KR102153457B1 - 다한증 치료용 항콜린성 글리코피롤레이트 에스테르 - Google Patents

다한증 치료용 항콜린성 글리코피롤레이트 에스테르 Download PDF

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KR102153457B1
KR102153457B1 KR1020197034502A KR20197034502A KR102153457B1 KR 102153457 B1 KR102153457 B1 KR 102153457B1 KR 1020197034502 A KR1020197034502 A KR 1020197034502A KR 20197034502 A KR20197034502 A KR 20197034502A KR 102153457 B1 KR102153457 B1 KR 102153457B1
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hydroxyacetoxy
cyclopentyl
phenyl
composition
compound
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KR20190133072A (ko
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니콜라스 에스. 보도르
데이비드 앙굴로
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보도르 라보래토리즈, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
KR1020197034502A 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르 Active KR102153457B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798073P 2013-03-15 2013-03-15
US61/798,073 2013-03-15
PCT/US2014/028332 WO2014144075A1 (en) 2013-03-15 2014-03-14 Anticholinergic glycopyrrolate esters for the treatment of hyperhidrosis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157028470A Division KR102050299B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207015539A Division KR102241660B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르

Publications (2)

Publication Number Publication Date
KR20190133072A KR20190133072A (ko) 2019-11-29
KR102153457B1 true KR102153457B1 (ko) 2020-09-08

Family

ID=50625156

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020197034502A Active KR102153457B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르
KR1020157028470A Active KR102050299B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르
KR1020217010876A Ceased KR20210043742A (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르
KR1020207015539A Active KR102241660B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020157028470A Active KR102050299B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르
KR1020217010876A Ceased KR20210043742A (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르
KR1020207015539A Active KR102241660B1 (ko) 2013-03-15 2014-03-14 다한증 치료용 항콜린성 글리코피롤레이트 에스테르

Country Status (22)

Country Link
US (5) US9220707B2 (enExample)
EP (1) EP2968267B1 (enExample)
JP (4) JP6223543B2 (enExample)
KR (4) KR102153457B1 (enExample)
CN (2) CN105050596A (enExample)
AU (1) AU2014227923B2 (enExample)
BR (1) BR112015023153A2 (enExample)
CA (1) CA2904724C (enExample)
DK (1) DK2968267T3 (enExample)
ES (1) ES2673098T3 (enExample)
HK (1) HK1217177A1 (enExample)
HU (1) HUE038448T2 (enExample)
IL (1) IL241307B (enExample)
MX (1) MX363601B (enExample)
MY (1) MY192033A (enExample)
PH (1) PH12015501987A1 (enExample)
PL (1) PL2968267T3 (enExample)
PT (1) PT2968267T (enExample)
SG (1) SG11201507602SA (enExample)
TR (1) TR201808040T4 (enExample)
WO (1) WO2014144075A1 (enExample)
ZA (1) ZA201506834B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2673098T3 (es) * 2013-03-15 2018-06-19 Bodor Laboratories, Inc. Esteres anticolinérgicos suaves para el tratamiento de la hiperhidrosis
WO2017015485A1 (en) 2015-07-21 2017-01-26 Bodor Laboratories, Inc. Formulation for soft anticholinergic analogs
US20150259283A1 (en) 2014-03-13 2015-09-17 Brickell Biotech, Inc. Formulation for soft anticholinergic analogs
JP2017507959A (ja) 2014-03-13 2017-03-23 ボドール ラボラトリーズ， インコーポレイテッド 選択された抗コリン作動性両性イオンの使用
ES2861052T3 (es) * 2015-04-30 2021-10-05 Hisamitsu Pharmaceutical Co Composición tópica que comprende oxibutinina para el tratamiento de la hiperhidrosis
EP3347007B1 (en) 2015-09-11 2023-03-29 Bodor Laboratories, Inc. Methods and compositions for soft anticholinergic esters
AU2016318594A1 (en) * 2015-09-11 2018-04-26 Bodor Laboratories, Inc. Methods and compositions for soft anticholinergic zwitterions
EP3478365A4 (en) * 2016-07-01 2020-03-04 Bodor Laboratories, Inc. COMPOSITIONS AND METHODS FOR TREATING COPD
TWI719046B (zh) 2016-07-21 2021-02-21 美商波德實驗股份有限公司 軟性抗膽鹼類似物之製劑
KR101951021B1 (ko) 2017-02-06 2019-02-22 주식회사 퍼슨 발한억제 기능을 가지는 자외선 차단 화장료 조성물 및 이를 사용한 자외선 차단제의 제조방법
ES2761325T3 (es) * 2017-07-17 2020-05-19 Dr August Wolff Gmbh & Co Kg Arzneimittel Emulsión de aceite en agua
EP3826631A1 (en) 2018-07-24 2021-06-02 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical emulsion of an anticholinergic compound
SG10201912063PA (en) * 2019-12-12 2021-07-29 Nat Skin Centre Singapore Pte Ltd A pharmaceutical formulation
CA3174550A1 (en) 2020-03-03 2021-09-10 Kaken Pharmaceutical Co., Ltd. Medicament containing sofpironium bromide
JPWO2021177257A1 (enExample) 2020-03-03 2021-09-10
KR20250006082A (ko) 2022-04-14 2025-01-10 독토르. 아우구스트 볼프 게엠베하 운트 코. 카게 아르쯔네이미텔 중증 다한증 및 과도 발한을 치료하기 위한 항콜린성 화합물의 국소 제형
EP4260852A1 (en) 2022-04-14 2023-10-18 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating
KR102611847B1 (ko) * 2023-03-27 2023-12-12 주식회사 이플라스크 무스카린 수용체 길항 활성을 갖는 신규한 피롤리디늄 화합물 및 이의 용도

Citations (2)

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WO2007058971A2 (en) 2005-11-10 2007-05-24 Bodor Nicholas S Soft anticholinergic esters
WO2009051818A1 (en) 2007-10-18 2009-04-23 Stiefel Research Australia Pty Ltd Topical glycopyrrolate formulations

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US5292530A (en) 1991-06-02 1994-03-08 Helene Curtis, Inc. Stable anhydrous topically-active composition and suspending agent therefor
WO2003026585A2 (en) 2001-09-26 2003-04-03 Lukacsko Alison B Compositions and methods for inhibiting eccrine perspiration in humans
US8252316B2 (en) 2002-05-03 2012-08-28 Purepharm Inc. Method of topically applying glycopyrrolate solution using absorbent pad to reduce sweating
GB0428418D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0428416D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
ATE529400T1 (de) 2005-11-10 2011-11-15 Nicholas S Bodor Weiche anticholinerge zwitterionen
US8071693B2 (en) 2006-06-22 2011-12-06 Sabic Innovative Plastics Ip B.V. Polysiloxane/polyimide copolymers and blends thereof
ES2673098T3 (es) * 2013-03-15 2018-06-19 Bodor Laboratories, Inc. Esteres anticolinérgicos suaves para el tratamiento de la hiperhidrosis

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2007058971A2 (en) 2005-11-10 2007-05-24 Bodor Nicholas S Soft anticholinergic esters
WO2009051818A1 (en) 2007-10-18 2009-04-23 Stiefel Research Australia Pty Ltd Topical glycopyrrolate formulations

Also Published As

Publication number Publication date
KR20190133072A (ko) 2019-11-29
US20160067214A1 (en) 2016-03-10
EP2968267B1 (en) 2018-04-25
MX2015012072A (es) 2016-05-05
JP7008988B2 (ja) 2022-01-25
HK1220369A1 (en) 2017-05-05
MX363601B (es) 2019-03-28
CA2904724A1 (en) 2014-09-18
PL2968267T3 (pl) 2018-09-28
SG11201507602SA (en) 2015-10-29
US9492429B2 (en) 2016-11-15
KR20210043742A (ko) 2021-04-21
AU2014227923A1 (en) 2015-10-08
IL241307A0 (en) 2015-11-30
US9895350B2 (en) 2018-02-20
CA2904724C (en) 2021-01-26
JP2016517431A (ja) 2016-06-16
JP6223543B2 (ja) 2017-11-01
PT2968267T (pt) 2018-06-15
US20160310464A1 (en) 2016-10-27
WO2014144075A8 (en) 2015-10-15
EP2968267A1 (en) 2016-01-20
CN105050596A (zh) 2015-11-11
JP2018115187A (ja) 2018-07-26
BR112015023153A2 (pt) 2017-07-18
US10772867B2 (en) 2020-09-15
KR102241660B1 (ko) 2021-04-19
PH12015501987A1 (en) 2016-01-11
KR102050299B1 (ko) 2019-11-29
US20180185331A1 (en) 2018-07-05
US20140275204A1 (en) 2014-09-18
JP6461214B2 (ja) 2019-01-30
CN109364066A (zh) 2019-02-22
US20190328707A1 (en) 2019-10-31
WO2014144075A1 (en) 2014-09-18
IL241307B (en) 2019-07-31
AU2014227923B2 (en) 2019-02-14
ZA201506834B (en) 2018-12-19
JP2020122002A (ja) 2020-08-13
KR20150128942A (ko) 2015-11-18
DK2968267T3 (en) 2018-06-25
TR201808040T4 (tr) 2018-06-21
US9220707B2 (en) 2015-12-29
JP2017105811A (ja) 2017-06-15
ES2673098T3 (es) 2018-06-19
US10383846B2 (en) 2019-08-20
JP6694908B2 (ja) 2020-05-20
KR20200065103A (ko) 2020-06-08
HK1217177A1 (zh) 2016-12-30
HUE038448T2 (hu) 2018-10-29
MY192033A (en) 2022-07-24

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