JP2016514950A5 - - Google Patents
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- JP2016514950A5 JP2016514950A5 JP2015555362A JP2015555362A JP2016514950A5 JP 2016514950 A5 JP2016514950 A5 JP 2016514950A5 JP 2015555362 A JP2015555362 A JP 2015555362A JP 2015555362 A JP2015555362 A JP 2015555362A JP 2016514950 A5 JP2016514950 A5 JP 2016514950A5
- Authority
- JP
- Japan
- Prior art keywords
- hypoxia
- target cell
- cells
- cell
- subpopulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 31
- 238000000034 method Methods 0.000 claims 30
- 206010021143 Hypoxia Diseases 0.000 claims 12
- 238000012258 culturing Methods 0.000 claims 7
- 230000007954 hypoxia Effects 0.000 claims 7
- 239000000758 substrate Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000010410 layer Substances 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 230000032823 cell division Effects 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 230000000877 morphologic effect Effects 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100030907 Aryl hydrocarbon receptor nuclear translocator Human genes 0.000 claims 1
- 210000001956 EPC Anatomy 0.000 claims 1
- 101000793115 Homo sapiens Aryl hydrocarbon receptor nuclear translocator Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 102100030482 Hypoxia-inducible factor 3-alpha Human genes 0.000 claims 1
- 101710083143 Hypoxia-inducible factor 3-alpha Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 230000009087 cell motility Effects 0.000 claims 1
- 210000003855 cell nucleus Anatomy 0.000 claims 1
- 210000003989 endothelium vascular Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 230000000704 physical effect Effects 0.000 claims 1
- 210000002243 primary neuron Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 239000003590 rho kinase inhibitor Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- AWGGTRWVHHHJAA-UHFFFAOYSA-N Cc1cccc2c1cccc2S(N1CCNCCC1)(=O)=O Chemical compound Cc1cccc2c1cccc2S(N1CCNCCC1)(=O)=O AWGGTRWVHHHJAA-UHFFFAOYSA-N 0.000 description 2
- IYOZTVGMEWJPKR-YWRZDDHQSA-N CC([C@H](CC1)CC[C@@H]1C(Nc1ccncc1)=O)N Chemical compound CC([C@H](CC1)CC[C@@H]1C(Nc1ccncc1)=O)N IYOZTVGMEWJPKR-YWRZDDHQSA-N 0.000 description 1
- 0 C[C@@]([C@](C[C@@]([C@]([C@](*)C1(C)C)O[C@@]1(C1)O[C@](CC=Cc2c[o]c([C@@](*)CCNC([C@]([C@]([C@](COC)N(C)C)O)O)=O)n2)[C@](C)[C@@]1O)OC)O)[C@@]([C@](C)C=C(C)C(C)=CC)O Chemical compound C[C@@]([C@](C[C@@]([C@]([C@](*)C1(C)C)O[C@@]1(C1)O[C@](CC=Cc2c[o]c([C@@](*)CCNC([C@]([C@]([C@](COC)N(C)C)O)O)=O)n2)[C@](C)[C@@]1O)OC)O)[C@@]([C@](C)C=C(C)C(C)=CC)O 0.000 description 1
- GYKJGOHGJINEIL-SFHVURJKSA-N Cc(cc1C([C@]2(CC3)O)=O)ccc1N=C2N3C1=CC=CCC1 Chemical compound Cc(cc1C([C@]2(CC3)O)=O)ccc1N=C2N3C1=CC=CCC1 GYKJGOHGJINEIL-SFHVURJKSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361756993P | 2013-01-25 | 2013-01-25 | |
| US61/756,993 | 2013-01-25 | ||
| US201361760626P | 2013-02-04 | 2013-02-04 | |
| US61/760,626 | 2013-02-04 | ||
| PCT/US2014/013048 WO2014117021A2 (en) | 2013-01-25 | 2014-01-24 | Methods, compositions, kits, and systems for selective enrichment of target cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016514950A JP2016514950A (ja) | 2016-05-26 |
| JP2016514950A5 true JP2016514950A5 (enExample) | 2017-02-23 |
| JP6509745B2 JP6509745B2 (ja) | 2019-05-08 |
Family
ID=51223330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555362A Expired - Fee Related JP6509745B2 (ja) | 2013-01-25 | 2014-01-24 | 標的細胞の選択的富化のための方法、組成物、キット、及びシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9857360B2 (enExample) |
| EP (1) | EP2948776B8 (enExample) |
| JP (1) | JP6509745B2 (enExample) |
| CN (2) | CN104956226B (enExample) |
| AU (1) | AU2014209218B2 (enExample) |
| CA (2) | CA2895791A1 (enExample) |
| GB (1) | GB2516196B (enExample) |
| WO (1) | WO2014117021A2 (enExample) |
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| DE102012213838A1 (de) | 2012-08-03 | 2014-02-06 | Katharina Pachmann | Verfahren zur Kultivierung einer Subpopulation zirkulierender epithelialer Tumorzellen aus einer Körperflüssigkeit |
| WO2016081554A1 (en) * | 2014-11-18 | 2016-05-26 | Neostem Oncology, Llc | Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use |
| CN108026500A (zh) | 2015-03-31 | 2018-05-11 | 兴盛生物科技股份有限公司 | 具有一体式细胞操纵系统的细胞培养培殖器 |
| CN107920496B (zh) | 2015-03-31 | 2021-10-15 | 兴盛生物科技股份有限公司 | 自动化细胞培养培殖器 |
| GB2555728A (en) * | 2015-04-17 | 2018-05-09 | Xcell Biosciences Inc | Cancer cell enrichment system |
| CN108367290B (zh) | 2015-10-01 | 2021-06-04 | 伯克利之光生命科技公司 | 井孔板培养器 |
| CA2999054A1 (en) * | 2015-10-20 | 2017-04-27 | Celcuity Llc | Methods of preparing a primary cell sample |
| CN105807054A (zh) * | 2015-11-22 | 2016-07-27 | 李静 | 一种子宫内膜癌特异性检测的试剂盒 |
| CN108884445A (zh) | 2016-03-09 | 2018-11-23 | 北京智康博药肿瘤医学研究有限公司 | 肿瘤细胞悬浮培养物和相关方法 |
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| US20200193140A1 (en) * | 2017-08-24 | 2020-06-18 | Nano Global | Detection of Biological Cells or Biological Substances |
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| JP7109719B2 (ja) | 2018-02-14 | 2022-08-01 | 住友ゴム工業株式会社 | 特定細胞捕捉方法 |
| CN108641956A (zh) * | 2018-06-19 | 2018-10-12 | 张起 | 一种贴壁型细胞培养系统 |
| CN109593720A (zh) * | 2018-11-20 | 2019-04-09 | 叶春玲 | 一种永生化人鳞状乳头型颅咽管瘤细胞株及其应用 |
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| CN109652376B (zh) * | 2019-01-08 | 2021-10-15 | 创芯国际生物科技(广州)有限公司 | 一种用于卵巢癌组织3d培养的培养基 |
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| CN109738309B (zh) * | 2019-01-31 | 2021-07-20 | 河北超威电源有限公司 | 基于数值分析的铅炭动力电池极板检测方法 |
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| CN111751543A (zh) * | 2019-03-27 | 2020-10-09 | 南方医科大学南方医院 | 一种稀有肿瘤细胞富集方法及试剂盒 |
| CN114126717A (zh) * | 2019-04-30 | 2022-03-01 | 艾克斯赛尔生物科学公司 | 用于调整细胞表型的系统和方法 |
| TWI790399B (zh) * | 2019-08-30 | 2023-01-21 | 長庚大學 | 循環腫瘤細胞資訊評估方法及其分析方法 |
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| PL2451964T3 (pl) | 2009-07-10 | 2018-08-31 | Histogen, Inc. | Kompozycje kondycjonowanego podłoża i macierzy zewnątrzkomórkowej z komórek hodowanych w warunkach hipoksji |
| US8501397B2 (en) * | 2009-07-24 | 2013-08-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Enrichment of stem cells from adult tissues |
| US8900860B2 (en) * | 2009-11-30 | 2014-12-02 | National Yang-Ming University | Method for expanding mesenchymal stem cells in low-density and hypoxic culture |
| US20130059783A1 (en) | 2010-03-12 | 2013-03-07 | Johan Flygare | Compositions and methods for expanding bfu-e cells |
| US20130164848A1 (en) | 2010-09-08 | 2013-06-27 | Shimadzu Corporation | Cell culture container and cell culture method using the container |
| DK2638149T3 (da) | 2010-11-12 | 2019-08-12 | Univ Georgetown | Immortalisering af epitelceller og fremgangsmåder til anvendelse |
| US9404986B2 (en) | 2011-05-06 | 2016-08-02 | The Regents Of The University Of California | Measuring biological tissue parameters using diffusion magnetic resonance imaging |
| US20150023911A1 (en) | 2012-02-03 | 2015-01-22 | Technische Universitaet Muenchen-Klimikum Rechts Der Isar | Device-based methods for localized delivery of cell-free carriers with stress-induced cellular factors |
| WO2013163296A1 (en) | 2012-04-24 | 2013-10-31 | The Brigham And Women's Hospital, Inc. | Generating pluripotent cells de novo |
| US9447378B2 (en) | 2012-04-27 | 2016-09-20 | Massachusetts Institute Of Technology | Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes |
| CN103014118B (zh) * | 2013-01-10 | 2014-05-14 | 贵州大学 | 一种用于抗癌药物筛选的细胞共培养方法 |
| CN103387963B (zh) * | 2013-08-12 | 2015-05-20 | 厦门大学附属中山医院 | 一株Ming氏人膨胀型胃癌细胞系及其应用 |
| WO2015056302A1 (ja) | 2013-10-15 | 2015-04-23 | 株式会社日立製作所 | 細胞培養装置 |
| US20150247112A1 (en) | 2014-03-03 | 2015-09-03 | Kiyatec Inc. | 3D Tissue Culture Devices and Systems |
-
2014
- 2014-01-24 CA CA2895791A patent/CA2895791A1/en not_active Abandoned
- 2014-01-24 JP JP2015555362A patent/JP6509745B2/ja not_active Expired - Fee Related
- 2014-01-24 CN CN201480006151.6A patent/CN104956226B/zh active Active
- 2014-01-24 CN CN201711433018.0A patent/CN108165603A/zh not_active Withdrawn
- 2014-01-24 CA CA3106271A patent/CA3106271A1/en not_active Abandoned
- 2014-01-24 US US14/163,456 patent/US9857360B2/en active Active
- 2014-01-24 AU AU2014209218A patent/AU2014209218B2/en active Active
- 2014-01-24 GB GB1419892.3A patent/GB2516196B/en active Active
- 2014-01-24 EP EP14743533.3A patent/EP2948776B8/en active Active
- 2014-01-24 WO PCT/US2014/013048 patent/WO2014117021A2/en not_active Ceased
-
2017
- 2017-11-20 US US15/817,872 patent/US20180267025A1/en not_active Abandoned
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