JP2016520403A5 - - Google Patents
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- Publication number
- JP2016520403A5 JP2016520403A5 JP2016518024A JP2016518024A JP2016520403A5 JP 2016520403 A5 JP2016520403 A5 JP 2016520403A5 JP 2016518024 A JP2016518024 A JP 2016518024A JP 2016518024 A JP2016518024 A JP 2016518024A JP 2016520403 A5 JP2016520403 A5 JP 2016520403A5
- Authority
- JP
- Japan
- Prior art keywords
- substrate
- group
- medical device
- active agent
- trihydroxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000758 substrate Substances 0.000 claims 37
- -1 trihydroxyphenyl group Chemical group 0.000 claims 20
- 239000013543 active substance Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 12
- 239000003146 anticoagulant agent Substances 0.000 claims 7
- BRRSNXCXLSVPFC-UHFFFAOYSA-N 2,3,4-Trihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1O BRRSNXCXLSVPFC-UHFFFAOYSA-N 0.000 claims 6
- IBHWREHFNDMRPR-UHFFFAOYSA-N 2,4,6-Trihydroxybenzoic acid Chemical compound OC(=O)C1=C(O)C=C(O)C=C1O IBHWREHFNDMRPR-UHFFFAOYSA-N 0.000 claims 6
- RGZHEOWNTDJLAQ-UHFFFAOYSA-N 3,4,5-trihydroxybenzaldehyde Chemical compound OC1=CC(C=O)=CC(O)=C1O RGZHEOWNTDJLAQ-UHFFFAOYSA-N 0.000 claims 6
- RBQIPEJXQPQFJX-UHFFFAOYSA-N 3,4,5-trihydroxybenzamide Chemical compound NC(=O)C1=CC(O)=C(O)C(O)=C1 RBQIPEJXQPQFJX-UHFFFAOYSA-N 0.000 claims 6
- 239000004599 antimicrobial Substances 0.000 claims 6
- 229940074391 gallic acid Drugs 0.000 claims 6
- 235000004515 gallic acid Nutrition 0.000 claims 6
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 6
- 239000002260 anti-inflammatory agent Substances 0.000 claims 5
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 5
- 229960004676 antithrombotic agent Drugs 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229920001661 Chitosan Polymers 0.000 claims 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 230000003100 immobilizing effect Effects 0.000 claims 4
- FBSFWRHWHYMIOG-UHFFFAOYSA-N methyl 3,4,5-trihydroxybenzoate Chemical compound COC(=O)C1=CC(O)=C(O)C(O)=C1 FBSFWRHWHYMIOG-UHFFFAOYSA-N 0.000 claims 4
- WEOHANUVLKERQI-UHFFFAOYSA-N (2,4-dioxoimidazolidin-1-yl)azanium;chloride Chemical compound Cl.NN1CC(=O)NC1=O WEOHANUVLKERQI-UHFFFAOYSA-N 0.000 claims 3
- CRPNQSVBEWWHIJ-UHFFFAOYSA-N 2,3,4-trihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C(O)=C1O CRPNQSVBEWWHIJ-UHFFFAOYSA-N 0.000 claims 3
- NYUABOGYMWADSF-UHFFFAOYSA-N 5-methylbenzene-1,2,3-triol Chemical compound CC1=CC(O)=C(O)C(O)=C1 NYUABOGYMWADSF-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 229920002492 poly(sulfone) Polymers 0.000 claims 3
- 239000004417 polycarbonate Substances 0.000 claims 3
- 229920000515 polycarbonate Polymers 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920001195 polyisoprene Polymers 0.000 claims 3
- 229940079877 pyrogallol Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229940127219 anticoagulant drug Drugs 0.000 claims 2
- 239000002519 antifouling agent Substances 0.000 claims 2
- 229960002897 heparin Drugs 0.000 claims 2
- 239000003999 initiator Substances 0.000 claims 2
- IBKQQKPQRYUGBJ-UHFFFAOYSA-N methyl gallate Natural products CC(=O)C1=CC(O)=C(O)C(O)=C1 IBKQQKPQRYUGBJ-UHFFFAOYSA-N 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 241001631457 Cannula Species 0.000 claims 1
- 229940124073 Complement inhibitor Drugs 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000004074 complement inhibitor Substances 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 239000002628 heparin derivative Substances 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 238000009832 plasma treatment Methods 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832488P | 2013-06-07 | 2013-06-07 | |
| US201361832477P | 2013-06-07 | 2013-06-07 | |
| US61/832,488 | 2013-06-07 | ||
| US61/832,477 | 2013-06-07 | ||
| PCT/US2014/041240 WO2014197768A1 (en) | 2013-06-07 | 2014-06-06 | Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520403A JP2016520403A (ja) | 2016-07-14 |
| JP2016520403A5 true JP2016520403A5 (https=) | 2017-06-22 |
| JP6513643B2 JP6513643B2 (ja) | 2019-05-15 |
Family
ID=51176459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016518024A Active JP6513643B2 (ja) | 2013-06-07 | 2014-06-06 | トリヒドロキシフェニル基を含む化合物を使用する基体上の活性剤の固定化 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9655917B2 (https=) |
| EP (1) | EP3003413B1 (https=) |
| JP (1) | JP6513643B2 (https=) |
| KR (1) | KR102271653B1 (https=) |
| CN (1) | CN105377315B (https=) |
| AU (1) | AU2014274766B2 (https=) |
| CA (1) | CA2914732C (https=) |
| ES (1) | ES2660595T3 (https=) |
| WO (1) | WO2014197768A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2012036238A1 (ja) * | 2010-09-17 | 2014-02-03 | テルモ株式会社 | 血液と接触する表面の血小板付着性を減少させる医療用機器の製造方法 |
| CA2906621A1 (en) | 2013-03-15 | 2014-09-25 | Baxter International Inc. | Immobilization of active agent on a substrate |
| KR102271653B1 (ko) | 2013-06-07 | 2021-07-05 | 백스터 인터내셔널 인코포레이티드 | 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화 |
| WO2017147145A1 (en) * | 2016-02-23 | 2017-08-31 | The Regents Of The University Of California | Macrocyclic polyphenols for universal coatings |
| WO2017188214A1 (ja) * | 2016-04-25 | 2017-11-02 | 学校法人早稲田大学 | 高い接着性を有する非水溶性自立性薄膜 |
| CN106119820B (zh) * | 2016-06-01 | 2018-06-22 | 华南理工大学 | 一种利用可控接枝技术提高材料表面血液相容性的方法 |
| CN107435043A (zh) * | 2017-07-30 | 2017-12-05 | 光合强化（北京）生物科技有限公司 | 基于聚碳酸酯改性的用于固定甲拌磷降解菌的功能材料 |
| CN108310473A (zh) * | 2018-01-31 | 2018-07-24 | 采纳科技股份有限公司 | 注射针硅油涂层材料及涂覆此涂层的注射针 |
| MX2021006372A (es) * | 2018-11-29 | 2021-08-11 | Ethicon Inc | Revestimientos lubricantes de silicona curada a baja temperatura. |
| WO2020263704A1 (en) * | 2019-06-25 | 2020-12-30 | Molecular Surface Technologies, Llc | Electrochemical attachment of phosphonic acids to metallic substrates and antimicrobial medical devices containing same |
| CN110665374B (zh) * | 2019-09-19 | 2022-01-28 | 深圳安吉尔饮水产业集团有限公司 | 季铵盐抗菌材料的制备方法及其制备的抗菌材料 |
| CN110694488B (zh) * | 2019-09-19 | 2022-01-28 | 深圳安吉尔饮水产业集团有限公司 | 一种抗菌过滤材料及其应用 |
| US11718753B2 (en) | 2020-05-28 | 2023-08-08 | Ethicon, Inc. | Topical skin closure compositions and systems |
| US12528913B2 (en) | 2020-05-28 | 2026-01-20 | Ethicon, Inc. | Antimicrobial anhydrous topical skin closure compositions and systems |
| US11518604B2 (en) | 2020-05-28 | 2022-12-06 | Ethicon, Inc. | Systems, methods and devices for aerosol spraying of silicone based topical skin adhesives for sealing wounds |
| US11479669B2 (en) | 2020-05-28 | 2022-10-25 | Ethicon, Inc. | Topical skin closure compositions and systems |
| US11712229B2 (en) | 2020-05-28 | 2023-08-01 | Ethicon, Inc. | Systems, devices and methods for dispensing and curing silicone based topical skin adhesives |
| US12465577B2 (en) | 2020-05-28 | 2025-11-11 | Ethicon, Inc. | Antimicrobial topical skin closure compositions and systems |
| US11589867B2 (en) | 2020-05-28 | 2023-02-28 | Ethicon, Inc. | Anisotropic wound closure systems |
| CN112843342A (zh) * | 2021-01-18 | 2021-05-28 | 成都鼎峰前瞻科技有限公司 | 具有生物抗污功能的材料、其制备方法及应用 |
| CN115245813B (zh) * | 2021-04-25 | 2023-09-26 | 中国科学院大连化学物理研究所 | 一种复合微球及其制备和在磷酸化肽吸附中的应用 |
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| CA2906621A1 (en) * | 2013-03-15 | 2014-09-25 | Baxter International Inc. | Immobilization of active agent on a substrate |
| KR102271653B1 (ko) | 2013-06-07 | 2021-07-05 | 백스터 인터내셔널 인코포레이티드 | 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화 |
-
2014
- 2014-06-06 KR KR1020167000009A patent/KR102271653B1/ko active Active
- 2014-06-06 JP JP2016518024A patent/JP6513643B2/ja active Active
- 2014-06-06 EP EP14738666.8A patent/EP3003413B1/en active Active
- 2014-06-06 AU AU2014274766A patent/AU2014274766B2/en active Active
- 2014-06-06 WO PCT/US2014/041240 patent/WO2014197768A1/en not_active Ceased
- 2014-06-06 CN CN201480032132.0A patent/CN105377315B/zh active Active
- 2014-06-06 US US14/298,693 patent/US9655917B2/en active Active
- 2014-06-06 CA CA2914732A patent/CA2914732C/en active Active
- 2014-06-06 ES ES14738666.8T patent/ES2660595T3/es active Active
-
2017
- 2017-04-18 US US15/490,412 patent/US10428200B2/en active Active
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