JP2016513657A5 - - Google Patents
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- JP2016513657A5 JP2016513657A5 JP2016502177A JP2016502177A JP2016513657A5 JP 2016513657 A5 JP2016513657 A5 JP 2016513657A5 JP 2016502177 A JP2016502177 A JP 2016502177A JP 2016502177 A JP2016502177 A JP 2016502177A JP 2016513657 A5 JP2016513657 A5 JP 2016513657A5
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- JP
- Japan
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- composition
- composition according
- bladder cancer
- bladder
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 34
- 206010005003 Bladder cancer Diseases 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 20
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 19
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 19
- 239000002105 nanoparticle Substances 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 10
- 229940124597 therapeutic agent Drugs 0.000 claims description 10
- 102000006311 Cyclin D1 Human genes 0.000 claims description 5
- 108010058546 Cyclin D1 Proteins 0.000 claims description 5
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 5
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims description 5
- 102000005465 Stathmin Human genes 0.000 claims description 5
- 108050003387 Stathmin Proteins 0.000 claims description 5
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims description 5
- 102000018252 Tumor Protein p73 Human genes 0.000 claims description 5
- 108010091356 Tumor Protein p73 Proteins 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims description 2
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 229930192392 Mitomycin Natural products 0.000 claims description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 2
- 229930012538 Paclitaxel Natural products 0.000 claims description 2
- 229940123237 Taxane Drugs 0.000 claims description 2
- 229940100198 alkylating agent Drugs 0.000 claims description 2
- 239000002168 alkylating agent Substances 0.000 claims description 2
- 239000003817 anthracycline antibiotic agent Substances 0.000 claims description 2
- 230000000340 anti-metabolite Effects 0.000 claims description 2
- 229940100197 antimetabolite Drugs 0.000 claims description 2
- 239000002256 antimetabolite Substances 0.000 claims description 2
- -1 apadicon Chemical compound 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
- 229960004316 cisplatin Drugs 0.000 claims description 2
- 229960003668 docetaxel Drugs 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- 229960001904 epirubicin Drugs 0.000 claims description 2
- 229960005277 gemcitabine Drugs 0.000 claims description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
- 239000002955 immunomodulating agent Substances 0.000 claims description 2
- 229940079322 interferon Drugs 0.000 claims description 2
- 229960004857 mitomycin Drugs 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 229960001592 paclitaxel Drugs 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 2
- 229960002930 sirolimus Drugs 0.000 claims description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 2
- 206010044412 transitional cell carcinoma Diseases 0.000 claims description 2
- 229960000653 valrubicin Drugs 0.000 claims description 2
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 claims description 2
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 27
- 206010027476 Metastases Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 208000029162 bladder disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- IGGVVGHJSQSLFO-UHFFFAOYSA-N indole-5,6-quinone Chemical compound O=C1C(=O)C=C2C=CNC2=C1 IGGVVGHJSQSLFO-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000026533 urinary bladder disease Diseases 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786167P | 2013-03-14 | 2013-03-14 | |
| US201361786175P | 2013-03-14 | 2013-03-14 | |
| US61/786,175 | 2013-03-14 | ||
| US61/786,167 | 2013-03-14 | ||
| PCT/US2014/026564 WO2014151853A1 (en) | 2013-03-14 | 2014-03-13 | Methods of treating bladder cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018010608A Division JP2018062531A (ja) | 2013-03-14 | 2018-01-25 | 膀胱がんを処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513657A JP2016513657A (ja) | 2016-05-16 |
| JP2016513657A5 true JP2016513657A5 (cg-RX-API-DMAC7.html) | 2017-04-06 |
| JP6309610B2 JP6309610B2 (ja) | 2018-04-11 |
Family
ID=51581053
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502177A Active JP6309610B2 (ja) | 2013-03-14 | 2014-03-13 | 膀胱がんを処置する方法 |
| JP2018010608A Pending JP2018062531A (ja) | 2013-03-14 | 2018-01-25 | 膀胱がんを処置する方法 |
| JP2020001289A Pending JP2020050680A (ja) | 2013-03-14 | 2020-01-08 | 膀胱がんを処置する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018010608A Pending JP2018062531A (ja) | 2013-03-14 | 2018-01-25 | 膀胱がんを処置する方法 |
| JP2020001289A Pending JP2020050680A (ja) | 2013-03-14 | 2020-01-08 | 膀胱がんを処置する方法 |
Country Status (17)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| LT2117520T (lt) | 2006-12-14 | 2018-12-10 | Abraxis Bioscience, Llc | Krūties vėžio terapija hormonų receptoriaus statuso pagrindu su nanodalelėmis, apimančiomis taksaną |
| MX380318B (es) * | 2007-03-07 | 2025-03-12 | Abraxis Bioscience Llc | Nanoparticula que comprende rapamicina y albumina como agente anticancer. |
| KR20120044279A (ko) | 2009-04-15 | 2012-05-07 | 아브락시스 바이오사이언스, 엘엘씨 | 무-프리온 나노입자 조성물 및 방법 |
| RU2016119999A (ru) | 2010-03-29 | 2018-11-08 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Способы лечения онкологических заболеваний |
| CN105147613A (zh) | 2010-03-29 | 2015-12-16 | 阿布拉科斯生物科学有限公司 | 增强药物递送和治疗剂有效性的方法 |
| EP2575804A4 (en) | 2010-06-04 | 2013-10-23 | Abraxis Bioscience Llc | METHOD FOR THE TREATMENT OF PANCREASCRE |
| WO2012149451A1 (en) | 2011-04-28 | 2012-11-01 | Abraxis Bioscience, Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
| RU2705998C2 (ru) | 2011-12-14 | 2019-11-13 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Применение полимерных эксципиентов для лиофилизации или заморозки частиц |
| US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
| US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| ES2804323T3 (es) | 2013-03-12 | 2021-02-05 | Abraxis Bioscience Llc | Procedimientos de tratamiento de cáncer de pulmón |
| CN105246468A (zh) | 2013-03-14 | 2016-01-13 | 阿布拉科斯生物科学有限公司 | 治疗膀胱癌的方法 |
| RU2672875C1 (ru) * | 2014-12-17 | 2018-11-20 | Пфайзер Инк. | Композиции PI3K/MTOR-ингибитора для внутривенного введения |
| HK1244847A1 (zh) * | 2014-12-24 | 2018-08-17 | 豪夫迈．罗氏有限公司 | 用於膀胱癌症的治疗，诊断和预後方法 |
| US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
| US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
| WO2016169042A1 (en) * | 2015-04-24 | 2016-10-27 | Genedia Biotech Co. Ltd. | Combination therapies for bladder cancer |
| AU2016285720C1 (en) | 2015-06-29 | 2022-02-03 | Abraxis Bioscience, Llc | Methods of treating epithelioid cell tumors |
| EA201890159A1 (ru) * | 2015-06-29 | 2018-11-30 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | СПОСОБЫ ЛЕЧЕНИЯ ГЕМАТОЛОГИЧЕСКОГО ЗЛОКАЧЕСТВЕННОГО НОВООБРАЗОВАНИЯ С ПОМОЩЬЮ КОМБИНИРОВАННОЙ ТЕРАПИИ ИНГИБИТОРОМ mTOR В ВИДЕ НАНОЧАСТИЦ |
| MX2017016519A (es) * | 2015-06-29 | 2018-08-16 | Abraxis Bioscience Llc | Biomarcadores para composiciones de nanoparticulas. |
| NZ738929A (en) * | 2015-06-29 | 2024-01-26 | Abraxis Bioscience Llc | Methods of treating solid tumors using nanoparticle mtor inhibitor combination therapy |
| WO2018064405A1 (en) * | 2016-09-28 | 2018-04-05 | Abraxis Bioscience, Llc | Methods of treating mitochondrial and metabolic disorders |
| SG11202009145PA (en) | 2018-03-20 | 2020-10-29 | Abraxis Bioscience Llc | Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin |
| US20220107320A1 (en) | 2019-02-15 | 2022-04-07 | Incelldx, Inc. | Assaying Bladder-Associated Samples, Identifying and Treating Bladder-Associated Neoplasia, and Kits for Use Therein |
| US20220054404A1 (en) * | 2019-03-19 | 2022-02-24 | Abraxis Bioscience, Llc | Subcutaneous administration of nanoparticles comprising an mtor inhibitor and albumin for treatment of diseases |
| WO2021086946A1 (en) | 2019-10-28 | 2021-05-06 | Abraxis Bioscience, Llc | Pharmaceutical compositions of albumin and rapamycin |
| WO2021096997A1 (en) * | 2019-11-11 | 2021-05-20 | Abraxis Bioscience, Llc | Biomarkers for nanoparticle compositions |
| WO2021258042A1 (en) * | 2020-06-19 | 2021-12-23 | Yale University | Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance |
| WO2022006596A1 (en) * | 2020-06-30 | 2022-01-06 | Northwestern University | A single patient classifier for t1 high grade bladder cancer |
| WO2024081674A1 (en) | 2022-10-11 | 2024-04-18 | Aadi Bioscience, Inc. | Combination therapies for the treatment of cancer |
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| CA2620389C (en) | 2005-08-31 | 2014-06-17 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
| PL3311805T3 (pl) | 2005-08-31 | 2020-07-27 | Abraxis Bioscience, Llc | Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe |
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| MX380318B (es) | 2007-03-07 | 2025-03-12 | Abraxis Bioscience Llc | Nanoparticula que comprende rapamicina y albumina como agente anticancer. |
| AU2013204187B2 (en) | 2007-03-07 | 2015-10-01 | Abraxis Bioscience, Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
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