JP2016508726A5 - - Google Patents
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- JP2016508726A5 JP2016508726A5 JP2015558982A JP2015558982A JP2016508726A5 JP 2016508726 A5 JP2016508726 A5 JP 2016508726A5 JP 2015558982 A JP2015558982 A JP 2015558982A JP 2015558982 A JP2015558982 A JP 2015558982A JP 2016508726 A5 JP2016508726 A5 JP 2016508726A5
- Authority
- JP
- Japan
- Prior art keywords
- hepatocytes
- stem cells
- item
- hepatocyte
- exogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000003494 hepatocyte Anatomy 0.000 claims description 52
- 238000000034 method Methods 0.000 claims description 52
- 210000000130 stem cell Anatomy 0.000 claims description 35
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 claims description 10
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims description 10
- 102100035961 Hematopoietically-expressed homeobox protein HHEX Human genes 0.000 claims description 10
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims description 10
- 101001021503 Homo sapiens Hematopoietically-expressed homeobox protein HHEX Proteins 0.000 claims description 10
- 101001062347 Homo sapiens Hepatocyte nuclear factor 3-beta Proteins 0.000 claims description 10
- 101000666775 Homo sapiens T-box transcription factor TBX3 Proteins 0.000 claims description 10
- 101000819074 Homo sapiens Transcription factor GATA-4 Proteins 0.000 claims description 10
- 102100038409 T-box transcription factor TBX3 Human genes 0.000 claims description 10
- 102100021380 Transcription factor GATA-4 Human genes 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 10
- 238000004114 suspension culture Methods 0.000 claims description 10
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 claims description 8
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 claims description 8
- 238000012258 culturing Methods 0.000 claims description 8
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 8
- 108010088751 Albumins Proteins 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 6
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical class C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 claims description 6
- 229940124647 MEK inhibitor Drugs 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 102000005427 Asialoglycoprotein Receptor Human genes 0.000 claims description 4
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 claims description 4
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 claims description 4
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 claims description 4
- 102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 claims description 4
- 108010066327 Keratin-18 Proteins 0.000 claims description 4
- 108010070511 Keratin-8 Proteins 0.000 claims description 4
- 102000004140 Oncostatin M Human genes 0.000 claims description 4
- 108090000630 Oncostatin M Proteins 0.000 claims description 4
- 108700008625 Reporter Genes Proteins 0.000 claims description 4
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims description 4
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims description 4
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims description 4
- 108010006523 asialoglycoprotein receptor Proteins 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 230000000144 pharmacologic effect Effects 0.000 claims description 4
- 230000002110 toxicologic effect Effects 0.000 claims description 4
- 231100000759 toxicological effect Toxicity 0.000 claims description 4
- DVKQVRZMKBDMDH-UUOKFMHZSA-N 8-Br-cAMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Br DVKQVRZMKBDMDH-UUOKFMHZSA-N 0.000 claims description 2
- 101150037123 APOE gene Proteins 0.000 claims description 2
- 101710187578 Alcohol dehydrogenase 1 Proteins 0.000 claims description 2
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 claims description 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims description 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims description 2
- 102100029470 Apolipoprotein E Human genes 0.000 claims description 2
- 102100021723 Arginase-1 Human genes 0.000 claims description 2
- 101710129000 Arginase-1 Proteins 0.000 claims description 2
- 102000007990 Organic Anion Transporters Human genes 0.000 claims description 2
- 108010089503 Organic Anion Transporters Proteins 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 210000000941 bile Anatomy 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 238000001784 detoxification Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 230000000877 morphologic effect Effects 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 239000002676 xenobiotic agent Substances 0.000 claims description 2
- 230000002034 xenobiotic effect Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768301P | 2013-02-22 | 2013-02-22 | |
| US61/768,301 | 2013-02-22 | ||
| PCT/US2014/017588 WO2014130770A1 (en) | 2013-02-22 | 2014-02-21 | Hepatocyte production via forward programming by combined genetic and chemical engineering |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508726A JP2016508726A (ja) | 2016-03-24 |
| JP2016508726A5 true JP2016508726A5 (OSRAM) | 2016-12-01 |
Family
ID=50336502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558982A Pending JP2016508726A (ja) | 2013-02-22 | 2014-02-21 | 組み合わせた遺伝的および化学的操作によるフォワードプログラミングを介した肝細胞の産生 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140242595A1 (OSRAM) |
| EP (1) | EP2958992A1 (OSRAM) |
| JP (1) | JP2016508726A (OSRAM) |
| CN (1) | CN105229144A (OSRAM) |
| AU (1) | AU2014218807A1 (OSRAM) |
| CA (1) | CA2901747A1 (OSRAM) |
| IL (1) | IL240747A0 (OSRAM) |
| WO (1) | WO2014130770A1 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| CN104830906B (zh) * | 2014-02-12 | 2018-09-04 | 北京维通达生物技术有限公司 | 一种重编程获得功能性人肝脏实质细胞的方法 |
| SG11201704291QA (en) | 2014-11-26 | 2017-06-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| CA2976376A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| US10006084B2 (en) | 2015-04-30 | 2018-06-26 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| WO2017043647A1 (ja) * | 2015-09-11 | 2017-03-16 | 国立研究開発法人理化学研究所 | 転写因子結合部位特異的なｄｎａ脱メチル化方法 |
| US10093903B2 (en) | 2015-10-19 | 2018-10-09 | FUJIFILM Cellular Dynamics, Inc. | Production of virus-receptive pluripotent stem cell (PSC)-derived hepatocytes |
| EP3397753B1 (en) | 2015-12-30 | 2021-10-27 | FUJIFILM Cellular Dynamics, Inc. | Microtissue formation using stem cell-derived human hepatocytes |
| AU2016402370B2 (en) * | 2016-04-15 | 2023-07-06 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| US10576167B2 (en) | 2016-08-17 | 2020-03-03 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CN108060120B (zh) * | 2016-11-07 | 2022-11-04 | 云南济慈再生医学研究院有限公司 | 用于分化的细胞重编程的小分子化合物组合、试剂盒及应用 |
| JP2019535272A (ja) * | 2016-11-16 | 2019-12-12 | アリール バイオテクノロジー アンド ファーマシューティカルズ， インコーポレイテッド | Ｒｎａでの幹細胞分化による肝細胞の誘導 |
| WO2019070888A1 (en) * | 2017-10-03 | 2019-04-11 | Children's Hospital And Clinics Of Minnesota | VECTORS AND METHODS OF USE |
| EP3749756A4 (en) * | 2018-02-05 | 2021-12-08 | Audentes Therapeutics, Inc. | ELEMENTS OF TRANSCRIPTION REGULATION AND ASSOCIATED USES |
| CN110055217B (zh) * | 2019-01-29 | 2021-03-30 | 中国人民解放军军事科学院军事医学研究院 | 获得巨核细胞及血小板的方法 |
| CN114450265B (zh) | 2019-07-03 | 2024-12-24 | 菲克特生物科学股份有限公司 | 阳离子脂质及其用途 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN111004770B (zh) * | 2019-09-25 | 2022-08-23 | 中国人民解放军军事科学院军事医学研究院 | 功能性肝细胞诱导方法及其专用三维诱导培养基和应用 |
| US20220409670A1 (en) * | 2019-11-20 | 2022-12-29 | Cornell University | Generation of kidney glomerular specific endothelial cells and methods of use |
| CN114480253B (zh) * | 2022-01-30 | 2023-02-28 | 深圳市三启生物技术有限公司 | 多能干细胞定向诱导分化为肝细胞的培养基及培养方法和用途 |
| CN114480495A (zh) * | 2022-02-14 | 2022-05-13 | 深圳市三启生物技术有限公司 | 一种alb融合蛋白的表达方法及其应用 |
| WO2025096798A2 (en) * | 2023-10-31 | 2025-05-08 | The Children's Medical Center Corporation | Endothelial cell factors and methods thereof |
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-
2014
- 2014-02-21 EP EP14711342.7A patent/EP2958992A1/en not_active Withdrawn
- 2014-02-21 CN CN201480022500.3A patent/CN105229144A/zh active Pending
- 2014-02-21 US US14/186,620 patent/US20140242595A1/en not_active Abandoned
- 2014-02-21 JP JP2015558982A patent/JP2016508726A/ja active Pending
- 2014-02-21 WO PCT/US2014/017588 patent/WO2014130770A1/en not_active Ceased
- 2014-02-21 AU AU2014218807A patent/AU2014218807A1/en not_active Abandoned
- 2014-02-21 CA CA2901747A patent/CA2901747A1/en not_active Abandoned
-
2015
- 2015-08-20 IL IL240747A patent/IL240747A0/en unknown
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