JP2017507970A5 - - Google Patents
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- Publication number
- JP2017507970A5 JP2017507970A5 JP2016556899A JP2016556899A JP2017507970A5 JP 2017507970 A5 JP2017507970 A5 JP 2017507970A5 JP 2016556899 A JP2016556899 A JP 2016556899A JP 2016556899 A JP2016556899 A JP 2016556899A JP 2017507970 A5 JP2017507970 A5 JP 2017507970A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydroxyacetoxy
- cyclopentyl
- phenyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 64
- 150000001875 compounds Chemical class 0.000 claims description 14
- 230000000699 topical effect Effects 0.000 claims description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 claims description 5
- 239000003125 aqueous solvent Substances 0.000 claims description 3
- 239000012062 aqueous buffer Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 12
- 210000004243 sweat Anatomy 0.000 claims 12
- FIAFMTCUJCWADZ-UHFFFAOYSA-M [1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OCC)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 FIAFMTCUJCWADZ-UHFFFAOYSA-M 0.000 claims 7
- BYLYKBTVPVGVIU-UHFFFAOYSA-M [1-(2-methoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OC)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 BYLYKBTVPVGVIU-UHFFFAOYSA-M 0.000 claims 7
- 208000008454 Hyperhidrosis Diseases 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 230000037315 hyperhidrosis Effects 0.000 claims 6
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 4
- 229940015042 glycopyrrolate Drugs 0.000 claims 4
- 238000011200 topical administration Methods 0.000 claims 4
- 229940051250 hexylene glycol Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 description 2
- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952505P | 2014-03-13 | 2014-03-13 | |
| US61/952,505 | 2014-03-13 | ||
| US14/285,488 US20150259283A1 (en) | 2014-03-13 | 2014-05-22 | Formulation for soft anticholinergic analogs |
| US14/285,488 | 2014-05-22 | ||
| PCT/US2015/020253 WO2015138776A1 (en) | 2014-03-13 | 2015-03-12 | Formulation for soft anticholinergic analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017176799A Division JP6461267B2 (ja) | 2014-03-13 | 2017-09-14 | ソフト型抗コリン作動薬類似体についての製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507970A JP2017507970A (ja) | 2017-03-23 |
| JP2017507970A5 true JP2017507970A5 (enExample) | 2017-10-26 |
| JP6293919B2 JP6293919B2 (ja) | 2018-03-14 |
Family
ID=54068191
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556899A Active JP6293919B2 (ja) | 2014-03-13 | 2015-03-12 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2017176799A Active JP6461267B2 (ja) | 2014-03-13 | 2017-09-14 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2018062716A Active JP6756763B2 (ja) | 2014-03-13 | 2018-03-28 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2019127508A Active JP6762047B2 (ja) | 2014-03-13 | 2019-07-09 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2020035073A Pending JP2020079321A (ja) | 2014-03-13 | 2020-03-02 | ソフト型抗コリン作動薬類似体についての製剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017176799A Active JP6461267B2 (ja) | 2014-03-13 | 2017-09-14 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2018062716A Active JP6756763B2 (ja) | 2014-03-13 | 2018-03-28 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2019127508A Active JP6762047B2 (ja) | 2014-03-13 | 2019-07-09 | ソフト型抗コリン作動薬類似体についての製剤 |
| JP2020035073A Pending JP2020079321A (ja) | 2014-03-13 | 2020-03-02 | ソフト型抗コリン作動薬類似体についての製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US20150259283A1 (enExample) |
| EP (1) | EP3116498B1 (enExample) |
| JP (5) | JP6293919B2 (enExample) |
| KR (3) | KR102433868B1 (enExample) |
| CN (3) | CN110420167B (enExample) |
| AU (2) | AU2015229243B2 (enExample) |
| BR (1) | BR112016021011B1 (enExample) |
| CA (1) | CA2941649C (enExample) |
| DK (2) | DK3116498T3 (enExample) |
| ES (1) | ES2710292T3 (enExample) |
| HU (1) | HUE041868T2 (enExample) |
| IL (1) | IL247571B (enExample) |
| MX (1) | MX369129B (enExample) |
| MY (1) | MY183531A (enExample) |
| PH (1) | PH12016501732A1 (enExample) |
| PL (1) | PL3116498T3 (enExample) |
| PT (2) | PT3116498T (enExample) |
| SG (1) | SG11201607480SA (enExample) |
| WO (1) | WO2015138776A1 (enExample) |
| ZA (1) | ZA201607071B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200707352B (en) * | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| ES2658897T3 (es) | 2011-08-24 | 2018-03-12 | Novan, Inc. | Macromoléculas de liberación de óxido nítrico ajustables que tienen múltiples estructuras donantes de óxido nítrico |
| US11813284B2 (en) | 2013-08-08 | 2023-11-14 | Novan, Inc. | Topical compositions and methods of using the same |
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| CN119033771A (zh) | 2015-07-21 | 2024-11-29 | 博多尔实验仪器公司 | 软性抗胆碱能药类似物的制剂 |
| TWI767507B (zh) | 2016-07-21 | 2022-06-11 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
| US11381304B2 (en) * | 2017-08-30 | 2022-07-05 | Iridium Satellite Llc | Satellite communications with multiple classes of terrestrial terminal devices |
| EP3972955A4 (en) * | 2019-05-23 | 2023-07-05 | Kaken Pharmaceutical Co., Ltd. | CRYSTALLINE FORM OF SOFPIRONIUM BROMIDE AND ASSOCIATED METHOD OF PREPARATION |
| SG10201912063PA (en) * | 2019-12-12 | 2021-07-29 | Nat Skin Centre Singapore Pte Ltd | A pharmaceutical formulation |
| WO2021177257A1 (ja) | 2020-03-03 | 2021-09-10 | 科研製薬株式会社 | 原発性腋窩多汗症の治療方法、及びその医薬 |
| CA3174550A1 (en) | 2020-03-03 | 2021-09-10 | Kaken Pharmaceutical Co., Ltd. | Medicament containing sofpironium bromide |
| KR102655121B1 (ko) | 2021-09-17 | 2024-04-08 | 한국식품연구원 | 락토바실러스 사케이 k040706 균주 검출용 프라이머 세트 및 이의 용도 |
| US11807604B1 (en) * | 2022-02-16 | 2023-11-07 | Miralogx Llc | Pharmaceutical compounds, pharmaceutical compositions, and methods of treating asthma and other disorders |
| WO2024026412A1 (en) * | 2022-07-28 | 2024-02-01 | Tff Pharmaceuticals, Inc. | Thin film freezing methods and compositions formulated from dispersed active agents |
| KR102611847B1 (ko) * | 2023-03-27 | 2023-12-12 | 주식회사 이플라스크 | 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK149832C (da) * | 1981-07-17 | 1987-05-18 | Riemann Claus | Antiperspirantpraeparat bestaaende af to komponenter |
| DK483587D0 (da) * | 1987-09-15 | 1987-09-15 | Riemann & Co Aps Claus | Antiperspirant praeparat |
| CA2014633C (en) * | 1989-06-02 | 2000-07-18 | Andrew D. Mccrea | Stable anhydrous compositions for topical delivery of active materials |
| US5292530A (en) * | 1991-06-02 | 1994-03-08 | Helene Curtis, Inc. | Stable anhydrous topically-active composition and suspending agent therefor |
| US5232689A (en) * | 1990-12-21 | 1993-08-03 | Dow Corning Corporation | Translucent antiperspirant compositions |
| US5143719A (en) | 1991-04-16 | 1992-09-01 | Chesebrough-Pond's Usa Co. | Anticalculus oral composition containing combinations of organophosphorus polycarboxylate cotelomers and inorganic polyphosphate salts |
| GB2280111B (en) | 1993-07-16 | 1997-05-07 | Union Camp Corp | Clear gel antiperpirant compositions |
| US5895644A (en) * | 1997-11-20 | 1999-04-20 | Colgate-Palmolive Company | Clear antiperspirant stick with dibenzylidene sorbitol and guar and process of making same |
| US6433003B1 (en) | 1999-04-23 | 2002-08-13 | Arthur M. Bobrove | Method for treating hyperhidrosis in mammals |
| US6319491B1 (en) | 2000-04-11 | 2001-11-20 | Michael B. Whipple | Anti-sweat lotion |
| EP1438001A4 (en) * | 2001-09-26 | 2006-03-15 | Alison B Lukacsko | COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS |
| JP2003113392A (ja) | 2001-10-04 | 2003-04-18 | Kiyomitsu Kawasaki | 芳香・消臭組成物および該芳香・消臭組成物を含有する人体用芳香・消臭剤 |
| US8252316B2 (en) * | 2002-05-03 | 2012-08-28 | Purepharm Inc. | Method of topically applying glycopyrrolate solution using absorbent pad to reduce sweating |
| BR0308051A (pt) | 2003-12-15 | 2005-09-06 | Natura Cosmeticos Sa | Composição base para preparação de formulações multifuncionais para o cuidado e proteção da pele e cabelo |
| US7087560B2 (en) * | 2004-10-25 | 2006-08-08 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Personal care composition with salts of dihydroxypropyltri(C1-C3 alkyl) ammonium monosubstituted polyols |
| US20060088496A1 (en) * | 2004-10-25 | 2006-04-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Personal care compositions with salts of hydroxypropyl trialkylammonium substituted mono-saccharide |
| GB0428416D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| WO2006069998A2 (de) * | 2004-12-27 | 2006-07-06 | Beiersdorf Ag | Glycopyrrolat in kosmetischen zubereitungen |
| CN101340884A (zh) * | 2005-10-19 | 2009-01-07 | 曼尼·马纳舍·辛格尔 | 用于治疗多汗症的方法 |
| ATE529400T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Weiche anticholinerge zwitterionen |
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| AU2006201878A1 (en) * | 2006-03-13 | 2007-09-27 | Foamix Ltd | Foamable composition for hyperhidrosis |
| JP5371235B2 (ja) * | 2006-12-06 | 2013-12-18 | ロート製薬株式会社 | 皮膚外用剤 |
| US10265265B2 (en) * | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
| ES2671874T3 (es) | 2007-10-18 | 2018-06-11 | Rose U, Llc | Formulaciones tópicas de glicopirrolato |
| US20100137357A1 (en) * | 2008-11-26 | 2010-06-03 | Koleng John J | Compositions and methods for hyperhidrosis |
| US20140037713A1 (en) * | 2012-08-03 | 2014-02-06 | Antares Pharma Ipl, Ag | Transdermal compositions for anti-cholinergic agents |
| WO2014144075A1 (en) | 2013-03-15 | 2014-09-18 | Bodor Laboratories, Inc. | Anticholinergic glycopyrrolate esters for the treatment of hyperhidrosis |
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| JP2017507959A (ja) | 2014-03-13 | 2017-03-23 | ボドール ラボラトリーズ， インコーポレイテッド | 選択された抗コリン作動性両性イオンの使用 |
| CN119033771A (zh) | 2015-07-21 | 2024-11-29 | 博多尔实验仪器公司 | 软性抗胆碱能药类似物的制剂 |
| TWI767507B (zh) | 2016-07-21 | 2022-06-11 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
-
2014
- 2014-05-22 US US14/285,488 patent/US20150259283A1/en not_active Abandoned
-
2015
- 2015-03-12 KR KR1020167028122A patent/KR102433868B1/ko active Active
- 2015-03-12 WO PCT/US2015/020253 patent/WO2015138776A1/en not_active Ceased
- 2015-03-12 KR KR1020237033837A patent/KR20230145522A/ko active Pending
- 2015-03-12 CN CN201910812881.XA patent/CN110420167B/zh active Active
- 2015-03-12 HU HUE15762178A patent/HUE041868T2/hu unknown
- 2015-03-12 PL PL15762178T patent/PL3116498T3/pl unknown
- 2015-03-12 ES ES15762178T patent/ES2710292T3/es active Active
- 2015-03-12 JP JP2016556899A patent/JP6293919B2/ja active Active
- 2015-03-12 DK DK15762178.0T patent/DK3116498T3/en active
- 2015-03-12 CN CN201580013622.0A patent/CN106456603B/zh active Active
- 2015-03-12 US US15/125,039 patent/US20170020845A1/en not_active Abandoned
- 2015-03-12 AU AU2015229243A patent/AU2015229243B2/en active Active
- 2015-03-12 PT PT15762178T patent/PT3116498T/pt unknown
- 2015-03-12 MX MX2016011529A patent/MX369129B/es active IP Right Grant
- 2015-03-12 CN CN201911319136.8A patent/CN110917124B/zh active Active
- 2015-03-12 SG SG11201607480SA patent/SG11201607480SA/en unknown
- 2015-03-12 MY MYPI2016703307A patent/MY183531A/en unknown
- 2015-03-12 KR KR1020227028128A patent/KR102586868B1/ko active Active
- 2015-03-12 EP EP15762178.0A patent/EP3116498B1/en active Active
- 2015-03-12 BR BR112016021011-5A patent/BR112016021011B1/pt active IP Right Grant
- 2015-03-12 CA CA2941649A patent/CA2941649C/en active Active
- 2015-07-21 US US14/805,114 patent/US20150320722A1/en not_active Abandoned
-
2016
- 2016-07-21 DK DK16828553.4T patent/DK3325487T3/da active
- 2016-07-21 PT PT168285534T patent/PT3325487T/pt unknown
- 2016-08-31 IL IL247571A patent/IL247571B/en active IP Right Grant
- 2016-09-02 PH PH12016501732A patent/PH12016501732A1/en unknown
- 2016-10-13 ZA ZA2016/07071A patent/ZA201607071B/en unknown
-
2017
- 2017-09-14 JP JP2017176799A patent/JP6461267B2/ja active Active
-
2018
- 2018-03-28 JP JP2018062716A patent/JP6756763B2/ja active Active
-
2019
- 2019-07-09 JP JP2019127508A patent/JP6762047B2/ja active Active
- 2019-10-30 AU AU2019257421A patent/AU2019257421B2/en active Active
- 2019-11-14 US US16/683,792 patent/US10961191B2/en active Active
- 2019-11-26 US US16/696,077 patent/US10947192B2/en active Active
-
2020
- 2020-03-02 JP JP2020035073A patent/JP2020079321A/ja active Pending
- 2020-11-16 US US17/099,163 patent/US11034652B2/en active Active
- 2020-12-09 US US17/116,501 patent/US11084788B2/en active Active
-
2021
- 2021-03-15 US US17/202,063 patent/US12398102B2/en active Active
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