JP2015509540A5 - - Google Patents
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- Publication number
- JP2015509540A5 JP2015509540A5 JP2014561069A JP2014561069A JP2015509540A5 JP 2015509540 A5 JP2015509540 A5 JP 2015509540A5 JP 2014561069 A JP2014561069 A JP 2014561069A JP 2014561069 A JP2014561069 A JP 2014561069A JP 2015509540 A5 JP2015509540 A5 JP 2015509540A5
- Authority
- JP
- Japan
- Prior art keywords
- alk
- disorder
- compound
- salt
- fak
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607305P | 2012-03-06 | 2012-03-06 | |
| US61/607,305 | 2012-03-06 | ||
| PCT/US2013/029304 WO2013134353A1 (en) | 2012-03-06 | 2013-03-06 | Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016188585A Division JP2017039741A (ja) | 2012-03-06 | 2016-09-27 | 二重のａｌｋおよびｆａｋ阻害剤としての縮合二環式２，４−ジアミノピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509540A JP2015509540A (ja) | 2015-03-30 |
| JP2015509540A5 true JP2015509540A5 (enExample) | 2016-02-25 |
| JP6016953B2 JP6016953B2 (ja) | 2016-10-26 |
Family
ID=47892060
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561069A Expired - Fee Related JP6016953B2 (ja) | 2012-03-06 | 2013-03-06 | 二重のａｌｋおよびｆａｋ阻害剤としての縮合二環式２，４−ジアミノピリミジン誘導体 |
| JP2016188585A Pending JP2017039741A (ja) | 2012-03-06 | 2016-09-27 | 二重のａｌｋおよびｆａｋ阻害剤としての縮合二環式２，４−ジアミノピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016188585A Pending JP2017039741A (ja) | 2012-03-06 | 2016-09-27 | 二重のａｌｋおよびｆａｋ阻害剤としての縮合二環式２，４−ジアミノピリミジン誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9132128B2 (enExample) |
| EP (2) | EP3056494B1 (enExample) |
| JP (2) | JP6016953B2 (enExample) |
| KR (1) | KR102068374B1 (enExample) |
| CN (2) | CN104159894B (enExample) |
| AU (1) | AU2013229995B2 (enExample) |
| CA (1) | CA2865420C (enExample) |
| CL (1) | CL2014002353A1 (enExample) |
| CY (1) | CY1117565T1 (enExample) |
| DK (1) | DK2822939T3 (enExample) |
| EA (2) | EA025859B1 (enExample) |
| ES (2) | ES2681487T3 (enExample) |
| HR (1) | HRP20160387T1 (enExample) |
| HU (1) | HUE027976T2 (enExample) |
| IL (2) | IL234239A (enExample) |
| ME (1) | ME02460B (enExample) |
| MX (2) | MX372740B (enExample) |
| MY (1) | MY177290A (enExample) |
| NZ (1) | NZ630251A (enExample) |
| PH (1) | PH12014501979A1 (enExample) |
| PL (1) | PL2822939T3 (enExample) |
| RS (1) | RS54689B1 (enExample) |
| SG (2) | SG10201507865QA (enExample) |
| SI (1) | SI2822939T1 (enExample) |
| SM (1) | SMT201600134B (enExample) |
| UA (1) | UA115052C2 (enExample) |
| WO (1) | WO2013134353A1 (enExample) |
| ZA (1) | ZA201406147B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2865420C (en) * | 2012-03-06 | 2020-06-02 | Cephalon, Inc. | Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor |
| JP6783224B2 (ja) | 2014-04-04 | 2020-11-11 | デル マー ファーマシューティカルズ | 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用 |
| WO2016105529A1 (en) | 2014-12-23 | 2016-06-30 | Cephalon, Inc. | Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives |
| US12257245B2 (en) | 2018-08-07 | 2025-03-25 | In3Bio Ltd. | Methods and compositions for inhibition of EGF/EGFR pathway in combination with anaplastic lymphoma kinase inhibitors |
| WO2024178339A2 (en) * | 2023-02-23 | 2024-08-29 | The Regents Of The University Of Michigan | Methods for treating neuroblastoma with a dual anaplastic lymphoma kinase and focal adhesion kinase inhibitor |
| CN121712509A (zh) | 2023-05-04 | 2026-03-20 | 锐新医药公司 | 用于ras相关疾病或病症的组合疗法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| IL327306A (en) | 2023-10-12 | 2026-05-01 | Revolution Medicines Inc | Macrocyclic RAS inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004259012C1 (en) | 2003-07-23 | 2012-08-02 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| TWI378923B (en) | 2003-08-15 | 2012-12-11 | Novartis Ag | Pyrimidine derivatives |
| CA2553785C (en) * | 2004-02-14 | 2011-02-08 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US7973061B2 (en) | 2004-03-31 | 2011-07-05 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| JP2009528295A (ja) * | 2006-02-24 | 2009-08-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋ経路の阻害のための組成物および方法 |
| ES2555803T3 (es) | 2006-10-23 | 2016-01-08 | Cephalon, Inc. | Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met |
| BRPI0722383A2 (pt) * | 2006-12-08 | 2012-06-05 | Irm Llc | compostos inibidores de proteìna quinase, composições contendo os mesmos bem como seus usos |
| AP2009005010A0 (en) * | 2007-04-18 | 2009-10-31 | Pfizer Prod Inc | Sulfonyl amide derivatives for the treatment of abnormal cell growth |
| ES2668775T3 (es) * | 2009-06-10 | 2018-05-22 | Chugai Seiyaku Kabushiki Kaisha | Compuestos tetracíclicos |
| CA2865420C (en) * | 2012-03-06 | 2020-06-02 | Cephalon, Inc. | Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor |
| KR101446742B1 (ko) * | 2012-08-10 | 2014-10-01 | 한국화학연구원 | Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| WO2016105529A1 (en) * | 2014-12-23 | 2016-06-30 | Cephalon, Inc. | Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives |
-
2013
- 2013-03-06 CA CA2865420A patent/CA2865420C/en active Active
- 2013-03-06 ES ES15202516.9T patent/ES2681487T3/es active Active
- 2013-03-06 EA EA201491641A patent/EA025859B1/ru not_active IP Right Cessation
- 2013-03-06 DK DK13710258.8T patent/DK2822939T3/en active
- 2013-03-06 NZ NZ630251A patent/NZ630251A/en unknown
- 2013-03-06 ME MEP-2016-68A patent/ME02460B/me unknown
- 2013-03-06 SI SI201330151T patent/SI2822939T1/sl unknown
- 2013-03-06 ES ES13710258T patent/ES2570976T3/es active Active
- 2013-03-06 MY MYPI2014002428A patent/MY177290A/en unknown
- 2013-03-06 AU AU2013229995A patent/AU2013229995B2/en active Active
- 2013-03-06 PL PL13710258T patent/PL2822939T3/pl unknown
- 2013-03-06 UA UAA201410832A patent/UA115052C2/uk unknown
- 2013-03-06 KR KR1020147027590A patent/KR102068374B1/ko active Active
- 2013-03-06 CN CN201380012764.6A patent/CN104159894B/zh active Active
- 2013-03-06 WO PCT/US2013/029304 patent/WO2013134353A1/en not_active Ceased
- 2013-03-06 HU HUE13710258A patent/HUE027976T2/en unknown
- 2013-03-06 MX MX2017006206A patent/MX372740B/es unknown
- 2013-03-06 MX MX2014010613A patent/MX347772B/es active IP Right Grant
- 2013-03-06 CN CN201610591742.5A patent/CN106166155B/zh active Active
- 2013-03-06 SG SG10201507865QA patent/SG10201507865QA/en unknown
- 2013-03-06 EP EP15202516.9A patent/EP3056494B1/en active Active
- 2013-03-06 JP JP2014561069A patent/JP6016953B2/ja not_active Expired - Fee Related
- 2013-03-06 SG SG11201405371PA patent/SG11201405371PA/en unknown
- 2013-03-06 EA EA201691574A patent/EA033124B1/ru not_active IP Right Cessation
- 2013-03-06 EP EP13710258.8A patent/EP2822939B1/en active Active
- 2013-03-06 HR HRP20160387TT patent/HRP20160387T1/hr unknown
- 2013-03-06 RS RS20160238A patent/RS54689B1/sr unknown
-
2014
- 2014-08-21 ZA ZA2014/06147A patent/ZA201406147B/en unknown
- 2014-08-21 IL IL234239A patent/IL234239A/en active IP Right Grant
- 2014-09-02 US US14/474,928 patent/US9132128B2/en active Active
- 2014-09-05 PH PH12014501979A patent/PH12014501979A1/en unknown
- 2014-09-05 CL CL2014002353A patent/CL2014002353A1/es unknown
-
2015
- 2015-08-12 US US14/824,750 patent/US9339502B2/en active Active
-
2016
- 2016-05-04 US US15/146,164 patent/US9623026B2/en not_active Expired - Fee Related
- 2016-05-10 SM SM201600134T patent/SMT201600134B/it unknown
- 2016-05-10 CY CY20161100390T patent/CY1117565T1/el unknown
- 2016-09-27 JP JP2016188585A patent/JP2017039741A/ja active Pending
-
2017
- 2017-03-07 US US15/451,960 patent/US10111872B2/en active Active
- 2017-05-18 IL IL252364A patent/IL252364B/en active IP Right Grant
-
2018
- 2018-10-26 US US16/172,368 patent/US10632119B2/en active Active
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