JP2017537936A5 - - Google Patents
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- Publication number
- JP2017537936A5 JP2017537936A5 JP2017531367A JP2017531367A JP2017537936A5 JP 2017537936 A5 JP2017537936 A5 JP 2017537936A5 JP 2017531367 A JP2017531367 A JP 2017531367A JP 2017531367 A JP2017531367 A JP 2017531367A JP 2017537936 A5 JP2017537936 A5 JP 2017537936A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- compound
- stilbene
- dihydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 8
- ZISJNXNHJRQYJO-CMDGGOBGSA-N 5-[(e)-2-phenylethenyl]-2-propan-2-ylbenzene-1,3-diol Chemical compound C1=C(O)C(C(C)C)=C(O)C=C1\C=C\C1=CC=CC=C1 ZISJNXNHJRQYJO-CMDGGOBGSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 208000002874 Acne Vulgaris Diseases 0.000 claims 5
- 206010000496 acne Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 238000011200 topical administration Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000002510 keratinocyte Anatomy 0.000 claims 2
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 210000004761 scalp Anatomy 0.000 claims 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 claims 1
- 235000021286 stilbenes Nutrition 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021086297A JP2021152018A (ja) | 2014-12-12 | 2021-05-21 | 新規な使用方法 |
| JP2023095048A JP2023123554A (ja) | 2014-12-12 | 2023-06-08 | 新規な使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462090908P | 2014-12-12 | 2014-12-12 | |
| US62/090,908 | 2014-12-12 | ||
| PCT/IB2015/059490 WO2016092493A1 (en) | 2014-12-12 | 2015-12-09 | Novel method of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021086297A Division JP2021152018A (ja) | 2014-12-12 | 2021-05-21 | 新規な使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537936A JP2017537936A (ja) | 2017-12-21 |
| JP2017537936A5 true JP2017537936A5 (enExample) | 2019-01-31 |
| JP7313117B2 JP7313117B2 (ja) | 2023-07-24 |
Family
ID=55025296
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531367A Active JP7313117B2 (ja) | 2014-12-12 | 2015-12-09 | 新規な使用方法 |
| JP2021086297A Pending JP2021152018A (ja) | 2014-12-12 | 2021-05-21 | 新規な使用方法 |
| JP2023095048A Pending JP2023123554A (ja) | 2014-12-12 | 2023-06-08 | 新規な使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021086297A Pending JP2021152018A (ja) | 2014-12-12 | 2021-05-21 | 新規な使用方法 |
| JP2023095048A Pending JP2023123554A (ja) | 2014-12-12 | 2023-06-08 | 新規な使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10376475B2 (enExample) |
| EP (1) | EP3229840B1 (enExample) |
| JP (3) | JP7313117B2 (enExample) |
| KR (1) | KR102607222B1 (enExample) |
| AR (1) | AR102973A1 (enExample) |
| AU (1) | AU2015358910B2 (enExample) |
| CA (1) | CA2970739C (enExample) |
| DK (1) | DK3229840T5 (enExample) |
| ES (1) | ES2829637T3 (enExample) |
| TW (1) | TWI692357B (enExample) |
| WO (1) | WO2016092493A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3297605B1 (en) | 2015-05-21 | 2022-05-04 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
| US11617724B2 (en) | 2015-05-21 | 2023-04-04 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
| US20170231922A1 (en) * | 2016-02-16 | 2017-08-17 | Horizon GenoMed Therapeutics, Inc | 3, 5-dihydroxy-4-isopropylstilbene (dhis) as miticidal agent and its therapeutic uses |
| JP6912664B2 (ja) | 2017-11-10 | 2021-08-04 | ダーマヴァント サイエンシーズ ゲーエムベーハー | タピナロフを調製するためのプロセス |
| US10967197B2 (en) | 2018-08-29 | 2021-04-06 | Azulite, Inc. | Phototherapy devices and methods for treating truncal acne and scars |
| US11497718B2 (en) | 2018-11-13 | 2022-11-15 | Dermavant Sciences GmbH | Use of tapinarof for the treatment of atopic dermatitis |
| US20220054467A1 (en) * | 2019-02-25 | 2022-02-24 | Sol-Gel Technologies Ltd. | Treatment of psoriasis with topical tapinarof-tazarotene combination compositions |
| WO2020194313A1 (en) * | 2019-03-26 | 2020-10-01 | Sol-Gel Technologies Ltd. | Treatment of hidradenitis suppurativa with tapinarof compositions |
| US20220287990A1 (en) * | 2019-07-24 | 2022-09-15 | Sol-Gel Technologies Ltd. | Topical jak inhibitor combination compositions for treatment of inflammatory skin conditions |
| US20220331268A1 (en) * | 2019-09-26 | 2022-10-20 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with topical combination compositions comprising tapinarof and an additional ahr activator |
| JP2023503132A (ja) * | 2019-11-24 | 2023-01-26 | ソル － ゲル テクノロジーズ リミテッド | タピナロフおよびｐｄｅ４阻害剤を含む局所用組成物による皮膚障害の治療 |
| CN116265421B (zh) * | 2021-12-17 | 2024-01-02 | 上海泽德曼医药科技有限公司 | 用于预防或治疗中枢神经系统相关疾病的化合物 |
| WO2023109859A1 (zh) * | 2021-12-15 | 2023-06-22 | 上海泽德曼医药科技有限公司 | 二苯乙烯类化合物及其在用于预防和/或治疗中枢神经系统相关疾病中的应用 |
| JP2025529076A (ja) * | 2022-08-30 | 2025-09-04 | ダーマヴァント サイエンシーズ ゲーエムベーハー | ＡｈＲ媒介疾患の治療に使用するタピナロおよびそのアナログ製剤 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7513994A (en) | 1993-07-27 | 1995-02-28 | Agro-Biotech Corporation | Novel fungicidal properties of metabolites, culture broth, stilbene derivatives and indole derivatives produced by the bacteria (xenorhabdus) and (photorhabdus) spp. |
| US5747482A (en) * | 1996-07-30 | 1998-05-05 | Bernstein; Lawrence R. | Methods and compositions to inhibit keratinocyte proliferation |
| US7321050B2 (en) * | 1999-12-06 | 2008-01-22 | Welichem Biotech Inc. | Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues |
| DE60043120D1 (de) | 1999-12-06 | 2009-11-19 | Welichem Biotech Inc | Polyhydroxystilbene und -stilbenoxide als antipsoriasismittel und proteinkinasehemmer |
| JP2006508930A (ja) * | 2002-10-01 | 2006-03-16 | ウェリケム バイオテック インコーポレーテッド | 新規生物活性ジフェニルエテン化合物およびその治療への適用 |
| FR2917427B1 (fr) * | 2007-06-18 | 2009-08-21 | Galderma Res & Dev | Inhibiteurs de tace dans le traitement de l'acne |
| WO2009108762A2 (en) * | 2008-02-26 | 2009-09-03 | The Penn State Research Foundation | Methods and compositions for treatment of retinoid-responsive conditions |
| US20100003315A1 (en) * | 2008-07-02 | 2010-01-07 | Willeford Kenneth L | Method and Composition for the Treatment of Skin Conditions |
| CN101531571B (zh) | 2009-04-17 | 2013-03-20 | 河北科技大学 | 六次甲基四胺氧化合成二苯乙烯类化合物的方法 |
| CN101633606B (zh) | 2009-08-13 | 2014-08-27 | 河北科技大学 | 盐酸非均相氯代合成茋类化合物的方法 |
| CN101648851B (zh) | 2009-09-03 | 2012-10-10 | 河北科技大学 | (e)-3,5-二羟基-4-异丙基二苯乙烯的清洁制备方法 |
| CN101830764A (zh) | 2010-05-05 | 2010-09-15 | 河北科技大学 | 利用Pfitzner-moffatt氧化反应合成茋类化合物的方法 |
| CN101838173A (zh) | 2010-05-07 | 2010-09-22 | 河北科技大学 | 利用Kornblum氧化反应合成茋类化合物的方法 |
| AU2012277951C1 (en) * | 2011-06-27 | 2019-02-21 | Galderma Research & Development | New Th17 differentiation markers for acne and uses thereof |
-
2015
- 2015-12-09 KR KR1020177018865A patent/KR102607222B1/ko active Active
- 2015-12-09 US US15/529,671 patent/US10376475B2/en active Active
- 2015-12-09 CA CA2970739A patent/CA2970739C/en active Active
- 2015-12-09 WO PCT/IB2015/059490 patent/WO2016092493A1/en not_active Ceased
- 2015-12-09 DK DK15816887.2T patent/DK3229840T5/da active
- 2015-12-09 EP EP15816887.2A patent/EP3229840B1/en active Active
- 2015-12-09 ES ES15816887T patent/ES2829637T3/es active Active
- 2015-12-09 JP JP2017531367A patent/JP7313117B2/ja active Active
- 2015-12-09 AU AU2015358910A patent/AU2015358910B2/en active Active
- 2015-12-10 TW TW104141446A patent/TWI692357B/zh active
- 2015-12-11 AR ARP150104041A patent/AR102973A1/es not_active Application Discontinuation
-
2021
- 2021-05-21 JP JP2021086297A patent/JP2021152018A/ja active Pending
-
2023
- 2023-06-08 JP JP2023095048A patent/JP2023123554A/ja active Pending
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