JP2015506469A5 - - Google Patents
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- Publication number
- JP2015506469A5 JP2015506469A5 JP2014549074A JP2014549074A JP2015506469A5 JP 2015506469 A5 JP2015506469 A5 JP 2015506469A5 JP 2014549074 A JP2014549074 A JP 2014549074A JP 2014549074 A JP2014549074 A JP 2014549074A JP 2015506469 A5 JP2015506469 A5 JP 2015506469A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- probes
- probe
- signal
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 20
- 239000012472 biological sample Substances 0.000 claims 9
- 230000003287 optical effect Effects 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 230000027756 respiratory electron transport chain Effects 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 230000001678 irradiating effect Effects 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- -1 amino, hydroxyl Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001642 boronic acid derivatives Chemical group 0.000 claims 2
- 150000001767 cationic compounds Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910001411 inorganic cation Inorganic materials 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000005562 fading Methods 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 150000002892 organic cations Chemical class 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000012284 sample analysis method Methods 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/336,409 US8568991B2 (en) | 2011-12-23 | 2011-12-23 | Photoactivated chemical bleaching of dyes |
| US13/336,409 | 2011-12-23 | ||
| PCT/US2012/067527 WO2013095896A1 (en) | 2011-12-23 | 2012-12-03 | Photoactivated chemical bleaching of dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506469A JP2015506469A (ja) | 2015-03-02 |
| JP2015506469A5 true JP2015506469A5 (enExample) | 2016-01-28 |
| JP6148682B2 JP6148682B2 (ja) | 2017-06-14 |
Family
ID=48655136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549074A Active JP6148682B2 (ja) | 2011-12-23 | 2012-12-03 | 色素の光活性化型化学退色 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8568991B2 (enExample) |
| EP (1) | EP2794908B1 (enExample) |
| JP (1) | JP6148682B2 (enExample) |
| KR (1) | KR102046194B1 (enExample) |
| CN (1) | CN104114713B (enExample) |
| AU (1) | AU2012355736B2 (enExample) |
| BR (1) | BR112014015603B1 (enExample) |
| CA (1) | CA2860097C (enExample) |
| RU (1) | RU2623880C2 (enExample) |
| SG (1) | SG11201403460SA (enExample) |
| WO (1) | WO2013095896A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3098487B2 (ja) | 1998-01-29 | 2000-10-16 | 日本電気株式会社 | 光ケーブル導入構造及び光ケーブル導入接続方法 |
| SG11201406104QA (en) | 2012-03-30 | 2014-10-30 | Clarient Diagnostic Services Inc | Methods for generating an image of a biological sample |
| BR112015013403A2 (pt) * | 2012-12-11 | 2017-07-11 | Clarient Diagnostic Services Inc | métodos para sondar alvos múltiplos em uma amostra biológica, para analisar amostra biológica de multiplexação de alto rendimento e para usar um kit, série de pelo menos duas imagens que representam alvos biológicos opticamente marcados, kit para alvejar um sinal para sondar alvos múltiplos em uma amostra biológica, e, processo automatizado para alvejamento químico fotoativado de uma amostra biológica |
| US10677802B2 (en) * | 2012-12-17 | 2020-06-09 | Ge Healthcare Bio-Sciences Corp. | Chemical bleaching of dyes using radical photoinitiators |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| EP3105354B1 (en) * | 2014-02-12 | 2020-05-06 | The Trustees of Columbia University in the City of New York | Single molecule electronic multiplex snp assay and pcr analysis |
| EP3256857B1 (en) * | 2015-02-13 | 2019-07-24 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| US9708349B2 (en) | 2015-02-13 | 2017-07-18 | General Electric Company | Borates for photoactivated chemical bleaching |
| US10101322B2 (en) | 2015-02-13 | 2018-10-16 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| CN105044059B (zh) * | 2015-07-13 | 2017-08-29 | 深圳市瀚海基因生物科技有限公司 | 一种可用于减缓单分子荧光漂白现象的除氧试剂及其应用方法 |
| US20170241911A1 (en) * | 2016-02-22 | 2017-08-24 | Miltenyi Biotec Gmbh | Automated analysis tool for biological specimens |
| US10371610B2 (en) | 2016-02-23 | 2019-08-06 | Noul Co., Ltd. | Contact-type patch, staining method using the same, and manufacturing method thereof |
| KR102478639B1 (ko) | 2016-02-23 | 2022-12-19 | 노을 주식회사 | 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치 |
| KR20170099739A (ko) | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법 |
| JP2020513796A (ja) | 2016-11-16 | 2020-05-21 | ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ | サイクリック蛍光イメージングのためのシステムおよび方法 |
| CZ309221B6 (cs) * | 2018-09-27 | 2022-06-01 | Mendelova Univerzita V Brně | Způsob identifikace přírodních vzorků, zejména kapalných |
| WO2023091909A1 (en) | 2021-11-16 | 2023-05-25 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| US20230140613A1 (en) * | 2022-03-30 | 2023-05-04 | Hasan Bagheri | Colorimetric system for detection of covid-19 using exhaled breath metabolites |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78065B (enExample) | 1982-02-19 | 1984-09-26 | Unilever Nv | |
| DK39592D0 (da) | 1992-03-25 | 1992-03-25 | Safefood Micro Systsm As | Method of detecting microorganisms |
| US6451551B1 (en) | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
| CA2235738C (en) | 1995-11-22 | 2005-07-26 | Minimed, Inc. | Detection of biological molecules using chemical amplification and optical sensors |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| EP1234026B1 (en) | 1999-11-30 | 2011-08-17 | Cyntellect, Inc. | Method and apparatus for selectively targeting specific cells within a cell population |
| DE10014685B4 (de) | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
| AU2001253193A1 (en) | 2000-04-04 | 2001-10-15 | The Regents Of The University Of California | Fluorescent lifetime assays for non-invasive quantification of analytes |
| US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US7470420B2 (en) * | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| DE10117430A1 (de) | 2001-04-06 | 2002-10-10 | Nicole Marme | Hochempfindlicher und hochspezifischer Enzymnachweis mit einer Nachweisgrenze bis in den femtomolaren Bereich |
| US7045361B2 (en) | 2001-09-12 | 2006-05-16 | Medtronic Minimed, Inc. | Analyte sensing via acridine-based boronate biosensors |
| US8062897B2 (en) | 2003-07-21 | 2011-11-22 | Aureon Laboratories, Inc. | Diagnostic histopathology using multiplex gene expression FISH |
| RU2305270C2 (ru) | 2005-05-18 | 2007-08-27 | Андрей Алексеевич Климов | Способ флуоресцентной наноскопии (варианты) |
| JP5406019B2 (ja) | 2006-05-17 | 2014-02-05 | セルーメン、インコーポレイテッド | 自動化組織分析のための方法 |
| US7993927B2 (en) | 2006-07-03 | 2011-08-09 | Beth Israel Deaconess Medical Center, Inc. | Histology methods |
| US8060348B2 (en) | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US20080032321A1 (en) | 2006-08-07 | 2008-02-07 | General Electric Company | System and methods for analyzing images of tissue samples |
| US8131476B2 (en) | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US20080124310A1 (en) | 2006-11-01 | 2008-05-29 | Marshall John G | Bead based receptor biology |
| US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| US7741045B2 (en) | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US20100216652A1 (en) | 2007-04-25 | 2010-08-26 | The Trustees Of The Universit Of Pennsylvania | Low Level Fluorescence Detection at the Light Microscopic Level |
| US7714303B2 (en) | 2007-05-10 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for analyzing fluorescent materials with reduced authofluorescence |
| US20090263612A1 (en) | 2008-04-18 | 2009-10-22 | Nbc Universal, Inc. | System and Method for Photobleaching of Optical Media |
| US9677125B2 (en) | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| EP2601513B1 (en) | 2010-08-05 | 2014-05-14 | Cambridge Research & Instrumentation, Inc. | Enhancing visual assessment of samples |
| US20140024024A1 (en) | 2012-07-17 | 2014-01-23 | General Electric Company | Methods of detecting dna, rna and protein in biological samples |
-
2011
- 2011-12-23 US US13/336,409 patent/US8568991B2/en not_active Expired - Fee Related
-
2012
- 2012-12-03 WO PCT/US2012/067527 patent/WO2013095896A1/en not_active Ceased
- 2012-12-03 CA CA2860097A patent/CA2860097C/en active Active
- 2012-12-03 BR BR112014015603A patent/BR112014015603B1/pt not_active IP Right Cessation
- 2012-12-03 AU AU2012355736A patent/AU2012355736B2/en not_active Ceased
- 2012-12-03 KR KR1020147020366A patent/KR102046194B1/ko not_active Expired - Fee Related
- 2012-12-03 EP EP12860159.8A patent/EP2794908B1/en active Active
- 2012-12-03 CN CN201280070449.4A patent/CN104114713B/zh active Active
- 2012-12-03 RU RU2014124974A patent/RU2623880C2/ru active
- 2012-12-03 JP JP2014549074A patent/JP6148682B2/ja active Active
- 2012-12-03 SG SG11201403460SA patent/SG11201403460SA/en unknown
-
2013
- 2013-08-27 US US14/010,889 patent/US9250245B2/en active Active
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