HK1214191A1 - 免疫調節寡核苷酸(iro)化合物以調節基於toll樣受體的免疫應答 - Google Patents
免疫調節寡核苷酸(iro)化合物以調節基於toll樣受體的免疫應答 Download PDFInfo
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- HK1214191A1 HK1214191A1 HK16102283.4A HK16102283A HK1214191A1 HK 1214191 A1 HK1214191 A1 HK 1214191A1 HK 16102283 A HK16102283 A HK 16102283A HK 1214191 A1 HK1214191 A1 HK 1214191A1
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- immune response
- regulatory oligonucleotide
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- C12N15/09—Recombinant DNA-technology
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750014P | 2013-01-08 | 2013-01-08 | |
| US61/750,014 | 2013-01-08 | ||
| PCT/US2014/010599 WO2014110081A1 (en) | 2013-01-08 | 2014-01-08 | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1214191A1 true HK1214191A1 (zh) | 2016-07-22 |
Family
ID=51061112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16102283.4A HK1214191A1 (zh) | 2013-01-08 | 2014-01-08 | 免疫調節寡核苷酸(iro)化合物以調節基於toll樣受體的免疫應答 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9260719B2 (https=) |
| EP (1) | EP2943251B1 (https=) |
| JP (1) | JP6385957B2 (https=) |
| KR (1) | KR101898177B1 (https=) |
| AU (2) | AU2014205544B2 (https=) |
| BR (1) | BR112015016420B1 (https=) |
| CA (1) | CA2896537C (https=) |
| HK (1) | HK1214191A1 (https=) |
| WO (1) | WO2014110081A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101898177B1 (ko) * | 2013-01-08 | 2018-09-12 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 (iro) 화합물 |
| US9688993B2 (en) | 2015-02-13 | 2017-06-27 | Idera Pharmaceuticals, Inc. | Toll-like receptor 9 antagonist and methods of use thereof |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| US11339396B2 (en) | 2016-06-08 | 2022-05-24 | President And Fellows Of Harvard College | Engineered viral vector reduces induction of inflammatory and immune responses |
| CN109983129A (zh) * | 2016-11-23 | 2019-07-05 | 柏林制药股份有限公司 | 用于抑制和/或压制tlr9激活的适体 |
| AU2018364542A1 (en) | 2017-11-08 | 2020-04-16 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| KR102890791B1 (ko) | 2018-04-09 | 2025-11-24 | 체크메이트 파마슈티칼스, 인크. | 바이러스-유사 입자 내로의 올리고뉴클레오타이드의 포장 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| AU9475001A (en) * | 2000-09-26 | 2002-04-08 | Hybridon Inc | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| US7176296B2 (en) * | 2001-04-30 | 2007-02-13 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| US7105495B2 (en) * | 2001-04-30 | 2006-09-12 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| WO2003035836A2 (en) * | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| AU2004206820B2 (en) * | 2003-01-16 | 2010-06-10 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides |
| US7354907B2 (en) * | 2003-02-07 | 2008-04-08 | Idera Pharmaceuticals, Inc. | Short immunomodulatory oligonucleotides |
| MXPA05013658A (es) * | 2003-06-11 | 2006-03-02 | Hybridon Inc | Oligonucleotidos inmunomoduladores estabilizados. |
| MXPA06000619A (es) * | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| US20050239733A1 (en) | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
| US20060014713A1 (en) * | 2004-06-15 | 2006-01-19 | Hybridon, Inc. | Immunostimulatory oligonucleotide multimers |
| US7427405B2 (en) * | 2004-06-15 | 2008-09-23 | Idera Pharmaceuticals, Inc. | Immunostimulatory oligonucleotide multimers |
| US8399423B2 (en) | 2005-10-12 | 2013-03-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US8426375B2 (en) | 2005-10-12 | 2013-04-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US8383598B2 (en) | 2005-10-12 | 2013-02-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| ES2544877T3 (es) * | 2005-10-12 | 2015-09-04 | Idera Pharmaceuticals | Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll |
| US7470674B2 (en) * | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| US7776834B2 (en) * | 2005-11-07 | 2010-08-17 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| US7709317B2 (en) * | 2005-11-14 | 2010-05-04 | International Business Machines Corporation | Method to increase strain enhancement with spacerless FET and dual liner process |
| US7786089B2 (en) * | 2005-12-20 | 2010-08-31 | Idera Pharmaceuticals, Inc. | Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments |
| EP2021008B1 (en) * | 2006-04-07 | 2015-12-02 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8 |
| US8377898B2 (en) | 2006-10-12 | 2013-02-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| MX2009006230A (es) * | 2006-12-12 | 2009-06-22 | Idera Pharmaceuticals Inc | Agonistas sinteticos de receptores de tipo toll 9. |
| US8713253B1 (en) * | 2007-06-18 | 2014-04-29 | Guidance-Tableau, Llc | Modular storage system |
| CA2692161C (en) * | 2007-07-09 | 2015-09-29 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory rna (simra) compounds |
| KR20100053598A (ko) * | 2007-08-01 | 2010-05-20 | 이데라 파마슈티칼즈, 인코포레이티드 | Tlr9의 신규한 합성 효능제 |
| MX2010001785A (es) * | 2007-08-15 | 2010-03-10 | Idera Pharmaceuticals Inc | Moduladores de receptores tipo larga distancia. |
| WO2009154609A1 (en) * | 2008-06-17 | 2009-12-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| AU2009302468A1 (en) | 2008-10-06 | 2010-04-15 | Idera Pharmaceuticals, Inc. | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto |
| US8987221B2 (en) * | 2009-06-01 | 2015-03-24 | Idera Pharmaceuticals, Inc. | Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9 |
| WO2011041311A2 (en) | 2009-09-29 | 2011-04-07 | Yale University | Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods |
| CN103153346A (zh) | 2010-06-16 | 2013-06-12 | 戴纳瓦克斯技术公司 | 使用tlr7和/或tlr9抑制剂的治疗方法 |
| KR101985382B1 (ko) * | 2010-11-19 | 2019-06-03 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(iro) 화합물 |
| KR102052215B1 (ko) * | 2011-06-01 | 2019-12-04 | 야누스 바이오테라퓨틱스, 인크. | 신규한 면역 시스템 조절제 |
| WO2013036829A1 (en) * | 2011-09-09 | 2013-03-14 | Genentech, Inc | Treatment of th17 mediated inflammatory diseases |
| US9603800B2 (en) * | 2012-04-12 | 2017-03-28 | Yale University | Methods of treating inflammatory and autoimmune diseases and disorders using nanolipogels |
| KR101898177B1 (ko) * | 2013-01-08 | 2018-09-12 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 (iro) 화합물 |
| EP3005607B1 (en) * | 2013-05-30 | 2020-01-08 | Intel Corporation | Adaptive authentication systems and methods |
| US9688993B2 (en) * | 2015-02-13 | 2017-06-27 | Idera Pharmaceuticals, Inc. | Toll-like receptor 9 antagonist and methods of use thereof |
-
2014
- 2014-01-08 KR KR1020157021207A patent/KR101898177B1/ko not_active Expired - Fee Related
- 2014-01-08 BR BR112015016420-0A patent/BR112015016420B1/pt not_active IP Right Cessation
- 2014-01-08 JP JP2015551852A patent/JP6385957B2/ja not_active Expired - Fee Related
- 2014-01-08 CA CA2896537A patent/CA2896537C/en active Active
- 2014-01-08 HK HK16102283.4A patent/HK1214191A1/zh unknown
- 2014-01-08 US US14/149,899 patent/US9260719B2/en not_active Expired - Fee Related
- 2014-01-08 WO PCT/US2014/010599 patent/WO2014110081A1/en not_active Ceased
- 2014-01-08 EP EP14738139.6A patent/EP2943251B1/en not_active Not-in-force
- 2014-01-08 AU AU2014205544A patent/AU2014205544B2/en not_active Ceased
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2016
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- 2016-07-13 US US15/209,333 patent/US10041076B2/en active Active
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2018
- 2018-10-12 AU AU2018247308A patent/AU2018247308B2/en not_active Ceased
Also Published As
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|---|---|
| BR112015016420A2 (https=) | 2017-09-05 |
| BR112015016420B1 (pt) | 2022-12-06 |
| JP2016510213A (ja) | 2016-04-07 |
| EP2943251A4 (en) | 2016-08-24 |
| US20160201060A1 (en) | 2016-07-14 |
| AU2014205544A2 (en) | 2015-08-06 |
| AU2018247308A1 (en) | 2018-11-08 |
| WO2014110081A1 (en) | 2014-07-17 |
| AU2014205544A1 (en) | 2015-07-23 |
| EP2943251B1 (en) | 2018-10-10 |
| KR20150103739A (ko) | 2015-09-11 |
| US9260719B2 (en) | 2016-02-16 |
| CA2896537A1 (en) | 2014-07-17 |
| EP2943251A1 (en) | 2015-11-18 |
| US10041076B2 (en) | 2018-08-07 |
| KR101898177B1 (ko) | 2018-09-12 |
| AU2014205544B2 (en) | 2018-07-12 |
| CA2896537C (en) | 2021-10-12 |
| JP6385957B2 (ja) | 2018-09-05 |
| US20160312225A1 (en) | 2016-10-27 |
| AU2018247308B2 (en) | 2020-07-09 |
| US10066230B2 (en) | 2018-09-04 |
| US20140193396A1 (en) | 2014-07-10 |
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