KR20150138251A - 부위 2 인슐린 유사체 - Google Patents

부위 2 인슐린 유사체 Download PDF

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Publication number
KR20150138251A
KR20150138251A KR1020157029605A KR20157029605A KR20150138251A KR 20150138251 A KR20150138251 A KR 20150138251A KR 1020157029605 A KR1020157029605 A KR 1020157029605A KR 20157029605 A KR20157029605 A KR 20157029605A KR 20150138251 A KR20150138251 A KR 20150138251A
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KR
South Korea
Prior art keywords
insulin
xaa
glu
gln
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020157029605A
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English (en)
Korean (ko)
Inventor
마이클 에이. 웨이쓰
Original Assignee
케이스 웨스턴 리저브 유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 케이스 웨스턴 리저브 유니버시티 filed Critical 케이스 웨스턴 리저브 유니버시티
Publication of KR20150138251A publication Critical patent/KR20150138251A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020157029605A 2013-03-15 2014-03-17 부위 2 인슐린 유사체 Ceased KR20150138251A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798165P 2013-03-15 2013-03-15
US61/798,165 2013-03-15
PCT/US2014/030387 WO2014145593A2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Publications (1)

Publication Number Publication Date
KR20150138251A true KR20150138251A (ko) 2015-12-09

Family

ID=51538504

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157029605A Ceased KR20150138251A (ko) 2013-03-15 2014-03-17 부위 2 인슐린 유사체

Country Status (10)

Country Link
US (1) US20160083448A1 (cg-RX-API-DMAC7.html)
EP (1) EP2968473A4 (cg-RX-API-DMAC7.html)
JP (1) JP2016516728A (cg-RX-API-DMAC7.html)
KR (1) KR20150138251A (cg-RX-API-DMAC7.html)
CN (1) CN105228643A (cg-RX-API-DMAC7.html)
AU (1) AU2014232894B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015023672A2 (cg-RX-API-DMAC7.html)
CA (1) CA2942524A1 (cg-RX-API-DMAC7.html)
IL (1) IL241357B (cg-RX-API-DMAC7.html)
WO (1) WO2014145593A2 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
KR20170106373A (ko) * 2015-01-20 2017-09-20 케이스 웨스턴 리저브 유니버시티 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체
BR112019000991A2 (pt) 2016-07-22 2019-07-02 University Of Utah Research Foundation análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica
MA46568A (fr) * 2016-10-24 2019-08-28 Novo Nordisk As Dosage biologique de formulations d'insuline
CA3294636A1 (en) 2016-11-21 2026-02-10 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
US20210371489A1 (en) * 2018-09-21 2021-12-02 Case Western Reserve University Site 2 single-chain insulin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (cg-RX-API-DMAC7.html) * 1991-02-27 1991-02-27 Novo Nordisk As
CN101573133B (zh) * 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
EP2296692A4 (en) * 2008-04-22 2012-06-06 Univ Case Western Reserve ISOFORM-SPECIFIC INSULIN ANALOG
MX2011001181A (es) * 2008-07-31 2011-04-05 Univ Case Western Reserve Insulina estabilizada con halogeno.

Also Published As

Publication number Publication date
EP2968473A2 (en) 2016-01-20
AU2014232894B2 (en) 2018-02-08
EP2968473A4 (en) 2016-11-23
BR112015023672A2 (pt) 2017-07-18
CN105228643A (zh) 2016-01-06
IL241357A0 (en) 2015-11-30
JP2016516728A (ja) 2016-06-09
CA2942524A1 (en) 2014-09-18
US20160083448A1 (en) 2016-03-24
IL241357B (en) 2021-08-31
WO2014145593A2 (en) 2014-09-18
WO2014145593A3 (en) 2015-01-08
AU2014232894A1 (en) 2015-11-05

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Patent event date: 20151015

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