JP6223543B2 - 多汗症の処置のための抗コリン作用性グリコピロレートエステル - Google Patents
多汗症の処置のための抗コリン作用性グリコピロレートエステル Download PDFInfo
- Publication number
- JP6223543B2 JP6223543B2 JP2016502761A JP2016502761A JP6223543B2 JP 6223543 B2 JP6223543 B2 JP 6223543B2 JP 2016502761 A JP2016502761 A JP 2016502761A JP 2016502761 A JP2016502761 A JP 2016502761A JP 6223543 B2 JP6223543 B2 JP 6223543B2
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- JP
- Japan
- Prior art keywords
- composition
- hydroxyacetoxy
- cyclopentyl
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798073P | 2013-03-15 | 2013-03-15 | |
| US61/798,073 | 2013-03-15 | ||
| PCT/US2014/028332 WO2014144075A1 (en) | 2013-03-15 | 2014-03-14 | Anticholinergic glycopyrrolate esters for the treatment of hyperhidrosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017018832A Division JP6461214B2 (ja) | 2013-03-15 | 2017-02-03 | ソフト抗コリン作用性エステルの投与の方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517431A JP2016517431A (ja) | 2016-06-16 |
| JP2016517431A5 JP2016517431A5 (enExample) | 2017-03-09 |
| JP6223543B2 true JP6223543B2 (ja) | 2017-11-01 |
Family
ID=50625156
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502761A Active JP6223543B2 (ja) | 2013-03-15 | 2014-03-14 | 多汗症の処置のための抗コリン作用性グリコピロレートエステル |
| JP2017018832A Active JP6461214B2 (ja) | 2013-03-15 | 2017-02-03 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2018054386A Active JP6694908B2 (ja) | 2013-03-15 | 2018-03-22 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2020074670A Active JP7008988B2 (ja) | 2013-03-15 | 2020-04-20 | ソフト抗コリン作用性エステルの投与の方法および使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017018832A Active JP6461214B2 (ja) | 2013-03-15 | 2017-02-03 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2018054386A Active JP6694908B2 (ja) | 2013-03-15 | 2018-03-22 | ソフト抗コリン作用性エステルの投与の方法および使用 |
| JP2020074670A Active JP7008988B2 (ja) | 2013-03-15 | 2020-04-20 | ソフト抗コリン作用性エステルの投与の方法および使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US9220707B2 (enExample) |
| EP (1) | EP2968267B1 (enExample) |
| JP (4) | JP6223543B2 (enExample) |
| KR (4) | KR102050299B1 (enExample) |
| CN (2) | CN105050596A (enExample) |
| AU (1) | AU2014227923B2 (enExample) |
| BR (1) | BR112015023153A2 (enExample) |
| CA (1) | CA2904724C (enExample) |
| DK (1) | DK2968267T3 (enExample) |
| ES (1) | ES2673098T3 (enExample) |
| HK (1) | HK1217177A1 (enExample) |
| HU (1) | HUE038448T2 (enExample) |
| IL (1) | IL241307B (enExample) |
| MX (1) | MX363601B (enExample) |
| MY (1) | MY192033A (enExample) |
| PH (1) | PH12015501987A1 (enExample) |
| PL (1) | PL2968267T3 (enExample) |
| PT (1) | PT2968267T (enExample) |
| SG (1) | SG11201507602SA (enExample) |
| TR (1) | TR201808040T4 (enExample) |
| WO (1) | WO2014144075A1 (enExample) |
| ZA (1) | ZA201506834B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6223543B2 (ja) * | 2013-03-15 | 2017-11-01 | ボドール ラボラトリーズ， インコーポレイテッド | 多汗症の処置のための抗コリン作用性グリコピロレートエステル |
| WO2015138700A1 (en) | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
| US20150259283A1 (en) * | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| JP6387458B2 (ja) * | 2015-04-30 | 2018-09-05 | 久光製薬株式会社 | 多汗症治療用外用剤 |
| US20180228770A1 (en) * | 2015-07-21 | 2018-08-16 | Bodor Laboratories, Inc. | Formulation for soft anticholinergic analogs |
| US20180235869A1 (en) * | 2015-09-11 | 2018-08-23 | Bodor Laboratories, Inc. | Methods and compositions for soft anticholinergic zwitterions |
| MY197265A (en) * | 2015-09-11 | 2023-06-08 | Bodor Laboratories Inc | Methods and compositions for soft anticholinergic esters |
| CA3029621A1 (en) * | 2016-07-01 | 2018-01-04 | Bodor Laboratories, Inc. | Compositions and methods for treatment of copd |
| TWI719046B (zh) | 2016-07-21 | 2021-02-21 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
| KR101951021B1 (ko) | 2017-02-06 | 2019-02-22 | 주식회사 퍼슨 | 발한억제 기능을 가지는 자외선 차단 화장료 조성물 및 이를 사용한 자외선 차단제의 제조방법 |
| DK3431072T3 (da) * | 2017-07-17 | 2020-02-17 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Olie-i-vand-emulsion |
| EP3826631A1 (en) | 2018-07-24 | 2021-06-02 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical emulsion of an anticholinergic compound |
| SG10201912063PA (en) * | 2019-12-12 | 2021-07-29 | Nat Skin Centre Singapore Pte Ltd | A pharmaceutical formulation |
| TW202146010A (zh) | 2020-03-03 | 2021-12-16 | 日商科研製藥股份有限公司 | 原發性腋窩多汗症的治療方法及其醫藥 |
| US20230149349A1 (en) | 2020-03-03 | 2023-05-18 | Kaken Pharmaceutical Co., Ltd. | Medicament containing sofpironium bromide |
| EP4333831B1 (en) | 2022-04-14 | 2024-08-14 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating |
| EP4260852A1 (en) | 2022-04-14 | 2023-10-18 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating |
| KR102611847B1 (ko) * | 2023-03-27 | 2023-12-12 | 주식회사 이플라스크 | 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292530A (en) | 1991-06-02 | 1994-03-08 | Helene Curtis, Inc. | Stable anhydrous topically-active composition and suspending agent therefor |
| EP1438001A4 (en) | 2001-09-26 | 2006-03-15 | Alison B Lukacsko | COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS |
| US8252316B2 (en) | 2002-05-03 | 2012-08-28 | Purepharm Inc. | Method of topically applying glycopyrrolate solution using absorbent pad to reduce sweating |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| CA2627982C (en) | 2005-11-10 | 2013-09-10 | Nicholas S. Bodor | Soft anticholinergic esters |
| US7399861B2 (en) | 2005-11-10 | 2008-07-15 | Bodor Nicholas S | Soft anticholinergic esters |
| US8071693B2 (en) | 2006-06-22 | 2011-12-06 | Sabic Innovative Plastics Ip B.V. | Polysiloxane/polyimide copolymers and blends thereof |
| US8618160B2 (en) | 2007-10-18 | 2013-12-31 | Rose U | Topical glycopyrrolate formulations |
| JP6223543B2 (ja) * | 2013-03-15 | 2017-11-01 | ボドール ラボラトリーズ， インコーポレイテッド | 多汗症の処置のための抗コリン作用性グリコピロレートエステル |
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2014
- 2014-03-14 JP JP2016502761A patent/JP6223543B2/ja active Active
- 2014-03-14 PT PT147203863T patent/PT2968267T/pt unknown
- 2014-03-14 MY MYPI2015702984A patent/MY192033A/en unknown
- 2014-03-14 DK DK14720386.3T patent/DK2968267T3/en active
- 2014-03-14 KR KR1020157028470A patent/KR102050299B1/ko active Active
- 2014-03-14 PL PL14720386T patent/PL2968267T3/pl unknown
- 2014-03-14 US US14/213,242 patent/US9220707B2/en active Active
- 2014-03-14 HU HUE14720386A patent/HUE038448T2/hu unknown
- 2014-03-14 BR BR112015023153A patent/BR112015023153A2/pt not_active Application Discontinuation
- 2014-03-14 TR TR2018/08040T patent/TR201808040T4/tr unknown
- 2014-03-14 WO PCT/US2014/028332 patent/WO2014144075A1/en not_active Ceased
- 2014-03-14 KR KR1020197034502A patent/KR102153457B1/ko active Active
- 2014-03-14 CN CN201480015677.0A patent/CN105050596A/zh active Pending
- 2014-03-14 EP EP14720386.3A patent/EP2968267B1/en active Active
- 2014-03-14 AU AU2014227923A patent/AU2014227923B2/en active Active
- 2014-03-14 MX MX2015012072A patent/MX363601B/es unknown
- 2014-03-14 KR KR1020217010876A patent/KR20210043742A/ko not_active Ceased
- 2014-03-14 KR KR1020207015539A patent/KR102241660B1/ko active Active
- 2014-03-14 CA CA2904724A patent/CA2904724C/en active Active
- 2014-03-14 ES ES14720386.3T patent/ES2673098T3/es active Active
- 2014-03-14 CN CN201811323473.XA patent/CN109364066A/zh active Pending
- 2014-03-14 SG SG11201507602SA patent/SG11201507602SA/en unknown
- 2014-03-14 HK HK16105192.7A patent/HK1217177A1/zh unknown
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2015
- 2015-09-07 PH PH12015501987A patent/PH12015501987A1/en unknown
- 2015-09-08 IL IL241307A patent/IL241307B/en active IP Right Grant
- 2015-09-15 ZA ZA2015/06834A patent/ZA201506834B/en unknown
- 2015-11-13 US US14/941,183 patent/US9492429B2/en active Active
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2016
- 2016-07-01 US US15/200,129 patent/US9895350B2/en active Active
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2017
- 2017-02-03 JP JP2017018832A patent/JP6461214B2/ja active Active
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2018
- 2018-02-16 US US15/932,334 patent/US10383846B2/en active Active
- 2018-03-22 JP JP2018054386A patent/JP6694908B2/ja active Active
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2019
- 2019-07-02 US US16/460,252 patent/US10772867B2/en active Active
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2020
- 2020-04-20 JP JP2020074670A patent/JP7008988B2/ja active Active
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| JP6461214B2 (ja) | ソフト抗コリン作用性エステルの投与の方法および使用 | |
| JP6461267B2 (ja) | ソフト型抗コリン作動薬類似体についての製剤 | |
| JP6647692B2 (ja) | ソフト抗コリン類似体のための製剤 | |
| HK1220369B (en) | Soft anticholinergic esters for the treatment of hyperhidrosis |
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