MX347772B - Derivado de 2,4-diaminopirimidina biciclico fusionado como un inhibidor dual de alk y fak. - Google Patents
Derivado de 2,4-diaminopirimidina biciclico fusionado como un inhibidor dual de alk y fak.Info
- Publication number
- MX347772B MX347772B MX2014010613A MX2014010613A MX347772B MX 347772 B MX347772 B MX 347772B MX 2014010613 A MX2014010613 A MX 2014010613A MX 2014010613 A MX2014010613 A MX 2014010613A MX 347772 B MX347772 B MX 347772B
- Authority
- MX
- Mexico
- Prior art keywords
- fused bicyclic
- fak inhibitor
- diaminopyrimidine derivative
- alk
- dual alk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención provee un compuesto de la fórmula (I) (ver Fórmula) o una de sus formas de sal. El compuesto de la fórmula (I) tiene actividad inhibitoria de ALK y FAK, y puede usarse para el tratamiento de trastornos proliferativos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261607305P | 2012-03-06 | 2012-03-06 | |
PCT/US2013/029304 WO2013134353A1 (en) | 2012-03-06 | 2013-03-06 | Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014010613A MX2014010613A (es) | 2014-09-18 |
MX347772B true MX347772B (es) | 2017-05-12 |
Family
ID=47892060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014010613A MX347772B (es) | 2012-03-06 | 2013-03-06 | Derivado de 2,4-diaminopirimidina biciclico fusionado como un inhibidor dual de alk y fak. |
Country Status (29)
Country | Link |
---|---|
US (5) | US9132128B2 (es) |
EP (2) | EP2822939B1 (es) |
JP (2) | JP6016953B2 (es) |
KR (1) | KR102068374B1 (es) |
CN (2) | CN106166155B (es) |
AU (1) | AU2013229995B2 (es) |
CA (1) | CA2865420C (es) |
CL (1) | CL2014002353A1 (es) |
CY (1) | CY1117565T1 (es) |
DK (1) | DK2822939T3 (es) |
EA (2) | EA025859B1 (es) |
ES (2) | ES2681487T3 (es) |
HK (2) | HK1205119A1 (es) |
HR (1) | HRP20160387T1 (es) |
HU (1) | HUE027976T2 (es) |
IL (2) | IL234239A (es) |
ME (1) | ME02460B (es) |
MX (1) | MX347772B (es) |
MY (1) | MY177290A (es) |
NZ (1) | NZ630251A (es) |
PH (1) | PH12014501979A1 (es) |
PL (1) | PL2822939T3 (es) |
RS (1) | RS54689B1 (es) |
SG (2) | SG10201507865QA (es) |
SI (1) | SI2822939T1 (es) |
SM (1) | SMT201600134B (es) |
UA (1) | UA115052C2 (es) |
WO (1) | WO2013134353A1 (es) |
ZA (1) | ZA201406147B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS54689B1 (en) * | 2012-03-06 | 2016-08-31 | Cephalon, Inc. | CONNECTED BICYCLIC 2,4- DIAMINOPYRIMIDINE DERIVATIVE AS DUAL ALK AND FAK INHIBITOR |
WO2015154064A2 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
JP6849594B2 (ja) * | 2014-12-23 | 2021-03-24 | セファロン、インク. | 縮合二環式2,4−ジアミノピリミジン誘導体を調整する方法 |
JP2021534094A (ja) | 2018-08-07 | 2021-12-09 | イン3バイオ・リミテッドIn3Bio Ltd. | 未分化リンパ腫キナーゼ阻害剤と組み合わせてegf/egfr経路を抑制するための方法および組成物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004259012C1 (en) | 2003-07-23 | 2012-08-02 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
SI1660458T1 (sl) | 2003-08-15 | 2012-05-31 | Novartis Ag | pirimidindiamini uporabni pri zdravljenju neoplastičnih bolezni vnetnih motenj in motenj imunskega sistema |
PL1713806T3 (pl) * | 2004-02-14 | 2013-09-30 | Irm Llc | Związki i kompozycje jako inhibitory kinaz białkowych |
US7973061B2 (en) | 2004-03-31 | 2011-07-05 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
US8962643B2 (en) * | 2006-02-24 | 2015-02-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
CA2669111C (en) * | 2006-10-23 | 2016-04-12 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
EP3012249A1 (en) * | 2006-12-08 | 2016-04-27 | Novartis AG | Compounds and composition as protein kinase inhibitors |
EA016679B1 (ru) * | 2007-04-18 | 2012-06-29 | Пфайзер Продактс Инк. | Сульфониламидные производные для лечения аномального роста клеток |
MA33418B1 (fr) * | 2009-06-10 | 2012-07-03 | Chugai Pharmaceutical Co Ltd | Composé tétracyclique |
RS54689B1 (en) * | 2012-03-06 | 2016-08-31 | Cephalon, Inc. | CONNECTED BICYCLIC 2,4- DIAMINOPYRIMIDINE DERIVATIVE AS DUAL ALK AND FAK INHIBITOR |
KR101446742B1 (ko) * | 2012-08-10 | 2014-10-01 | 한국화학연구원 | N2,n4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
JP6849594B2 (ja) * | 2014-12-23 | 2021-03-24 | セファロン、インク. | 縮合二環式2,4−ジアミノピリミジン誘導体を調整する方法 |
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2013
- 2013-03-06 RS RS20160238A patent/RS54689B1/en unknown
- 2013-03-06 EA EA201491641A patent/EA025859B1/ru not_active IP Right Cessation
- 2013-03-06 CN CN201610591742.5A patent/CN106166155B/zh active Active
- 2013-03-06 MX MX2014010613A patent/MX347772B/es active IP Right Grant
- 2013-03-06 ES ES15202516.9T patent/ES2681487T3/es active Active
- 2013-03-06 JP JP2014561069A patent/JP6016953B2/ja active Active
- 2013-03-06 CN CN201380012764.6A patent/CN104159894B/zh active Active
- 2013-03-06 UA UAA201410832A patent/UA115052C2/uk unknown
- 2013-03-06 SG SG10201507865QA patent/SG10201507865QA/en unknown
- 2013-03-06 EP EP13710258.8A patent/EP2822939B1/en active Active
- 2013-03-06 EA EA201691574A patent/EA033124B1/ru not_active IP Right Cessation
- 2013-03-06 PL PL13710258T patent/PL2822939T3/pl unknown
- 2013-03-06 ES ES13710258T patent/ES2570976T3/es active Active
- 2013-03-06 ME MEP-2016-68A patent/ME02460B/me unknown
- 2013-03-06 CA CA2865420A patent/CA2865420C/en active Active
- 2013-03-06 NZ NZ630251A patent/NZ630251A/en unknown
- 2013-03-06 KR KR1020147027590A patent/KR102068374B1/ko active IP Right Grant
- 2013-03-06 SI SI201330151T patent/SI2822939T1/sl unknown
- 2013-03-06 EP EP15202516.9A patent/EP3056494B1/en active Active
- 2013-03-06 DK DK13710258.8T patent/DK2822939T3/en active
- 2013-03-06 HU HUE13710258A patent/HUE027976T2/en unknown
- 2013-03-06 MY MYPI2014002428A patent/MY177290A/en unknown
- 2013-03-06 AU AU2013229995A patent/AU2013229995B2/en active Active
- 2013-03-06 WO PCT/US2013/029304 patent/WO2013134353A1/en active Application Filing
- 2013-03-06 SG SG11201405371PA patent/SG11201405371PA/en unknown
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2014
- 2014-08-21 IL IL234239A patent/IL234239A/en active IP Right Grant
- 2014-08-21 ZA ZA2014/06147A patent/ZA201406147B/en unknown
- 2014-09-02 US US14/474,928 patent/US9132128B2/en active Active
- 2014-09-05 PH PH12014501979A patent/PH12014501979A1/en unknown
- 2014-09-05 CL CL2014002353A patent/CL2014002353A1/es unknown
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2015
- 2015-06-19 HK HK15105852.9A patent/HK1205119A1/zh unknown
- 2015-08-12 US US14/824,750 patent/US9339502B2/en active Active
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2016
- 2016-04-14 HR HRP20160387TT patent/HRP20160387T1/hr unknown
- 2016-05-04 US US15/146,164 patent/US9623026B2/en active Active
- 2016-05-10 SM SM201600134T patent/SMT201600134B/it unknown
- 2016-05-10 CY CY20161100390T patent/CY1117565T1/el unknown
- 2016-09-27 JP JP2016188585A patent/JP2017039741A/ja active Pending
- 2016-12-22 HK HK16114598A patent/HK1226300A1/zh unknown
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2017
- 2017-03-07 US US15/451,960 patent/US10111872B2/en active Active
- 2017-05-18 IL IL252364A patent/IL252364B/en active IP Right Grant
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2018
- 2018-10-26 US US16/172,368 patent/US10632119B2/en active Active
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