JP2016512545A5 - - Google Patents
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- JP2016512545A5 JP2016512545A5 JP2016501663A JP2016501663A JP2016512545A5 JP 2016512545 A5 JP2016512545 A5 JP 2016512545A5 JP 2016501663 A JP2016501663 A JP 2016501663A JP 2016501663 A JP2016501663 A JP 2016501663A JP 2016512545 A5 JP2016512545 A5 JP 2016512545A5
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- 239000000203 mixture Substances 0.000 claims description 215
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 40
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 36
- 235000000346 sugar Nutrition 0.000 claims description 28
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 20
- 235000011187 glycerol Nutrition 0.000 claims description 20
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 20
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 20
- 229940068977 polysorbate 20 Drugs 0.000 claims description 20
- 239000005711 Benzoic acid Substances 0.000 claims description 18
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 18
- 235000010233 benzoic acid Nutrition 0.000 claims description 18
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 18
- 239000000811 xylitol Substances 0.000 claims description 18
- 235000010447 xylitol Nutrition 0.000 claims description 18
- 229960002675 xylitol Drugs 0.000 claims description 18
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 18
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 16
- 239000000600 sorbitol Substances 0.000 claims description 16
- 235000010356 sorbitol Nutrition 0.000 claims description 16
- 150000008163 sugars Chemical class 0.000 claims description 16
- 239000003755 preservative agent Substances 0.000 claims description 15
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 12
- 235000019477 peppermint oil Nutrition 0.000 claims description 12
- 239000000796 flavoring agent Substances 0.000 claims description 11
- 235000013355 food flavoring agent Nutrition 0.000 claims description 11
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 239000002562 thickening agent Substances 0.000 claims description 10
- 208000002925 dental caries Diseases 0.000 claims description 9
- 208000025157 Oral disease Diseases 0.000 claims description 8
- 208000030194 mouth disease Diseases 0.000 claims description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 8
- 210000004195 gingiva Anatomy 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- 206010006326 Breath odour Diseases 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 208000032139 Halitosis Diseases 0.000 claims description 6
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 229920000136 polysorbate Polymers 0.000 claims description 6
- 229950008882 polysorbate Drugs 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 206010013781 dry mouth Diseases 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 4
- 208000005946 Xerostomia Diseases 0.000 claims description 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims description 4
- 238000001804 debridement Methods 0.000 claims description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 4
- 208000007565 gingivitis Diseases 0.000 claims description 4
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 229940060184 oil ingredients Drugs 0.000 claims description 4
- 201000001245 periodontitis Diseases 0.000 claims description 4
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 claims description 4
- 230000003449 preventive effect Effects 0.000 claims description 4
- 239000011775 sodium fluoride Substances 0.000 claims description 4
- 235000013024 sodium fluoride Nutrition 0.000 claims description 4
- 239000002344 surface layer Substances 0.000 claims description 4
- 230000008961 swelling Effects 0.000 claims description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 4
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical group COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 235000012054 meals Nutrition 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 2
- KFZXVMNBUMVKLN-UHFFFAOYSA-N 4-chloro-5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1O KFZXVMNBUMVKLN-UHFFFAOYSA-N 0.000 claims description 2
- 235000007173 Abies balsamea Nutrition 0.000 claims description 2
- 239000004857 Balsam Substances 0.000 claims description 2
- 235000002566 Capsicum Nutrition 0.000 claims description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
- 241000723346 Cinnamomum camphora Species 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 2
- 239000005770 Eugenol Substances 0.000 claims description 2
- 239000001293 FEMA 3089 Substances 0.000 claims description 2
- 241000628997 Flos Species 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- 108010068370 Glutens Proteins 0.000 claims description 2
- 244000018716 Impatiens biflora Species 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 239000006002 Pepper Substances 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 2
- 235000011613 Pinus brutia Nutrition 0.000 claims description 2
- 241000018646 Pinus brutia Species 0.000 claims description 2
- 235000016761 Piper aduncum Nutrition 0.000 claims description 2
- 240000003889 Piper guineense Species 0.000 claims description 2
- 235000017804 Piper guineense Nutrition 0.000 claims description 2
- 235000008184 Piper nigrum Nutrition 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 2
- 241000277331 Salmonidae Species 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 241000194019 Streptococcus mutans Species 0.000 claims description 2
- 241000194023 Streptococcus sanguinis Species 0.000 claims description 2
- 239000005844 Thymol Substances 0.000 claims description 2
- 241000589892 Treponema denticola Species 0.000 claims description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 229940011037 anethole Drugs 0.000 claims description 2
- 239000010617 anise oil Substances 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 2
- 239000007961 artificial flavoring substance Substances 0.000 claims description 2
- 239000008122 artificial sweetener Substances 0.000 claims description 2
- 235000021311 artificial sweeteners Nutrition 0.000 claims description 2
- 239000010620 bay oil Substances 0.000 claims description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 229960000846 camphor Drugs 0.000 claims description 2
- 229930008380 camphor Natural products 0.000 claims description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 2
- 229960003260 chlorhexidine Drugs 0.000 claims description 2
- 229940031956 chlorothymol Drugs 0.000 claims description 2
- 229960005233 cineole Drugs 0.000 claims description 2
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 2
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000010630 cinnamon oil Substances 0.000 claims description 2
- 239000010632 citronella oil Substances 0.000 claims description 2
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 239000010634 clove oil Substances 0.000 claims description 2
- 239000011280 coal tar Substances 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 230000003628 erosive effect Effects 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 239000010642 eucalyptus oil Substances 0.000 claims description 2
- 229940044949 eucalyptus oil Drugs 0.000 claims description 2
- 229960002217 eugenol Drugs 0.000 claims description 2
- 150000004673 fluoride salts Chemical group 0.000 claims description 2
- 229960002442 glucosamine Drugs 0.000 claims description 2
- 235000021312 gluten Nutrition 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229940107702 grapefruit seed extract Drugs 0.000 claims description 2
- 229960001867 guaiacol Drugs 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 229960002163 hydrogen peroxide Drugs 0.000 claims description 2
- 230000007803 itching Effects 0.000 claims description 2
- -1 kuentou Natural products 0.000 claims description 2
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229960001855 mannitol Drugs 0.000 claims description 2
- 239000001683 mentha spicata herb oil Substances 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical group CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 2
- 229960000282 metronidazole Drugs 0.000 claims description 2
- 210000002200 mouth mucosa Anatomy 0.000 claims description 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims description 2
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 claims description 2
- 230000001717 pathogenic effect Effects 0.000 claims description 2
- 150000002978 peroxides Chemical class 0.000 claims description 2
- 229960000969 phenyl salicylate Drugs 0.000 claims description 2
- 125000005498 phthalate group Chemical class 0.000 claims description 2
- 239000010665 pine oil Substances 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 239000010668 rosemary oil Substances 0.000 claims description 2
- 229940058206 rosemary oil Drugs 0.000 claims description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- 229940081974 saccharin Drugs 0.000 claims description 2
- 235000019204 saccharin Nutrition 0.000 claims description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 239000010672 sassafras oil Substances 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 235000019721 spearmint oil Nutrition 0.000 claims description 2
- 229940087124 spike lavender oil Drugs 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 claims description 2
- 239000010678 thyme oil Substances 0.000 claims description 2
- 229960000790 thymol Drugs 0.000 claims description 2
- 208000004371 toothache Diseases 0.000 claims description 2
- 229960003500 triclosan Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000009637 wintergreen oil Substances 0.000 claims description 2
- 206010067721 Oropharyngeal plaque Diseases 0.000 claims 1
- 241000605894 Porphyromonas Species 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940064004 antiseptic throat preparations Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 238000000034 method Methods 0.000 description 30
- 0 CC(C(C(C1O)N*)OC(CO)C1O)OC(C(CO)OC(C(C)OC(C(CO)OC(C1N*)O)C1O)C1N*)C1O Chemical compound CC(C(C(C1O)N*)OC(CO)C1O)OC(C(CO)OC(C(C)OC(C(CO)OC(C1N*)O)C1O)C1N*)C1O 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 208000025371 Taste disease Diseases 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- OIRWWHMHVIJKAB-ZETCQYMHSA-N CC(C)C([C@H](CCCNC(N)=N)N)=O Chemical compound CC(C)C([C@H](CCCNC(N)=N)N)=O OIRWWHMHVIJKAB-ZETCQYMHSA-N 0.000 description 1
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- 206010049047 Chapped lips Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
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- 206010015150 Erythema Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 206010031009 Oral pain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241001148134 Veillonella Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
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- 230000037444 atrophy Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 208000015181 infectious disease Diseases 0.000 description 1
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- 235000019656 metallic taste Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
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- 230000000306 recurrent effect Effects 0.000 description 1
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- 235000019613 sensory perceptions of taste Nutrition 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361778077P | 2013-03-12 | 2013-03-12 | |
| US61/778,077 | 2013-03-12 | ||
| PCT/US2014/024864 WO2014165226A2 (en) | 2013-03-12 | 2014-03-12 | Oral formulation of polyglucosamine derivatives in combination with a non-fermentable sugar |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104482A Division JP2019137702A (ja) | 2013-03-12 | 2019-06-04 | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512545A JP2016512545A (ja) | 2016-04-28 |
| JP2016512545A5 true JP2016512545A5 (https=) | 2017-04-13 |
| JP6842916B2 JP6842916B2 (ja) | 2021-03-17 |
Family
ID=51659323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501663A Active JP6842916B2 (ja) | 2013-03-12 | 2014-03-12 | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
| JP2019104482A Pending JP2019137702A (ja) | 2013-03-12 | 2019-06-04 | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104482A Pending JP2019137702A (ja) | 2013-03-12 | 2019-06-04 | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20160022564A1 (https=) |
| EP (1) | EP2968080B1 (https=) |
| JP (2) | JP6842916B2 (https=) |
| AU (2) | AU2014248562B2 (https=) |
| CA (1) | CA2905404C (https=) |
| WO (1) | WO2014165226A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3144324A1 (en) | 2006-06-02 | 2017-03-22 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| CA3004707C (en) | 2009-09-02 | 2022-05-31 | Synedgen Inc. | Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds |
| EP2555760B1 (en) | 2010-04-06 | 2019-10-16 | Synedgen, Inc. | Chitosan derivatives for the treatment of mucositis or ulceration |
| WO2014047506A1 (en) | 2012-09-20 | 2014-03-27 | Synedgen, Inc. | Methods for treatment or prevention of damage resulting from radiation, trauma or shock |
| JP6842916B2 (ja) | 2013-03-12 | 2021-03-17 | シネジェン， インコーポレイテッド | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
| CA2960998A1 (en) | 2014-09-11 | 2016-03-17 | Synedgen, Inc. | Compositions and methods of use thereof |
| ITUB20155193A1 (it) * | 2015-11-03 | 2017-05-03 | Italfarmaco Spa | Sospensioni orali di Givinostat fisicamente e chimicamente stabili |
| GB201701404D0 (en) | 2017-01-27 | 2017-03-15 | Micropharm Ltd | Therapies for treating inflammatory disorders |
| CN107334782A (zh) * | 2017-07-26 | 2017-11-10 | 吉林省始祖生物波医学研究院有限公司 | 一种抑菌消炎剂及其制备方法和应用 |
| CN111511362A (zh) | 2017-12-20 | 2020-08-07 | 3M创新有限公司 | 口腔组合物及使用方法 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| GB201812261D0 (en) * | 2018-07-27 | 2018-09-12 | Micropharm Ltd | Therapies for treating oral mucositis |
| US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
| WO2021221656A1 (en) | 2020-04-30 | 2021-11-04 | Synedgen, Inc. | Compositions and methods of use thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4229430A (en) | 1978-08-21 | 1980-10-21 | Fahim Mostafa S | Oral composition for improving oral health |
| US4512968A (en) * | 1982-11-30 | 1985-04-23 | Lion Corporation | Oral compositions |
| US4839156A (en) * | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
| NL9301837A (nl) * | 1993-10-22 | 1995-05-16 | Sara Lee De Nv | Mondverzorgingsmiddel. |
| US5541165A (en) * | 1994-09-27 | 1996-07-30 | Turgeon; Jean A. | Saliva substitute |
| JP2004517038A (ja) | 2000-06-30 | 2004-06-10 | ザ、プロクター、エンド、ギャンブル、カンパニー | 全身の健康増進 |
| US6723305B2 (en) | 2002-03-04 | 2004-04-20 | Colgate Palmolive Company | Anti-microbial breath freshening mouthrinse |
| BR0315194A (pt) * | 2002-10-31 | 2005-08-23 | Umd Inc | Composições terapêuticas para liberação de droga para a, e através da, cobertura epitelial |
| US20040103821A1 (en) * | 2002-11-29 | 2004-06-03 | Freund Industrial Co., Ltd. | Aqueous shellac coating agent and production process therefor, and coated food and production process therefor, coated drug and production process therefor, glazing composition for oil-based confectionary, glazing process, and glazed oil-based confectionary using same |
| US20050084551A1 (en) | 2003-09-26 | 2005-04-21 | Jensen Claude J. | Morinda citrifolia-based oral care compositions and methods |
| US20080024794A1 (en) | 2004-06-04 | 2008-01-31 | Yoko Miyazaki | Semiconductor Surface Inspection Apparatus and Method of Illumination |
| WO2006005211A1 (de) | 2004-07-12 | 2006-01-19 | Gaba International Ag | Mundpflegemittel enthaltend chitosanderivat |
| US8858920B2 (en) | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| JP2007314505A (ja) | 2006-04-28 | 2007-12-06 | Nagasaki Univ | 機能性チューインガム |
| EP3144324A1 (en) | 2006-06-02 | 2017-03-22 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| US20080248508A1 (en) | 2006-08-17 | 2008-10-09 | Shenda Baker | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials |
| WO2008063503A2 (en) | 2006-11-13 | 2008-05-29 | Hawaii Chitopure, Inc. | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials. |
| EP1955710A1 (en) * | 2007-02-09 | 2008-08-13 | The Jordanian Pharmaceutical Manufacturing Co. | Aqueous composition comprising chitosan and an acidic drug |
| WO2010021930A1 (en) * | 2008-08-16 | 2010-02-25 | Synedgen, Inc. | Prevention and treatment of mrsa infections with chitosan-derivatives |
| US8916542B2 (en) * | 2008-11-12 | 2014-12-23 | Synedgen, Inc. | Chitosan derivatives, compositions and related methods of use |
| EP2364153B1 (en) | 2008-11-12 | 2015-05-06 | Synedgen, Inc. | Chitosan derivatives to optimize animal weight gain |
| WO2010081204A2 (en) * | 2009-01-14 | 2010-07-22 | Katholieke Universiteit Leuven | Activators of the autophagic pathway |
| EP2391387A1 (en) | 2009-01-29 | 2011-12-07 | Synedgen, Inc. | Nucleic acid delivery using modified chitosans |
| FR2941846B1 (fr) * | 2009-02-10 | 2012-05-11 | Dominique Valeri | Adjuvant alimentaire comme agent reducteur de pouvoir cariogene de produits sucres |
| JP2013503897A (ja) * | 2009-09-02 | 2013-02-04 | シネジェン， インコーポレイテッド | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| CA3004707C (en) | 2009-09-02 | 2022-05-31 | Synedgen Inc. | Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds |
| EP2555760B1 (en) | 2010-04-06 | 2019-10-16 | Synedgen, Inc. | Chitosan derivatives for the treatment of mucositis or ulceration |
| CN102085371B (zh) | 2011-01-28 | 2013-03-13 | 武汉耦合医学科技有限责任公司 | 一种口腔干燥症含漱液医疗用品及其制备方法 |
| AU2012279209A1 (en) | 2011-07-01 | 2014-01-23 | Synedgen, Inc. | Methods and compositions of reducing and preventing bacterial growth and the formation of biofilm on a surface utilizing chitosan-derivative compounds |
| WO2013134129A2 (en) | 2012-03-05 | 2013-09-12 | Synedgen, Inc. | Derivatized polyglucosamines for delivery of small molecules, peptides, and proteins |
| WO2014047506A1 (en) | 2012-09-20 | 2014-03-27 | Synedgen, Inc. | Methods for treatment or prevention of damage resulting from radiation, trauma or shock |
| JP6842916B2 (ja) | 2013-03-12 | 2021-03-17 | シネジェン， インコーポレイテッド | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
| WO2014172040A1 (en) | 2013-03-15 | 2014-10-23 | Synedgen Inc. | Compositions and methods of use for wound healing |
-
2014
- 2014-03-12 JP JP2016501663A patent/JP6842916B2/ja active Active
- 2014-03-12 WO PCT/US2014/024864 patent/WO2014165226A2/en not_active Ceased
- 2014-03-12 EP EP14779111.5A patent/EP2968080B1/en active Active
- 2014-03-12 US US14/775,679 patent/US20160022564A1/en not_active Abandoned
- 2014-03-12 AU AU2014248562A patent/AU2014248562B2/en active Active
- 2014-03-12 CA CA2905404A patent/CA2905404C/en active Active
-
2018
- 2018-04-09 US US15/948,446 patent/US10765616B2/en active Active
-
2019
- 2019-03-26 AU AU2019202092A patent/AU2019202092A1/en not_active Abandoned
- 2019-06-04 JP JP2019104482A patent/JP2019137702A/ja active Pending
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