IL241357B - 2-site insulin analogs, and their uses - Google Patents
2-site insulin analogs, and their usesInfo
- Publication number
- IL241357B IL241357B IL241357A IL24135715A IL241357B IL 241357 B IL241357 B IL 241357B IL 241357 A IL241357 A IL 241357A IL 24135715 A IL24135715 A IL 24135715A IL 241357 B IL241357 B IL 241357B
- Authority
- IL
- Israel
- Prior art keywords
- site
- insulin analogues
- analogues
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798165P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/030387 WO2014145593A2 (en) | 2013-03-15 | 2014-03-17 | Site 2 insulin analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL241357A0 IL241357A0 (en) | 2015-11-30 |
| IL241357B true IL241357B (en) | 2021-08-31 |
Family
ID=51538504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL241357A IL241357B (en) | 2013-03-15 | 2015-09-09 | 2-site insulin analogs, and their uses |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160083448A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2968473A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2016516728A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20150138251A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105228643A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014232894B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015023672A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2942524A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL241357B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145593A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102351111B1 (ko) | 2014-01-13 | 2022-01-14 | 써멀린 다이어비티즈, 엘엘씨 | 초속효성 인슐린 제형 및 약제학적 전달 시스템 |
| KR20170106373A (ko) * | 2015-01-20 | 2017-09-20 | 케이스 웨스턴 리저브 유니버시티 | 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체 |
| BR112019000991A2 (pt) | 2016-07-22 | 2019-07-02 | University Of Utah Research Foundation | análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica |
| MA46568A (fr) * | 2016-10-24 | 2019-08-28 | Novo Nordisk As | Dosage biologique de formulations d'insuline |
| CA3294636A1 (en) | 2016-11-21 | 2026-02-10 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| US20210371489A1 (en) * | 2018-09-21 | 2021-12-02 | Case Western Reserve University | Site 2 single-chain insulin analogues |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK158390D0 (da) * | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
| DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| DK33591D0 (cg-RX-API-DMAC7.html) * | 1991-02-27 | 1991-02-27 | Novo Nordisk As | |
| CN101573133B (zh) * | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| EP2296692A4 (en) * | 2008-04-22 | 2012-06-06 | Univ Case Western Reserve | ISOFORM-SPECIFIC INSULIN ANALOG |
| MX2011001181A (es) * | 2008-07-31 | 2011-04-05 | Univ Case Western Reserve | Insulina estabilizada con halogeno. |
-
2014
- 2014-03-17 BR BR112015023672A patent/BR112015023672A2/pt not_active Application Discontinuation
- 2014-03-17 EP EP14764949.5A patent/EP2968473A4/en not_active Withdrawn
- 2014-03-17 US US14/774,109 patent/US20160083448A1/en not_active Abandoned
- 2014-03-17 JP JP2016503388A patent/JP2016516728A/ja active Pending
- 2014-03-17 CA CA2942524A patent/CA2942524A1/en not_active Abandoned
- 2014-03-17 WO PCT/US2014/030387 patent/WO2014145593A2/en not_active Ceased
- 2014-03-17 KR KR1020157029605A patent/KR20150138251A/ko not_active Ceased
- 2014-03-17 CN CN201480026485.XA patent/CN105228643A/zh active Pending
- 2014-03-17 AU AU2014232894A patent/AU2014232894B2/en not_active Ceased
-
2015
- 2015-09-09 IL IL241357A patent/IL241357B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2968473A2 (en) | 2016-01-20 |
| AU2014232894B2 (en) | 2018-02-08 |
| EP2968473A4 (en) | 2016-11-23 |
| BR112015023672A2 (pt) | 2017-07-18 |
| CN105228643A (zh) | 2016-01-06 |
| IL241357A0 (en) | 2015-11-30 |
| JP2016516728A (ja) | 2016-06-09 |
| KR20150138251A (ko) | 2015-12-09 |
| CA2942524A1 (en) | 2014-09-18 |
| US20160083448A1 (en) | 2016-03-24 |
| WO2014145593A2 (en) | 2014-09-18 |
| WO2014145593A3 (en) | 2015-01-08 |
| AU2014232894A1 (en) | 2015-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL274355B (en) | Aza-pyridone compounds and their uses | |
| ZA201507104B (en) | Novel insulin analog and use thereof | |
| GB2535911B (en) | Strigolactone formulations and uses thereof | |
| GB202005995D0 (en) | Patient interface and aspects thereof | |
| IL246439A0 (en) | Ring-linked morphines and their use | |
| GB201323008D0 (en) | Compounds and uses thereof | |
| IL240221A0 (en) | Benzomorphan analogs and their use | |
| SG11201507327TA (en) | Pyrazole-amide compound and medicinal uses therefor | |
| SG11201508167PA (en) | Therapeutic compositions and uses thereof | |
| GB2519982B (en) | Fungicidal composition and the use thereof | |
| PT2943239T (pt) | Elemento de fixação e seringa | |
| EP2976091C0 (de) | Antioxidativ wirksame zusammensetzung und deren verwendung | |
| IL244751A0 (en) | Cyclic thianouracil-carboxamides and their use | |
| IL241357B (en) | 2-site insulin analogs, and their uses | |
| GB201307233D0 (en) | Compounds and uses thereof | |
| TWI562776B (en) | Pharmaceutical composition and uses thereof | |
| ZA201601880B (en) | Hetero-transglycosylase and uses thereof | |
| GB201301979D0 (en) | New composition and use thereof | |
| SG11201509661WA (en) | Tacrolimus and analogues thereof for medical use | |
| HK40128703A (en) | 4'-thionucleoside analogues and their pharmaceutical use | |
| TWM488991U (en) | The improved medicine mortar and pestle | |
| GB201317814D0 (en) | California 4 | |
| GB201317813D0 (en) | California 3 | |
| GB201317812D0 (en) | California 2 | |
| GB201323005D0 (en) | Compounds and uses thereof |