JP2016516091A - 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ - Google Patents
血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ Download PDFInfo
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- JP2016516091A JP2016516091A JP2016506585A JP2016506585A JP2016516091A JP 2016516091 A JP2016516091 A JP 2016516091A JP 2016506585 A JP2016506585 A JP 2016506585A JP 2016506585 A JP2016506585 A JP 2016506585A JP 2016516091 A JP2016516091 A JP 2016516091A
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- Engineering & Computer Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361807401P | 2013-04-02 | 2013-04-02 | |
| US61/807,401 | 2013-04-02 | ||
| PCT/US2014/032696 WO2014165602A1 (en) | 2013-04-02 | 2014-04-02 | Compositions and methods for induction and modulation of angiogenesis and methods and assays for identifying angiogenesis modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016516091A true JP2016516091A (ja) | 2016-06-02 |
| JP2016516091A5 JP2016516091A5 (enExample) | 2017-05-18 |
Family
ID=51621067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016506585A Pending JP2016516091A (ja) | 2013-04-02 | 2014-04-02 | 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9821013B2 (enExample) |
| EP (1) | EP2981273B1 (enExample) |
| JP (1) | JP2016516091A (enExample) |
| KR (1) | KR20150139569A (enExample) |
| AU (1) | AU2014248198B2 (enExample) |
| CA (1) | CA2908562A1 (enExample) |
| HK (1) | HK1221402A1 (enExample) |
| WO (1) | WO2014165602A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101316602B (zh) | 2005-09-27 | 2015-06-03 | 组织技术公司 | 羊膜制品和纯化的组合物及其使用方法 |
| US9526770B2 (en) | 2011-04-28 | 2016-12-27 | Tissuetech, Inc. | Methods of modulating bone remodeling |
| EP2717888B1 (en) | 2011-06-10 | 2020-09-09 | Tissuetech, Inc. | Methods of processing fetal support tissues |
| JP2016516091A (ja) | 2013-04-02 | 2016-06-02 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ |
| TW201603818A (zh) | 2014-06-03 | 2016-02-01 | 組織科技股份有限公司 | 組成物及方法 |
| US20160243288A1 (en) | 2015-02-23 | 2016-08-25 | Tissuetech, Inc. | Apparatuses and methods for treating ophthalmic diseases and disorders |
| TWI720984B (zh) | 2015-05-20 | 2021-03-11 | 美商帝聖工業公司 | 用於防止上皮細胞增生及上皮-間質轉移之組合物及方法 |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| TW201733600A (zh) | 2016-01-29 | 2017-10-01 | 帝聖工業公司 | 胎兒扶持組織物及使用方法 |
| WO2020036245A1 (ko) * | 2018-08-17 | 2020-02-20 | 고려대학교 산학협력단 | 인간 신경줄기세포의 기능강화 및 생산을 위한 태반유래 세포 조건화 배지 및 이의 용도 |
| US20210369630A1 (en) * | 2018-10-17 | 2021-12-02 | University Of Florida Research Foundation | Magnetically responsive composite microparticles for triggered delivery of biologically active agents |
| EP3947637A1 (en) | 2019-04-04 | 2022-02-09 | THT Biomaterials GmbH | A novel human-material-based platform technology for tissue engineering |
| WO2023038924A1 (en) * | 2021-09-07 | 2023-03-16 | Plakous Therapeutics, Inc. | Acellular placental therapies |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62129222A (ja) * | 1985-08-30 | 1987-06-11 | アメリカ合衆国 | 細胞培養組成物およびその用途 |
| JPS63152322A (ja) * | 1986-09-30 | 1988-06-24 | Ichimaru Pharcos Co Ltd | プラセンタ−組織由来フイブロネクチン含有溶液 |
| JPS63501953A (ja) * | 1985-12-17 | 1988-08-04 | サイナ−ゲン,インコ−ポレ−テツド | 毛管内皮細胞プロテア−ゼ合成、dna合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子 |
| JPH0931100A (ja) * | 1995-07-24 | 1997-02-04 | Nippon Ham Kk | 変性コラーゲン及びその製造方法 |
| WO2003082305A1 (en) * | 2002-04-03 | 2003-10-09 | Naohide Yamashita | Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells |
| JP2004517117A (ja) * | 2001-01-05 | 2004-06-10 | バイロメッド・リミテッド | 抗血管新生タンパク質をコードする遺伝子またはその部分を含む慢性関節リウマチ治療用医薬組成物 |
| JP2005065661A (ja) * | 2003-08-20 | 2005-03-17 | Akihiro Yamaguchi | ヒト血管内皮細胞のVEGF誘導性活性化及び血管新生におけるIdの役割 |
| JP2009510091A (ja) * | 2005-09-27 | 2009-03-12 | ティッシュテク・インコーポレーテッド | 羊膜調製物及び精製組成物及びその使用方法 |
| JP2010539938A (ja) * | 2007-09-24 | 2010-12-24 | ノーティス,インク. | 灌流可能な微小血管システムを作製するための方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994559A (en) | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
| CA2005600A1 (en) | 1988-12-20 | 1990-06-20 | Cal-Henrik Heldin | Endothelial cell growth factor |
| AUPM425294A0 (en) * | 1994-03-04 | 1994-03-31 | Australian National University, The | In-vitro angiogenesis assay |
| US5770565A (en) | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
| CA2375617A1 (en) | 1999-06-07 | 2000-12-14 | Edwards Lifesciences Corporation | Targeted angiogenesis |
| US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| AU2003237078C1 (en) | 2002-04-12 | 2009-10-08 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| US8940292B2 (en) * | 2003-01-28 | 2015-01-27 | Wake Forest University Health Sciences | Enhancement of angiogenesis to grafts using cells engineered to produce growth factors |
| WO2005003317A2 (en) | 2003-07-01 | 2005-01-13 | Regents Of The University Of Minnesota | Engineered blood vessels |
| US7775965B2 (en) | 2004-03-09 | 2010-08-17 | The Board Of Regents Of The University Of Oklahoma | Decellularized grafts from umbilical cord vessels and process for preparing and using same |
| US8187639B2 (en) | 2005-09-27 | 2012-05-29 | Tissue Tech, Inc. | Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment |
| WO2008042441A1 (en) | 2006-10-03 | 2008-04-10 | Anthrogenesis Corporation | Use of umbilical cord biomaterial for ocular surgery |
| CA2700613C (en) | 2007-09-26 | 2022-09-20 | Celgene Cellular Therapeutics | Angiogenic cells from human placental perfusate |
| WO2009100128A1 (en) * | 2008-02-04 | 2009-08-13 | Massachusetts Institute Of Technology | Particulate delivery vehicles for embryoid bodies |
| SG188918A1 (enExample) * | 2008-03-17 | 2013-04-30 | Agency Science Tech & Res | |
| US8685634B2 (en) * | 2009-03-06 | 2014-04-01 | University of Pittsburgh—of the Commonwealth System of Higher Education | Neural scaffolds |
| CA2769038A1 (en) | 2009-07-31 | 2011-02-03 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Antiangiogenic small molecules and methods of use |
| KR101118017B1 (ko) | 2009-09-04 | 2012-02-24 | (주)차바이오앤디오스텍 | 태반 추출물을 제조하는 방법 및 태반 추출물 |
| CN102822521B (zh) * | 2010-03-30 | 2016-01-27 | 西门子公司 | 具有间接蒸发的太阳能热发电站和运行这种太阳能热发电站的方法 |
| KR20140071813A (ko) | 2012-12-04 | 2014-06-12 | 삼성전자주식회사 | 파이버 상에 형성된 저항성 메모리 소자 및 그 제종 방법 |
| JP2016516091A (ja) | 2013-04-02 | 2016-06-02 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ |
-
2014
- 2014-04-02 JP JP2016506585A patent/JP2016516091A/ja active Pending
- 2014-04-02 EP EP14779851.6A patent/EP2981273B1/en active Active
- 2014-04-02 CA CA2908562A patent/CA2908562A1/en not_active Abandoned
- 2014-04-02 HK HK16109532.8A patent/HK1221402A1/zh unknown
- 2014-04-02 KR KR1020157031446A patent/KR20150139569A/ko not_active Withdrawn
- 2014-04-02 US US14/243,123 patent/US9821013B2/en active Active
- 2014-04-02 WO PCT/US2014/032696 patent/WO2014165602A1/en not_active Ceased
- 2014-04-02 AU AU2014248198A patent/AU2014248198B2/en not_active Ceased
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2015
- 2015-05-07 US US15/309,306 patent/US10300091B2/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62129222A (ja) * | 1985-08-30 | 1987-06-11 | アメリカ合衆国 | 細胞培養組成物およびその用途 |
| JPS63501953A (ja) * | 1985-12-17 | 1988-08-04 | サイナ−ゲン,インコ−ポレ−テツド | 毛管内皮細胞プロテア−ゼ合成、dna合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子 |
| JPS63152322A (ja) * | 1986-09-30 | 1988-06-24 | Ichimaru Pharcos Co Ltd | プラセンタ−組織由来フイブロネクチン含有溶液 |
| JPH0931100A (ja) * | 1995-07-24 | 1997-02-04 | Nippon Ham Kk | 変性コラーゲン及びその製造方法 |
| JP2004517117A (ja) * | 2001-01-05 | 2004-06-10 | バイロメッド・リミテッド | 抗血管新生タンパク質をコードする遺伝子またはその部分を含む慢性関節リウマチ治療用医薬組成物 |
| WO2003082305A1 (en) * | 2002-04-03 | 2003-10-09 | Naohide Yamashita | Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells |
| JP2005065661A (ja) * | 2003-08-20 | 2005-03-17 | Akihiro Yamaguchi | ヒト血管内皮細胞のVEGF誘導性活性化及び血管新生におけるIdの役割 |
| JP2009510091A (ja) * | 2005-09-27 | 2009-03-12 | ティッシュテク・インコーポレーテッド | 羊膜調製物及び精製組成物及びその使用方法 |
| JP2010539938A (ja) * | 2007-09-24 | 2010-12-24 | ノーティス,インク. | 灌流可能な微小血管システムを作製するための方法 |
Non-Patent Citations (2)
| Title |
|---|
| BIOSCIENCE REPORTS, vol. 5, JPN6017049123, 1985, pages 783 - 790, ISSN: 0004008859 * |
| 日本創傷治癒学会プログラム・抄録集, vol. 42nd, JPN6017049125, 2012, pages 152 - 094, ISSN: 0004008860 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150139569A (ko) | 2015-12-11 |
| US20140294780A1 (en) | 2014-10-02 |
| US10300091B2 (en) | 2019-05-28 |
| AU2014248198B2 (en) | 2018-11-29 |
| CA2908562A1 (en) | 2014-10-09 |
| US20170209497A1 (en) | 2017-07-27 |
| EP2981273B1 (en) | 2020-09-16 |
| WO2014165602A1 (en) | 2014-10-09 |
| EP2981273A4 (en) | 2016-10-26 |
| EP2981273A1 (en) | 2016-02-10 |
| HK1221402A1 (zh) | 2017-06-02 |
| AU2014248198A1 (en) | 2015-10-29 |
| US9821013B2 (en) | 2017-11-21 |
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