JP2016516808A5 - - Google Patents
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- Publication number
- JP2016516808A5 JP2016516808A5 JP2016508288A JP2016508288A JP2016516808A5 JP 2016516808 A5 JP2016516808 A5 JP 2016516808A5 JP 2016508288 A JP2016508288 A JP 2016508288A JP 2016508288 A JP2016508288 A JP 2016508288A JP 2016516808 A5 JP2016516808 A5 JP 2016516808A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- bcl
- activity
- amount
- downregulates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 18
- 230000000694 effects Effects 0.000 claims 12
- 102100026596 Bcl-2-like protein 1 Human genes 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 4
- 230000003902 lesion Effects 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- HPLNQCPCUACXLM-PGUFJCEWSA-N ABT-737 Chemical group C([C@@H](CCN(C)C)NC=1C(=CC(=CC=1)S(=O)(=O)NC(=O)C=1C=CC(=CC=1)N1CCN(CC=2C(=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1)[N+]([O-])=O)SC1=CC=CC=C1 HPLNQCPCUACXLM-PGUFJCEWSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 1
- 101710157567 Cyclin-dependent kinase inhibitor 1 Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 229940123457 Free radical scavenger Drugs 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 229940124091 Keratolytic Drugs 0.000 claims 1
- 206010023421 Kidney fibrosis Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 239000013043 chemical agent Substances 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000002085 irritant Substances 0.000 claims 1
- 230000001530 keratinolytic effect Effects 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 claims 1
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical group C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims 1
- 229950004847 navitoclax Drugs 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 201000007094 prostatitis Diseases 0.000 claims 1
- 239000002516 radical scavenger Substances 0.000 claims 1
- 230000036573 scar formation Effects 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361814286P | 2013-04-21 | 2013-04-21 | |
| US61/814,286 | 2013-04-21 | ||
| PCT/IL2014/050358 WO2014174511A1 (en) | 2013-04-21 | 2014-04-13 | Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016516808A JP2016516808A (ja) | 2016-06-09 |
| JP2016516808A5 true JP2016516808A5 (enExample) | 2017-05-25 |
Family
ID=50877543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016508288A Pending JP2016516808A (ja) | 2013-04-21 | 2014-04-13 | Ｂｃｌ−ｘＬおよび／またはＢｃｌ−ｗの活性および／または量を下方制御するための薬剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160122758A1 (enExample) |
| EP (1) | EP2988767A1 (enExample) |
| JP (1) | JP2016516808A (enExample) |
| CN (1) | CN105377289A (enExample) |
| BR (1) | BR112015026702A2 (enExample) |
| CA (1) | CA2909380A1 (enExample) |
| MX (1) | MX2015014582A (enExample) |
| RU (1) | RU2015149680A (enExample) |
| WO (1) | WO2014174511A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120156134A1 (en) | 2007-12-20 | 2012-06-21 | Shayne Squires | Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease |
| US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| CA2859385A1 (en) | 2011-12-13 | 2013-06-20 | Buck Institute For Research On Aging | Methods for improving medical therapies |
| WO2013158664A2 (en) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
| US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
| US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
| US10279018B2 (en) | 2012-12-03 | 2019-05-07 | Unity Biotechnology, Inc. | Immunogenic compositions for inducing an immune response for elimination of senescent cells |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US9993472B2 (en) | 2014-01-28 | 2018-06-12 | Unity Biotechnology, Inc. | Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 |
| CN106456699B (zh) | 2014-05-05 | 2021-07-02 | 生物风险投资有限责任公司 | 作为抗老化剂抑制抗凋亡的Bcl-2蛋白的组合物和方法 |
| CA2955972A1 (en) | 2014-07-22 | 2016-01-28 | Bioventures, Llc. | Compositions and methods for selectively depleting senescent cells |
| JP2018508569A (ja) * | 2015-02-06 | 2018-03-29 | ユニティ バイオテクノロジー インコーポレイテッド | 老化関連状態の治療における化合物および使用 |
| US20180000816A1 (en) * | 2015-02-06 | 2018-01-04 | Unity Biotechnology, Inc. | Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions |
| US20180345047A1 (en) * | 2015-02-26 | 2018-12-06 | Yeda Research And Development Co. Ltd. | Method of promoting hair growth |
| WO2016185481A2 (en) | 2015-05-20 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Method of targeting senescent cells |
| WO2017002120A1 (en) * | 2015-07-02 | 2017-01-05 | Yeda Research And Development Co. Ltd. | Selective inhibitors of senescent cells and uses thereof |
| US11111259B2 (en) | 2015-12-18 | 2021-09-07 | Unity Biotechnology, Inc. | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders |
| CN109152933B (zh) | 2016-04-21 | 2022-12-02 | 生物风险投资有限责任公司 | 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 |
| US11123314B2 (en) * | 2017-02-22 | 2021-09-21 | National Cancer Center | Pharmaceutical composition for preventing and treating pancreatic cancer, containing gossypol and phenformin as active ingredients |
| US20200354336A9 (en) | 2017-08-11 | 2020-11-12 | Unity Biotechnology, Inc. | Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells |
| CN111372598A (zh) * | 2017-08-11 | 2020-07-03 | 联合生物科技公司 | 使用消除衰老细胞的药剂治疗诸如黄斑变性,青光眼,和糖尿病性视网膜病变等眼科状况 |
| US10588916B2 (en) | 2017-10-31 | 2020-03-17 | Unity Biotechnology, Inc. | Technology to inhibit vascular changes that lead to vision loss in the eye |
| US10689416B2 (en) | 2017-12-30 | 2020-06-23 | Unity Biotechnology, Inc. | Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer |
| ES3041854T3 (en) | 2018-01-22 | 2025-11-17 | Bioventures Llc | Bcl-2 proteins degraders for cancer treatment |
| WO2019213151A1 (en) | 2018-04-30 | 2019-11-07 | Unity Biotechnology | Phosphonamidates that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| WO2019221755A1 (en) | 2018-05-18 | 2019-11-21 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
| CN109387493B (zh) * | 2018-09-21 | 2020-12-22 | 山东大学 | 一种pH响应型自辅因子DNAzyme ZnO纳米探针及其制备方法与应用 |
| WO2020116537A1 (ja) * | 2018-12-05 | 2020-06-11 | 日東電工株式会社 | がん処置用ＲＮＡｉ分子 |
| IL275186A (en) | 2020-06-07 | 2022-01-01 | Yeda Res & Dev | Human antibodies against grp94 and uses |
| CN111973578A (zh) * | 2020-08-03 | 2020-11-24 | 天津医科大学 | C188-9、Venetoclax、Bumetanide在纤维化疾病药物中的应用 |
| CN112294962B (zh) * | 2020-11-13 | 2023-06-06 | 上海长海医院 | Bcl-2及bcl-xl抑制剂在瘢痕治疗中的应用 |
| EP4267741A2 (en) * | 2020-12-28 | 2023-11-01 | 1E Therapeutics, Ltd. | P21 mrna target areas for silencing |
| AU2021416356B2 (en) | 2020-12-28 | 2026-02-26 | 1E Therapeutics, Ltd. | P21 mrna targeting dnazymes |
| CN113633642A (zh) * | 2021-08-26 | 2021-11-12 | 山东第一医科大学附属青岛眼科医院(山东省眼科研究所、青岛眼科医院) | Abt-263在制备抑制角膜移植免疫排斥反应的药物中的应用 |
| US20250000892A1 (en) * | 2021-10-14 | 2025-01-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Programmable delivery platforms for rna structures |
| WO2023096448A1 (ko) * | 2021-11-29 | 2023-06-01 | 에스케이케미칼 주식회사 | 오바토클락스 대사성 질환 및 섬유화 질환 치료 용도 |
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| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
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| US20110301192A1 (en) | 2008-10-01 | 2011-12-08 | The Regents Of The University Of California | Inhibitors of Cyclin Kinase Inhibitor p21 |
| US20110020221A1 (en) * | 2009-04-09 | 2011-01-27 | The Johns Hopkins University | Cancer stem cell expression patterns and compounds to target cancer stem cells |
| KR20120085781A (ko) * | 2009-09-20 | 2012-08-01 | 아보트 러보러터리즈 | Ｂｃｌ-２ 단백질 관련 질환을 치료하는데 사용하기 위한 ａｂｔ-２６３ 결정 형태 및 용매화물 |
| KR101762724B1 (ko) * | 2011-01-25 | 2017-07-28 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2/bcl-xl 억제제 및 이를 이용한 치료 방법 |
| BR112013025798A2 (pt) * | 2011-04-08 | 2016-12-20 | Afraxis Holdings Inc | 8-etil-6-(aril)pirido[2,3-d]pirimidin-7(8h)-onas para o tratamento de câncer e distúrbios de sistema nervoso |
| EP2717907B1 (en) * | 2011-06-09 | 2015-05-27 | Isdin, S. A. | Use of photolyase for reducing or improving subclinical field cancerization associated with actinic keratosis |
| US10001485B2 (en) * | 2011-11-07 | 2018-06-19 | The Regents Of The University Of California | Methods for sensitizing a quiescent cancer stem cell to a BCR-ABL inhibitor |
| US10093640B2 (en) * | 2012-09-21 | 2018-10-09 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors |
-
2014
- 2014-04-13 BR BR112015026702A patent/BR112015026702A2/pt not_active IP Right Cessation
- 2014-04-13 CN CN201480035042.7A patent/CN105377289A/zh active Pending
- 2014-04-13 RU RU2015149680A patent/RU2015149680A/ru not_active Application Discontinuation
- 2014-04-13 WO PCT/IL2014/050358 patent/WO2014174511A1/en not_active Ceased
- 2014-04-13 EP EP14727628.1A patent/EP2988767A1/en not_active Withdrawn
- 2014-04-13 JP JP2016508288A patent/JP2016516808A/ja active Pending
- 2014-04-13 CA CA2909380A patent/CA2909380A1/en not_active Abandoned
- 2014-04-13 US US14/784,312 patent/US20160122758A1/en not_active Abandoned
- 2014-04-13 MX MX2015014582A patent/MX2015014582A/es unknown
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