AU2014232894B2 - Site 2 insulin analogues - Google Patents

Site 2 insulin analogues Download PDF

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Publication number
AU2014232894B2
AU2014232894B2 AU2014232894A AU2014232894A AU2014232894B2 AU 2014232894 B2 AU2014232894 B2 AU 2014232894B2 AU 2014232894 A AU2014232894 A AU 2014232894A AU 2014232894 A AU2014232894 A AU 2014232894A AU 2014232894 B2 AU2014232894 B2 AU 2014232894B2
Authority
AU
Australia
Prior art keywords
insulin
chain
pct
glu
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014232894A
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English (en)
Other versions
AU2014232894A1 (en
Inventor
Michael A. Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of AU2014232894A1 publication Critical patent/AU2014232894A1/en
Application granted granted Critical
Publication of AU2014232894B2 publication Critical patent/AU2014232894B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2014232894A 2013-03-15 2014-03-17 Site 2 insulin analogues Ceased AU2014232894B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798165P 2013-03-15 2013-03-15
US61/798,165 2013-03-15
PCT/US2014/030387 WO2014145593A2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Publications (2)

Publication Number Publication Date
AU2014232894A1 AU2014232894A1 (en) 2015-11-05
AU2014232894B2 true AU2014232894B2 (en) 2018-02-08

Family

ID=51538504

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014232894A Ceased AU2014232894B2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Country Status (10)

Country Link
US (1) US20160083448A1 (cg-RX-API-DMAC7.html)
EP (1) EP2968473A4 (cg-RX-API-DMAC7.html)
JP (1) JP2016516728A (cg-RX-API-DMAC7.html)
KR (1) KR20150138251A (cg-RX-API-DMAC7.html)
CN (1) CN105228643A (cg-RX-API-DMAC7.html)
AU (1) AU2014232894B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015023672A2 (cg-RX-API-DMAC7.html)
CA (1) CA2942524A1 (cg-RX-API-DMAC7.html)
IL (1) IL241357B (cg-RX-API-DMAC7.html)
WO (1) WO2014145593A2 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
KR20170106373A (ko) * 2015-01-20 2017-09-20 케이스 웨스턴 리저브 유니버시티 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체
BR112019000991A2 (pt) 2016-07-22 2019-07-02 University Of Utah Research Foundation análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica
MA46568A (fr) * 2016-10-24 2019-08-28 Novo Nordisk As Dosage biologique de formulations d'insuline
CA3294636A1 (en) 2016-11-21 2026-02-10 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
US20210371489A1 (en) * 2018-09-21 2021-12-02 Case Western Reserve University Site 2 single-chain insulin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (cg-RX-API-DMAC7.html) * 1991-02-27 1991-02-27 Novo Nordisk As
CN101573133B (zh) * 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
EP2296692A4 (en) * 2008-04-22 2012-06-06 Univ Case Western Reserve ISOFORM-SPECIFIC INSULIN ANALOG
MX2011001181A (es) * 2008-07-31 2011-04-05 Univ Case Western Reserve Insulina estabilizada con halogeno.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRISTENSEN ET AL., "Alanine Scanning Mutagenesis of Insulin", J BIOLOGICAL CHEMISTRY, 1997, vol. 272, no. 20, pages 12978 - 12983 *

Also Published As

Publication number Publication date
EP2968473A2 (en) 2016-01-20
EP2968473A4 (en) 2016-11-23
BR112015023672A2 (pt) 2017-07-18
CN105228643A (zh) 2016-01-06
IL241357A0 (en) 2015-11-30
JP2016516728A (ja) 2016-06-09
KR20150138251A (ko) 2015-12-09
CA2942524A1 (en) 2014-09-18
US20160083448A1 (en) 2016-03-24
IL241357B (en) 2021-08-31
WO2014145593A2 (en) 2014-09-18
WO2014145593A3 (en) 2015-01-08
AU2014232894A1 (en) 2015-11-05

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired