SG10202009095VA - Induced hepatocytes and uses thereof - Google Patents

Induced hepatocytes and uses thereof

Info

Publication number
SG10202009095VA
SG10202009095VA SG10202009095VA SG10202009095VA SG10202009095VA SG 10202009095V A SG10202009095V A SG 10202009095VA SG 10202009095V A SG10202009095V A SG 10202009095VA SG 10202009095V A SG10202009095V A SG 10202009095VA SG 10202009095V A SG10202009095V A SG 10202009095VA
Authority
SG
Singapore
Prior art keywords
induced hepatocytes
hepatocytes
induced
Prior art date
Application number
SG10202009095VA
Inventor
Jau-Nan Lee
Tony Tung-Yin Lee
Yuta Lee
Eing-Mei Tsai
Original Assignee
Accelerated Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accelerated Biosciences Corp filed Critical Accelerated Biosciences Corp
Publication of SG10202009095VA publication Critical patent/SG10202009095VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/237—Oncostatin M [OSM]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65—MicroRNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
SG10202009095VA 2014-11-26 2015-11-25 Induced hepatocytes and uses thereof SG10202009095VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462085185P 2014-11-26 2014-11-26

Publications (1)

Publication Number Publication Date
SG10202009095VA true SG10202009095VA (en) 2020-10-29

Family

ID=56075041

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201704291QA SG11201704291QA (en) 2014-11-26 2015-11-25 Induced hepatocytes and uses thereof
SG10202009095VA SG10202009095VA (en) 2014-11-26 2015-11-25 Induced hepatocytes and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201704291QA SG11201704291QA (en) 2014-11-26 2015-11-25 Induced hepatocytes and uses thereof

Country Status (9)

Country Link
US (5) US9808490B2 (en)
EP (1) EP3224347A4 (en)
JP (3) JP6836990B2 (en)
CN (1) CN107208054B (en)
AU (1) AU2015353521B2 (en)
CA (2) CA2968065C (en)
GB (1) GB2548059B (en)
SG (2) SG11201704291QA (en)
WO (1) WO2016086132A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011329002C1 (en) 2010-11-15 2017-05-25 Accelerated Biosciences Corp. Generation of neural stem cells from human trophoblast stem cells
JP6457947B2 (en) 2012-11-30 2019-01-23 アクセラレイテッド・バイオサイエンシズ・コーポレーション Method for differentiating stem cells by regulating miR-124
SG11201704291QA (en) 2014-11-26 2017-06-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
GB201614455D0 (en) 2016-08-24 2016-10-05 Univ Oxford Innovation Ltd Biomarkers
CN117229994A (en) * 2016-11-04 2023-12-15 儿童医院医学中心 Liver organoid disease model and methods of making and using the same
GB201622149D0 (en) * 2016-12-23 2017-02-08 Insphero Ag Screenable liver disease models and methods
GB201900741D0 (en) * 2019-01-18 2019-03-06 Synpromics Ltd Liver-specifc inducible prometers and methods of use thereof
KR20210155390A (en) * 2019-04-11 2021-12-22 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Minimally Invasive Cell Transplantation Procedure to Induce Development of Organogenesis in Vivo
CN111808915B (en) * 2019-04-12 2023-04-25 郑州大学 Relevant enzyme metabolic activity detection kit and application thereof
CA3138884A1 (en) * 2019-05-06 2020-11-12 Accelerated Biosciences Corp. Precursory regulatory cytotrophoblast cells and uses thereof
CN110973060B (en) * 2019-12-06 2021-10-22 武汉大学 Animal model of fetal-derived adult cholestatic liver injury, specific biomarker and application thereof
CN111979179B (en) * 2020-08-24 2022-12-27 扬州大学 Pig liver tissue organoid model and in-vitro construction method thereof
CN112725260B (en) * 2021-01-15 2022-10-14 北京大学 Method for obtaining hepatic stellate cells from embryonic stem cell differentiation
JP2022158210A (en) * 2021-04-01 2022-10-17 国立大学法人大阪大学 Method for producing cell aggregate
CN113564098B (en) * 2021-06-15 2022-07-08 广东乾晖生物科技有限公司 Culture method for enhancing hepatocyte functionality and hepatocyte culture solution used in culture method
CN114588320B (en) * 2022-01-25 2023-01-13 北京唐颐惠康生物医学技术有限公司 Composite coating stent and preparation method thereof
CN115651893B (en) * 2022-11-18 2023-11-07 中国水产科学研究院黑龙江水产研究所 Construction method and application of rainbow trout ovary granule cell line

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2545100B1 (en) * 1983-04-29 1985-12-20 Inst Nat Sante Rech Med PROCESS FOR OBTAINING CULTURES OF HUMAN HEPATOCYTES, THE CULTURES OBTAINED AND THEIR BIOLOGICAL AND BIOCHEMICAL APPLICATIONS
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
DE69233087T2 (en) 1991-11-22 2003-12-24 Affymetrix Inc N D Ges D Staat Process for the production of polymer arrays
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6330349B1 (en) 1995-11-30 2001-12-11 Chromavision Medical Systems, Inc. Automated method for image analysis of residual protein
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc Nucleic acid analysis techniques
US6033860A (en) 1997-10-31 2000-03-07 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
CA2345397A1 (en) 1998-09-23 2000-03-30 Mount Sinai Hospital Trophoblast cell preparations
US20020187133A1 (en) * 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
US20010046489A1 (en) 1999-12-06 2001-11-29 Habener Joel E. Stem cells of the islets of langerhans and their use in treating diabetes mellitus
US20030175255A1 (en) * 2000-10-03 2003-09-18 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
CN1258589C (en) 2000-10-03 2006-06-07 北卡罗来纳大学 Method of isolating bipotent hepatic progenitor cells
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
AU2002319780A1 (en) 2001-08-06 2003-02-24 Bresagen, Ltd. Alternative compositions and methods for the culture of stem cells
BR0212098A (en) 2001-08-23 2004-08-03 Reliance Life Sciences Pvt Ltd Internal cell mass isolation method for the establishment of human embryonic stem cell lines (hesc)
CN1194086C (en) 2002-02-01 2005-03-23 北京科宇联合干细胞生物技术有限公司 Neural stem cell preparation, preparing method thereof and use of same
EP1540348A4 (en) * 2002-08-27 2006-10-11 Stemcells California Inc Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
JP2006509497A (en) 2002-09-24 2006-03-23 ニューロ セラピューティクス エービー Methods and substances related to neurogenesis
US8029984B2 (en) 2003-08-08 2011-10-04 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis and therapy
JP2005087018A (en) 2003-09-12 2005-04-07 Kaneka Corp New neural stem cell marker
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
AU2004309421B2 (en) 2003-12-23 2011-04-21 Viacyte, Inc. Definitive endoderm
US7642091B2 (en) 2005-02-24 2010-01-05 Jau-Nan Lee Human trophoblast stem cells and use thereof
ITMI20051248A1 (en) 2005-07-01 2007-01-02 Vimar Spa MODEM FOR BUS FOR CIVIL AND INDUSTRIAL ELECTRICAL SYSTEMS
KR20080075494A (en) 2005-09-21 2008-08-18 다스크 테크날러지, 엘엘씨 Methods and compositions for organ and tissue functionality
DE602006020071D1 (en) * 2005-12-21 2011-03-24 Univ Catholique Louvain ISOLATED LIVESTOCK CELLS
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
JP5421767B2 (en) 2006-04-10 2014-02-19 ウィスコンシン・アルムニ・リサーチ・ファウンデーション Reagents and methods for assessing the toxicity of pharmaceutical compounds and other chemicals using human embryonic stem cells
US20090208466A1 (en) 2006-04-21 2009-08-20 James Yoo Ink-jet printing of tissues
US20070259423A1 (en) 2006-05-02 2007-11-08 Jon Odorico Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
EP2024492B1 (en) * 2006-06-02 2017-03-29 Asterias Biotherapeutics, Inc. Differentiation of primate pluripotent cells to hepatocyte-lineage cells
RU2009102643A (en) 2006-06-28 2010-08-10 Дзе Юниверсити Оф Канзас (Us) DIFFERENTIATION OF STEM CELLS FROM THE URBINE MATRIX TO CELLS OF THE HEPATOCYTES LINE
WO2008013664A2 (en) 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
CN102083967B (en) * 2007-07-20 2013-05-15 塞拉提斯股份公司 A novel population of hepatocytes derived via definitive endoderm (DE-hep) from human blastocysts stem cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086333A2 (en) * 2007-12-20 2009-07-09 Stemcells California, Inc Antibodies and methods for identifying and tracking engraftment, migratation, and differentiation of human stem, progenitor, and engrafting cell populations
CN101497872B (en) * 2008-02-02 2012-10-03 中国人民解放军军事医学科学院野战输血研究所 Special culture medium of inducing human embryo stem cell
WO2009102484A2 (en) 2008-02-14 2009-08-20 Wake Forest University Health Sciences Inkjet printing of tissues and cells
WO2010060080A1 (en) 2008-11-24 2010-05-27 Immunotrex Corporation Three dimensional tissue generation
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
EP2398897B1 (en) 2009-02-20 2017-06-28 Cellular Dynamics International, Inc. Methods and compositions for the differentiation of stem cells
CN102666855A (en) 2009-06-10 2012-09-12 脑干生物技术有限公司 Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells
JP5736368B2 (en) * 2009-06-25 2015-06-17 コミッサリア ア レネルジ アトミック エ オー エネルジ アルターネイティブスＣｏｍｍｉｓｓａｒｉａｔ Ａ Ｌ’Ｅｎｅｒｇｉｅ Ａｔｏｍｉｑｕｅ Ｅｔ Ａｕｘ Ｅｎｅｒｇｉｅｓ Ａｌｔｅｒｎａｔｉｖｅｓ HLA-G multimeric polypeptide comprising at least two α3 domains and use thereof as a medicament
US20110136162A1 (en) 2009-08-31 2011-06-09 Drexel University Compositions and Methods for Functionalized Patterning of Tissue Engineering Substrates Including Bioprinting Cell-Laden Constructs for Multicompartment Tissue Chambers
WO2011038373A2 (en) 2009-09-28 2011-03-31 Virginia Tech Intellectual Properties, Inc. Three-dimensional bioprinting of biosynthetic cellulose (bc) implants and scaffolds for tissue engineering
MX353245B (en) 2009-10-31 2018-01-08 New World Laboratories Inc Star METHODS FOR REPROGRAMMING CELLS and USES THEREOF.
WO2011054100A1 (en) 2009-11-05 2011-05-12 Lisheng Wang Stem cell extracts and uses thereof for immune modulation
WO2011064549A2 (en) 2009-11-27 2011-06-03 Stem Cells For Safer Medicines Limited Composition and method for differentiation of human embryonic stem cells
US9607202B2 (en) 2009-12-17 2017-03-28 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of generating trophectoderm and neurectoderm from human embryonic stem cells
US9039998B2 (en) 2010-03-04 2015-05-26 Institut National De La Sante Et De La Recherche Medical (Inserm) Bioprinting station, assembly comprising such bioprinting station and bioprinting method
US9267099B2 (en) 2010-03-15 2016-02-23 Indiana University Research And Technology Corporation Engineered lumenized vascular networks and support matrix
MX366709B (en) 2010-08-20 2019-07-22 Rice Univ Star Continuous digital light processing additive manufacturing of implants.
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
EP2629975B1 (en) 2010-10-21 2022-03-09 Organovo, Inc. Devices for the fabrication of tissue
AU2011329002C1 (en) 2010-11-15 2017-05-25 Accelerated Biosciences Corp. Generation of neural stem cells from human trophoblast stem cells
EP2670842A2 (en) * 2011-01-31 2013-12-11 Katholieke Universiteit Leuven KU Leuven Research & Development Methods for making cells with an extra-embryonic endodermal precursor phenotype
US10048668B2 (en) 2011-03-03 2018-08-14 Cornell University Method for specifying and fabricating an object, associated apparatus, and applications
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
US20120277111A1 (en) 2011-04-08 2012-11-01 Crabtree Gerald R MicroRNA Mediated Neuronal Cell Induction
JP2014526318A (en) 2011-09-12 2014-10-06 オルガノボ，インク． Platform for engineered implantable tissues and organs and method of manufacturing the same
DE102011121317A1 (en) * 2011-12-16 2013-06-20 Universitätsklinikum Hamburg-Eppendorf Scaffold-free liver cell aggregates for use in transplantation
TWI449789B (en) 2012-03-29 2014-08-21 Univ Nat Yang Ming Methods for rapid generating mature hepatocytes from human induced pluripotent stem cells, and use thereof for treatment of liver diseases
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
CA2876855A1 (en) 2012-05-30 2013-12-05 New York University Tissue repair devices and scaffolds
US20140099709A1 (en) 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
WO2013189521A1 (en) * 2012-06-19 2013-12-27 Waclawczyk Simon Method of generating cells of hepatocyte phenotype
EP2679669A1 (en) 2012-06-26 2014-01-01 ETH Zurich Fabrication of three-dimensional hydrogel objects
CN105612176B (en) * 2012-07-31 2021-01-19 阿格克斯治疗有限公司 HLA G-modified cells and methods
AU2013312924A1 (en) 2012-09-04 2015-03-19 Anthrogenesis Corporation Methods of tissue generation
JP6457947B2 (en) 2012-11-30 2019-01-23 アクセラレイテッド・バイオサイエンシズ・コーポレーション Method for differentiating stem cells by regulating miR-124
US20140242595A1 (en) * 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
SG11201704291QA (en) 2014-11-26 2017-06-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof

Also Published As

Publication number Publication date
US20230338431A1 (en) 2023-10-26
JP2021072852A (en) 2021-05-13
WO2016086132A1 (en) 2016-06-02
GB2548059B (en) 2020-09-02
AU2015353521B2 (en) 2021-11-04
US9808490B2 (en) 2017-11-07
AU2015353521A1 (en) 2017-06-29
CA2968065C (en) 2024-04-09
EP3224347A1 (en) 2017-10-04
CN107208054A (en) 2017-09-26
US11026979B2 (en) 2021-06-08
EP3224347A4 (en) 2018-08-15
CA2968065A1 (en) 2016-06-02
GB201710061D0 (en) 2017-08-09
JP2018504093A (en) 2018-02-15
US20200345788A1 (en) 2020-11-05
US10765704B2 (en) 2020-09-08
US20180000868A1 (en) 2018-01-04
JP2023030001A (en) 2023-03-07
GB2548059A (en) 2017-09-06
CN107208054B (en) 2021-09-17
US20210330713A1 (en) 2021-10-28
JP6836990B2 (en) 2021-03-03
CA3148687A1 (en) 2016-06-02
US20160199416A1 (en) 2016-07-14
SG11201704291QA (en) 2017-06-29

Similar Documents

Publication Publication Date Title
HK1255067A1 (en) Anti-c10orf54 antibodies and uses thereof
HK1243440A1 (en) Anti-interleukin-33 antibodies and uses thereof
GB2548059B (en) Induced hepatocytes and uses thereof
IL249184B (en) Anti-tnf-alpha glycoantibodies and uses thereof
HK1231471A1 (en) 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof 6-- 6--2-
IL247407B (en) Anti-egfrviii antibodies and uses thereof
IL252216A0 (en) Difluoromethyl-aminopyridines and difluoromethyl-aminopyrimidines
PL3152226T3 (en) Modified cyclopentapeptides and uses thereof
IL251001B (en) Anti-il-25 antibodies and uses thereof
HK1243077A1 (en) Piperidinylpyrazolopyrimidinones and their use
SG11201610514SA (en) Bioreactor and uses thereof
GB201408091D0 (en) Methods and uses
PL3229772T3 (en) 6-aryl-9-glycosylpurines and use thereof
GB201416086D0 (en) Methods and uses
GB201416073D0 (en) Methods and uses
GB201404728D0 (en) Disc-over incorporating disc-heads and disc-earning