JP2016516065A5 - - Google Patents

Info

Publication number

JP2016516065A5

JP2016516065A5 JP2016503156A JP2016503156A JP2016516065A5 JP 2016516065 A5 JP2016516065 A5 JP 2016516065A5 JP 2016503156 A JP2016503156 A JP 2016503156A JP 2016503156 A JP2016503156 A JP 2016503156A JP 2016516065 A5 JP2016516065 A5 JP 2016516065A5

Authority

JP

Japan

Prior art keywords

synthetic peptidoglycan

collagen

binding

hyaluronic acid

peptide

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 58
• MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims description 50
• 108010013639 Peptidoglycan Proteins 0.000 claims description 50
• 230000027455 binding Effects 0.000 claims description 42
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 24
• 102000008186 Collagen Human genes 0.000 claims description 24
• 108010035532 Collagen Proteins 0.000 claims description 24
• 229920001436 collagen Polymers 0.000 claims description 24
• 229920002674 hyaluronan Polymers 0.000 claims description 24
• 229960003160 hyaluronic acid Drugs 0.000 claims description 24
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 20
• 150000004676 glycans Chemical class 0.000 claims description 17
• 239000008194 pharmaceutical composition Substances 0.000 claims description 14
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 8
• 229920001287 Chondroitin sulfate Polymers 0.000 claims description 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
• 229940059329 chondroitin sulfate Drugs 0.000 claims description 8
• 230000007850 degeneration Effects 0.000 claims description 8
• 230000027948 extracellular matrix binding Effects 0.000 claims description 7
• 229920000045 Dermatan sulfate Polymers 0.000 claims description 6
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 5
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 5
• 210000002744 extracellular matrix Anatomy 0.000 claims description 5
• 102000012422 Collagen Type I Human genes 0.000 claims description 4
• 108010022452 Collagen Type I Proteins 0.000 claims description 4
• 102000000503 Collagen Type II Human genes 0.000 claims description 4
• 108010041390 Collagen Type II Proteins 0.000 claims description 4
• 210000000845 cartilage Anatomy 0.000 claims description 4
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 4
• 229940051593 dermatan sulfate Drugs 0.000 claims description 4
• 210000001519 tissue Anatomy 0.000 claims description 4
• OEANUJAFZLQYOD-CXAZCLJRSA-N (2r,3s,4r,5r,6r)-6-[(2r,3r,4r,5r,6r)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](OC)O[C@H](CO)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O1 OEANUJAFZLQYOD-CXAZCLJRSA-N 0.000 claims description 2
• 229920002567 Chondroitin Polymers 0.000 claims description 2
• 102000001187 Collagen Type III Human genes 0.000 claims description 2
• 108010069502 Collagen Type III Proteins 0.000 claims description 2
• 102000004266 Collagen Type IV Human genes 0.000 claims description 2
• 108010042086 Collagen Type IV Proteins 0.000 claims description 2
• 229920002307 Dextran Polymers 0.000 claims description 2
• 229920002971 Heparan sulfate Polymers 0.000 claims description 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
• 229920000288 Keratan sulfate Polymers 0.000 claims description 2
• 102000011782 Keratins Human genes 0.000 claims description 2
• 108010076876 Keratins Proteins 0.000 claims description 2
• 230000015556 catabolic process Effects 0.000 claims description 2
• DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims description 2
• 229940096422 collagen type i Drugs 0.000 claims description 2
• 238000006731 degradation reaction Methods 0.000 claims description 2
• 229920000669 heparin Polymers 0.000 claims description 2
• 229960002897 heparin Drugs 0.000 claims description 2
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 2
• KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims description 2
• 210000004127 vitreous body Anatomy 0.000 claims description 2
• 238000000034 method Methods 0.000 description 6
• 230000015572 biosynthetic process Effects 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1