CN108310473A - 注射针硅油涂层材料及涂覆此涂层的注射针 - Google Patents

注射针硅油涂层材料及涂覆此涂层的注射针 Download PDF

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CN108310473A
CN108310473A CN201810093322.3A CN201810093322A CN108310473A CN 108310473 A CN108310473 A CN 108310473A CN 201810093322 A CN201810093322 A CN 201810093322A CN 108310473 A CN108310473 A CN 108310473A
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陆军
赵丽杰
倪琳
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Abstract

本发明公开了注射针硅油涂层材料，其通过注射针针头浸注聚硅氧烷涂布溶液在针头表面形成硅油涂层，或通过向注射针针头喷洒或擦拭聚硅氧烷涂布溶液在针头表面形成硅油涂层；聚硅氧烷涂布溶液为聚硅氧烷混合于混合溶剂中形成，所述混合溶剂包括重量份数为2～4份的硝化纤维素、1～3份的邻苯二甲酸二丁酯、0.5～1.5份的丙酮、10～30份的乙醇、15～30份的乙酸乙酯、20～30份的甲苯、0.3～1.2份的异丙醇及3～8份的二甲基甲酰胺；所述聚硅氧烷的质量浓度为1.86～1.93。本发明在针头表面设置螺旋槽，便于穿刺一些硬质皮肤的动物以便于注射药液；其硅油涂层的设置能够极大地降低穿刺时病体的疼痛，注射完成后拔出针尖，伤口还不会流血。

Description

注射针硅油涂层材料及涂覆此涂层的注射针
技术领域
本发明涉及注射针硅油涂层材料。
背景技术
注射针在穿刺病体时会给病体带来疼痛，现在一般在针头表面涂覆硅油涂层增加针头的润滑性以减少注射针的穿刺阻力，以减少病体的疼痛；对于兽用注射针，尤其是用于牛、马等具有硬质肤质的兽用注射针，则在注射时穿刺较难，更是增加了病体的疼痛；另外，现在的注射针基本注射完毕后拔出针尖时病体还会流血，有的病体如果体制特别，比如患有血友病，还会存在注射后血流不止的情况。
发明内容
本发明的目的在于，克服现有技术中存在的缺陷，提供注射针硅油涂层材料，能轻易穿刺一些硬质皮肤的动物以便于注射药液，且能够极大地降低穿刺时病体的疼痛，注射完成后拔出针尖，伤口还不会流血。
为实现上述目的，本发明的技术方案是设计注射针硅油涂层材料，其通过注射针针头浸注聚硅氧烷涂布溶液在针头表面形成硅油涂层，或通过向注射针针头喷洒或擦拭聚硅氧烷涂布溶液在针头表面形成硅油涂层；聚硅氧烷涂布溶液为聚硅氧烷混合于混合溶剂中形成，所述混合溶剂包括重量份数为2～4份的硝化纤维素、1～3份的邻苯二甲酸二丁酯、0.5～1.5份的丙酮、10～30份的乙醇、15～30份的乙酸乙酯、20～30份的甲苯、0.3～1.2份的异丙醇及3～8份的二甲基甲酰胺；所述聚硅氧烷的质量浓度为1.86～1.93。
进一步的技术方案是，混合溶剂包括重量份数为3.81份的硝化纤维素、2.55份的邻苯二甲酸二丁酯、1.42份的丙酮、26.04份的乙醇、28.81份的乙酸乙酯、29.63份的甲苯、0.81份的异丙醇及6.91份的二甲基甲酰胺；所述聚硅氧烷的重量份数为0.73～1.46份。采用这样的配方制成的硅油涂层可以极大地增加针头的润滑性，大大减轻刺穿病体的痛苦。
进一步的技术方案是，注射针针头在浸注聚硅氧烷涂布溶液时同时向注射针针孔内通气，浸注完毕后对注射针针头自然干燥或加温干燥；加温干燥的温度低于250℃。浸注时通气是为了只让针头的外表面涂覆涂层，而针头的内壁没有硅油涂层。
进一步的技术方案为，聚硅氧烷为聚二甲基硅氧烷。硅油涂层采用甲基硅油。
进一步的技术方案为，涂覆硅油涂层的注射针，所述注射针的针头表面设置用于辅助针头穿刺的螺旋槽，螺旋槽表面涂覆注射针硅油涂层材料。这样的设置使得在使用本注射针对牛或马等具有硬质皮肤的动物注射药液时不再有那么大的阻力，能够减轻病体的疼痛，使用时不再像以往的注射针那样直接往病体皮肤内插入进去，而是在插入时还旋转针头，由于螺旋槽的设置，这样在插入时螺旋槽辅助针头穿刺，对于这种硬质肤质的动物病体的药液注射是很有效果的。
进一步的技术方案为，注射针硅油涂层材料与针头之间还设置止血涂层，所述止血涂层涂覆在针头表面，注射针硅油涂层材料涂覆在止血涂层上。
进一步的技术方案为，止血涂层为针头浸注儿茶酚-壳聚糖水凝胶后形成的，儿茶酚-壳聚糖水凝胶的制备包括如下步骤：将重量份数为10份的壳聚糖置于10份醋酸水溶液中在室温下并搅拌，醋酸水溶液其醋酸的体积分数为0.3％；再加入0.033份的2，3，4-三羟基苯甲醛和0.033份的2，4，5-三羟基苯甲醛并在室温下搅拌1小时，即制得儿茶酚-壳聚糖水凝胶。由于本止血涂层的设置，这样在注射完成后拔出针尖，伤口不会流血。也可以在本儿茶酚-壳聚糖水凝胶中加入聚硅氧烷涂布溶液，然后再给针头表面涂覆本混合涂层，这样既能止血又能提高针头的润滑性。
本发明的优点和有益效果在于：本发明在针头表面设置螺旋槽，便于穿刺一些硬质皮肤的动物以便于注射药液；其硅油涂层的设置能够极大地降低穿刺时病体的疼痛，注射完成后拔出针尖，伤口还不会流血；采用本发明的配方制成的硅油涂层可以极大地增加针头的润滑性，大大减轻刺穿病体的痛苦；浸注时通气是可以只让针头的外表面涂覆涂层，而针头的内壁没有硅油涂层。螺旋槽的设置使得在使用本注射针对牛或马等具有硬质皮肤的动物注射药液时不再有那么大的阻力，能够减轻病体的疼痛，使用时不再像以往的注射针那样直接往病体皮肤内插入进去，而是在插入时还旋转针头，由于螺旋槽的设置，这样在插入时螺旋槽辅助针头穿刺，对于这种硬质肤质的动物病体的药液注射是很有效果的。
具体实施方式
下面结合实施例，对本发明的具体实施方式作进一步描述。以下实施例仅用于更加清楚地说明本发明的技术方案，而不能以此来限制本发明的保护范围。
实施例一：
本发明是注射针硅油涂层材料，其通过注射针针头浸注聚硅氧烷涂布溶液在针头表面形成硅油涂层，或通过向注射针针头喷洒或擦拭聚硅氧烷涂布溶液在针头表面形成硅油涂层；聚硅氧烷涂布溶液为聚硅氧烷混合于混合溶剂中形成，混合溶剂包括5.23g的硝化纤维素、3.5g的邻苯二甲酸二丁酯、2.50ml的丙酮、45.30ml的乙醇、44.00ml的乙酸乙酯、46.80ml的甲苯、1.40ml的异丙醇及10.00ml的二甲基甲酰胺；所述聚硅氧烷为1g。注射针针头在浸注聚硅氧烷涂布溶液时同时向注射针针孔内通气，浸注完毕后对注射针针头自然干燥。聚硅氧烷为聚二甲基硅氧烷。涂覆硅油涂层的注射针，所述注射针的针头表面设置用于辅助针头穿刺的螺旋槽，螺旋槽表面涂覆注射针硅油涂层材料。注射针硅油涂层材料与针头之间还设置止血涂层，所述止血涂层涂覆在针头表面，注射针硅油涂层材料涂覆在止血涂层上。止血涂层为针头浸注儿茶酚-壳聚糖水凝胶后形成的，儿茶酚-壳聚糖水凝胶的制备包括如下步骤：将10g的壳聚糖置于10ml醋酸水溶液中在室温下并搅拌，醋酸水溶液其醋酸的体积分数为0.3％；再加入0.033g的2，3，4-三羟基苯甲醛和0.033g的2，4，5-三羟基苯甲醛并在室温下搅拌1小时，即制得儿茶酚-壳聚糖水凝胶。
实施例二：
与实施例一的不同在于，所述聚硅氧烷为2g；浸注完毕后对注射针针头加温干燥；加温干燥的温度低于250℃。
分别采用本发明实施例一和实施例二的涂层涂覆在不同规格的针头上的最大穿刺力，按照GB15811-2001一次性使用无菌注射针测试后，如下表：
可见，采用本发明的配方制得的涂层远低于GB15811-2001对于最大刺穿力的要求，刺穿力越低，病体的疼痛感越小，且拔出针尖时病体不会流血。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (7)

1.注射针硅油涂层材料，其特征在于，其通过注射针针头浸注聚硅氧烷涂布溶液在针头表面形成硅油涂层，或通过向注射针针头喷洒或擦拭聚硅氧烷涂布溶液在针头表面形成硅油涂层；聚硅氧烷涂布溶液为聚硅氧烷混合于混合溶剂中形成，所述混合溶剂包括重量份数为2～4份的硝化纤维素、1～3份的邻苯二甲酸二丁酯、0.5～1.5份的丙酮、10～30份的乙醇、15～30份的乙酸乙酯、20～30份的甲苯、0.3～1.2份的异丙醇及3～8份的二甲基甲酰胺；所述聚硅氧烷的质量浓度为1.86～1.93。
2.如权利要求1所述的注射针硅油涂层材料，其特征在于，所述混合溶剂包括重量份数为3.81份的硝化纤维素、2.55份的邻苯二甲酸二丁酯、1.42份的丙酮、26.04份的乙醇、28.81份的乙酸乙酯、29.63份的甲苯、0.81份的异丙醇及6.91份的二甲基甲酰胺；所述聚硅氧烷的重量份数为0.73～1.46份。
3.如权利要求2所述的注射针硅油涂层材料，其特征在于，所述注射针针头在浸注聚硅氧烷涂布溶液时同时向注射针针孔内通气，浸注完毕后对注射针针头自然干燥或加温干燥；加温干燥的温度低于250℃。
4.如权利要求3所述的注射针硅油涂层材料，其特征在于，所述聚硅氧烷为聚二甲基硅氧烷。
5.涂覆权利要求1至4中任一项所述硅油涂层的注射针，其特征在于，所述注射针的针头表面设置用于辅助针头穿刺的螺旋槽，螺旋槽表面涂覆注射针硅油涂层材料。
6.如权利要求5所述的注射针，其特征在于，所述注射针硅油涂层材料与针头之间还设置止血涂层，所述止血涂层涂覆在针头表面，注射针硅油涂层材料涂覆在止血涂层上。
7.如权利要求6所述的注射针，其特征在于，所述止血涂层为针头浸注儿茶酚-壳聚糖水凝胶后形成的，儿茶酚-壳聚糖水凝胶的制备包括如下步骤：将重量份数为10份的壳聚糖置于10份醋酸水溶液中在室温下并搅拌，醋酸水溶液其醋酸的体积分数为0.3％；再加入0.033份的2，3，4-三羟基苯甲醛和0.033份的2，4，5-三羟基苯甲醛并在室温下搅拌1小时，即制得儿茶酚-壳聚糖水凝胶。
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