JP2016516722A5 - - Google Patents
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- JP2016516722A5 JP2016516722A5 JP2016503069A JP2016503069A JP2016516722A5 JP 2016516722 A5 JP2016516722 A5 JP 2016516722A5 JP 2016503069 A JP2016503069 A JP 2016503069A JP 2016503069 A JP2016503069 A JP 2016503069A JP 2016516722 A5 JP2016516722 A5 JP 2016516722A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- item
- composition according
- pharmaceutical
- polysorbate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 115
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 86
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 63
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 61
- 229920001184 polypeptide Polymers 0.000 claims description 61
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 61
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 60
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 50
- 239000011780 sodium chloride Substances 0.000 claims description 43
- 208000032843 Hemorrhage Diseases 0.000 claims description 31
- 150000001413 amino acids Chemical class 0.000 claims description 31
- 208000034158 bleeding Diseases 0.000 claims description 31
- 230000000740 bleeding effect Effects 0.000 claims description 31
- 229930006000 Sucrose Natural products 0.000 claims description 30
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 30
- 239000005720 sucrose Substances 0.000 claims description 30
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 26
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 26
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 26
- 229940068977 polysorbate 20 Drugs 0.000 claims description 26
- 229960002885 histidine Drugs 0.000 claims description 25
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 25
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 25
- 229920000053 polysorbate 80 Polymers 0.000 claims description 25
- 229940068968 polysorbate 80 Drugs 0.000 claims description 25
- 229940024606 amino acid Drugs 0.000 claims description 21
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims description 17
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims description 17
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 15
- 229960002713 calcium chloride Drugs 0.000 claims description 15
- 239000001110 calcium chloride Substances 0.000 claims description 15
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 15
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 claims description 11
- 229940052299 calcium chloride dihydrate Drugs 0.000 claims description 11
- 239000008176 lyophilized powder Substances 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
- 239000008227 sterile water for injection Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 208000024891 symptom Diseases 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 208000031220 Hemophilia Diseases 0.000 claims description 2
- 208000009292 Hemophilia A Diseases 0.000 claims description 2
- 208000015294 blood coagulation disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 description 59
- 235000001014 amino acid Nutrition 0.000 description 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000000069 prophylactic effect Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 108010076504 Protein Sorting Signals Proteins 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 206010034827 Pharyngeal haemorrhage Diseases 0.000 description 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 2
- 206010051297 Soft tissue haemorrhage Diseases 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 229940050526 hydroxyethylstarch Drugs 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 206010072043 Central nervous system haemorrhage Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010028024 Mouth haemorrhage Diseases 0.000 description 1
- 206010061298 Mucosal haemorrhage Diseases 0.000 description 1
- 206010028309 Muscle haemorrhage Diseases 0.000 description 1
- 229940031675 advate Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 208000002085 hemarthrosis Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 208000012310 mouth bleeding Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 210000000574 retroperitoneal space Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800293P | 2013-03-15 | 2013-03-15 | |
| US61/800,293 | 2013-03-15 | ||
| US201361817085P | 2013-04-29 | 2013-04-29 | |
| US61/817,085 | 2013-04-29 | ||
| US201361829884P | 2013-05-31 | 2013-05-31 | |
| US61/829,884 | 2013-05-31 | ||
| US201361839477P | 2013-06-26 | 2013-06-26 | |
| US61/839,477 | 2013-06-26 | ||
| US201361863860P | 2013-08-08 | 2013-08-08 | |
| US61/863,860 | 2013-08-08 | ||
| US201361876927P | 2013-09-12 | 2013-09-12 | |
| US61/876,927 | 2013-09-12 | ||
| US201361879955P | 2013-09-19 | 2013-09-19 | |
| US61/879,955 | 2013-09-19 | ||
| US201361897742P | 2013-10-30 | 2013-10-30 | |
| US61/897,742 | 2013-10-30 | ||
| PCT/US2014/029354 WO2014144795A1 (en) | 2013-03-15 | 2014-03-14 | Factor viii polypeptide formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018082321A Division JP2018123161A (ja) | 2013-03-15 | 2018-04-23 | 第ｖｉｉｉ因子ポリペプチド製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516722A JP2016516722A (ja) | 2016-06-09 |
| JP2016516722A5 true JP2016516722A5 (https=) | 2017-04-20 |
| JP6330026B2 JP6330026B2 (ja) | 2018-05-23 |
Family
ID=50771579
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503069A Active JP6330026B2 (ja) | 2013-03-15 | 2014-03-14 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2018082321A Ceased JP2018123161A (ja) | 2013-03-15 | 2018-04-23 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2020138637A Active JP6934994B2 (ja) | 2013-03-15 | 2020-08-19 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2021136162A Active JP7240457B2 (ja) | 2013-03-15 | 2021-08-24 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2023032892A Active JP7700164B2 (ja) | 2013-03-15 | 2023-03-03 | 第ｖｉｉｉ因子ポリペプチド製剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018082321A Ceased JP2018123161A (ja) | 2013-03-15 | 2018-04-23 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2020138637A Active JP6934994B2 (ja) | 2013-03-15 | 2020-08-19 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2021136162A Active JP7240457B2 (ja) | 2013-03-15 | 2021-08-24 | 第ｖｉｉｉ因子ポリペプチド製剤 |
| JP2023032892A Active JP7700164B2 (ja) | 2013-03-15 | 2023-03-03 | 第ｖｉｉｉ因子ポリペプチド製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9623088B2 (https=) |
| EP (3) | EP4122487A1 (https=) |
| JP (5) | JP6330026B2 (https=) |
| AU (4) | AU2014228506A1 (https=) |
| CA (1) | CA2899737A1 (https=) |
| CL (1) | CL2015002720A1 (https=) |
| DK (1) | DK2968477T3 (https=) |
| EA (2) | EA201890671A1 (https=) |
| ES (2) | ES2776195T3 (https=) |
| HU (1) | HUE047933T2 (https=) |
| LT (1) | LT2968477T (https=) |
| PH (2) | PH12015501801B1 (https=) |
| PL (2) | PL3666283T3 (https=) |
| PT (2) | PT2968477T (https=) |
| RS (1) | RS60003B1 (https=) |
| SG (2) | SG10201805207QA (https=) |
| SI (1) | SI2968477T1 (https=) |
| TW (2) | TWI629993B (https=) |
| UY (1) | UY35462A (https=) |
| WO (1) | WO2014144795A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2506868T1 (en) * | 2009-12-06 | 2018-04-30 | Bioverativ Therapeutics Inc. | HYPER AND HYBRID POLYPETTIDES FACTOR VIII-FC AND METHODS FOR THEIR USE |
| EP4122487A1 (en) | 2013-03-15 | 2023-01-25 | Bioverativ Therapeutics Inc. | Factor viii polypeptide formulations |
| WO2014144549A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Factor ix polypeptide formulations |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN106317226B (zh) | 2016-08-19 | 2017-09-05 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| MX2019006444A (es) | 2016-12-02 | 2019-10-30 | Bioverativ Therapeutics Inc | Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos. |
| JP2019536794A (ja) | 2016-12-02 | 2019-12-19 | バイオベラティブ セラピューティクス インコーポレイテッド | 凝固因子に対する免疫寛容を誘導する方法 |
| JP7039308B2 (ja) * | 2017-02-08 | 2022-03-22 | 三洋化成工業株式会社 | 細胞培養用担体 |
| NZ762100A (en) | 2017-08-09 | 2025-12-19 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof |
| JP7370974B2 (ja) | 2017-11-07 | 2023-10-30 | ラニ セラピューティクス， エルエルシー | 嚥下可能薬物送達デバイスを使用する腸管組織への送達のための凝固因子調製物 |
| PL3793588T3 (pl) | 2018-05-18 | 2025-09-01 | Bioverativ Therapeutics Inc. | Sposoby leczenia hemofilii a |
| EP3833766A1 (en) | 2018-08-09 | 2021-06-16 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| JP7672334B2 (ja) * | 2018-10-23 | 2025-05-07 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | 第ｖｉｉｉ因子機能を調節するための組成物および方法 |
| WO2020175594A1 (ja) * | 2019-02-28 | 2020-09-03 | 公立大学法人横浜市立大学 | 血液凝固および／または補体異常疾患の治療用組成物 |
| SG11202111290WA (en) | 2019-04-17 | 2021-11-29 | Codiak Biosciences Inc | Compositions of exosomes and aav |
| CN114007637A (zh) | 2019-06-19 | 2022-02-01 | 比奥维拉迪维治疗股份有限公司 | 用于治疗血友病和低骨矿物质密度的重组因子viii-fc |
| WO2023219378A1 (ko) * | 2022-05-10 | 2023-11-16 | 주식회사 녹십자 | 혈장 단백질에 대한 신규한 액상 제형물 |
| TW202400224A (zh) * | 2022-05-10 | 2024-01-01 | 南韓商綠十字股份有限公司 | 用於冷凍乾燥血漿蛋白之新穎液體調配物 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| ES8801674A1 (es) | 1985-04-12 | 1988-02-16 | Genetics Inst | Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante. |
| KR910006424B1 (ko) | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
| DE3785102T2 (de) | 1986-01-03 | 1993-07-22 | Genetics Inst | Verfahren zur herstellung von faktor-viii:c-typ-proteinen. |
| US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| US5543502A (en) | 1986-06-24 | 1996-08-06 | Novo Nordisk A/S | Process for producing a coagulation active complex of factor VIII fragments |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| CA1331157C (en) | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
| US6060447A (en) | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| IL86693A (en) | 1987-06-12 | 1994-06-24 | Stichting Centraal Lab | Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them |
| US6346513B1 (en) | 1987-06-12 | 2002-02-12 | Baxter Trading Gmbh | Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| DE3720246A1 (de) | 1987-06-19 | 1988-12-29 | Behringwerke Ag | Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet |
| FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| US4994371A (en) | 1987-08-28 | 1991-02-19 | Davie Earl W | DNA preparation of Christmas factor and use of DNA sequences |
| US5004803A (en) | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| JP3045539B2 (ja) | 1989-02-21 | 2000-05-29 | ワシントン ユニバーシティ | 改変型生殖ホルモン |
| SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| ATE240740T1 (de) | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
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| US6376463B1 (en) | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
| US5364771A (en) | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
| US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
| CA2124690C (en) * | 1992-10-02 | 2007-09-11 | Thomas Osterberg | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| US5563045A (en) | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| IL113010A (en) * | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| CA2225189C (en) | 1997-03-06 | 2010-05-25 | Queen's University At Kingston | Canine factor viii gene, protein and methods of use |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| DK1820516T3 (da) * | 1999-02-22 | 2013-10-28 | Univ Connecticut | Nye albuminfrie faktor VIII-præparater |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| GB0207092D0 (en) | 2002-03-26 | 2002-05-08 | Sod Conseils Rech Applic | Stable pharmaceutical composition containing factor VIII |
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| PL2298347T3 (pl) | 2003-05-06 | 2016-03-31 | Bioverativ Therapeutics Inc | Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy |
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