JP2016509842A5 - - Google Patents
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- JP2016509842A5 JP2016509842A5 JP2015560302A JP2015560302A JP2016509842A5 JP 2016509842 A5 JP2016509842 A5 JP 2016509842A5 JP 2015560302 A JP2015560302 A JP 2015560302A JP 2015560302 A JP2015560302 A JP 2015560302A JP 2016509842 A5 JP2016509842 A5 JP 2016509842A5
- Authority
- JP
- Japan
- Prior art keywords
- synthase
- acid
- thca
- cbda
- cbca
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 23
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 18
- 101000712615 Cannabis sativa Tetrahydrocannabinolic acid synthase Proteins 0.000 claims 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 12
- 239000011541 reaction mixture Substances 0.000 claims 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 9
- WVOLTBSCXRRQFR-DLBZAZTESA-N cannabidiolic acid Chemical compound OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-N 0.000 claims 9
- 229930003827 cannabinoid Natural products 0.000 claims 9
- 239000003557 cannabinoid Substances 0.000 claims 9
- 108010075293 Cannabidiolic acid synthase Proteins 0.000 claims 8
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 claims 7
- HRHJHXJQMNWQTF-UHFFFAOYSA-N cannabichromenic acid Chemical compound O1C(C)(CCC=C(C)C)C=CC2=C1C=C(CCCCC)C(C(O)=O)=C2O HRHJHXJQMNWQTF-UHFFFAOYSA-N 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- WVOLTBSCXRRQFR-SJORKVTESA-N Cannabidiolic acid Natural products OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@@H]1[C@@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-SJORKVTESA-N 0.000 claims 3
- 229920000858 Cyclodextrin Polymers 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 claims 2
- QXACEHWTBCFNSA-UHFFFAOYSA-N cannabigerol Natural products CCCCCC1=CC(O)=C(CC=C(C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- KTPDAZGMXXWSMU-UHFFFAOYSA-N Cannabichromen Natural products CCCCc1cc(O)c2C=CC(C)(CCC=C(C)C)Oc2c1 KTPDAZGMXXWSMU-UHFFFAOYSA-N 0.000 claims 1
- UVOLYTDXHDXWJU-NRFANRHFSA-N Cannabichromene Natural products C1=C[C@](C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-NRFANRHFSA-N 0.000 claims 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims 1
- 108030003705 Tetrahydrocannabinolic acid synthases Proteins 0.000 claims 1
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims 1
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims 1
- 229950011318 cannabidiol Drugs 0.000 claims 1
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims 1
- WVOLTBSCXRRQFR-DLBZAZTESA-M cannabidiolate Chemical compound OC1=C(C([O-])=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-M 0.000 claims 1
- SEEZIOZEUUMJME-FOWTUZBSSA-N cannabigerolic acid Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1C(O)=O SEEZIOZEUUMJME-FOWTUZBSSA-N 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims 1
- 229960004242 dronabinol Drugs 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770766P | 2013-02-28 | 2013-02-28 | |
| US61/770,766 | 2013-02-28 | ||
| PCT/US2014/018944 WO2014134281A1 (en) | 2013-02-28 | 2014-02-27 | Biosynthesis of cannabinoids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018025851A Division JP6724052B2 (ja) | 2013-02-28 | 2018-02-16 | カンナビノイドの生合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016509842A JP2016509842A (ja) | 2016-04-04 |
| JP2016509842A5 true JP2016509842A5 (enExample) | 2017-02-16 |
| JP6581509B2 JP6581509B2 (ja) | 2019-09-25 |
Family
ID=51428796
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560302A Expired - Fee Related JP6581509B2 (ja) | 2013-02-28 | 2014-02-27 | 化合物を合成する化学工学プロセス及び装置 |
| JP2018025851A Expired - Fee Related JP6724052B2 (ja) | 2013-02-28 | 2018-02-16 | カンナビノイドの生合成 |
| JP2019205366A Pending JP2020022507A (ja) | 2013-02-28 | 2019-11-13 | カンナビノイドの生合成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018025851A Expired - Fee Related JP6724052B2 (ja) | 2013-02-28 | 2018-02-16 | カンナビノイドの生合成 |
| JP2019205366A Pending JP2020022507A (ja) | 2013-02-28 | 2019-11-13 | カンナビノイドの生合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US9359625B2 (enExample) |
| EP (1) | EP2961402B1 (enExample) |
| JP (3) | JP6581509B2 (enExample) |
| CN (1) | CN105555265A (enExample) |
| AU (2) | AU2014223458A1 (enExample) |
| BR (1) | BR112015020332A2 (enExample) |
| CA (2) | CA3012383C (enExample) |
| IL (1) | IL240830B (enExample) |
| WO (1) | WO2014134281A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6581509B2 (ja) | 2013-02-28 | 2019-09-25 | ティーウィノット テクノロジーズ リミテッド | 化合物を合成する化学工学プロセス及び装置 |
| US11293038B2 (en) | 2014-07-14 | 2022-04-05 | Librede Inc. | Production of cannabinoids in yeast |
| US9822384B2 (en) | 2014-07-14 | 2017-11-21 | Librede Inc. | Production of cannabinoids in yeast |
| AU2015308136B2 (en) * | 2014-08-25 | 2020-07-09 | Teewinot Technologies Limited | Apparatus and methods for the simultaneous production of cannabinoid compounds |
| BR122021018502B1 (pt) | 2014-10-21 | 2022-05-03 | United Cannabis Corp | Formulação de canabinoide líquida |
| US10350165B2 (en) | 2014-12-12 | 2019-07-16 | Ojai Energetics Pbc | Methods and systems for forming stable droplets |
| MX395015B (es) | 2014-12-12 | 2025-03-24 | Ojai Energetics Pbc | Composiciones microencapsuladas de cannabinoides |
| WO2017175064A1 (en) * | 2016-04-04 | 2017-10-12 | Full Spectrum Laboratories Ltd | Bioenzymatic synthesis of tetrahydrocannabivarin (thc-v), cannabinol (cbn), and cannabivarin (cbv) and their use as therapeutic agents |
| EP3442953A1 (en) * | 2016-04-15 | 2019-02-20 | Teewinot Technologies Limited | Biosynthesis of cannabinoid prodrugs |
| US10588974B2 (en) | 2016-04-22 | 2020-03-17 | Receptor Holdings, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
| EP3471745B1 (en) * | 2016-06-15 | 2025-03-26 | Ojai Energetics PBC | Compositions for reducing oxidative stress |
| EP3541772A1 (en) * | 2016-11-15 | 2019-09-25 | Teewinot Technologies Limited | Bio-stable cannabinoid compounds and methods for enhancing their physiological concentration |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| AU2018220470B2 (en) | 2017-02-17 | 2022-02-24 | Hyasynth Biologicals Inc. | Method and cell line for production of polyketides in yeast |
| WO2018176055A2 (en) | 2017-03-24 | 2018-09-27 | Trait Biosciences, Inc. | High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems |
| AU2018260710B2 (en) * | 2017-04-26 | 2022-07-21 | Teewinot Technologies Limited | Apparatus, methods and composition for synthesis of cannabinoid compounds |
| EP3615667B1 (en) * | 2017-04-27 | 2021-08-11 | The Regents of The University of California | Microorganisms and methods for producing cannabinoids and cannabinoid derivatives |
| US11905543B2 (en) | 2017-07-11 | 2024-02-20 | Trait Biosceinces, Inc. | In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures |
| EP3730145A1 (en) | 2017-07-11 | 2020-10-28 | Trait Biosciences, Inc. | Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter |
| US11946059B2 (en) | 2017-07-11 | 2024-04-02 | Trait Biosciences, Inc. | In vivo generation of water-soluble cannabinoids in plant cell suspension cultures |
| EP3652327A4 (en) | 2017-07-12 | 2021-04-21 | Biomedican, Inc. | Production of cannabinoids in yeast |
| SG11202001924XA (en) | 2017-09-05 | 2020-04-29 | Inmed Pharmaceuticals Inc | Metabolic engineering of e. coli for the biosynthesis of cannabinoid products |
| EP3691442A4 (en) | 2017-10-03 | 2021-07-07 | The Regents of the University of Colorado | PROCESS FOR DIFFERENTIATING CANNABIS PLANT CULTIVARS BASED ON CANNABINOID SYNTHASE PARALOGUES |
| KR102398709B1 (ko) | 2017-10-20 | 2022-05-16 | 제이에프이 스틸 가부시키가이샤 | 고강도 강판 및 그 제조 방법 |
| EP3745884A1 (en) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hemp powder |
| WO2019209885A2 (en) | 2018-04-23 | 2019-10-31 | Renew Biopharma, Inc. | Enzyme engineering to alter the functional repertoire of cannabinoid synthases |
| US10801049B2 (en) | 2018-06-14 | 2020-10-13 | Syntiva Therapeutics, Inc. | Genetically engineered microorganisms and processes for the production of cannabinoids from a carbon source precursor |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| EP3873459A1 (en) | 2018-10-31 | 2021-09-08 | Enantia, S.L. | Solid compositions of cocrystals of cannabinoids |
| US12303487B2 (en) | 2018-11-19 | 2025-05-20 | Spoke Sciences, Inc. | N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions |
| CN109734591A (zh) * | 2018-12-26 | 2019-05-10 | 江苏暨明医药科技有限公司 | 一种大麻二酚中间体及其制备方法与及应用 |
| EP3931330A4 (en) | 2019-02-25 | 2023-03-15 | Ginkgo Bioworks, Inc. | BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS |
| CA3129535A1 (en) | 2019-03-07 | 2020-09-10 | Oludare ODUMOSU | Formulations for treating cluster symptoms associated with autism spectrum disorder |
| SG11202111975UA (en) * | 2019-05-22 | 2021-11-29 | Demetrix Inc | Optimized cannabinoid synthase polypeptides |
| EP4067330B1 (en) | 2019-06-11 | 2024-03-20 | Symrise AG | Cosmetic use of cannabigerol |
| US10717056B1 (en) | 2019-09-09 | 2020-07-21 | Michael Cem Gokay | Method and apparatus for purification of cannabinoid extracts |
| KR20220110476A (ko) * | 2019-10-08 | 2022-08-08 | 베서, 파마 엘엘씨 | 칸나비노이드 및 칸나비노이드산의 제조공정 |
| WO2021071438A1 (en) * | 2019-10-11 | 2021-04-15 | National University Of Singapore | Biosynthesis of cannabinoids from cannabigerolic acid using novel cannabinoid synthases |
| AU2020364933A1 (en) * | 2019-10-11 | 2022-04-21 | National University Of Singapore | Sustainable production of cannabinoids from simple precursor feedstocks using |
| WO2021211611A1 (en) | 2020-04-14 | 2021-10-21 | Genomatica, Inc. | Cannabinoid synthase variants and methods for their use |
| WO2021226711A1 (en) * | 2020-05-12 | 2021-11-18 | Canopy Growth Corporation | Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof |
| CA3132439A1 (en) * | 2020-05-12 | 2021-11-12 | Canopy Growth Corporation | Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof |
| CA3203361A1 (en) | 2020-12-31 | 2022-07-07 | Parker BERLING | Compositions comprising cannabis and mushroom extracts, and uses thereof |
| WO2022204207A1 (en) * | 2021-03-22 | 2022-09-29 | Cb Therapeutics, Inc. | Biosynthetic methods for the modification of cannabinoids |
| US20240368643A1 (en) * | 2021-06-04 | 2024-11-07 | Amyris, Inc. | Methods of purifying cannabinoids |
| WO2023043946A2 (en) * | 2021-09-15 | 2023-03-23 | The Regents Of The University Of California | Cannabinoid production in bacteria |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5086646A (en) | 1989-09-12 | 1992-02-11 | Jamison Dale E | Apparatus and method for analyzing well fluid sag |
| US5290701A (en) * | 1991-08-28 | 1994-03-01 | Wilkins Judd R | Microbial detection system and process |
| US5302525A (en) * | 1992-11-23 | 1994-04-12 | National Research Council Of Canada | Methylobacterium extorquwns microorganism useful for the preparation of poly-β-hydroxybutyric acid polymers |
| US7530461B2 (en) * | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6113940A (en) | 1997-03-03 | 2000-09-05 | Brooke; Lawrence L. | Cannabinoid patch and method for cannabis transdermal delivery |
| JP2000078979A (ja) | 1998-09-04 | 2000-03-21 | Taisho Pharmaceut Co Ltd | テトラヒドロカンナビノール酸シンターゼ遺伝子 |
| AR022383A1 (es) * | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
| US6403126B1 (en) | 1999-05-26 | 2002-06-11 | Websar Innovations Inc. | Cannabinoid extraction method |
| US6949582B1 (en) | 1999-05-27 | 2005-09-27 | Wallace Walter H | Method of relieving analgesia and reducing inflamation using a cannabinoid delivery topical liniment |
| JP2001029082A (ja) * | 1999-07-22 | 2001-02-06 | Yukihiro Masayama | カンナビジオール酸シンターゼをコードするｄｎａ |
| US6730330B2 (en) | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
| US6946150B2 (en) | 2002-08-14 | 2005-09-20 | Gw Pharma Limited | Pharmaceutical formulation |
| AU2003263895A1 (en) | 2002-08-16 | 2004-03-03 | Immugen Pharmaceuticals, Inc. | Contraceptive methods and formulations |
| GB0222077D0 (en) | 2002-09-23 | 2002-10-30 | Gw Pharma Ltd | Methods of preparing cannabinoids from plant material |
| DE10335130A1 (de) * | 2003-07-31 | 2005-02-24 | Blue Membranes Gmbh | Immobilisierung von Katalysatoren auf porösen Körpern auf Kohlenstoffbasis |
| GB2418612A (en) | 2004-10-01 | 2006-04-05 | Gw Pharma Ltd | Inhibition of tumour cell migration with cannabinoids |
| KR20070101359A (ko) * | 2005-01-28 | 2007-10-16 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 신규한 방향족 프레닐트랜스퍼라제, 이것을 코드화한 핵산및 그의 용도 |
| KR20070118157A (ko) | 2005-04-01 | 2007-12-13 | 바스프 악티엔게젤샤프트 | 해유화제로서의 단백질의 용도 |
| US20090197308A1 (en) * | 2005-05-12 | 2009-08-06 | Jian Liu | Enzymatic synthesis of sulfated polysaccharides |
| JP2007020466A (ja) | 2005-07-15 | 2007-02-01 | Institute Of Physical & Chemical Research | 大麻ＣａｎｎａｂｉｓｓａｔｉｖａＬ．の識別方法 |
| DK1903866T3 (en) | 2005-11-07 | 2016-07-25 | Murty Pharmaceuticals Inc | Improved release of tetrahydrocannabinol |
| US9265724B2 (en) | 2005-11-07 | 2016-02-23 | Ram B. Murty | Oral dosage form of tetrahydrocannabinol and a method of avoiding and/or suppressing hepatic first pass metabolism via targeted chylomicron/lipoprotein delivery |
| GB2434312B (en) | 2006-01-18 | 2011-06-29 | Gw Pharma Ltd | Cannabinoid-containing plant extracts as neuroprotective agents |
| GB2450493A (en) * | 2007-06-25 | 2008-12-31 | Gw Pharma Ltd | Cannabigerol for use in treatment of diseases benefiting from agonism of CB1 and CB2 cannabinoid receptors |
| US20110091930A1 (en) | 2008-02-14 | 2011-04-21 | The General Hospital Corporation | Well-based flow system for cell culture |
| GB2459125B (en) | 2008-04-10 | 2013-01-02 | Gw Pharma Ltd | Method if extracting cannabichromene and its acid from Cannabis sativa plant material |
| US9921576B2 (en) * | 2008-05-05 | 2018-03-20 | Finesse Solutions, Inc. | Virtual transmitter for bioreactor automation system |
| EP2293677B1 (en) * | 2008-06-13 | 2017-11-15 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
| KR101292379B1 (ko) | 2009-04-08 | 2013-08-09 | 브리스톨-마이어스 스큅 컴퍼니 | Ｐｄｈ 및 ｆｄｈ 효소를 발현하는 유전적으로 안정한 플라스미드 |
| DE102009019322A1 (de) * | 2009-04-30 | 2010-11-11 | The Health Concept Gmbh | Verfahren zur Herstellung von Synthetischen Cannabinoiden |
| US20120117686A1 (en) | 2009-05-04 | 2012-05-10 | The Regentsof The University Of California | Stress-tolerant plants expressing mannosylglycerate-producing enzymes |
| US20110003703A1 (en) * | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
| US8884100B2 (en) | 2009-08-12 | 2014-11-11 | National Research Council Of Canada | Aromatic prenyltransferase from Cannabis |
| HUE033099T2 (en) * | 2009-12-01 | 2017-11-28 | Abbvie Inc | Novel tricyclic compounds |
| GB2478595B (en) | 2010-03-12 | 2018-04-04 | Gw Pharma Ltd | Phytocannabinoids in the treatment of glioma |
| WO2011127589A1 (en) * | 2010-04-15 | 2011-10-20 | National Research Council Of Canada | Genes and proteins for aromatic polyketide synthesis |
| JP5751661B2 (ja) | 2010-11-02 | 2015-07-22 | 国立研究開発法人農業・食品産業技術総合研究機構 | デキストラングルカナーゼ |
| JP2012130294A (ja) | 2010-12-22 | 2012-07-12 | Tosoh Corp | 抗体結合タンパク質およびその製造方法 |
| US8808734B2 (en) * | 2011-07-11 | 2014-08-19 | Full Spectrum Laboratories Limited | Cannabinoid formulations |
| DK2732037T3 (en) | 2011-07-13 | 2018-02-26 | Nat Res Council Canada | GENES AND PROTEINS FOR ALKANOYL-COA SYNTHESIS |
| US20140057251A1 (en) | 2011-08-18 | 2014-02-27 | Medicinal Genomics Corporation | Cannabis Genomes and Uses Thereof |
| GB2494461A (en) | 2011-09-12 | 2013-03-13 | Gw Pharma Ltd | Phytocannabinoids for use in the treatment of invasive cancers or metastases |
| GB2495118B (en) | 2011-09-29 | 2016-05-18 | Otsuka Pharma Co Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| GB2496688B (en) | 2011-11-21 | 2016-06-29 | Gw Pharma Ltd | Tetrahydrocannabivarin for use in the treatment of intestinal inflammatory diseases |
| CA2868447C (en) | 2012-03-30 | 2020-09-15 | The Scripps Research Institute | Cyclic prodrugs of duocarmycin analogs |
| CA2872528C (en) | 2012-05-03 | 2021-01-05 | Echo Pharmaceuticals B.V. | Cannabis plant isolate comprising .delta.9-tetrahydrocannabinol and a method for preparing such an isolate |
| JP6581509B2 (ja) | 2013-02-28 | 2019-09-25 | ティーウィノット テクノロジーズ リミテッド | 化合物を合成する化学工学プロセス及び装置 |
| WO2014145490A2 (en) | 2013-03-15 | 2014-09-18 | Biotech Institute, Llc | Breeding, production, processing and use of specialty cannabis |
| ES2525137B1 (es) | 2013-06-13 | 2016-01-18 | Servicio Andaluz De Salud | Agentes para tratar el mieloma múltiple |
| WO2015003012A2 (en) | 2013-07-01 | 2015-01-08 | Olivier Berteau | Distributed perfusion bioreactor system for continuous culture of biological cells |
| US9326967B2 (en) | 2013-08-22 | 2016-05-03 | Stephen C. Perry | Vaporizable cannabinoid compositions |
| WO2015142500A2 (en) | 2014-03-21 | 2015-09-24 | Bodybio Inc. | Compositions and methods for treating addiction |
| CA2956919C (en) * | 2014-07-21 | 2022-07-19 | Glia, Llc | Method for treating radiotherapy- and chemotherapy-associated cognitive or emotional impairment with cannabinoids |
| AU2015308136B2 (en) | 2014-08-25 | 2020-07-09 | Teewinot Technologies Limited | Apparatus and methods for the simultaneous production of cannabinoid compounds |
| AU2018260710B2 (en) * | 2017-04-26 | 2022-07-21 | Teewinot Technologies Limited | Apparatus, methods and composition for synthesis of cannabinoid compounds |
-
2014
- 2014-02-27 JP JP2015560302A patent/JP6581509B2/ja not_active Expired - Fee Related
- 2014-02-27 EP EP14757297.8A patent/EP2961402B1/en active Active
- 2014-02-27 WO PCT/US2014/018944 patent/WO2014134281A1/en not_active Ceased
- 2014-02-27 CA CA3012383A patent/CA3012383C/en active Active
- 2014-02-27 BR BR112015020332A patent/BR112015020332A2/pt not_active IP Right Cessation
- 2014-02-27 CA CA2902452A patent/CA2902452C/en active Active
- 2014-02-27 AU AU2014223458A patent/AU2014223458A1/en not_active Abandoned
- 2014-02-27 IL IL240830A patent/IL240830B/en unknown
- 2014-02-27 CN CN201480023902.5A patent/CN105555265A/zh active Pending
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2015
- 2015-08-26 US US14/836,339 patent/US9359625B2/en active Active
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2016
- 2016-06-02 US US15/171,517 patent/US9526715B1/en not_active Expired - Fee Related
- 2016-08-19 US US15/242,189 patent/US9861609B2/en active Active
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2017
- 2017-02-10 US US15/430,122 patent/US10081818B2/en active Active
- 2017-02-23 US US15/441,109 patent/US20170159080A1/en not_active Abandoned
- 2017-05-12 US US15/594,348 patent/US10214753B2/en active Active
- 2017-09-22 US US15/713,304 patent/US10472652B2/en active Active
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2018
- 2018-02-16 JP JP2018025851A patent/JP6724052B2/ja not_active Expired - Fee Related
- 2018-09-10 AU AU2018228329A patent/AU2018228329A1/en not_active Abandoned
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2019
- 2019-10-15 US US16/601,984 patent/US20200048664A1/en not_active Abandoned
- 2019-11-13 JP JP2019205366A patent/JP2020022507A/ja active Pending
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