JP2016510213A5 - - Google Patents

Download PDF

Info

Publication number
JP2016510213A5
JP2016510213A5 JP2015551852A JP2015551852A JP2016510213A5 JP 2016510213 A5 JP2016510213 A5 JP 2016510213A5 JP 2015551852 A JP2015551852 A JP 2015551852A JP 2015551852 A JP2015551852 A JP 2015551852A JP 2016510213 A5 JP2016510213 A5 JP 2016510213A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
disease
iro compound
composition according
iro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015551852A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016510213A (ja
JP6385957B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/010599 external-priority patent/WO2014110081A1/en
Publication of JP2016510213A publication Critical patent/JP2016510213A/ja
Publication of JP2016510213A5 publication Critical patent/JP2016510213A5/ja
Application granted granted Critical
Publication of JP6385957B2 publication Critical patent/JP6385957B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015551852A 2013-01-08 2014-01-08 トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド(iro)化合物 Expired - Fee Related JP6385957B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361750014P 2013-01-08 2013-01-08
US61/750,014 2013-01-08
PCT/US2014/010599 WO2014110081A1 (en) 2013-01-08 2014-01-08 Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

Publications (3)

Publication Number Publication Date
JP2016510213A JP2016510213A (ja) 2016-04-07
JP2016510213A5 true JP2016510213A5 (https=) 2016-12-28
JP6385957B2 JP6385957B2 (ja) 2018-09-05

Family

ID=51061112

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015551852A Expired - Fee Related JP6385957B2 (ja) 2013-01-08 2014-01-08 トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド(iro)化合物

Country Status (9)

Country Link
US (3) US9260719B2 (https=)
EP (1) EP2943251B1 (https=)
JP (1) JP6385957B2 (https=)
KR (1) KR101898177B1 (https=)
AU (2) AU2014205544B2 (https=)
BR (1) BR112015016420B1 (https=)
CA (1) CA2896537C (https=)
HK (1) HK1214191A1 (https=)
WO (1) WO2014110081A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101898177B1 (ko) * 2013-01-08 2018-09-12 이데라 파마슈티칼즈, 인코포레이티드 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 (iro) 화합물
US9688993B2 (en) 2015-02-13 2017-06-27 Idera Pharmaceuticals, Inc. Toll-like receptor 9 antagonist and methods of use thereof
WO2017173334A1 (en) 2016-04-01 2017-10-05 Checkmate Pharmaceuticals, Inc. Fc receptor-mediated drug delivery
US11339396B2 (en) 2016-06-08 2022-05-24 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses
CN109983129A (zh) * 2016-11-23 2019-07-05 柏林制药股份有限公司 用于抑制和/或压制tlr9激活的适体
AU2018364542A1 (en) 2017-11-08 2020-04-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses
US12246031B2 (en) 2018-02-13 2025-03-11 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
KR102890791B1 (ko) 2018-04-09 2025-11-24 체크메이트 파마슈티칼스, 인크. 바이러스-유사 입자 내로의 올리고뉴클레오타이드의 포장

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426334B1 (en) 1997-04-30 2002-07-30 Hybridon, Inc. Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
AU9475001A (en) * 2000-09-26 2002-04-08 Hybridon Inc Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
US7176296B2 (en) * 2001-04-30 2007-02-13 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
US7105495B2 (en) * 2001-04-30 2006-09-12 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
WO2003035836A2 (en) * 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
AU2004206820B2 (en) * 2003-01-16 2010-06-10 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
US7354907B2 (en) * 2003-02-07 2008-04-08 Idera Pharmaceuticals, Inc. Short immunomodulatory oligonucleotides
MXPA05013658A (es) * 2003-06-11 2006-03-02 Hybridon Inc Oligonucleotidos inmunomoduladores estabilizados.
MXPA06000619A (es) * 2003-07-15 2006-04-11 Hybridon Inc Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion.
US20050239733A1 (en) 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
US20060014713A1 (en) * 2004-06-15 2006-01-19 Hybridon, Inc. Immunostimulatory oligonucleotide multimers
US7427405B2 (en) * 2004-06-15 2008-09-23 Idera Pharmaceuticals, Inc. Immunostimulatory oligonucleotide multimers
US8399423B2 (en) 2005-10-12 2013-03-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8426375B2 (en) 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8383598B2 (en) 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
ES2544877T3 (es) * 2005-10-12 2015-09-04 Idera Pharmaceuticals Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
US7470674B2 (en) * 2005-11-07 2008-12-30 Idera Pharmaceuticals, Inc. Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
US7776834B2 (en) * 2005-11-07 2010-08-17 Idera Pharmaceuticals, Inc. Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
US7709317B2 (en) * 2005-11-14 2010-05-04 International Business Machines Corporation Method to increase strain enhancement with spacerless FET and dual liner process
US7786089B2 (en) * 2005-12-20 2010-08-31 Idera Pharmaceuticals, Inc. Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments
EP2021008B1 (en) * 2006-04-07 2015-12-02 Idera Pharmaceuticals, Inc. Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8
US8377898B2 (en) 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
MX2009006230A (es) * 2006-12-12 2009-06-22 Idera Pharmaceuticals Inc Agonistas sinteticos de receptores de tipo toll 9.
US8713253B1 (en) * 2007-06-18 2014-04-29 Guidance-Tableau, Llc Modular storage system
CA2692161C (en) * 2007-07-09 2015-09-29 Idera Pharmaceuticals, Inc. Stabilized immune modulatory rna (simra) compounds
KR20100053598A (ko) * 2007-08-01 2010-05-20 이데라 파마슈티칼즈, 인코포레이티드 Tlr9의 신규한 합성 효능제
MX2010001785A (es) * 2007-08-15 2010-03-10 Idera Pharmaceuticals Inc Moduladores de receptores tipo larga distancia.
WO2009154609A1 (en) * 2008-06-17 2009-12-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
AU2009302468A1 (en) 2008-10-06 2010-04-15 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
US8987221B2 (en) * 2009-06-01 2015-03-24 Idera Pharmaceuticals, Inc. Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9
WO2011041311A2 (en) 2009-09-29 2011-04-07 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
CN103153346A (zh) 2010-06-16 2013-06-12 戴纳瓦克斯技术公司 使用tlr7和/或tlr9抑制剂的治疗方法
KR101985382B1 (ko) * 2010-11-19 2019-06-03 이데라 파마슈티칼즈, 인코포레이티드 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(iro) 화합물
KR102052215B1 (ko) * 2011-06-01 2019-12-04 야누스 바이오테라퓨틱스, 인크. 신규한 면역 시스템 조절제
WO2013036829A1 (en) * 2011-09-09 2013-03-14 Genentech, Inc Treatment of th17 mediated inflammatory diseases
US9603800B2 (en) * 2012-04-12 2017-03-28 Yale University Methods of treating inflammatory and autoimmune diseases and disorders using nanolipogels
KR101898177B1 (ko) * 2013-01-08 2018-09-12 이데라 파마슈티칼즈, 인코포레이티드 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 (iro) 화합물
EP3005607B1 (en) * 2013-05-30 2020-01-08 Intel Corporation Adaptive authentication systems and methods
US9688993B2 (en) * 2015-02-13 2017-06-27 Idera Pharmaceuticals, Inc. Toll-like receptor 9 antagonist and methods of use thereof

Similar Documents

Publication Publication Date Title
JP2016510213A5 (https=)
ES2967453T3 (es) Compuestos de pirrolizina sustituidos y usos de los mismos
JP2010536787A5 (https=)
AU2024202047A1 (en) Compounds and methods for treatment of viral infections
EP4378487A3 (en) Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues
JP2018523668A5 (https=)
TR201906470T4 (tr) İmmünomodülatörler.
JP2015517489A5 (https=)
JP2006524669A5 (https=)
JP2016538885A5 (https=)
PH12017500797A1 (en) Substituted chromanes and methods of use
JP2020508310A5 (https=)
ES2897599T3 (es) Mejora de la administración de genes a células asesinas naturales, células madre hematopoyéticas y macrófagos
JP2017526728A5 (https=)
JP2019501133A5 (https=)
JP2017531002A5 (https=)
JP2009533348A5 (https=)
JP2012176990A5 (https=)
PH12014500724A1 (en) Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication
Zhang et al. The response to interferon is influenced by hepatitis B virus genotype in vitro and in vivo
NZ625592A (en) Compositions and methods for the treatment of hepatic diseases and disorders
JP2015505843A5 (https=)
EA202090465A1 (ru) Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк- и/или днк-содержащими вирусами, и сопутствующих заболеваний
JP2016517446A5 (https=)
JP2018509380A5 (https=)