JP2016516728A5 - - Google Patents
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- Publication number
- JP2016516728A5 JP2016516728A5 JP2016503388A JP2016503388A JP2016516728A5 JP 2016516728 A5 JP2016516728 A5 JP 2016516728A5 JP 2016503388 A JP2016503388 A JP 2016503388A JP 2016503388 A JP2016503388 A JP 2016503388A JP 2016516728 A5 JP2016516728 A5 JP 2016516728A5
- Authority
- JP
- Japan
- Prior art keywords
- patent document
- insulin
- international publication
- international
- publication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000012867 alanine scanning Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000004791 biological behavior Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798165P | 2013-03-15 | 2013-03-15 | |
| US61/798,165 | 2013-03-15 | ||
| PCT/US2014/030387 WO2014145593A2 (en) | 2013-03-15 | 2014-03-17 | Site 2 insulin analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016516728A JP2016516728A (ja) | 2016-06-09 |
| JP2016516728A5 true JP2016516728A5 (cg-RX-API-DMAC7.html) | 2017-03-30 |
Family
ID=51538504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503388A Pending JP2016516728A (ja) | 2013-03-15 | 2014-03-17 | 第２部位インスリン類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160083448A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2968473A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2016516728A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20150138251A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105228643A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014232894B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015023672A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2942524A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL241357B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145593A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102351111B1 (ko) | 2014-01-13 | 2022-01-14 | 써멀린 다이어비티즈, 엘엘씨 | 초속효성 인슐린 제형 및 약제학적 전달 시스템 |
| KR20170106373A (ko) * | 2015-01-20 | 2017-09-20 | 케이스 웨스턴 리저브 유니버시티 | 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체 |
| BR112019000991A2 (pt) | 2016-07-22 | 2019-07-02 | University Of Utah Research Foundation | análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica |
| MA46568A (fr) * | 2016-10-24 | 2019-08-28 | Novo Nordisk As | Dosage biologique de formulations d'insuline |
| CA3294636A1 (en) | 2016-11-21 | 2026-02-10 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| US20210371489A1 (en) * | 2018-09-21 | 2021-12-02 | Case Western Reserve University | Site 2 single-chain insulin analogues |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK158390D0 (da) * | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
| DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| DK33591D0 (cg-RX-API-DMAC7.html) * | 1991-02-27 | 1991-02-27 | Novo Nordisk As | |
| CN101573133B (zh) * | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| EP2296692A4 (en) * | 2008-04-22 | 2012-06-06 | Univ Case Western Reserve | ISOFORM-SPECIFIC INSULIN ANALOG |
| MX2011001181A (es) * | 2008-07-31 | 2011-04-05 | Univ Case Western Reserve | Insulina estabilizada con halogeno. |
-
2014
- 2014-03-17 BR BR112015023672A patent/BR112015023672A2/pt not_active Application Discontinuation
- 2014-03-17 EP EP14764949.5A patent/EP2968473A4/en not_active Withdrawn
- 2014-03-17 US US14/774,109 patent/US20160083448A1/en not_active Abandoned
- 2014-03-17 JP JP2016503388A patent/JP2016516728A/ja active Pending
- 2014-03-17 CA CA2942524A patent/CA2942524A1/en not_active Abandoned
- 2014-03-17 WO PCT/US2014/030387 patent/WO2014145593A2/en not_active Ceased
- 2014-03-17 KR KR1020157029605A patent/KR20150138251A/ko not_active Ceased
- 2014-03-17 CN CN201480026485.XA patent/CN105228643A/zh active Pending
- 2014-03-17 AU AU2014232894A patent/AU2014232894B2/en not_active Ceased
-
2015
- 2015-09-09 IL IL241357A patent/IL241357B/en unknown
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