DK3325487T3 - Formulering til bløde, anticholinerge analoger - Google Patents

Formulering til bløde, anticholinerge analoger Download PDF

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Publication number
DK3325487T3
DK3325487T3 DK16828553.4T DK16828553T DK3325487T3 DK 3325487 T3 DK3325487 T3 DK 3325487T3 DK 16828553 T DK16828553 T DK 16828553T DK 3325487 T3 DK3325487 T3 DK 3325487T3
Authority
DK
Denmark
Prior art keywords
anticholinerge
analogs
formulation
soft
anticholinerge analogs
Prior art date
Application number
DK16828553.4T
Other languages
English (en)
Inventor
John J Koleng
David Angulo
Nicholas S Bodor
Original Assignee
Bodor Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bodor Laboratories Inc filed Critical Bodor Laboratories Inc
Priority claimed from PCT/US2016/043380 external-priority patent/WO2017015485A1/en
Application granted granted Critical
Publication of DK3325487T3 publication Critical patent/DK3325487T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00Anti-perspirants or body deodorants
DK16828553.4T 2014-03-13 2016-07-21 Formulering til bløde, anticholinerge analoger DK3325487T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461952505P 2014-03-13 2014-03-13
US14/805,114 US20150320722A1 (en) 2014-03-13 2015-07-21 Formulation for soft anticholinergic analogs
PCT/US2016/043380 WO2017015485A1 (en) 2015-07-21 2016-07-21 Formulation for soft anticholinergic analogs

Publications (1)

Publication Number Publication Date
DK3325487T3 true DK3325487T3 (da) 2021-08-02

Family

ID=54068191

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15762178.0T DK3116498T3 (da) 2014-03-13 2015-03-12 Formulering til bløde anticholinerge analoger
DK16828553.4T DK3325487T3 (da) 2014-03-13 2016-07-21 Formulering til bløde, anticholinerge analoger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15762178.0T DK3116498T3 (da) 2014-03-13 2015-03-12 Formulering til bløde anticholinerge analoger

Country Status (20)

Country Link
US (8) US20150259283A1 (da)
EP (1) EP3116498B1 (da)
JP (5) JP6293919B2 (da)
KR (3) KR102586868B1 (da)
CN (3) CN110917124B (da)
AU (2) AU2015229243B2 (da)
BR (1) BR112016021011B1 (da)
CA (1) CA2941649C (da)
DK (2) DK3116498T3 (da)
ES (1) ES2710292T3 (da)
HU (1) HUE041868T2 (da)
IL (1) IL247571B (da)
MX (1) MX369129B (da)
MY (1) MY183531A (da)
PH (1) PH12016501732A1 (da)
PL (1) PL3116498T3 (da)
PT (2) PT3116498T (da)
SG (1) SG11201607480SA (da)
WO (1) WO2015138776A1 (da)
ZA (1) ZA201607071B (da)

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KR102321169B1 (ko) 2013-08-08 2021-11-02 노반, 인크. 국소 조성물 및 그의 사용 방법
US20150259283A1 (en) 2014-03-13 2015-09-17 Brickell Biotech, Inc. Formulation for soft anticholinergic analogs
WO2017015485A1 (en) 2015-07-21 2017-01-26 Bodor Laboratories, Inc. Formulation for soft anticholinergic analogs
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
TWI767507B (zh) * 2016-07-21 2022-06-11 美商波德實驗股份有限公司 軟性抗膽鹼類似物之製劑
US11381304B2 (en) * 2017-08-30 2022-07-05 Iridium Satellite Llc Satellite communications with multiple classes of terrestrial terminal devices
CN114008023B (zh) * 2019-05-23 2024-02-09 科研制药株式会社 索吡溴铵的晶型及其制备方法
TW202146010A (zh) 2020-03-03 2021-12-16 日商科研製藥股份有限公司 原發性腋窩多汗症的治療方法及其醫藥
KR20220149550A (ko) 2020-03-03 2022-11-08 가켄 세이야쿠 가부시키가이샤 소피로늄 브로마이드를 포함하는 의약
KR102655121B1 (ko) 2021-09-17 2024-04-08 한국식품연구원 락토바실러스 사케이 k040706 균주 검출용 프라이머 세트 및 이의 용도
US11807604B1 (en) * 2022-02-16 2023-11-07 Miralogx Llc Pharmaceutical compounds, pharmaceutical compositions, and methods of treating asthma and other disorders
WO2024026412A1 (en) * 2022-07-28 2024-02-01 Tff Pharmaceuticals, Inc. Thin film freezing methods and compositions formulated from dispersed active agents
KR102611847B1 (ko) * 2023-03-27 2023-12-12 주식회사 이플라스크 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도

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CA2014633C (en) * 1989-06-02 2000-07-18 Andrew D. Mccrea Stable anhydrous compositions for topical delivery of active materials
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Also Published As

Publication number Publication date
CN106456603B (zh) 2020-01-10
AU2015229243A1 (en) 2016-10-20
PT3325487T (pt) 2021-07-29
MY183531A (en) 2021-02-25
CN110420167A (zh) 2019-11-08
KR102433868B1 (ko) 2022-08-19
MX369129B (es) 2019-10-30
EP3116498A1 (en) 2017-01-18
CN110420167B (zh) 2023-02-17
US11084788B2 (en) 2021-08-10
US20210198195A1 (en) 2021-07-01
WO2015138776A1 (en) 2015-09-17
AU2015229243B2 (en) 2019-11-21
US20200113869A1 (en) 2020-04-16
JP6461267B2 (ja) 2019-01-30
BR112016021011A2 (pt) 2017-08-15
IL247571A0 (en) 2016-11-30
CN110917124B (zh) 2023-06-20
JP2017507970A (ja) 2017-03-23
KR20230145522A (ko) 2023-10-17
KR102586868B1 (ko) 2023-10-11
PH12016501732B1 (en) 2017-02-06
CN110917124A (zh) 2020-03-27
JP6756763B2 (ja) 2020-09-16
CA2941649A1 (en) 2015-09-17
US11034652B2 (en) 2021-06-15
CN106456603A (zh) 2017-02-22
JP2018115203A (ja) 2018-07-26
PL3116498T3 (pl) 2019-05-31
US20210078946A1 (en) 2021-03-18
JP2020079321A (ja) 2020-05-28
CA2941649C (en) 2021-03-02
US20200093791A1 (en) 2020-03-26
KR20220119517A (ko) 2022-08-29
JP6762047B2 (ja) 2020-09-30
US20170020845A1 (en) 2017-01-26
JP6293919B2 (ja) 2018-03-14
US20150259283A1 (en) 2015-09-17
HUE041868T2 (hu) 2019-05-28
KR20160133492A (ko) 2016-11-22
US10961191B2 (en) 2021-03-30
EP3116498A4 (en) 2017-11-08
PT3116498T (pt) 2019-02-11
US10947192B2 (en) 2021-03-16
MX2016011529A (es) 2016-12-07
ZA201607071B (en) 2018-12-19
DK3116498T3 (da) 2019-03-11
ES2710292T3 (es) 2019-04-24
AU2019257421A1 (en) 2019-11-21
JP2017214429A (ja) 2017-12-07
IL247571B (en) 2020-03-31
SG11201607480SA (en) 2016-10-28
US20210087142A1 (en) 2021-03-25
EP3116498B1 (en) 2018-12-12
PH12016501732A1 (en) 2017-02-06
US20150320722A1 (en) 2015-11-12
BR112016021011B1 (pt) 2022-12-13
AU2019257421B2 (en) 2021-10-21
JP2019189650A (ja) 2019-10-31
BR112016021011A8 (pt) 2021-07-20

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