IL240747A0 - Production of the phosit through preliminary programming by combined genetic and chemical engineering - Google Patents
Production of the phosit through preliminary programming by combined genetic and chemical engineeringInfo
- Publication number
- IL240747A0 IL240747A0 IL240747A IL24074715A IL240747A0 IL 240747 A0 IL240747 A0 IL 240747A0 IL 240747 A IL240747 A IL 240747A IL 24074715 A IL24074715 A IL 24074715A IL 240747 A0 IL240747 A0 IL 240747A0
- Authority
- IL
- Israel
- Prior art keywords
- chemical engineering
- production via
- via forward
- forward programming
- combined genetic
- Prior art date
Links
- 238000003889 chemical engineering Methods 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 238000010353 genetic engineering Methods 0.000 title 1
- 210000003494 hepatocyte Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/237—Oncostatin M [OSM]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768301P | 2013-02-22 | 2013-02-22 | |
| PCT/US2014/017588 WO2014130770A1 (en) | 2013-02-22 | 2014-02-21 | Hepatocyte production via forward programming by combined genetic and chemical engineering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL240747A0 true IL240747A0 (en) | 2015-10-29 |
Family
ID=50336502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL240747A IL240747A0 (en) | 2013-02-22 | 2015-08-20 | Production of the phosit through preliminary programming by combined genetic and chemical engineering |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140242595A1 (OSRAM) |
| EP (1) | EP2958992A1 (OSRAM) |
| JP (1) | JP2016508726A (OSRAM) |
| CN (1) | CN105229144A (OSRAM) |
| AU (1) | AU2014218807A1 (OSRAM) |
| CA (1) | CA2901747A1 (OSRAM) |
| IL (1) | IL240747A0 (OSRAM) |
| WO (1) | WO2014130770A1 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| CN104830906B (zh) * | 2014-02-12 | 2018-09-04 | 北京维通达生物技术有限公司 | 一种重编程获得功能性人肝脏实质细胞的方法 |
| SG10202009095VA (en) | 2014-11-26 | 2020-10-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| JP7199809B2 (ja) | 2015-02-13 | 2023-01-06 | ファクター バイオサイエンス インコーポレイテッド | 核酸製品及びその投与方法 |
| US10006084B2 (en) | 2015-04-30 | 2018-06-26 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| JP6937513B2 (ja) * | 2015-09-11 | 2021-09-22 | 国立研究開発法人理化学研究所 | 転写因子結合部位特異的なｄｎａ脱メチル化方法 |
| JP6800987B2 (ja) | 2015-10-19 | 2020-12-16 | フジフィルム セルラー ダイナミクス，インコーポレイテッド | ウイルス受容性多能性幹細胞（ｐｓｃ）由来肝細胞の生産 |
| WO2017117333A1 (en) | 2015-12-30 | 2017-07-06 | Cellular Dynamics International, Inc. | Microtissue formation using stem cell-derived human hepatocytes |
| CA2983930C (en) * | 2016-04-15 | 2023-05-02 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| EP3500585A4 (en) | 2016-08-17 | 2020-04-01 | Factor Bioscience Inc. | NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION |
| CN108060120B (zh) * | 2016-11-07 | 2022-11-04 | 云南济慈再生医学研究院有限公司 | 用于分化的细胞重编程的小分子化合物组合、试剂盒及应用 |
| TWI882943B (zh) * | 2016-11-16 | 2025-05-11 | 美商綠陽生物科技及製藥公司 | 以rna藉由幹細胞分化誘導肝細胞 |
| EP3692141A1 (en) * | 2017-10-03 | 2020-08-12 | Children's Hospital and Clinics of Minnesota | Vectors and methods of use |
| EP3749756A4 (en) * | 2018-02-05 | 2021-12-08 | Audentes Therapeutics, Inc. | ELEMENTS OF TRANSCRIPTION REGULATION AND ASSOCIATED USES |
| CN110055217B (zh) * | 2019-01-29 | 2021-03-30 | 中国人民解放军军事科学院军事医学研究院 | 获得巨核细胞及血小板的方法 |
| CN114450265B (zh) | 2019-07-03 | 2024-12-24 | 菲克特生物科学股份有限公司 | 阳离子脂质及其用途 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN111004770B (zh) * | 2019-09-25 | 2022-08-23 | 中国人民解放军军事科学院军事医学研究院 | 功能性肝细胞诱导方法及其专用三维诱导培养基和应用 |
| EP4061400A4 (en) * | 2019-11-20 | 2024-01-10 | Cornell University | Generation of kidney glomerular specific endothelial cells and methods of use |
| CN114480253B (zh) * | 2022-01-30 | 2023-02-28 | 深圳市三启生物技术有限公司 | 多能干细胞定向诱导分化为肝细胞的培养基及培养方法和用途 |
| CN114480495A (zh) * | 2022-02-14 | 2022-05-13 | 深圳市三启生物技术有限公司 | 一种alb融合蛋白的表达方法及其应用 |
| WO2025096798A2 (en) * | 2023-10-31 | 2025-05-08 | The Children's Medical Center Corporation | Endothelial cell factors and methods thereof |
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| EP3586868B1 (en) | 2008-04-22 | 2023-11-08 | Vib Vzw | Liver-specific nucleic acid regulatory elements and methods and use thereof |
| US8278105B2 (en) * | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| EP3260534A1 (en) * | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| EP2558569A4 (en) * | 2010-04-13 | 2014-03-05 | Cellular Dynamics Int Inc | HEPATOCYTE PRODUCTION BY ADVANCED PROGRAMMING |
| AU2010363437B2 (en) * | 2010-11-01 | 2015-11-19 | Kabushiki Kaisha Maghouse | Soil improvement device |
| JP6124347B2 (ja) * | 2011-08-02 | 2017-05-10 | 石川 哲也 | ＴＧＦ−βシグナリング阻害剤および／またはＹ−２７６３２による肝前駆細胞の誘導方法および製造方法、並びに当該肝前駆細胞から肝細胞の製造方法 |
-
2014
- 2014-02-21 CN CN201480022500.3A patent/CN105229144A/zh active Pending
- 2014-02-21 AU AU2014218807A patent/AU2014218807A1/en not_active Abandoned
- 2014-02-21 CA CA2901747A patent/CA2901747A1/en not_active Abandoned
- 2014-02-21 JP JP2015558982A patent/JP2016508726A/ja active Pending
- 2014-02-21 EP EP14711342.7A patent/EP2958992A1/en not_active Withdrawn
- 2014-02-21 WO PCT/US2014/017588 patent/WO2014130770A1/en not_active Ceased
- 2014-02-21 US US14/186,620 patent/US20140242595A1/en not_active Abandoned
-
2015
- 2015-08-20 IL IL240747A patent/IL240747A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014130770A1 (en) | 2014-08-28 |
| US20140242595A1 (en) | 2014-08-28 |
| AU2014218807A1 (en) | 2015-09-03 |
| JP2016508726A (ja) | 2016-03-24 |
| CA2901747A1 (en) | 2014-08-28 |
| EP2958992A1 (en) | 2015-12-30 |
| CN105229144A (zh) | 2016-01-06 |
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