JP2016508213A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016508213A5 JP2016508213A5 JP2015545948A JP2015545948A JP2016508213A5 JP 2016508213 A5 JP2016508213 A5 JP 2016508213A5 JP 2015545948 A JP2015545948 A JP 2015545948A JP 2015545948 A JP2015545948 A JP 2015545948A JP 2016508213 A5 JP2016508213 A5 JP 2016508213A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- signal
- probe
- targets
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 54
- 238000000034 method Methods 0.000 claims 41
- 239000012472 biological sample Substances 0.000 claims 14
- 239000003153 chemical reaction reagent Substances 0.000 claims 11
- 230000027756 respiratory electron transport chain Effects 0.000 claims 11
- 239000000654 additive Substances 0.000 claims 10
- 230000000996 additive effect Effects 0.000 claims 10
- 238000004061 bleaching Methods 0.000 claims 9
- 238000012986 modification Methods 0.000 claims 9
- 230000004048 modification Effects 0.000 claims 9
- 230000003287 optical effect Effects 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 230000001678 irradiating effect Effects 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 150000001642 boronic acid derivatives Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000001351 cycling effect Effects 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- -1 amino, hydroxyl Chemical group 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- KUGSJJNCCNSRMM-UHFFFAOYSA-N ethoxyboronic acid Chemical class CCOB(O)O KUGSJJNCCNSRMM-UHFFFAOYSA-N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000002516 radical scavenger Substances 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- BKZXZGWHTRCFPX-UHFFFAOYSA-N 2-tert-butyl-6-methylphenol Chemical compound CC1=CC=CC(C(C)(C)C)=C1O BKZXZGWHTRCFPX-UHFFFAOYSA-N 0.000 claims 1
- FUDBXNPJURCNPC-UHFFFAOYSA-N 6-methylcyclohexa-1,4-diene-1-carboxamide Chemical compound CC1C=CCC=C1C(N)=O FUDBXNPJURCNPC-UHFFFAOYSA-N 0.000 claims 1
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 claims 1
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical group OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000001767 cationic compounds Chemical class 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- CHVJITGCYZJHLR-UHFFFAOYSA-N cyclohepta-1,3,5-triene Chemical compound C1C=CC=CC=C1 CHVJITGCYZJHLR-UHFFFAOYSA-N 0.000 claims 1
- 229960001305 cysteine hydrochloride Drugs 0.000 claims 1
- 239000012973 diazabicyclooctane Substances 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910001411 inorganic cation Inorganic materials 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000877 morphologic effect Effects 0.000 claims 1
- 150000002892 organic cations Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000012284 sample analysis method Methods 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 claims 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735586P | 2012-12-11 | 2012-12-11 | |
| US61/735,586 | 2012-12-11 | ||
| PCT/US2013/074328 WO2014093455A1 (en) | 2012-12-11 | 2013-12-11 | Photoactivated chemical bleaching of dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016508213A JP2016508213A (ja) | 2016-03-17 |
| JP2016508213A5 true JP2016508213A5 (enExample) | 2017-01-26 |
| JP6335187B2 JP6335187B2 (ja) | 2018-05-30 |
Family
ID=49885438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545948A Active JP6335187B2 (ja) | 2012-12-11 | 2013-12-11 | 色素の光活性化型ケミカルブリーチング |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10175174B2 (enExample) |
| EP (1) | EP2932270B1 (enExample) |
| JP (1) | JP6335187B2 (enExample) |
| KR (1) | KR20150095755A (enExample) |
| CN (1) | CN105143885B (enExample) |
| AU (1) | AU2013359393B2 (enExample) |
| BR (1) | BR112015013403A2 (enExample) |
| CA (1) | CA2893953A1 (enExample) |
| NZ (1) | NZ708935A (enExample) |
| RU (1) | RU2015120176A (enExample) |
| SG (1) | SG11201504129SA (enExample) |
| WO (1) | WO2014093455A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014099222A1 (en) * | 2012-12-17 | 2014-06-26 | Clarient Diagnostic Services, Inc. | Chemical bleaching of dyes using radical photoinitiators |
| US10597697B2 (en) * | 2015-02-05 | 2020-03-24 | Ge Healthcare Bio-Sciences Corp. | Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample |
| US20160230960A1 (en) * | 2015-02-06 | 2016-08-11 | Lg Chem, Ltd. | Color conversion film and back light unit and display apparatus comprising the same |
| US10101322B2 (en) | 2015-02-13 | 2018-10-16 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| WO2016128533A1 (en) * | 2015-02-13 | 2016-08-18 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| US9708349B2 (en) | 2015-02-13 | 2017-07-18 | General Electric Company | Borates for photoactivated chemical bleaching |
| WO2017210841A1 (en) | 2016-06-06 | 2017-12-14 | University Of Washington | Nanoparticle transducer sensors and methods of use thereof |
| WO2018094113A1 (en) * | 2016-11-16 | 2018-05-24 | University Of Washington | Systems and methods for cyclic fluorescence imaging |
| CN108226105A (zh) * | 2017-01-14 | 2018-06-29 | 安庆师范大学 | 一种对毒死蜱及其水解产物具有可视化检测的罗丹明b修饰金纳米颗粒探针及其制备方法 |
| EP3427829A1 (en) * | 2017-07-12 | 2019-01-16 | Lunaphore Technologies SA | Methods of in situ antigen retrieval of a biological sample & imaging thereof |
| CN111492241B (zh) * | 2017-09-29 | 2023-04-18 | 由联邦材料研究和检测机构主席所代表的经济与能源部长所代表的德意志联邦共和国 | 检测土壤和水中的烃污染 |
| US11002682B2 (en) * | 2018-03-12 | 2021-05-11 | Ondavia, Inc. | Aldehyde detection and analysis using surface-enhanced Raman spectroscopy |
| US12421266B2 (en) | 2018-09-27 | 2025-09-23 | The Regents Of The University Of California | Diverse and flexible chemical modification of nucleic acids |
| MX2021003771A (es) | 2018-11-30 | 2021-05-27 | Illumina Inc | Analisis de analitos multiples usando un ensayo unico. |
| CN111351924B (zh) * | 2018-12-20 | 2021-05-11 | 中国科学院福建物质结构研究所 | 一种基于酶诱导磷酸根离子激活的近红外荧光免疫分析试剂盒及检测方法 |
| JP7611859B2 (ja) * | 2019-05-20 | 2025-01-10 | インシリクサ， インコーポレイテッド | 光によりトリガーされる核酸構築物および分子検出のための方法 |
| CN121203660A (zh) * | 2024-04-30 | 2025-12-26 | 黄淮学院 | 一种次氯酸检测用红光荧光探针及其应用 |
| WO2026024645A1 (en) * | 2024-07-23 | 2026-01-29 | Bruker Nano, Inc. | Methods and compositions for enhanced and selective photobleaching |
| CN119147342A (zh) * | 2024-11-14 | 2024-12-17 | 江苏凯基生物技术股份有限公司 | 一种增强型抗荧光淬灭的封片剂及其制备方法、封片方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169473A (en) | 1990-05-21 | 1992-12-08 | The Dow Chemical Company | Latent catalysts, epoxy compositions incorporating same, and coating, impregnating and bonding methods employing the compositions |
| SG43193A1 (en) * | 1990-05-21 | 1997-10-17 | Dow Chemical Co | Latent catalysts cure-inhibited epoxy resin compositions and laminates prepared therfrom |
| US6342379B1 (en) * | 1995-06-07 | 2002-01-29 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
| US5661035A (en) | 1995-06-07 | 1997-08-26 | The Regents Of The University Of California | Voltage sensing by fluorescence resonance energy transfer |
| JPH11315117A (ja) | 1998-05-01 | 1999-11-16 | Canon Inc | 高分子化合物、及びこれを合成するために用いる重合性単量体 |
| JP2002531807A (ja) * | 1998-07-10 | 2002-09-24 | アイアトロクエスト コーポレイション | ホトルミネセンス半導体材料 |
| EP1198703A1 (en) | 1998-07-10 | 2002-04-24 | Iatroquest Corporation | Photoluminescent semiconductor materials |
| JP2002365218A (ja) | 2001-04-02 | 2002-12-18 | Mitsubishi Chemicals Corp | 一重項酸素発生量子効率の測定方法および化合物の耐光性試験方法 |
| US7858386B2 (en) * | 2006-03-07 | 2010-12-28 | The United States Of America As Represented By The Secretary Of The Navy | Method of controlling quantum dot photoluminescence and other intrinsic properties through biological specificity |
| US8060348B2 (en) | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| EP2042870A1 (en) * | 2007-09-28 | 2009-04-01 | Fujifilm Corporation | Method of high sensitive immunoassay |
| US20090234202A1 (en) * | 2008-03-05 | 2009-09-17 | Goix Philippe J | Method and compositions for highly sensitive detection of molecules |
| US20090253163A1 (en) | 2008-04-02 | 2009-10-08 | General Electric Company | Iterative staining of biological samples |
| US20090263612A1 (en) * | 2008-04-18 | 2009-10-22 | Nbc Universal, Inc. | System and Method for Photobleaching of Optical Media |
| JP5730311B2 (ja) * | 2009-08-31 | 2015-06-10 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 反応性シアニン化合物 |
| US8673643B2 (en) | 2010-11-30 | 2014-03-18 | General Electric Company | Closed loop monitoring of automated molecular pathology system |
| US8568991B2 (en) * | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| US8900529B2 (en) | 2012-04-27 | 2014-12-02 | General Electric Company | Microfluidic chamber device and fabrication |
-
2013
- 2013-12-11 US US14/648,176 patent/US10175174B2/en active Active
- 2013-12-11 EP EP13814736.8A patent/EP2932270B1/en active Active
- 2013-12-11 KR KR1020157018103A patent/KR20150095755A/ko not_active Withdrawn
- 2013-12-11 WO PCT/US2013/074328 patent/WO2014093455A1/en not_active Ceased
- 2013-12-11 SG SG11201504129SA patent/SG11201504129SA/en unknown
- 2013-12-11 CN CN201380072726.XA patent/CN105143885B/zh active Active
- 2013-12-11 RU RU2015120176A patent/RU2015120176A/ru not_active Application Discontinuation
- 2013-12-11 CA CA2893953A patent/CA2893953A1/en active Pending
- 2013-12-11 NZ NZ708935A patent/NZ708935A/en not_active IP Right Cessation
- 2013-12-11 AU AU2013359393A patent/AU2013359393B2/en not_active Ceased
- 2013-12-11 JP JP2015545948A patent/JP6335187B2/ja active Active
- 2013-12-11 BR BR112015013403A patent/BR112015013403A2/pt not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015120176A (ru) | Фотоактивированное химическое обесцвечивание красителей | |
| JP2015506469A5 (enExample) | ||
| RU2014124974A (ru) | Фотоактивируемое химическое обесцвечивание красителей | |
| JP6433901B2 (ja) | 光透過性に優れた生物材料を調製するための組成物およびその利用 | |
| Wang et al. | Rapid sequential in situ multiplexing with DNA exchange imaging in neuronal cells and tissues | |
| JP6475718B2 (ja) | 定量的なｄｎａベースのイメージング及び超解像イメージング | |
| JP7068354B2 (ja) | システムレベル較正 | |
| Kumar et al. | FLIM FRET technology for drug discovery: Automated multiwell‐plate high‐content analysis, multiplexed readouts and application in situ | |
| Carrasco et al. | Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis | |
| CN103562702A (zh) | 生物材料用透明化试剂、及其利用 | |
| JP2016513794A (ja) | Ｈ＆ｅ染色された生体試料を分析する方法 | |
| JP2020519852A (ja) | 蛍光画像における標的分子密度決定 | |
| JP6966435B2 (ja) | 断層撮影の結像方法 | |
| KR20150024423A (ko) | 생물학적 시료의 처리 및 촬영을 위한 시스템 및 방법 | |
| CN105623645A (zh) | 一种基于聚集诱导发光原理的荧光探针及其制备方法、应用和检测内毒素方法 | |
| US20130178392A1 (en) | Methods of analyzing an h&e stained biological sample | |
| JP6950922B2 (ja) | 染色方法、染色剤、及び染色キット | |
| Burgin et al. | Absolute quantification of protein copy number using a single-molecule-sensitive microarray | |
| JP2006038816A (ja) | マイクロアレイ読取装置 | |
| JP2023507809A (ja) | Ｒｎａ検出 | |
| Woods et al. | Tracking protein dynamics with photoconvertible Dendra2 on spinning disk confocal systems | |
| JP2016048232A (ja) | 癌の検出方法、及び癌の検出装置 | |
| Kelly et al. | An automated multiwell plate reading FLIM microscope for live cell autofluorescence lifetime assays | |
| CN109369455A (zh) | 一种双光子近红外双大斯托克斯位移荧光染料及其合成方法与应用 | |
| RU2490635C1 (ru) | Усовершенствованный способ приготовления препаратов фиксированных клеток для флуоресцентной in situ гибридизации |