CN105050596A - 用于治疗多汗症的抗胆碱能格隆溴铵酯 - Google Patents

用于治疗多汗症的抗胆碱能格隆溴铵酯 Download PDF

Info

Publication number
CN105050596A
CN105050596A CN201480015677.0A CN201480015677A CN105050596A CN 105050596 A CN105050596 A CN 105050596A CN 201480015677 A CN201480015677 A CN 201480015677A CN 105050596 A CN105050596 A CN 105050596A
Authority
CN
China
Prior art keywords
phenyl
cyclopenta
oxygen base
methyl
methyl bromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480015677.0A
Other languages
English (en)
Chinese (zh)
Inventor
N·S·博多尔
D·安古洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bodor Laboratories Inc
Original Assignee
Bodor Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50625156&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN105050596(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bodor Laboratories Inc filed Critical Bodor Laboratories Inc
Priority to CN201811323473.XA priority Critical patent/CN109364066A/zh
Publication of CN105050596A publication Critical patent/CN105050596A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
CN201480015677.0A 2013-03-15 2014-03-14 用于治疗多汗症的抗胆碱能格隆溴铵酯 Pending CN105050596A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811323473.XA CN109364066A (zh) 2013-03-15 2014-03-14 用于治疗多汗症的软性抗胆碱能酯

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798073P 2013-03-15 2013-03-15
US61/798,073 2013-03-15
PCT/US2014/028332 WO2014144075A1 (en) 2013-03-15 2014-03-14 Anticholinergic glycopyrrolate esters for the treatment of hyperhidrosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811323473.XA Division CN109364066A (zh) 2013-03-15 2014-03-14 用于治疗多汗症的软性抗胆碱能酯

Publications (1)

Publication Number Publication Date
CN105050596A true CN105050596A (zh) 2015-11-11

Family

ID=50625156

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480015677.0A Pending CN105050596A (zh) 2013-03-15 2014-03-14 用于治疗多汗症的抗胆碱能格隆溴铵酯
CN201811323473.XA Pending CN109364066A (zh) 2013-03-15 2014-03-14 用于治疗多汗症的软性抗胆碱能酯

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811323473.XA Pending CN109364066A (zh) 2013-03-15 2014-03-14 用于治疗多汗症的软性抗胆碱能酯

Country Status (22)

Country Link
US (5) US9220707B2 (enExample)
EP (1) EP2968267B1 (enExample)
JP (4) JP6223543B2 (enExample)
KR (4) KR102050299B1 (enExample)
CN (2) CN105050596A (enExample)
AU (1) AU2014227923B2 (enExample)
BR (1) BR112015023153A2 (enExample)
CA (1) CA2904724C (enExample)
DK (1) DK2968267T3 (enExample)
ES (1) ES2673098T3 (enExample)
HK (1) HK1217177A1 (enExample)
HU (1) HUE038448T2 (enExample)
IL (1) IL241307B (enExample)
MX (1) MX363601B (enExample)
MY (1) MY192033A (enExample)
PH (1) PH12015501987A1 (enExample)
PL (1) PL2968267T3 (enExample)
PT (1) PT2968267T (enExample)
SG (1) SG11201507602SA (enExample)
TR (1) TR201808040T4 (enExample)
WO (1) WO2014144075A1 (enExample)
ZA (1) ZA201506834B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427582A (zh) * 2015-04-30 2017-12-01 久光制药株式会社 多汗症治疗用外用剂
CN110709054A (zh) * 2017-07-17 2020-01-17 奥古斯特沃尔夫博士有限两合公司-医药 水包油乳液
CN114760997A (zh) * 2019-12-12 2022-07-15 全国皮肤中心 用于抑制身体异味的药物制剂

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6223543B2 (ja) * 2013-03-15 2017-11-01 ボドール ラボラトリーズ， インコーポレイテッド 多汗症の処置のための抗コリン作用性グリコピロレートエステル
WO2015138700A1 (en) 2014-03-13 2015-09-17 Bodor Laboratories, Inc. Use of selected anticholinergic zwitterions
US20150259283A1 (en) * 2014-03-13 2015-09-17 Brickell Biotech, Inc. Formulation for soft anticholinergic analogs
US20180228770A1 (en) * 2015-07-21 2018-08-16 Bodor Laboratories, Inc. Formulation for soft anticholinergic analogs
US20180235869A1 (en) * 2015-09-11 2018-08-23 Bodor Laboratories, Inc. Methods and compositions for soft anticholinergic zwitterions
MY197265A (en) * 2015-09-11 2023-06-08 Bodor Laboratories Inc Methods and compositions for soft anticholinergic esters
CA3029621A1 (en) * 2016-07-01 2018-01-04 Bodor Laboratories, Inc. Compositions and methods for treatment of copd
TWI719046B (zh) 2016-07-21 2021-02-21 美商波德實驗股份有限公司 軟性抗膽鹼類似物之製劑
KR101951021B1 (ko) 2017-02-06 2019-02-22 주식회사 퍼슨 발한억제 기능을 가지는 자외선 차단 화장료 조성물 및 이를 사용한 자외선 차단제의 제조방법
EP3826631A1 (en) 2018-07-24 2021-06-02 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical emulsion of an anticholinergic compound
TW202146010A (zh) 2020-03-03 2021-12-16 日商科研製藥股份有限公司 原發性腋窩多汗症的治療方法及其醫藥
US20230149349A1 (en) 2020-03-03 2023-05-18 Kaken Pharmaceutical Co., Ltd. Medicament containing sofpironium bromide
EP4333831B1 (en) 2022-04-14 2024-08-14 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating
EP4260852A1 (en) 2022-04-14 2023-10-18 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating
KR102611847B1 (ko) * 2023-03-27 2023-12-12 주식회사 이플라스크 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058971A2 (en) * 2005-11-10 2007-05-24 Bodor Nicholas S Soft anticholinergic esters
WO2009051818A1 (en) * 2007-10-18 2009-04-23 Stiefel Research Australia Pty Ltd Topical glycopyrrolate formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292530A (en) 1991-06-02 1994-03-08 Helene Curtis, Inc. Stable anhydrous topically-active composition and suspending agent therefor
EP1438001A4 (en) 2001-09-26 2006-03-15 Alison B Lukacsko COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS
US8252316B2 (en) 2002-05-03 2012-08-28 Purepharm Inc. Method of topically applying glycopyrrolate solution using absorbent pad to reduce sweating
GB0428416D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0428418D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
US7399861B2 (en) 2005-11-10 2008-07-15 Bodor Nicholas S Soft anticholinergic esters
US8071693B2 (en) 2006-06-22 2011-12-06 Sabic Innovative Plastics Ip B.V. Polysiloxane/polyimide copolymers and blends thereof
JP6223543B2 (ja) * 2013-03-15 2017-11-01 ボドール ラボラトリーズ， インコーポレイテッド 多汗症の処置のための抗コリン作用性グリコピロレートエステル

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058971A2 (en) * 2005-11-10 2007-05-24 Bodor Nicholas S Soft anticholinergic esters
WO2009051818A1 (en) * 2007-10-18 2009-04-23 Stiefel Research Australia Pty Ltd Topical glycopyrrolate formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JI F.等: "Synthesis and pharmacological effects of new, N-substituted soft anticholinergics based on glycopyrrolate", 《JOURNAL OF PHARMACY AND PHARMACOLOGY》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427582A (zh) * 2015-04-30 2017-12-01 久光制药株式会社 多汗症治疗用外用剂
CN107427582B (zh) * 2015-04-30 2021-03-05 久光制药株式会社 多汗症治疗用外用剂
CN110709054A (zh) * 2017-07-17 2020-01-17 奥古斯特沃尔夫博士有限两合公司-医药 水包油乳液
CN110709054B (zh) * 2017-07-17 2023-05-12 奥古斯特沃尔夫博士有限两合公司-医药 水包油乳液
CN114760997A (zh) * 2019-12-12 2022-07-15 全国皮肤中心 用于抑制身体异味的药物制剂

Also Published As

Publication number Publication date
DK2968267T3 (en) 2018-06-25
MY192033A (en) 2022-07-24
JP2016517431A (ja) 2016-06-16
KR102153457B1 (ko) 2020-09-08
US20140275204A1 (en) 2014-09-18
IL241307A0 (en) 2015-11-30
US20190328707A1 (en) 2019-10-31
US20160310464A1 (en) 2016-10-27
SG11201507602SA (en) 2015-10-29
ZA201506834B (en) 2018-12-19
KR20190133072A (ko) 2019-11-29
KR20200065103A (ko) 2020-06-08
JP6694908B2 (ja) 2020-05-20
EP2968267B1 (en) 2018-04-25
CA2904724A1 (en) 2014-09-18
US20180185331A1 (en) 2018-07-05
MX363601B (es) 2019-03-28
JP7008988B2 (ja) 2022-01-25
MX2015012072A (es) 2016-05-05
CN109364066A (zh) 2019-02-22
US9492429B2 (en) 2016-11-15
HK1217177A1 (zh) 2016-12-30
PT2968267T (pt) 2018-06-15
CA2904724C (en) 2021-01-26
IL241307B (en) 2019-07-31
WO2014144075A1 (en) 2014-09-18
PL2968267T3 (pl) 2018-09-28
ES2673098T3 (es) 2018-06-19
HK1220369A1 (en) 2017-05-05
US10772867B2 (en) 2020-09-15
AU2014227923B2 (en) 2019-02-14
AU2014227923A1 (en) 2015-10-08
KR20150128942A (ko) 2015-11-18
TR201808040T4 (tr) 2018-06-21
US20160067214A1 (en) 2016-03-10
JP2018115187A (ja) 2018-07-26
KR20210043742A (ko) 2021-04-21
EP2968267A1 (en) 2016-01-20
US9220707B2 (en) 2015-12-29
JP2020122002A (ja) 2020-08-13
KR102050299B1 (ko) 2019-11-29
KR102241660B1 (ko) 2021-04-19
JP6461214B2 (ja) 2019-01-30
BR112015023153A2 (pt) 2017-07-18
US10383846B2 (en) 2019-08-20
US9895350B2 (en) 2018-02-20
JP2017105811A (ja) 2017-06-15
PH12015501987A1 (en) 2016-01-11
HUE038448T2 (hu) 2018-10-29
WO2014144075A8 (en) 2015-10-15
JP6223543B2 (ja) 2017-11-01

Similar Documents

Publication Publication Date Title
US10772867B2 (en) Method of dosing and use of soft anticholinergic esters
US6433003B1 (en) Method for treating hyperhidrosis in mammals
CN110420167B (zh) 软性抗胆碱能药类似物的制剂
CN108137612A (zh) 软性抗胆碱能药类似物的制剂
WO2010062930A1 (en) Compositions and methods for hyperhidrosis
HK1220369B (en) Soft anticholinergic esters for the treatment of hyperhidrosis
DE102004040630A1 (de) Kombinationstherapie mit Procain
HK40016903B (en) Formulation for soft anticholinergic analogs

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1217177

Country of ref document: HK

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20151111

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1217177

Country of ref document: HK