CA2942524A1 - Site 2 insulin analogues - Google Patents

Site 2 insulin analogues Download PDF

Info

Publication number
CA2942524A1
CA2942524A1 CA2942524A CA2942524A CA2942524A1 CA 2942524 A1 CA2942524 A1 CA 2942524A1 CA 2942524 A CA2942524 A CA 2942524A CA 2942524 A CA2942524 A CA 2942524A CA 2942524 A1 CA2942524 A1 CA 2942524A1
Authority
CA
Canada
Prior art keywords
insulin
glu
gln
chain
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2942524A
Other languages
English (en)
French (fr)
Inventor
Michael A. Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of CA2942524A1 publication Critical patent/CA2942524A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2942524A 2013-03-15 2014-03-17 Site 2 insulin analogues Abandoned CA2942524A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798165P 2013-03-15 2013-03-15
US61/798,165 2013-03-15
PCT/US2014/030387 WO2014145593A2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Publications (1)

Publication Number Publication Date
CA2942524A1 true CA2942524A1 (en) 2014-09-18

Family

ID=51538504

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2942524A Abandoned CA2942524A1 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Country Status (10)

Country Link
US (1) US20160083448A1 (cg-RX-API-DMAC7.html)
EP (1) EP2968473A4 (cg-RX-API-DMAC7.html)
JP (1) JP2016516728A (cg-RX-API-DMAC7.html)
KR (1) KR20150138251A (cg-RX-API-DMAC7.html)
CN (1) CN105228643A (cg-RX-API-DMAC7.html)
AU (1) AU2014232894B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015023672A2 (cg-RX-API-DMAC7.html)
CA (1) CA2942524A1 (cg-RX-API-DMAC7.html)
IL (1) IL241357B (cg-RX-API-DMAC7.html)
WO (1) WO2014145593A2 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
KR20170106373A (ko) * 2015-01-20 2017-09-20 케이스 웨스턴 리저브 유니버시티 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체
BR112019000991A2 (pt) 2016-07-22 2019-07-02 University Of Utah Research Foundation análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica
MA46568A (fr) * 2016-10-24 2019-08-28 Novo Nordisk As Dosage biologique de formulations d'insuline
CA3294636A1 (en) 2016-11-21 2026-02-10 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
US20210371489A1 (en) * 2018-09-21 2021-12-02 Case Western Reserve University Site 2 single-chain insulin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (cg-RX-API-DMAC7.html) * 1991-02-27 1991-02-27 Novo Nordisk As
CN101573133B (zh) * 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
EP2296692A4 (en) * 2008-04-22 2012-06-06 Univ Case Western Reserve ISOFORM-SPECIFIC INSULIN ANALOG
MX2011001181A (es) * 2008-07-31 2011-04-05 Univ Case Western Reserve Insulina estabilizada con halogeno.

Also Published As

Publication number Publication date
EP2968473A2 (en) 2016-01-20
AU2014232894B2 (en) 2018-02-08
EP2968473A4 (en) 2016-11-23
BR112015023672A2 (pt) 2017-07-18
CN105228643A (zh) 2016-01-06
IL241357A0 (en) 2015-11-30
JP2016516728A (ja) 2016-06-09
KR20150138251A (ko) 2015-12-09
US20160083448A1 (en) 2016-03-24
IL241357B (en) 2021-08-31
WO2014145593A2 (en) 2014-09-18
WO2014145593A3 (en) 2015-01-08
AU2014232894A1 (en) 2015-11-05

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20161012

FZDE Discontinued

Effective date: 20200923