JP2016515815A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016515815A5 JP2016515815A5 JP2016502986A JP2016502986A JP2016515815A5 JP 2016515815 A5 JP2016515815 A5 JP 2016515815A5 JP 2016502986 A JP2016502986 A JP 2016502986A JP 2016502986 A JP2016502986 A JP 2016502986A JP 2016515815 A5 JP2016515815 A5 JP 2016515815A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- nucleic acid
- alkyl
- composition according
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798495P | 2013-03-15 | 2013-03-15 | |
| US61/798,495 | 2013-03-15 | ||
| PCT/US2014/029116 WO2014172045A1 (en) | 2013-03-15 | 2014-03-14 | Lipid nanoparticles for transfection and related methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515815A JP2016515815A (ja) | 2016-06-02 |
| JP2016515815A5 true JP2016515815A5 (https=) | 2017-04-06 |
| JP6605446B2 JP6605446B2 (ja) | 2019-11-13 |
Family
ID=51731753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502986A Active JP6605446B2 (ja) | 2013-03-15 | 2014-03-14 | 形質移入用の脂質ナノ粒子および関連方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10342760B2 (https=) |
| EP (1) | EP2971013B1 (https=) |
| JP (1) | JP6605446B2 (https=) |
| CN (1) | CN105143456A (https=) |
| CA (1) | CA2906732C (https=) |
| WO (1) | WO2014172045A1 (https=) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| CN106794141B (zh) * | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| WO2016138175A1 (en) * | 2015-02-24 | 2016-09-01 | The University Of British Columbia | Continuous flow microfluidic system |
| EP4353257A3 (en) | 2015-04-13 | 2024-08-07 | CureVac Manufacturing GmbH | Method for producing rna compositions |
| EP3288671A4 (en) * | 2015-04-28 | 2019-01-16 | The University Of British Columbia | DISPOSABLE MICROFLUIDIC CARTRIDGE |
| USD772427S1 (en) | 2015-04-28 | 2016-11-22 | University Of British Columbia | Microfluidic cartridge |
| USD771834S1 (en) | 2015-04-28 | 2016-11-15 | University Of British Columbia | Microfluidic cartridge |
| USD771833S1 (en) | 2015-04-28 | 2016-11-15 | University Of British Columbia | Microfluidic cartridge |
| MA42543A (fr) | 2015-07-30 | 2018-06-06 | Modernatx Inc | Arn épitope peptidiques concatémériques |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| AU2016342045A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| EP4011451A1 (en) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Metapneumovirus mrna vaccines |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| AU2016341309A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Cancer vaccines |
| PL3386484T3 (pl) * | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| EP3400097B1 (en) | 2016-01-06 | 2021-01-27 | The University Of British Columbia | Bifurcating mixers and methods of their use and manufacture |
| CN105622473B (zh) * | 2016-02-06 | 2017-07-25 | 吴国球 | 一种阳离子氨基脂质及其合成方法和用途 |
| WO2017201328A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | POLYNUCLEOTIDES ENCODING α-GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE |
| WO2017218704A1 (en) | 2016-06-14 | 2017-12-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| KR102447457B1 (ko) | 2016-07-06 | 2022-09-27 | 프레시젼 나노시스템스 유엘씨 | 지능형 미세 유체 혼합 기기 및 카트리지 |
| WO2018064755A1 (en) * | 2016-10-03 | 2018-04-12 | Precision Nanosystems Inc. | Compositions for transfecting resistant cell types |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | HUMAN CYTOMEGALOVIRUS VACCINE |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| MA46766A (fr) | 2016-11-11 | 2019-09-18 | Modernatx Inc | Vaccin antigrippal |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| CA3055653A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| EP3595713A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | RESPIRATORY SYNCYTIAL VIRUS Vaccine |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| US11905525B2 (en) | 2017-04-05 | 2024-02-20 | Modernatx, Inc. | Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| CN107488137B (zh) * | 2017-08-15 | 2019-03-29 | 浙江大学 | 一种小分子量的季铵盐及其制备方法和应用 |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| US20230140670A1 (en) * | 2017-09-29 | 2023-05-04 | Intellia Therapeutics, Inc. | Formulations |
| EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA Vaccines |
| US11679159B2 (en) | 2018-04-29 | 2023-06-20 | Precision NanoSystems ULC | Compositions for transfecting resistant cell types |
| WO2020061295A1 (en) * | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| WO2020061367A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| HRP20240586T1 (hr) * | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| KR20210133218A (ko) * | 2019-01-31 | 2021-11-05 | 모더나티엑스, 인크. | 볼텍스 믹서 및 연계된 방법, 시스템 및 이의 장치 |
| KR102732019B1 (ko) * | 2019-04-15 | 2024-11-20 | 글로벌 라이프 사이언시즈 솔루션즈 캐나다 유엘씨 | T 세포 유전자 발현의 비바이러스 변형 |
| ES2973521T3 (es) | 2019-06-20 | 2024-06-20 | Prec Nanosystems Ulc | Lípidos ionizables para la administración de ácidos nucleicos |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CN115778904B (zh) * | 2019-10-29 | 2025-03-28 | 珠海丽凡达生物技术有限公司 | 一种用于体外转染和体内递送mRNA的制剂 |
| CA3169669A1 (en) | 2020-01-31 | 2021-08-05 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| IL297419B2 (en) | 2020-04-22 | 2025-02-01 | BioNTech SE | Coronavirus vaccine |
| EP3915544A1 (en) * | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Method for producing a liposome dispersion |
| GB202011367D0 (en) * | 2020-07-22 | 2020-09-02 | Micropore Tech Limited | Method of preparing liposomes |
| EP4192432A1 (en) | 2020-08-06 | 2023-06-14 | ModernaTX, Inc. | Methods of preparing lipid nanoparticles |
| MA71659A (fr) | 2020-08-06 | 2025-05-30 | Modernatx, Inc. | Compositions pour l'administration de molécules de charge utile à l'épithélium des voies respiratoires |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| WO2022104131A1 (en) | 2020-11-13 | 2022-05-19 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| DE102020214601A1 (de) | 2020-11-19 | 2022-05-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren und Vorrichtung zur Herstellung einer Flüssigkeit enthaltend Liposomen und hergestellte Flüssigkeit |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| EP4346901A4 (en) * | 2021-06-01 | 2025-04-23 | The University of British Columbia | MRNA DELIVERY USING LIPID NANOPARTICLES |
| WO2023009422A1 (en) | 2021-07-26 | 2023-02-02 | Modernatx, Inc. | Processes for preparing lipid nanoparticle compositions for the delivery of payload molecules to airway epithelium |
| WO2023009421A1 (en) | 2021-07-26 | 2023-02-02 | Modernatx, Inc. | Processes for preparing lipid nanoparticle compositions |
| CN115671294A (zh) * | 2021-07-27 | 2023-02-03 | 中国医学科学院基础医学研究所 | St类脂质化合物在制备核酸递送试剂中的应用及相关产品 |
| EP4379055A4 (en) | 2021-07-27 | 2025-08-06 | Sk Bioscience Co Ltd | MRNA FOR PROTEIN EXPRESSION AND TEMPLATE FOR IT |
| WO2023076598A1 (en) | 2021-10-29 | 2023-05-04 | Modernatx, Inc. | Lipid amines |
| CN118829423A (zh) | 2021-11-12 | 2024-10-22 | 摩登纳特斯有限公司 | 用于将有效载荷分子递送至气道上皮的组合物 |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| EP4475882A1 (en) | 2022-02-09 | 2024-12-18 | ModernaTX, Inc. | Mucosal administration methods and formulations |
| WO2023190170A1 (ja) * | 2022-03-28 | 2023-10-05 | 日油株式会社 | 核酸内封脂質ナノ粒子の製造方法及びこれを含む医薬品組成物の製造方法、並びに、核酸を細胞内又は標的細胞内に導入する方法 |
| WO2024002985A1 (en) | 2022-06-26 | 2024-01-04 | BioNTech SE | Coronavirus vaccine |
| IT202200016386A1 (it) * | 2022-08-02 | 2024-02-02 | Univ Degli Studi Roma La Sapienza | Nanoparticelle lipidiche multicomponenti ad elevata fusogenicità cellulare per la veicolazione di acidi nucleici e relativo processo di preparazione |
| WO2024197404A1 (en) * | 2023-03-30 | 2024-10-03 | Ho Emmanuel Abraham | Bacteria-responsive particles, methods for preparation, and use in packaging or on surfaces |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| CN117070570A (zh) * | 2023-08-28 | 2023-11-17 | 南通大学 | 提高脂质体转染试剂的转染效率的方法 |
| EP4516295A1 (en) * | 2023-09-04 | 2025-03-05 | ETH Zurich | Ph-inducible structure-switching lipid nanovectors, semi-synthetic extracellular vesicles, methods of making same and uses thereof |
| WO2025063214A1 (ja) * | 2023-09-22 | 2025-03-27 | 国立大学法人東北大学 | 核酸を内封したリガンド修飾脂質ナノ粒子の製造方法 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| CN1173776C (zh) | 1996-06-28 | 2004-11-03 | 卡钳技术有限公司 | 在微规模流体性设备里的高通过量的筛选分析系统 |
| EP1030733A4 (en) | 1997-02-05 | 2000-08-30 | California Inst Of Techn | Microfluidic sub-millisecond mixers |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| WO2000029103A1 (en) | 1998-11-13 | 2000-05-25 | Optime Therapeutics, Inc. | Method and apparatus for liposome production |
| EP1203614A1 (de) | 2000-11-03 | 2002-05-08 | Polymun Scientific Immunbiologische Forschung GmbH | Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln |
| US8137699B2 (en) | 2002-03-29 | 2012-03-20 | Trustees Of Princeton University | Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use |
| WO2002087541A1 (en) * | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| EP1412065A2 (en) | 2001-07-27 | 2004-04-28 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| US7252928B1 (en) | 2002-03-12 | 2007-08-07 | Caliper Life Sciences, Inc. | Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels |
| US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
| WO2003097805A2 (en) | 2002-05-15 | 2003-11-27 | California Pacific Medical Center | Delivery of nucleic acid-like compounds |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| US7214348B2 (en) | 2002-07-26 | 2007-05-08 | Applera Corporation | Microfluidic size-exclusion devices, systems, and methods |
| MXPA05010499A (es) | 2003-03-31 | 2006-05-25 | Johnson & Johnson | Particulas lipidicas que tienen un revestimiento lipidico asimetrico y metodo de preparacion de las mismas. |
| US7160025B2 (en) | 2003-06-11 | 2007-01-09 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
| EP1668355A4 (en) | 2003-08-28 | 2011-11-09 | Celula Inc | METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US20050175683A1 (en) | 2003-10-24 | 2005-08-11 | Yuanpeng Zhang | Preparation of lipid particles |
| EP1537858A1 (en) | 2003-12-04 | 2005-06-08 | Vectron Therapeutics AG | Drug delivery vehicles and uses thereof |
| US7507380B2 (en) | 2004-03-19 | 2009-03-24 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microchemical nanofactories |
| EP1750673B1 (en) | 2004-05-17 | 2009-12-02 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
| JP4764426B2 (ja) | 2004-06-07 | 2011-09-07 | プロチバ バイオセラピューティクス インコーポレイティッド | カチオン性脂質および使用方法 |
| US7871632B2 (en) | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| WO2006027787A1 (en) | 2004-09-09 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal compositions of glucocorticoid and glucocorticoid derivatives |
| EP1804964A1 (en) | 2004-10-01 | 2007-07-11 | Velocys Inc. | Multiphase mixing process using microchannel process technology |
| EP1679115A1 (en) | 2005-01-07 | 2006-07-12 | Corning Incorporated | High performance microreactor |
| AU2006226744B2 (en) | 2005-03-23 | 2012-02-23 | Velocys, Inc. | Surface features in microprocess technology |
| US20060219307A1 (en) | 2005-03-31 | 2006-10-05 | National Taiwan University | Micromixer apparatus and method therefor |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| CA2623531C (en) | 2005-10-07 | 2013-12-10 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Matrix metalloproteinase 11 vaccine |
| US20070087045A1 (en) * | 2005-10-14 | 2007-04-19 | Industrial Technology Research Institute | Lipid carrier and method of preparing the same |
| JP2007252979A (ja) | 2006-03-20 | 2007-10-04 | National Institute Of Advanced Industrial & Technology | マイクロリアクタによる化合物の製造方法、そのマイクロリアクタ、及びマイクロリアクタ用の分流器 |
| US7794136B2 (en) | 2006-05-09 | 2010-09-14 | National Tsing Hua University | Twin-vortex micromixer for enforced mass exchange |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| WO2008053988A1 (fr) | 2006-11-02 | 2008-05-08 | National University Corporation Nagoya University | Procédé de production de microcapsules |
| CN101209243B (zh) | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术（石家庄）有限公司 | 一种脂质体药物及其制备方法 |
| CN101765423B (zh) | 2007-05-31 | 2014-08-06 | 安特里奥公司 | 核酸纳米粒子和其用途 |
| EP2167233B1 (en) | 2007-06-26 | 2013-01-23 | Micronit Microfluidics B.V. | Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| US8414182B2 (en) | 2008-03-28 | 2013-04-09 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Micromixers for nanomaterial production |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| US8187554B2 (en) | 2008-04-23 | 2012-05-29 | Microfluidics International Corporation | Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems |
| WO2010012005A2 (en) | 2008-07-25 | 2010-01-28 | S.K. Pharmaceuticals, Inc. | Methods and systems for production of nanoparticles |
| CN111808084A (zh) | 2008-11-10 | 2020-10-23 | 阿布特斯生物制药公司 | 用于递送治疗剂的新型脂质和组合物 |
| EP3243504A1 (en) * | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| KR101766408B1 (ko) * | 2009-06-10 | 2017-08-10 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| AP2015008874A0 (en) * | 2009-08-14 | 2015-11-30 | Alnylam Pharmaceuticals Inc | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| CA2781527C (en) | 2009-09-23 | 2017-10-24 | Indu Javeri | Methods for the preparation of liposomes |
| CN107028886A (zh) * | 2009-11-04 | 2017-08-11 | 不列颠哥伦比亚大学 | 含有核酸的脂质粒子及相关的方法 |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| US8361415B2 (en) | 2010-09-13 | 2013-01-29 | The Regents Of The University Of California | Inertial particle focusing system |
-
2014
- 2014-03-14 CN CN201480022785.0A patent/CN105143456A/zh active Pending
- 2014-03-14 CA CA2906732A patent/CA2906732C/en active Active
- 2014-03-14 WO PCT/US2014/029116 patent/WO2014172045A1/en not_active Ceased
- 2014-03-14 EP EP14785963.1A patent/EP2971013B1/en active Active
- 2014-03-14 US US14/775,539 patent/US10342760B2/en active Active
- 2014-03-14 JP JP2016502986A patent/JP6605446B2/ja active Active
-
2019
- 2019-06-21 US US16/449,176 patent/US20190307689A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016515815A5 (https=) | ||
| JP7753190B2 (ja) | 核酸の送達のための改善された脂質ナノ粒子 | |
| CN114746401B (zh) | 用于核酸递送的可离子化脂质 | |
| CN112996519B (zh) | 用于核酸的器官特异性递送的组合物和方法 | |
| JP6605446B2 (ja) | 形質移入用の脂質ナノ粒子および関連方法 | |
| JP2016028031A5 (https=) | ||
| Yang et al. | A microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia | |
| CN120360966A (zh) | 用于核酸的器官特异性递送的组合物和方法 | |
| JP2013510096A5 (https=) | ||
| CN103153347A (zh) | 用于寡核苷酸递送的新型低分子量阳离子脂质 | |
| CN115297850A (zh) | 用于肝纤维化和其他与纤维化相关的疾病的基于外排体的治疗 | |
| US20250345284A1 (en) | Lipid nanoparticle (lnp) compositions and methods of use thereof | |
| US20070054873A1 (en) | Glucocorticoid modulation of nucleic acid-mediated immune stimulation | |
| CN121443279A (zh) | 用于细胞疗法的脂质纳米颗粒制剂和相关方法 | |
| JP2025528441A (ja) | 核酸を含む活性剤の送達のための組成物及び方法 | |
| EP4519243A2 (en) | Siloxane-based lipids, lipid nanoparticle compositions comprising the same, and methods of use thereof for targeted delivery | |
| Luo | Development of Lipid-like Nanoparticles for mRNA Delivery | |
| WO2025072150A1 (en) | Zwitterionic lipid nanoparticle compositions, and methods of use | |
| JP2025516241A (ja) | ピコルナウイルスをコードするｒｎａポリヌクレオチドの製造 | |
| KR20250029907A (ko) | 백신용 지질 나노입자 제제 | |
| HK40055120B (zh) | 用於核酸的器官特异性递送的组合物和方法 | |
| Yung | Nanoparticle Drug Delivery Systems for Cancer Therapy | |
| HK40055907A (en) | Compositions and methods for organ specific delivery of nucleic acids |