JP2016515029A5 - - Google Patents
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- Publication number
- JP2016515029A5 JP2016515029A5 JP2016502451A JP2016502451A JP2016515029A5 JP 2016515029 A5 JP2016515029 A5 JP 2016515029A5 JP 2016502451 A JP2016502451 A JP 2016502451A JP 2016502451 A JP2016502451 A JP 2016502451A JP 2016515029 A5 JP2016515029 A5 JP 2016515029A5
- Authority
- JP
- Japan
- Prior art keywords
- substrate
- group
- active agent
- primer
- trihydroxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000758 substrate Substances 0.000 claims 31
- -1 trihydroxyphenyl group Chemical group 0.000 claims 18
- 239000013543 active substance Substances 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 14
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 8
- RGZHEOWNTDJLAQ-UHFFFAOYSA-N 3,4,5-trihydroxybenzaldehyde Chemical compound OC1=CC(C=O)=CC(O)=C1O RGZHEOWNTDJLAQ-UHFFFAOYSA-N 0.000 claims 6
- FBSFWRHWHYMIOG-UHFFFAOYSA-N methyl 3,4,5-trihydroxybenzoate Chemical compound COC(=O)C1=CC(O)=C(O)C(O)=C1 FBSFWRHWHYMIOG-UHFFFAOYSA-N 0.000 claims 6
- 230000000269 nucleophilic effect Effects 0.000 claims 6
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 5
- 229940074391 gallic acid Drugs 0.000 claims 4
- 235000004515 gallic acid Nutrition 0.000 claims 4
- 229920000669 heparin Polymers 0.000 claims 4
- CRPNQSVBEWWHIJ-UHFFFAOYSA-N 2,3,4-trihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C(O)=C1O CRPNQSVBEWWHIJ-UHFFFAOYSA-N 0.000 claims 3
- NYUABOGYMWADSF-UHFFFAOYSA-N 5-methylbenzene-1,2,3-triol Chemical compound CC1=CC(O)=C(O)C(O)=C1 NYUABOGYMWADSF-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 239000003527 fibrinolytic agent Substances 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- IBKQQKPQRYUGBJ-UHFFFAOYSA-N methyl gallate Natural products CC(=O)C1=CC(O)=C(O)C(O)=C1 IBKQQKPQRYUGBJ-UHFFFAOYSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229940079877 pyrogallol Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- WEOHANUVLKERQI-UHFFFAOYSA-N (2,4-dioxoimidazolidin-1-yl)azanium;chloride Chemical compound Cl.NN1CC(=O)NC1=O WEOHANUVLKERQI-UHFFFAOYSA-N 0.000 claims 2
- BRRSNXCXLSVPFC-UHFFFAOYSA-N 2,3,4-Trihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1O BRRSNXCXLSVPFC-UHFFFAOYSA-N 0.000 claims 2
- RBQIPEJXQPQFJX-UHFFFAOYSA-N 3,4,5-trihydroxybenzamide Chemical compound NC(=O)C1=CC(O)=C(O)C(O)=C1 RBQIPEJXQPQFJX-UHFFFAOYSA-N 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 2
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical compound C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000000151 deposition Methods 0.000 claims 2
- 238000000502 dialysis Methods 0.000 claims 2
- 230000003100 immobilizing effect Effects 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical group 0.000 claims 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 229940124073 Complement inhibitor Drugs 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 230000003187 abdominal effect Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000002519 antifouling agent Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000004074 complement inhibitor Substances 0.000 claims 1
- 238000003851 corona treatment Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 239000002628 heparin derivative Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 229910052809 inorganic oxide Inorganic materials 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000007915 intraurethral administration Methods 0.000 claims 1
- 238000009832 plasma treatment Methods 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920000768 polyamine Chemical group 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920000307 polymer substrate Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 239000004065 semiconductor Substances 0.000 claims 1
- 150000004756 silanes Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- TXDNPSYEJHXKMK-UHFFFAOYSA-N sulfanylsilane Chemical class S[SiH3] TXDNPSYEJHXKMK-UHFFFAOYSA-N 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798765P | 2013-03-15 | 2013-03-15 | |
| US61/798,765 | 2013-03-15 | ||
| PCT/US2014/027466 WO2014152551A1 (en) | 2013-03-15 | 2014-03-14 | Immobilization of active agent on a substrate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515029A JP2016515029A (ja) | 2016-05-26 |
| JP2016515029A5 true JP2016515029A5 (https=) | 2017-04-13 |
| JP6336563B2 JP6336563B2 (ja) | 2018-06-06 |
Family
ID=50896500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502451A Active JP6336563B2 (ja) | 2013-03-15 | 2014-03-14 | 基板への活性作用剤の固定 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9642949B2 (https=) |
| EP (1) | EP2968676B1 (https=) |
| JP (1) | JP6336563B2 (https=) |
| KR (1) | KR102253319B1 (https=) |
| CN (1) | CN105263536B (https=) |
| AU (1) | AU2014239600B2 (https=) |
| BR (1) | BR112015022379B1 (https=) |
| CA (1) | CA2906621A1 (https=) |
| MX (1) | MX363474B (https=) |
| RU (1) | RU2667966C2 (https=) |
| WO (1) | WO2014152551A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102271653B1 (ko) * | 2013-06-07 | 2021-07-05 | 백스터 인터내셔널 인코포레이티드 | 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화 |
| CN108926490B (zh) * | 2017-05-25 | 2021-01-26 | 南方医科大学南方医院 | 一种抗凝胃管的制作方法 |
| US12251496B2 (en) | 2018-05-30 | 2025-03-18 | Wisconsin Alumni Research Foundation | Wavy multi-component vascular grafts with biomimetic mechanical properties, antithrombogenicity, and endothelial cell affinity |
| WO2019232177A1 (en) * | 2018-05-30 | 2019-12-05 | Wisconsin Alumni Research Foundation | PROMOTING ENDOTHELIAL CELL AFFINITY AND ANTITHROMBOGENICITY OF POLYTETRAFLUOROETHYLENE (ptfe) BY MUSSEL-INSPIRED MODIFICATION AND RGD/HEPARIN GRAFTING |
| US11484626B2 (en) | 2018-05-30 | 2022-11-01 | Wisconsin Alumni Research Foundation | Promoting endothelial cell affinity and antithrombogenicity of polytetrafluoroethylene (PTFE) by mussel-inspired modification and RGD/heparin grafting |
| CN108498878B (zh) * | 2018-07-05 | 2019-06-11 | 四川大学 | 一种具有“三明治”夹心结构的生物医用水凝胶涂层及其制备方法 |
| CN108796491B (zh) * | 2018-07-05 | 2019-07-09 | 四川大学 | 一种具有高耐腐蚀性和表面功能化的镁基金属转化涂层及其制备方法 |
| CN108969805B (zh) * | 2018-07-05 | 2019-06-11 | 四川大学 | 一种可催化一氧化氮释放的抗凝血水凝胶涂层及其制备方法 |
| CN108686267B (zh) * | 2018-07-05 | 2020-07-28 | 四川大学 | 一种兼具抗凝血、抗炎、抗增生功能的涂层及其制备方法 |
| CN108815587B (zh) * | 2018-07-05 | 2020-07-21 | 四川大学 | 一种具有长期抗菌功能的水凝胶涂层及其制备方法 |
| MX2021006372A (es) * | 2018-11-29 | 2021-08-11 | Ethicon Inc | Revestimientos lubricantes de silicona curada a baja temperatura. |
| US11718753B2 (en) | 2020-05-28 | 2023-08-08 | Ethicon, Inc. | Topical skin closure compositions and systems |
| US11518604B2 (en) | 2020-05-28 | 2022-12-06 | Ethicon, Inc. | Systems, methods and devices for aerosol spraying of silicone based topical skin adhesives for sealing wounds |
| US12528913B2 (en) | 2020-05-28 | 2026-01-20 | Ethicon, Inc. | Antimicrobial anhydrous topical skin closure compositions and systems |
| US11479669B2 (en) | 2020-05-28 | 2022-10-25 | Ethicon, Inc. | Topical skin closure compositions and systems |
| US11589867B2 (en) | 2020-05-28 | 2023-02-28 | Ethicon, Inc. | Anisotropic wound closure systems |
| US11712229B2 (en) | 2020-05-28 | 2023-08-01 | Ethicon, Inc. | Systems, devices and methods for dispensing and curing silicone based topical skin adhesives |
| US12465577B2 (en) | 2020-05-28 | 2025-11-11 | Ethicon, Inc. | Antimicrobial topical skin closure compositions and systems |
| CN112618791A (zh) * | 2020-12-25 | 2021-04-09 | 福建医科大学附属协和医院 | 聚醚醚酮三维多孔化并修饰聚多巴胺/庆大霉素用于植入物抗菌、抗炎及促进骨整合 |
| US20220211478A1 (en) * | 2021-01-06 | 2022-07-07 | Medtronic Inc. | Surgical system and methods of use |
| CN113244897B (zh) * | 2021-05-26 | 2021-10-01 | 高频美特利环境科技（北京）有限公司 | 一种水体除氟开孔聚合物泡沫材料及其制备方法和应用 |
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| US10179114B2 (en) * | 2013-01-24 | 2019-01-15 | Northwestern University | Phenolic coatings and methods of making and using same |
| KR102271653B1 (ko) | 2013-06-07 | 2021-07-05 | 백스터 인터내셔널 인코포레이티드 | 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화 |
-
2014
- 2014-03-14 CA CA2906621A patent/CA2906621A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/027466 patent/WO2014152551A1/en not_active Ceased
- 2014-03-14 EP EP14728708.0A patent/EP2968676B1/en active Active
- 2014-03-14 KR KR1020157028563A patent/KR102253319B1/ko active Active
- 2014-03-14 BR BR112015022379-6A patent/BR112015022379B1/pt active IP Right Grant
- 2014-03-14 US US14/212,325 patent/US9642949B2/en active Active
- 2014-03-14 CN CN201480015897.3A patent/CN105263536B/zh active Active
- 2014-03-14 AU AU2014239600A patent/AU2014239600B2/en active Active
- 2014-03-14 RU RU2015144297A patent/RU2667966C2/ru active
- 2014-03-14 JP JP2016502451A patent/JP6336563B2/ja active Active
- 2014-03-14 MX MX2015012627A patent/MX363474B/es unknown
-
2017
- 2017-03-03 US US15/449,752 patent/US9895468B2/en active Active
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