Chemical class 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798073P | 2013-03-15 | 2013-03-15 | |
| US61/798,073 | 2013-03-15 | ||
| PCT/US2014/028332 WO2014144075A1 (en) | 2013-03-15 | 2014-03-14 | Anticholinergic glycopyrrolate esters for the treatment of hyperhidrosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017018832A Division JP6461214B2 (ja) | 2013-03-15 | 2017-02-03 | ソフト抗コリン作用性エステルの投与の方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517431A JP2016517431A (ja) | 2016-06-16 |
| JP2016517431A5 true JP2016517431A5 (enExample) | 2017-03-09 |
| JP6223543B2 JP6223543B2 (ja) | 2017-11-01 |
Family
ID=50625156
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502761A Active JP6223543B2 (ja) | 2013-03-15 | 2014-03-14 | 多汗症の処置のための抗コリン作用性グリコピロレートエステル |
| JP2017018832A Active JP6461214B2 (ja) | 2013-03-15 | 2017-02-03 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2018054386A Active JP6694908B2 (ja) | 2013-03-15 | 2018-03-22 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2020074670A Active JP7008988B2 (ja) | 2013-03-15 | 2020-04-20 | ソフト抗コリン作用性エステルの投与の方法および使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017018832A Active JP6461214B2 (ja) | 2013-03-15 | 2017-02-03 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2018054386A Active JP6694908B2 (ja) | 2013-03-15 | 2018-03-22 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2020074670A Active JP7008988B2 (ja) | 2013-03-15 | 2020-04-20 | ソフト抗コリン作用性エステルの投与の方法および使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US9220707B2 (enExample) |
| EP (1) | EP2968267B1 (enExample) |
| JP (4) | JP6223543B2 (enExample) |
| KR (4) | KR102050299B1 (enExample) |
| CN (2) | CN105050596A (enExample) |
| AU (1) | AU2014227923B2 (enExample) |
| BR (1) | BR112015023153A2 (enExample) |
| CA (1) | CA2904724C (enExample) |
| DK (1) | DK2968267T3 (enExample) |
| ES (1) | ES2673098T3 (enExample) |
| HK (1) | HK1217177A1 (enExample) |
| HU (1) | HUE038448T2 (enExample) |
| IL (1) | IL241307B (enExample) |
| MX (1) | MX363601B (enExample) |
| MY (1) | MY192033A (enExample) |
| PH (1) | PH12015501987A1 (enExample) |
| PL (1) | PL2968267T3 (enExample) |
| PT (1) | PT2968267T (enExample) |
| SG (1) | SG11201507602SA (enExample) |
| TR (1) | TR201808040T4 (enExample) |
| WO (1) | WO2014144075A1 (enExample) |
| ZA (1) | ZA201506834B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6223543B2 (ja) * | 2013-03-15 | 2017-11-01 | ボドール ラボラトリーズ， インコーポレイテッド | 多汗症の処置のための抗コリン作用性グリコピロレートエステル |
| WO2015138700A1 (en) | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
| US20150259283A1 (en) * | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| JP6387458B2 (ja) * | 2015-04-30 | 2018-09-05 | 久光製薬株式会社 | 多汗症治療用外用剤 |
| US20180228770A1 (en) * | 2015-07-21 | 2018-08-16 | Bodor Laboratories, Inc. | Formulation for soft anticholinergic analogs |
| US20180235869A1 (en) * | 2015-09-11 | 2018-08-23 | Bodor Laboratories, Inc. | Methods and compositions for soft anticholinergic zwitterions |
| MY197265A (en) * | 2015-09-11 | 2023-06-08 | Bodor Laboratories Inc | Methods and compositions for soft anticholinergic esters |
| CA3029621A1 (en) * | 2016-07-01 | 2018-01-04 | Bodor Laboratories, Inc. | Compositions and methods for treatment of copd |
| TWI719046B (zh) | 2016-07-21 | 2021-02-21 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
| KR101951021B1 (ko) | 2017-02-06 | 2019-02-22 | 주식회사 퍼슨 | 발한억제 기능을 가지는 자외선 차단 화장료 조성물 및 이를 사용한 자외선 차단제의 제조방법 |
| DK3431072T3 (da) * | 2017-07-17 | 2020-02-17 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Olie-i-vand-emulsion |
| EP3826631A1 (en) | 2018-07-24 | 2021-06-02 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical emulsion of an anticholinergic compound |
| SG10201912063PA (en) * | 2019-12-12 | 2021-07-29 | Nat Skin Centre Singapore Pte Ltd | A pharmaceutical formulation |
| TW202146010A (zh) | 2020-03-03 | 2021-12-16 | 日商科研製藥股份有限公司 | 原發性腋窩多汗症的治療方法及其醫藥 |
| US20230149349A1 (en) | 2020-03-03 | 2023-05-18 | Kaken Pharmaceutical Co., Ltd. | Medicament containing sofpironium bromide |
| EP4333831B1 (en) | 2022-04-14 | 2024-08-14 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating |
| EP4260852A1 (en) | 2022-04-14 | 2023-10-18 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating |
| KR102611847B1 (ko) * | 2023-03-27 | 2023-12-12 | 주식회사 이플라스크 | 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292530A (en) | 1991-06-02 | 1994-03-08 | Helene Curtis, Inc. | Stable anhydrous topically-active composition and suspending agent therefor |
| EP1438001A4 (en) | 2001-09-26 | 2006-03-15 | Alison B Lukacsko | COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS |
| US8252316B2 (en) | 2002-05-03 | 2012-08-28 | Purepharm Inc. | Method of topically applying glycopyrrolate solution using absorbent pad to reduce sweating |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| CA2627982C (en) | 2005-11-10 | 2013-09-10 | Nicholas S. Bodor | Soft anticholinergic esters |
| US7399861B2 (en) | 2005-11-10 | 2008-07-15 | Bodor Nicholas S | Soft anticholinergic esters |
| US8071693B2 (en) | 2006-06-22 | 2011-12-06 | Sabic Innovative Plastics Ip B.V. | Polysiloxane/polyimide copolymers and blends thereof |
| US8618160B2 (en) | 2007-10-18 | 2013-12-31 | Rose U | Topical glycopyrrolate formulations |
| JP6223543B2 (ja) * | 2013-03-15 | 2017-11-01 | ボドール ラボラトリーズ， インコーポレイテッド | 多汗症の処置のための抗コリン作用性グリコピロレートエステル |
-
2014
- 2014-03-14 JP JP2016502761A patent/JP6223543B2/ja active Active
- 2014-03-14 PT PT147203863T patent/PT2968267T/pt unknown
- 2014-03-14 MY MYPI2015702984A patent/MY192033A/en unknown
- 2014-03-14 DK DK14720386.3T patent/DK2968267T3/en active
- 2014-03-14 KR KR1020157028470A patent/KR102050299B1/ko active Active
- 2014-03-14 PL PL14720386T patent/PL2968267T3/pl unknown
- 2014-03-14 US US14/213,242 patent/US9220707B2/en active Active
- 2014-03-14 HU HUE14720386A patent/HUE038448T2/hu unknown
- 2014-03-14 BR BR112015023153A patent/BR112015023153A2/pt not_active Application Discontinuation
- 2014-03-14 TR TR2018/08040T patent/TR201808040T4/tr unknown
- 2014-03-14 WO PCT/US2014/028332 patent/WO2014144075A1/en not_active Ceased
- 2014-03-14 KR KR1020197034502A patent/KR102153457B1/ko active Active
- 2014-03-14 CN CN201480015677.0A patent/CN105050596A/zh active Pending
- 2014-03-14 EP EP14720386.3A patent/EP2968267B1/en active Active
- 2014-03-14 AU AU2014227923A patent/AU2014227923B2/en active Active
- 2014-03-14 MX MX2015012072A patent/MX363601B/es unknown
- 2014-03-14 KR KR1020217010876A patent/KR20210043742A/ko not_active Ceased
- 2014-03-14 KR KR1020207015539A patent/KR102241660B1/ko active Active
- 2014-03-14 CA CA2904724A patent/CA2904724C/en active Active
- 2014-03-14 ES ES14720386.3T patent/ES2673098T3/es active Active
- 2014-03-14 CN CN201811323473.XA patent/CN109364066A/zh active Pending
- 2014-03-14 SG SG11201507602SA patent/SG11201507602SA/en unknown
- 2014-03-14 HK HK16105192.7A patent/HK1217177A1/zh unknown
-
2015
- 2015-09-07 PH PH12015501987A patent/PH12015501987A1/en unknown
- 2015-09-08 IL IL241307A patent/IL241307B/en active IP Right Grant
- 2015-09-15 ZA ZA2015/06834A patent/ZA201506834B/en unknown
- 2015-11-13 US US14/941,183 patent/US9492429B2/en active Active
-
2016
- 2016-07-01 US US15/200,129 patent/US9895350B2/en active Active
-
2017
- 2017-02-03 JP JP2017018832A patent/JP6461214B2/ja active Active
-
2018
- 2018-02-16 US US15/932,334 patent/US10383846B2/en active Active
- 2018-03-22 JP JP2018054386A patent/JP6694908B2/ja active Active
-
2019
- 2019-07-02 US US16/460,252 patent/US10772867B2/en active Active
-
2020
- 2020-04-20 JP JP2020074670A patent/JP7008988B2/ja active Active
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