|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US5981216A
(en)
|
1985-04-01 |
1999-11-09 |
Alusuisse Holdings A.G. |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
WO1988007054A1
(en)
|
1987-03-18 |
1988-09-22 |
Research Corporation Limited |
Complement-binding peptide
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
GB8709290D0
(en)
|
1987-04-16 |
1987-05-20 |
Secretary Trade Ind Brit |
Precision motion slideways
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
CA2006596C
(en)
|
1988-12-22 |
2000-09-05 |
Rika Ishikawa |
Chemically-modified g-csf
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
ATE356869T1
(de)
|
1990-01-12 |
2007-04-15 |
Amgen Fremont Inc |
Bildung von xenogenen antikörpern
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
CA2089661C
(en)
|
1990-08-29 |
2007-04-03 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
GB9022543D0
(en)
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Antibody production
|
|
EP1291360A1
(en)
|
1991-12-13 |
2003-03-12 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
AU4116793A
(en)
|
1992-04-24 |
1993-11-29 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
SG48760A1
(en)
|
1992-07-24 |
2003-03-18 |
Abgenix Inc |
Generation of xenogenetic antibodies
|
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
|
US6091001A
(en)
|
1995-03-29 |
2000-07-18 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
ATE390933T1
(de)
|
1995-04-27 |
2008-04-15 |
Amgen Fremont Inc |
Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
|
|
AUPN568095A0
(en)
|
1995-09-27 |
1995-10-26 |
Austin Research Institute, The |
Anti-Galalpha(1,3)Gal antibody binding peptides
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
WO1998019167A2
(en)
|
1996-10-29 |
1998-05-07 |
Fred Hutchinson Cancer Research Center, Inc. |
Cell stress regulated human mhc class i gene
|
|
EP2314625B1
(en)
|
1996-12-03 |
2014-05-07 |
Amgen Fremont Inc. |
Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US5830698A
(en)
|
1997-03-14 |
1998-11-03 |
Idec Pharmaceuticals Corporation |
Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
|
|
EP0983303B1
(en)
|
1997-05-21 |
2006-03-08 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
DE69937291T2
(de)
|
1998-04-02 |
2008-07-10 |
Genentech, Inc., South San Francisco |
Antikörpervarianten und fragmente davon
|
|
PT2180007E
(pt)
|
1998-04-20 |
2013-11-25 |
Roche Glycart Ag |
Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
KR101155191B1
(ko)
|
1999-01-15 |
2012-06-13 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
ES2568899T3
(es)
|
1999-04-09 |
2016-05-05 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de una molécula inmunofuncional
|
|
US20090175821A1
(en)
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
|
US6475220B1
(en)
|
1999-10-15 |
2002-11-05 |
Whiteside Biomechanics, Inc. |
Spinal cable system
|
|
HUP0204475A2
(en)
|
2000-02-11 |
2003-04-28 |
Merck Patent Gmbh |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
US6725230B2
(en)
|
2000-07-18 |
2004-04-20 |
Aegis Analytical Corporation |
System, method and computer program for assembling process data of multi-database origins using a hierarchical display
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US20040115198A1
(en)
|
2001-02-28 |
2004-06-17 |
Fred Hutchinson Cancer Research Center |
Activation of lymphocyte populations expressing NKG2D using anti-NKG2D antibodies and ligand derivatives
|
|
WO2002068615A2
(en)
|
2001-02-28 |
2002-09-06 |
Fred Hutchinson Cancer Research Center, Inc. |
Activation of lymphocyte populations expressing nkg2d using anti-nkg2d antibodies and ligand derivatives
|
|
US6566208B2
(en)
|
2001-07-25 |
2003-05-20 |
Chartered Semiconductor Manufacturing Ltd. |
Method to form elevated source/drain using poly spacer
|
|
US7084257B2
(en)
|
2001-10-05 |
2006-08-01 |
Amgen Inc. |
Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
|
|
ES2326964T3
(es)
|
2001-10-25 |
2009-10-22 |
Genentech, Inc. |
Composiciones de glicoproteina.
|
|
US7745140B2
(en)
|
2002-01-03 |
2010-06-29 |
The Trustees Of The University Of Pennsylvania |
Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7771718B2
(en)
*
|
2002-04-22 |
2010-08-10 |
Fred Hutchinson Cancer Research Center |
Soluble MIC polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions
|
|
AU2003234196A1
(en)
|
2002-04-22 |
2003-11-03 |
University Of Florida |
Functionalized nanoparticles and methods of use
|
|
CA2495251C
(en)
|
2002-08-14 |
2018-03-06 |
Macrogenics, Inc. |
Fc.gamma.riib-specific antibodies and methods of use thereof
|
|
KR100980065B1
(ko)
|
2002-09-27 |
2010-09-03 |
젠코어 인코포레이티드 |
최적화된 Ｆｃ 변이체 및 그의 제조 방법
|
|
AU2003286467B2
(en)
|
2002-10-15 |
2009-10-01 |
Abbvie Biotherapeutics Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
WO2004063351A2
(en)
|
2003-01-09 |
2004-07-29 |
Macrogenics, Inc. |
IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
|
|
US7666417B2
(en)
|
2003-04-22 |
2010-02-23 |
Fred Hutchinson Cancer Research Center |
Methods and compositions for treating autoimmune diseases or conditions
|
|
EP3679951A1
(en)
|
2003-06-27 |
2020-07-15 |
Amgen Fremont Inc. |
Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
|
|
CN1317861C
(zh)
|
2003-07-21 |
2007-05-23 |
中兴通讯股份有限公司 |
无线局域网接入点设备虚拟局域网的实现方法
|
|
US7871610B2
(en)
|
2003-08-12 |
2011-01-18 |
Dyax Corp. |
Antibodies to Tie1 ectodomain
|
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
PT1706424E
(pt)
|
2004-01-12 |
2009-10-01 |
Applied Molecular Evolution |
Variantes da região fc
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
PL1776384T3
(pl)
|
2004-08-04 |
2013-10-31 |
Mentrik Biotech Llc |
WARIANTY REGIONÓW Fc
|
|
NZ554725A
(en)
|
2004-10-25 |
2009-10-30 |
Merck & Co Inc |
Anti-ADDL antibodies and uses thereof
|
|
JP4884395B2
(ja)
|
2004-12-21 |
2012-02-29 |
アストラゼネカ エービー |
アンジオポエチン−２に対する抗体およびそれらの使用
|
|
US20080148432A1
(en)
|
2005-12-21 |
2008-06-19 |
Mark Scott Abad |
Transgenic plants with enhanced agronomic traits
|
|
BRPI0611766A2
(pt)
|
2005-06-08 |
2011-12-20 |
Dana Farber Cancer Inst Inc |
métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada
|
|
JP2009514528A
(ja)
|
2005-11-03 |
2009-04-09 |
フレッド ハッチンソン キャンサー リサーチ センター |
Ｎｋｇ２ｄ陽性ｃｄ４＋細胞による免疫応答の負の免疫調節法
|
|
DE102006009847A1
(de)
|
2006-03-01 |
2007-09-06 |
Sweredjuk, Robert, Dr. |
Verfahren von Absorbieren von Schadstoffen und Gerüchen
|
|
MX2009001412A
(es)
|
2006-08-07 |
2009-04-24 |
Harvard College |
Vacunas de matriz de proteinas y metodos de hacer y administrar tales vacunas.
|
|
US20110060120A1
(en)
|
2006-09-08 |
2011-03-10 |
Obeid Michel Sarkis |
Immunogenic treatment of cancer by peptides inducing the plasma membrane exposure of erp57
|
|
WO2008036981A1
(en)
|
2006-09-22 |
2008-03-27 |
Dana-Farber Cancer Research, Inc. |
Methods for treating mica-related disorders
|
|
US9492518B2
(en)
|
2006-10-04 |
2016-11-15 |
Dana-Farber Cancer Institute, Inc. |
Tumor immunity
|
|
CA3011859A1
(en)
|
2007-04-23 |
2008-10-30 |
Fred Hutchinson Cancer Research Center |
Negative immunomodulation of immune responses by erp5
|
|
WO2008143954A2
(en)
|
2007-05-14 |
2008-11-27 |
Biogen Idec Ma Inc. |
Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
|
|
US9370558B2
(en)
|
2008-02-13 |
2016-06-21 |
President And Fellows Of Harvard College |
Controlled delivery of TLR agonists in structural polymeric devices
|
|
WO2011063336A2
(en)
|
2009-11-20 |
2011-05-26 |
President And Fellows Of Harvard College |
Secondary site of antigen stimulation for therapeutic vaccination
|
|
EP2254602B1
(en)
|
2008-02-13 |
2018-11-21 |
President and Fellows of Harvard College |
Continuous cell programming devices
|
|
JO2913B1
(en)
|
2008-02-20 |
2015-09-15 |
امجين إنك, |
Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
|
|
US8182809B1
(en)
|
2008-09-08 |
2012-05-22 |
University Of Washington |
Methods for treating cancer by inhibiting MIC shedding
|
|
US8133979B2
(en)
|
2008-12-16 |
2012-03-13 |
Hoffmann-La Roche Inc. |
Antibodies against human angiopoietin 2
|
|
US8207497B2
(en)
|
2009-05-08 |
2012-06-26 |
Ionsense, Inc. |
Sampling of confined spaces
|
|
JO3182B1
(ar)
|
2009-07-29 |
2018-03-08 |
Regeneron Pharma |
مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
|
|
KR101688522B1
(ko)
|
2009-12-15 |
2016-12-21 |
삼성전자주식회사 |
안지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도
|
|
US8796420B2
(en)
|
2009-12-31 |
2014-08-05 |
Avidbiotics Corp. |
Non-natural MIC proteins
|
|
US8753640B2
(en)
|
2011-05-31 |
2014-06-17 |
University Of Washington Through Its Center For Commercialization |
MIC-binding antibodies and methods of use thereof
|
|
CN102911270A
(zh)
|
2011-08-05 |
2013-02-06 |
浙江大学 |
一种抑制移植器官慢性排斥反应的抗体的制备及纯化方法
|
|
PE20142361A1
(es)
*
|
2011-09-30 |
2015-01-16 |
Dana Farber Cancer Inst Inc |
Peptidos terapeuticos
|
|
SG11201404177PA
(en)
*
|
2012-02-07 |
2014-08-28 |
Innate Pharma |
Mica binding agents
|
|
EP3666886A1
(en)
|
2013-03-15 |
2020-06-17 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides
|
|
US9572898B2
(en)
|
2013-09-09 |
2017-02-21 |
Seton Hall University |
Functionalized fluorine containing phthalocyanine molecules
|
|
CA2932767A1
(en)
|
2013-12-06 |
2015-06-11 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides
|
|
CA2939006A1
(en)
|
2014-03-14 |
2015-09-17 |
Dana-Farber Cancer Institute, Inc. |
Vaccine compositions and methods for restoring nkg2d pathway function against cancers
|
|
EP3145953A1
(en)
|
2014-05-21 |
2017-03-29 |
Dana-Farber Cancer Institute, Inc. |
Methods for treating cancer with anti bip or anti mica antibodies
|