CY1117565T1 - Συνενωμενο δικυκλικο παραγωγο 2,4-διαμινοπυριδινης ως διπλος αναστολεας alk και fak - Google Patents
Συνενωμενο δικυκλικο παραγωγο 2,4-διαμινοπυριδινης ως διπλος αναστολεας alk και fakInfo
- Publication number
- CY1117565T1 CY1117565T1 CY20161100390T CY161100390T CY1117565T1 CY 1117565 T1 CY1117565 T1 CY 1117565T1 CY 20161100390 T CY20161100390 T CY 20161100390T CY 161100390 T CY161100390 T CY 161100390T CY 1117565 T1 CY1117565 T1 CY 1117565T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alk
- fak
- diaminopyridine
- producer
- double
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μία ένωση τύπου (I) ή μία μορφή άλατος αυτής. Η ένωση τύπου (I) έχει δράση αναστολέα ALK και FAK και μπορεί να χρησιμοποιηθεί για αγωγή πολλαπλασιαστικών διαταραχών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607305P | 2012-03-06 | 2012-03-06 | |
| EP13710258.8A EP2822939B1 (en) | 2012-03-06 | 2013-03-06 | Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117565T1 true CY1117565T1 (el) | 2017-04-26 |
Family
ID=47892060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100390T CY1117565T1 (el) | 2012-03-06 | 2016-05-10 | Συνενωμενο δικυκλικο παραγωγο 2,4-διαμινοπυριδινης ως διπλος αναστολεας alk και fak |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US9132128B2 (el) |
| EP (2) | EP3056494B1 (el) |
| JP (2) | JP6016953B2 (el) |
| KR (1) | KR102068374B1 (el) |
| CN (2) | CN104159894B (el) |
| AU (1) | AU2013229995B2 (el) |
| CA (1) | CA2865420C (el) |
| CL (1) | CL2014002353A1 (el) |
| CY (1) | CY1117565T1 (el) |
| DK (1) | DK2822939T3 (el) |
| EA (2) | EA025859B1 (el) |
| ES (2) | ES2570976T3 (el) |
| HK (2) | HK1205119A1 (el) |
| HR (1) | HRP20160387T1 (el) |
| HU (1) | HUE027976T2 (el) |
| IL (2) | IL234239A (el) |
| ME (1) | ME02460B (el) |
| MX (1) | MX347772B (el) |
| MY (1) | MY177290A (el) |
| NZ (1) | NZ630251A (el) |
| PH (1) | PH12014501979A1 (el) |
| PL (1) | PL2822939T3 (el) |
| RS (1) | RS54689B1 (el) |
| SG (2) | SG10201507865QA (el) |
| SI (1) | SI2822939T1 (el) |
| SM (1) | SMT201600134B (el) |
| UA (1) | UA115052C2 (el) |
| WO (1) | WO2013134353A1 (el) |
| ZA (1) | ZA201406147B (el) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2822939T3 (pl) * | 2012-03-06 | 2016-08-31 | Cephalon Inc | Skondensowane bicykliczne pochodne 2,4-diaminopirymidyny jako podwójne inhibitory ALK i FAK |
| CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
| JP6849594B2 (ja) * | 2014-12-23 | 2021-03-24 | セファロン、インク． | 縮合二環式２，４−ジアミノピリミジン誘導体を調整する方法 |
| JP2021534094A (ja) | 2018-08-07 | 2021-12-09 | イン3バイオ・リミテッドIn3Bio Ltd. | 未分化リンパ腫キナーゼ阻害剤と組み合わせてｅｇｆ／ｅｇｆｒ経路を抑制するための方法および組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005009389A2 (en) | 2003-07-23 | 2005-02-03 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| PL2287156T3 (pl) | 2003-08-15 | 2013-11-29 | Novartis Ag | 2,4-Di(fenyloamino)-pirymidyny stosowane w leczeniu chorób nowotworowych, chorób zapalnych i zaburzeń układu immunologicznego |
| CA2553785C (en) | 2004-02-14 | 2011-02-08 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| JP2008502595A (ja) | 2004-03-31 | 2008-01-31 | エグゼリクシス， インコーポレイテッド | 未分化リンパ腫キナーゼモジュレータおよびその使用方法 |
| JP2009528295A (ja) * | 2006-02-24 | 2009-08-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋ経路の阻害のための組成物および方法 |
| MX2009004426A (es) | 2006-10-23 | 2009-08-12 | Cephalon Inc | Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met. |
| EP2311807B1 (en) * | 2006-12-08 | 2015-11-11 | Novartis AG | Compounds and composition as protein kinase inhibitors |
| GEP20125581B (en) * | 2007-04-18 | 2012-07-25 | Pfizer Prod Inc | Sulfonyl amide derivatives for treatment of abnormal cell growth |
| HUE039167T2 (hu) * | 2009-06-10 | 2018-12-28 | Chugai Pharmaceutical Co Ltd | Tetraciklikus vegyületek |
| PL2822939T3 (pl) * | 2012-03-06 | 2016-08-31 | Cephalon Inc | Skondensowane bicykliczne pochodne 2,4-diaminopirymidyny jako podwójne inhibitory ALK i FAK |
| KR101446742B1 (ko) * | 2012-08-10 | 2014-10-01 | 한국화학연구원 | Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| JP6849594B2 (ja) * | 2014-12-23 | 2021-03-24 | セファロン、インク． | 縮合二環式２，４−ジアミノピリミジン誘導体を調整する方法 |
-
2013
- 2013-03-06 PL PL13710258T patent/PL2822939T3/pl unknown
- 2013-03-06 EP EP15202516.9A patent/EP3056494B1/en active Active
- 2013-03-06 CN CN201380012764.6A patent/CN104159894B/zh active Active
- 2013-03-06 WO PCT/US2013/029304 patent/WO2013134353A1/en active Application Filing
- 2013-03-06 HU HUE13710258A patent/HUE027976T2/en unknown
- 2013-03-06 SG SG10201507865QA patent/SG10201507865QA/en unknown
- 2013-03-06 RS RS20160238A patent/RS54689B1/en unknown
- 2013-03-06 MY MYPI2014002428A patent/MY177290A/en unknown
- 2013-03-06 ES ES13710258T patent/ES2570976T3/es active Active
- 2013-03-06 ES ES15202516.9T patent/ES2681487T3/es active Active
- 2013-03-06 KR KR1020147027590A patent/KR102068374B1/ko active IP Right Grant
- 2013-03-06 JP JP2014561069A patent/JP6016953B2/ja active Active
- 2013-03-06 AU AU2013229995A patent/AU2013229995B2/en active Active
- 2013-03-06 EA EA201491641A patent/EA025859B1/ru not_active IP Right Cessation
- 2013-03-06 EP EP13710258.8A patent/EP2822939B1/en active Active
- 2013-03-06 SG SG11201405371PA patent/SG11201405371PA/en unknown
- 2013-03-06 MX MX2014010613A patent/MX347772B/es active IP Right Grant
- 2013-03-06 NZ NZ630251A patent/NZ630251A/en unknown
- 2013-03-06 DK DK13710258.8T patent/DK2822939T3/en active
- 2013-03-06 UA UAA201410832A patent/UA115052C2/uk unknown
- 2013-03-06 ME MEP-2016-68A patent/ME02460B/me unknown
- 2013-03-06 CN CN201610591742.5A patent/CN106166155B/zh active Active
- 2013-03-06 SI SI201330151T patent/SI2822939T1/sl unknown
- 2013-03-06 EA EA201691574A patent/EA033124B1/ru not_active IP Right Cessation
- 2013-03-06 CA CA2865420A patent/CA2865420C/en active Active
-
2014
- 2014-08-21 IL IL234239A patent/IL234239A/en active IP Right Grant
- 2014-08-21 ZA ZA2014/06147A patent/ZA201406147B/en unknown
- 2014-09-02 US US14/474,928 patent/US9132128B2/en active Active
- 2014-09-05 PH PH12014501979A patent/PH12014501979A1/en unknown
- 2014-09-05 CL CL2014002353A patent/CL2014002353A1/es unknown
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2015
- 2015-06-19 HK HK15105852.9A patent/HK1205119A1/zh unknown
- 2015-08-12 US US14/824,750 patent/US9339502B2/en active Active
-
2016
- 2016-04-14 HR HRP20160387TT patent/HRP20160387T1/hr unknown
- 2016-05-04 US US15/146,164 patent/US9623026B2/en active Active
- 2016-05-10 SM SM201600134T patent/SMT201600134B/it unknown
- 2016-05-10 CY CY20161100390T patent/CY1117565T1/el unknown
- 2016-09-27 JP JP2016188585A patent/JP2017039741A/ja active Pending
- 2016-12-22 HK HK16114598A patent/HK1226300A1/zh unknown
-
2017
- 2017-03-07 US US15/451,960 patent/US10111872B2/en active Active
- 2017-05-18 IL IL252364A patent/IL252364B/en active IP Right Grant
-
2018
- 2018-10-26 US US16/172,368 patent/US10632119B2/en active Active
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