CA2895791A1 - Methods, compositions, kits, and systems for selective enrichment of target cells - Google Patents
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- CA2895791A1 CA2895791A1 CA2895791A CA2895791A CA2895791A1 CA 2895791 A1 CA2895791 A1 CA 2895791A1 CA 2895791 A CA2895791 A CA 2895791A CA 2895791 A CA2895791 A CA 2895791A CA 2895791 A1 CA2895791 A1 CA 2895791A1
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
Landscapes
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| CN109738309A (zh) * | 2019-01-31 | 2019-05-10 | 河北超威电源有限公司 | 基于数值分析的铅炭动力电池极板检测方法 |
Families Citing this family (43)
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| WO2016081554A1 (en) * | 2014-11-18 | 2016-05-26 | Neostem Oncology, Llc | Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use |
| CN108026500A (zh) | 2015-03-31 | 2018-05-11 | 兴盛生物科技股份有限公司 | 具有一体式细胞操纵系统的细胞培养培殖器 |
| CN107920496B (zh) | 2015-03-31 | 2021-10-15 | 兴盛生物科技股份有限公司 | 自动化细胞培养培殖器 |
| GB2555728A (en) * | 2015-04-17 | 2018-05-09 | Xcell Biosciences Inc | Cancer cell enrichment system |
| CN108367290B (zh) | 2015-10-01 | 2021-06-04 | 伯克利之光生命科技公司 | 井孔板培养器 |
| CA2999054A1 (en) * | 2015-10-20 | 2017-04-27 | Celcuity Llc | Methods of preparing a primary cell sample |
| CN105807054A (zh) * | 2015-11-22 | 2016-07-27 | 李静 | 一种子宫内膜癌特异性检测的试剂盒 |
| CN108884445A (zh) | 2016-03-09 | 2018-11-23 | 北京智康博药肿瘤医学研究有限公司 | 肿瘤细胞悬浮培养物和相关方法 |
| JP6779483B2 (ja) | 2016-09-29 | 2020-11-04 | 住友ゴム工業株式会社 | 医療用検査装置及び細胞検査方法 |
| US10941374B2 (en) | 2016-09-29 | 2021-03-09 | Sumitomo Rubber Industries, Ltd. | Medical analysis device and cell analysis method |
| JP6485783B2 (ja) * | 2016-09-29 | 2019-03-20 | 住友ゴム工業株式会社 | 医療用検査装置及び細胞検査方法 |
| WO2018218485A1 (en) * | 2017-05-31 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Epithelial tumor cell cultures |
| WO2018090375A1 (en) * | 2016-11-21 | 2018-05-24 | Beijing Percans Oncology Co. Ltd. | Epithelial tumor cell cultures |
| WO2018102781A1 (en) * | 2016-12-01 | 2018-06-07 | Berkeley Lights, Inc. | Well-plate incubator |
| IT201700024609A1 (it) * | 2017-03-06 | 2018-09-06 | Mollace Vincenzo | Metodo e kit per la diagnosi e/o prognosi di tumori non ematologici |
| TWI616526B (zh) * | 2017-05-15 | 2018-03-01 | Cell separation and purification device | |
| US20200193140A1 (en) * | 2017-08-24 | 2020-06-18 | Nano Global | Detection of Biological Cells or Biological Substances |
| KR101996218B1 (ko) * | 2017-09-05 | 2019-10-01 | 주식회사 싸이토젠 | Axl 기반 암환자 스크리닝 방법 |
| CA3078625C (en) | 2017-10-09 | 2023-01-17 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
| WO2019090355A1 (en) * | 2017-11-06 | 2019-05-09 | Children's National Medical Center | Cells expressing antibodies and methods of treatment using the same |
| US11618875B2 (en) * | 2017-11-20 | 2023-04-04 | Nano Global Corporation | Data collection and analytics based on detection of biological cells or biological substances |
| CN107858433B (zh) * | 2017-12-15 | 2019-01-25 | 武汉迈特维尔生物科技有限公司 | 一种用于检测精原细胞瘤的试剂盒 |
| WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| JP7109719B2 (ja) | 2018-02-14 | 2022-08-01 | 住友ゴム工業株式会社 | 特定細胞捕捉方法 |
| CN108641956A (zh) * | 2018-06-19 | 2018-10-12 | 张起 | 一种贴壁型细胞培养系统 |
| CN109593720A (zh) * | 2018-11-20 | 2019-04-09 | 叶春玲 | 一种永生化人鳞状乳头型颅咽管瘤细胞株及其应用 |
| US12220465B2 (en) * | 2018-11-28 | 2025-02-11 | Washington University | Compositions and methods for targeted treatment and imaging of cancer or tumors |
| WO2020118282A1 (en) * | 2018-12-07 | 2020-06-11 | The Johns Hopkins University | Methods, compositions and kits for treating multiple sclerosis and other disorders |
| CN109652376B (zh) * | 2019-01-08 | 2021-10-15 | 创芯国际生物科技(广州)有限公司 | 一种用于卵巢癌组织3d培养的培养基 |
| US11614440B2 (en) | 2019-01-24 | 2023-03-28 | Sumitomo Rubber Industries, Ltd. | Specific cell fractionating and capturing methods |
| WO2020159879A2 (en) * | 2019-01-28 | 2020-08-06 | Nano Global Corp. | Amelioration based on detection of biological cells or biological substances |
| CN111487404B (zh) * | 2019-01-28 | 2024-01-05 | 猎源(上海)生物医药科技有限公司 | 体液肿瘤细胞dna提取试剂盒 |
| CA3224729A1 (en) | 2019-03-14 | 2020-09-17 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
| CN111751543A (zh) * | 2019-03-27 | 2020-10-09 | 南方医科大学南方医院 | 一种稀有肿瘤细胞富集方法及试剂盒 |
| CN114126717A (zh) * | 2019-04-30 | 2022-03-01 | 艾克斯赛尔生物科学公司 | 用于调整细胞表型的系统和方法 |
| TWI790399B (zh) * | 2019-08-30 | 2023-01-21 | 長庚大學 | 循環腫瘤細胞資訊評估方法及其分析方法 |
| US20210284969A1 (en) * | 2020-03-12 | 2021-09-16 | eXo Cell, LLC | Methods and systems for transportation and culture of buoyant tissue |
| KR102400263B1 (ko) * | 2020-04-08 | 2022-05-20 | 이엔셀 주식회사 | 줄기세포 초기 수율 촉진을 위한 줄기세포 배양 방법 |
| CN111754457B (zh) * | 2020-05-15 | 2023-08-18 | 中山大学 | 一种基于角膜共聚焦图像的菌丝筛查系统 |
| CN113025712A (zh) * | 2021-02-09 | 2021-06-25 | 中国人民解放军海军军医大学 | 一种检测肿瘤干细胞中遗传和表观遗传变化的方法 |
| CN113981148A (zh) * | 2021-11-18 | 2022-01-28 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 一种鉴别rv感染以及鉴定病毒基因型的方法及其应用 |
| CN117448270B (zh) * | 2023-12-22 | 2024-07-26 | 上海元戊医学技术有限公司 | 一种高效诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4034062A (en) | 1975-03-20 | 1977-07-05 | Borden, Inc. | Removal of oxygen from gas stream with copper catalyst |
| US5330915A (en) | 1991-10-18 | 1994-07-19 | Endotronics, Inc. | Pressure control system for a bioreactor |
| US6322989B1 (en) | 1991-11-25 | 2001-11-27 | Yoreh Biotechnologies, Ltd. | Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit |
| US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| US5882914A (en) * | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
| US20040072722A1 (en) | 2002-10-10 | 2004-04-15 | Kornblith Paul L. | Methods for assessing efficacy of chemotherapeutic agents |
| WO1999021533A2 (en) | 1997-10-24 | 1999-05-06 | Neorx Corporation | Delivery vehicles for bioactive agents and uses thereof |
| US7282350B2 (en) | 1998-02-12 | 2007-10-16 | Immunivest Corporation | Labeled cell sets for use as functional controls in rare cell detection assays |
| EP1062515B1 (en) | 1998-02-12 | 2009-11-25 | Immunivest Corporation | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
| ATE227338T1 (de) | 1998-03-18 | 2002-11-15 | Massachusetts Inst Technology | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
| US6184035B1 (en) | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
| US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US8131053B2 (en) | 1999-01-25 | 2012-03-06 | Amnis Corporation | Detection of circulating tumor cells using imaging flow cytometry |
| US6656683B1 (en) | 2000-07-05 | 2003-12-02 | Board Of Regents, The University Of Texas System | Laser scanning cytology with digital image capture |
| DE60142691D1 (de) | 2000-09-09 | 2010-09-09 | Univ New York State Res Found | Verfahren und zusammensetzungen zur isolierung von metastatischen krebszellen und anwendung zur messung des metastatischen potentials eines krebses |
| US20040151705A1 (en) | 2002-03-22 | 2004-08-05 | Shuichi Mizuno | Neo-cartilage constructs and a method for preparation thereof |
| US7863012B2 (en) | 2004-02-17 | 2011-01-04 | Veridex, Llc | Analysis of circulating tumor cells, fragments, and debris |
| US20030092178A1 (en) | 2001-11-15 | 2003-05-15 | Biospherix, Ltd. | Cell culture incubator with dynamic oxygen control |
| US20050244843A1 (en) | 2001-11-16 | 2005-11-03 | Wen-Tien Chen | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
| US7435587B2 (en) * | 2002-03-01 | 2008-10-14 | Memorial Sloan-Kettering Cancer Center | Apparatus for growing cells under variable hydrostatic pressures |
| WO2003076942A2 (fr) | 2002-03-13 | 2003-09-18 | Biomerieux | Quantification de cellules tumorales circulantes issues de cancers solides |
| JP2004180675A (ja) | 2002-11-19 | 2004-07-02 | Sanyo Electric Co Ltd | インキュベータ |
| US7367550B2 (en) | 2003-11-18 | 2008-05-06 | Massachusetts Institute Of Technology | Peristaltic mixing and oxygenation system |
| ATE527369T1 (de) | 2003-12-23 | 2011-10-15 | Monsanto Technology Llc | Verwendung einer sauerstoffarmen umgebung bei der transformation von pflanzen |
| GB0403611D0 (en) | 2004-02-18 | 2004-03-24 | Univ Glasgow | Analysis of cell morphology and motility |
| JP2007537759A (ja) | 2004-05-19 | 2007-12-27 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 灌流三次元細胞/組織疾患モデル |
| US7629128B2 (en) | 2004-08-30 | 2009-12-08 | Prolx Pharmaceuticals Corp. | Methods of identifying respondents to hypoxia inducible factor 1-α inhibitors |
| US20060094109A1 (en) | 2004-11-02 | 2006-05-04 | Immunivest Corporation | Device and method for analytical cell imaging |
| JP4913727B2 (ja) | 2005-03-18 | 2012-04-11 | 株式会社日本触媒 | 酸素除去触媒および当該触媒を用いた酸素除去方法 |
| US7476541B1 (en) | 2005-03-29 | 2009-01-13 | Timothy F. Dutra | Bioreactor system and method for the production and collection of blood cells from engineered bone marrow tissue |
| US20070026417A1 (en) | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| KR101617319B1 (ko) * | 2005-04-12 | 2016-05-02 | 메소블라스트, 아이엔씨. | 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리 |
| JP4744187B2 (ja) * | 2005-05-10 | 2011-08-10 | オリンパス株式会社 | 細胞観察装置 |
| US8709793B2 (en) | 2005-07-20 | 2014-04-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bioreactor device, and method and system for fabricating tissues in the bioreactor device |
| ES2420834T3 (es) | 2006-01-30 | 2013-08-27 | The Scripps Research Institute | Métodos de detección de células tumorales circulantes y métodos de diagnóstico del cáncer en un sujeto mamífero |
| ES2614510T3 (es) | 2006-02-07 | 2017-05-31 | Spinalcyte, Llc | Método y composiciones para la reparación del cartílago usando un biorreactor in vivo |
| EP2007874A4 (en) | 2006-03-13 | 2009-06-10 | Veridex Llc | PROPAGATION OF PRIMARY CELLS |
| WO2007139551A1 (en) | 2006-05-30 | 2007-12-06 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells from adipose tissue |
| EP2027470B1 (en) | 2006-06-02 | 2012-11-21 | Pfizer Products Inc. | Circulating tumor cell assay |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US7819934B2 (en) | 2006-07-14 | 2010-10-26 | Xcellerex, Inc. | Environmental containment systems |
| US7735670B2 (en) | 2006-10-17 | 2010-06-15 | Honeywell International Inc. | Oxygen removal system |
| EP2136630A4 (en) * | 2007-03-23 | 2010-06-02 | Precision Therapeutics Inc | METHODS FOR ASSESSING ANGIOGENIC POTENTIAL IN CULTURE |
| CN105861443A (zh) | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| WO2008131048A2 (en) | 2007-04-16 | 2008-10-30 | Cellpoint Diagnotics, Inc. | Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells |
| US9029147B2 (en) | 2007-06-15 | 2015-05-12 | Massachusetts Institute Of Technology | Methods and compositions for enhanced differentiation from embryonic stem cells |
| GB0713121D0 (en) | 2007-07-06 | 2007-08-15 | Univ Keele | Refrigerated gas equilibration device |
| WO2009052393A1 (en) | 2007-10-18 | 2009-04-23 | Curators Of The University Of Missouri | A device for transfecting cells using shock waves generated by the ignition of nanoenergetic materials |
| US8071395B2 (en) | 2007-12-12 | 2011-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and apparatus for magnetic separation of cells |
| US20090186006A1 (en) * | 2008-01-16 | 2009-07-23 | Murphy Michael P | Placental vascular lobule stem cells |
| EP2307539B1 (en) | 2008-07-30 | 2014-11-19 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| WO2010028160A1 (en) | 2008-09-05 | 2010-03-11 | The Scripps Research Institute | Methods for the detection of circulating tumor cells |
| JP5974233B2 (ja) | 2008-11-12 | 2016-08-24 | リージェンメド(ケイマン)エルティーディー. | 単離した腎細胞およびその使用 |
| WO2010057013A1 (en) | 2008-11-14 | 2010-05-20 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| KR101109125B1 (ko) * | 2009-03-24 | 2012-02-15 | 한국과학기술연구원 | 줄기세포를 혈관세포로 분화시키는 방법 및 이를 이용한 생체 내 혈관신생 유도 |
| US20120100538A1 (en) | 2009-03-24 | 2012-04-26 | Biocept, Inc. | Devices and methods of cell capture and analysis |
| WO2010115187A1 (en) | 2009-04-03 | 2010-10-07 | Duke University | Methods of making cell sheets, tissue sheets and tissue engineered blood vessels |
| WO2010135603A2 (en) | 2009-05-20 | 2010-11-25 | California Institute Of Technology | Method for cancer detection, diagnosis and prognosis |
| PL2451964T3 (pl) | 2009-07-10 | 2018-08-31 | Histogen, Inc. | Kompozycje kondycjonowanego podłoża i macierzy zewnątrzkomórkowej z komórek hodowanych w warunkach hipoksji |
| US8501397B2 (en) * | 2009-07-24 | 2013-08-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Enrichment of stem cells from adult tissues |
| US8900860B2 (en) * | 2009-11-30 | 2014-12-02 | National Yang-Ming University | Method for expanding mesenchymal stem cells in low-density and hypoxic culture |
| US20130059783A1 (en) | 2010-03-12 | 2013-03-07 | Johan Flygare | Compositions and methods for expanding bfu-e cells |
| US20130164848A1 (en) | 2010-09-08 | 2013-06-27 | Shimadzu Corporation | Cell culture container and cell culture method using the container |
| DK2638149T3 (da) | 2010-11-12 | 2019-08-12 | Univ Georgetown | Immortalisering af epitelceller og fremgangsmåder til anvendelse |
| US9404986B2 (en) | 2011-05-06 | 2016-08-02 | The Regents Of The University Of California | Measuring biological tissue parameters using diffusion magnetic resonance imaging |
| US20150023911A1 (en) | 2012-02-03 | 2015-01-22 | Technische Universitaet Muenchen-Klimikum Rechts Der Isar | Device-based methods for localized delivery of cell-free carriers with stress-induced cellular factors |
| WO2013163296A1 (en) | 2012-04-24 | 2013-10-31 | The Brigham And Women's Hospital, Inc. | Generating pluripotent cells de novo |
| US9447378B2 (en) | 2012-04-27 | 2016-09-20 | Massachusetts Institute Of Technology | Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes |
| CN103014118B (zh) * | 2013-01-10 | 2014-05-14 | 贵州大学 | 一种用于抗癌药物筛选的细胞共培养方法 |
| CN103387963B (zh) * | 2013-08-12 | 2015-05-20 | 厦门大学附属中山医院 | 一株Ming氏人膨胀型胃癌细胞系及其应用 |
| WO2015056302A1 (ja) | 2013-10-15 | 2015-04-23 | 株式会社日立製作所 | 細胞培養装置 |
| US20150247112A1 (en) | 2014-03-03 | 2015-09-03 | Kiyatec Inc. | 3D Tissue Culture Devices and Systems |
-
2014
- 2014-01-24 CA CA2895791A patent/CA2895791A1/en not_active Abandoned
- 2014-01-24 JP JP2015555362A patent/JP6509745B2/ja not_active Expired - Fee Related
- 2014-01-24 CN CN201480006151.6A patent/CN104956226B/zh active Active
- 2014-01-24 CN CN201711433018.0A patent/CN108165603A/zh not_active Withdrawn
- 2014-01-24 CA CA3106271A patent/CA3106271A1/en not_active Abandoned
- 2014-01-24 US US14/163,456 patent/US9857360B2/en active Active
- 2014-01-24 AU AU2014209218A patent/AU2014209218B2/en active Active
- 2014-01-24 GB GB1419892.3A patent/GB2516196B/en active Active
- 2014-01-24 EP EP14743533.3A patent/EP2948776B8/en active Active
- 2014-01-24 WO PCT/US2014/013048 patent/WO2014117021A2/en not_active Ceased
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2017
- 2017-11-20 US US15/817,872 patent/US20180267025A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109738309A (zh) * | 2019-01-31 | 2019-05-10 | 河北超威电源有限公司 | 基于数值分析的铅炭动力电池极板检测方法 |
| CN109738309B (zh) * | 2019-01-31 | 2021-07-20 | 河北超威电源有限公司 | 基于数值分析的铅炭动力电池极板检测方法 |
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| GB2516196A (en) | 2015-01-14 |
| WO2014117021A3 (en) | 2014-10-09 |
| GB2516196A8 (en) | 2015-02-18 |
| AU2014209218A1 (en) | 2015-07-02 |
| EP2948776B1 (en) | 2019-12-04 |
| US20140212895A1 (en) | 2014-07-31 |
| AU2014209218B2 (en) | 2018-06-07 |
| GB201419892D0 (en) | 2014-12-24 |
| CN104956226A (zh) | 2015-09-30 |
| JP6509745B2 (ja) | 2019-05-08 |
| WO2014117021A2 (en) | 2014-07-31 |
| CA3106271A1 (en) | 2014-07-31 |
| GB2516196B (en) | 2015-09-09 |
| JP2016514950A (ja) | 2016-05-26 |
| EP2948776B8 (en) | 2020-02-26 |
| CN104956226B (zh) | 2018-02-02 |
| EP2948776A2 (en) | 2015-12-02 |
| CN108165603A (zh) | 2018-06-15 |
| EP2948776A4 (en) | 2016-08-24 |
| US9857360B2 (en) | 2018-01-02 |
| US20180267025A1 (en) | 2018-09-20 |
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