HK1243430A1 - 通過施用il-6r拮抗劑治療乾眼病的方法 - Google Patents

通過施用il-6r拮抗劑治療乾眼病的方法

Info

Publication number
HK1243430A1
HK1243430A1 HK18102869.4A HK18102869A HK1243430A1 HK 1243430 A1 HK1243430 A1 HK 1243430A1 HK 18102869 A HK18102869 A HK 18102869A HK 1243430 A1 HK1243430 A1 HK 1243430A1
Authority
HK
Hong Kong
Prior art keywords
antagonist
administering
methods
dry eye
eye disease
Prior art date
Application number
HK18102869.4A
Other languages
English (en)
Inventor
Jingtai Cao
Ying Hu
Carmelo Romano
Stanley J Wiegand
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1243430A1 publication Critical patent/HK1243430A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK18102869.4A 2014-12-02 2018-02-28 通過施用il-6r拮抗劑治療乾眼病的方法 HK1243430A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086216P 2014-12-02 2014-12-02
US201562139037P 2015-03-27 2015-03-27
PCT/US2015/063209 WO2016089886A2 (en) 2014-12-02 2015-12-01 Methods for treating dry eye disease by administering an il-6r antagonist

Publications (1)

Publication Number Publication Date
HK1243430A1 true HK1243430A1 (zh) 2018-07-13

Family

ID=56078762

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18102869.4A HK1243430A1 (zh) 2014-12-02 2018-02-28 通過施用il-6r拮抗劑治療乾眼病的方法

Country Status (6)

Country Link
US (1) US20160152717A1 (zh)
EP (1) EP3226899A4 (zh)
JP (1) JP2017536391A (zh)
AU (1) AU2015355150A1 (zh)
HK (1) HK1243430A1 (zh)
WO (1) WO2016089886A2 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201628649A (zh) 2014-10-09 2016-08-16 再生元醫藥公司 減少醫藥調配物中微可見顆粒之方法
IL264631B2 (en) 2016-08-16 2024-05-01 Regeneron Pharma A method for quantifying individual antibodies from a mixture
SG11201902667UA (en) 2016-10-25 2019-05-30 Regeneron Pharma Methods and systems for chromatography data analysis
RU2020111737A (ru) 2017-09-13 2021-10-13 Цзянсу Хэнжуй Медицин Ко., Лтд. Антитело против il-6r и его антигенсвязывающий фрагмент и медицинское применение
SG11202001564QA (en) 2017-09-19 2020-04-29 Regeneron Pharma Methods of reducing particle formation and compositions formed thereby
JP7171724B2 (ja) 2017-12-13 2022-11-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド クロマトグラフィーカラム床支持体の管理のための装置及びシステム、ならびに関連する方法
WO2019124591A1 (ko) * 2017-12-21 2019-06-27 주식회사 화이바이오메드 무선구동 스마트 콘택트렌즈
TW202348297A (zh) 2018-05-02 2023-12-16 美商里珍納龍藥品有限公司 用於評估生化過濾器的適合性的方法
US11884698B2 (en) 2018-07-02 2024-01-30 Regeneron Pharmaceuticals, Inc. Systems and methods for preparing a polypeptide from a mixture
WO2024088921A1 (en) * 2022-10-24 2024-05-02 F. Hoffmann-La Roche Ag Predicting response to il-6 antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2041177T3 (pl) * 2006-06-02 2012-09-28 Regeneron Pharma Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6
EP2174667B1 (en) * 2007-07-26 2017-01-04 Osaka University Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient
US8992920B2 (en) * 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
JP2013541594A (ja) * 2010-11-08 2013-11-14 ジェネンテック， インコーポレイテッド 皮下投与される抗ｉｌ−６受容体抗体
SG11201502876RA (en) * 2012-11-08 2015-06-29 Eleven Biotherapeutics Inc Il-6 antagonists and uses thereof

Also Published As

Publication number Publication date
AU2015355150A1 (en) 2017-06-08
EP3226899A2 (en) 2017-10-11
WO2016089886A3 (en) 2016-07-28
EP3226899A4 (en) 2018-09-05
WO2016089886A2 (en) 2016-06-09
US20160152717A1 (en) 2016-06-02
JP2017536391A (ja) 2017-12-07

Similar Documents

Publication Publication Date Title
IL283561B (en) Methods for treating eye diseases
HK1243430A1 (zh) 通過施用il-6r拮抗劑治療乾眼病的方法
LT3386511T (lt) Hantingtono ligos gydymo būdai
PL3110848T3 (pl) Sposoby leczenia zakażenia skóry przez podawanie antagonisty il-4r
ZA201605563B (en) Polymer formulations for nasolacrimal stimulation
GB2526427B8 (en) Ophthalmologic apparatus
PT3107575T (pt) Métodos de tratamento e prevenção de asma administrando um antagonista de il-4r
IL246791A0 (en) Compositions and methods for treating eye diseases
ZA201700416B (en) Methods for treating or preventing ophthalmological conditions
IL249480A0 (en) Optogenetic treatments for movement disorders
GB201410816D0 (en) Therapeutic agents
HUE049518T2 (hu) Készítmények és eljárások a szem megbetegedéseinek kezelésére és diagnosztizálására
GB201417165D0 (en) Treatments for Autoimmune Disease
PT3020430T (pt) Cânula para terapia de implantação de sutura catgut
PT3164394T (pt) Inibidores gls1 para o tratamento de doenças
IL250017A0 (en) Eye examination devices
GB201410817D0 (en) Therapeutic agents
GB201410815D0 (en) Therapeutic agents
HK1222578A1 (zh) 皮膚用乳液組合物
GB2525310B (en) Ophthalmologic apparatus
IL252904A0 (en) Methods and factors for treating diseases
SG11201700059WA (en) Therapeutic agent for keratoconjunctive disorder
GB201409603D0 (en) An inhalable medicament
GB201401806D0 (en) Novel methods for diagnosis and therapy
IL246913B (en) Methods for treating dermatitis by administering an antagonist to -il-4r