CN104114713B - 染料的光敏化化学漂白 - Google Patents
染料的光敏化化学漂白 Download PDFInfo
- Publication number
- CN104114713B CN104114713B CN201280070449.4A CN201280070449A CN104114713B CN 104114713 B CN104114713 B CN 104114713B CN 201280070449 A CN201280070449 A CN 201280070449A CN 104114713 B CN104114713 B CN 104114713B
- Authority
- CN
- China
- Prior art keywords
- sample
- signal
- probe
- signal generator
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/336,409 US8568991B2 (en) | 2011-12-23 | 2011-12-23 | Photoactivated chemical bleaching of dyes |
| US13/336409 | 2011-12-23 | ||
| US13/336,409 | 2011-12-23 | ||
| PCT/US2012/067527 WO2013095896A1 (en) | 2011-12-23 | 2012-12-03 | Photoactivated chemical bleaching of dyes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104114713A CN104114713A (zh) | 2014-10-22 |
| CN104114713B true CN104114713B (zh) | 2018-04-03 |
Family
ID=48655136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280070449.4A Active CN104114713B (zh) | 2011-12-23 | 2012-12-03 | 染料的光敏化化学漂白 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8568991B2 (enExample) |
| EP (1) | EP2794908B1 (enExample) |
| JP (1) | JP6148682B2 (enExample) |
| KR (1) | KR102046194B1 (enExample) |
| CN (1) | CN104114713B (enExample) |
| AU (1) | AU2012355736B2 (enExample) |
| BR (1) | BR112014015603B1 (enExample) |
| CA (1) | CA2860097C (enExample) |
| RU (1) | RU2623880C2 (enExample) |
| SG (1) | SG11201403460SA (enExample) |
| WO (1) | WO2013095896A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3098487B2 (ja) | 1998-01-29 | 2000-10-16 | 日本電気株式会社 | 光ケーブル導入構造及び光ケーブル導入接続方法 |
| SG11201406104QA (en) | 2012-03-30 | 2014-10-30 | Clarient Diagnostic Services Inc | Methods for generating an image of a biological sample |
| BR112015013403A2 (pt) * | 2012-12-11 | 2017-07-11 | Clarient Diagnostic Services Inc | métodos para sondar alvos múltiplos em uma amostra biológica, para analisar amostra biológica de multiplexação de alto rendimento e para usar um kit, série de pelo menos duas imagens que representam alvos biológicos opticamente marcados, kit para alvejar um sinal para sondar alvos múltiplos em uma amostra biológica, e, processo automatizado para alvejamento químico fotoativado de uma amostra biológica |
| US10677802B2 (en) * | 2012-12-17 | 2020-06-09 | Ge Healthcare Bio-Sciences Corp. | Chemical bleaching of dyes using radical photoinitiators |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| EP3105354B1 (en) * | 2014-02-12 | 2020-05-06 | The Trustees of Columbia University in the City of New York | Single molecule electronic multiplex snp assay and pcr analysis |
| EP3256857B1 (en) * | 2015-02-13 | 2019-07-24 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| US9708349B2 (en) | 2015-02-13 | 2017-07-18 | General Electric Company | Borates for photoactivated chemical bleaching |
| US10101322B2 (en) | 2015-02-13 | 2018-10-16 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| CN105044059B (zh) * | 2015-07-13 | 2017-08-29 | 深圳市瀚海基因生物科技有限公司 | 一种可用于减缓单分子荧光漂白现象的除氧试剂及其应用方法 |
| US20170241911A1 (en) * | 2016-02-22 | 2017-08-24 | Miltenyi Biotec Gmbh | Automated analysis tool for biological specimens |
| US10371610B2 (en) | 2016-02-23 | 2019-08-06 | Noul Co., Ltd. | Contact-type patch, staining method using the same, and manufacturing method thereof |
| KR102478639B1 (ko) | 2016-02-23 | 2022-12-19 | 노을 주식회사 | 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치 |
| KR20170099739A (ko) | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법 |
| JP2020513796A (ja) | 2016-11-16 | 2020-05-21 | ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ | サイクリック蛍光イメージングのためのシステムおよび方法 |
| CZ309221B6 (cs) * | 2018-09-27 | 2022-06-01 | Mendelova Univerzita V Brně | Způsob identifikace přírodních vzorků, zejména kapalných |
| WO2023091909A1 (en) | 2021-11-16 | 2023-05-25 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| US20230140613A1 (en) * | 2022-03-30 | 2023-05-04 | Hasan Bagheri | Colorimetric system for detection of covid-19 using exhaled breath metabolites |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1479870A (zh) * | 2000-12-05 | 2004-03-03 | ���������Ǵ�ѧ���»� | 利用硼酸加合物光学检测葡萄糖 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78065B (enExample) | 1982-02-19 | 1984-09-26 | Unilever Nv | |
| DK39592D0 (da) | 1992-03-25 | 1992-03-25 | Safefood Micro Systsm As | Method of detecting microorganisms |
| US6451551B1 (en) | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
| CA2235738C (en) | 1995-11-22 | 2005-07-26 | Minimed, Inc. | Detection of biological molecules using chemical amplification and optical sensors |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| EP1234026B1 (en) | 1999-11-30 | 2011-08-17 | Cyntellect, Inc. | Method and apparatus for selectively targeting specific cells within a cell population |
| DE10014685B4 (de) | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
| AU2001253193A1 (en) | 2000-04-04 | 2001-10-15 | The Regents Of The University Of California | Fluorescent lifetime assays for non-invasive quantification of analytes |
| US7470420B2 (en) * | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| DE10117430A1 (de) | 2001-04-06 | 2002-10-10 | Nicole Marme | Hochempfindlicher und hochspezifischer Enzymnachweis mit einer Nachweisgrenze bis in den femtomolaren Bereich |
| US7045361B2 (en) | 2001-09-12 | 2006-05-16 | Medtronic Minimed, Inc. | Analyte sensing via acridine-based boronate biosensors |
| US8062897B2 (en) | 2003-07-21 | 2011-11-22 | Aureon Laboratories, Inc. | Diagnostic histopathology using multiplex gene expression FISH |
| RU2305270C2 (ru) | 2005-05-18 | 2007-08-27 | Андрей Алексеевич Климов | Способ флуоресцентной наноскопии (варианты) |
| JP5406019B2 (ja) | 2006-05-17 | 2014-02-05 | セルーメン、インコーポレイテッド | 自動化組織分析のための方法 |
| US7993927B2 (en) | 2006-07-03 | 2011-08-09 | Beth Israel Deaconess Medical Center, Inc. | Histology methods |
| US8060348B2 (en) | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US20080032321A1 (en) | 2006-08-07 | 2008-02-07 | General Electric Company | System and methods for analyzing images of tissue samples |
| US8131476B2 (en) | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US20080124310A1 (en) | 2006-11-01 | 2008-05-29 | Marshall John G | Bead based receptor biology |
| US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| US7741045B2 (en) | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US20100216652A1 (en) | 2007-04-25 | 2010-08-26 | The Trustees Of The Universit Of Pennsylvania | Low Level Fluorescence Detection at the Light Microscopic Level |
| US7714303B2 (en) | 2007-05-10 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for analyzing fluorescent materials with reduced authofluorescence |
| US20090263612A1 (en) | 2008-04-18 | 2009-10-22 | Nbc Universal, Inc. | System and Method for Photobleaching of Optical Media |
| US9677125B2 (en) | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| EP2601513B1 (en) | 2010-08-05 | 2014-05-14 | Cambridge Research & Instrumentation, Inc. | Enhancing visual assessment of samples |
| US20140024024A1 (en) | 2012-07-17 | 2014-01-23 | General Electric Company | Methods of detecting dna, rna and protein in biological samples |
-
2011
- 2011-12-23 US US13/336,409 patent/US8568991B2/en not_active Expired - Fee Related
-
2012
- 2012-12-03 WO PCT/US2012/067527 patent/WO2013095896A1/en not_active Ceased
- 2012-12-03 CA CA2860097A patent/CA2860097C/en active Active
- 2012-12-03 BR BR112014015603A patent/BR112014015603B1/pt not_active IP Right Cessation
- 2012-12-03 AU AU2012355736A patent/AU2012355736B2/en not_active Ceased
- 2012-12-03 KR KR1020147020366A patent/KR102046194B1/ko not_active Expired - Fee Related
- 2012-12-03 EP EP12860159.8A patent/EP2794908B1/en active Active
- 2012-12-03 CN CN201280070449.4A patent/CN104114713B/zh active Active
- 2012-12-03 RU RU2014124974A patent/RU2623880C2/ru active
- 2012-12-03 JP JP2014549074A patent/JP6148682B2/ja active Active
- 2012-12-03 SG SG11201403460SA patent/SG11201403460SA/en unknown
-
2013
- 2013-08-27 US US14/010,889 patent/US9250245B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1479870A (zh) * | 2000-12-05 | 2004-03-03 | ���������Ǵ�ѧ���»� | 利用硼酸加合物光学检测葡萄糖 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2794908B1 (en) | 2017-08-02 |
| JP2015506469A (ja) | 2015-03-02 |
| BR112014015603A2 (pt) | 2017-06-13 |
| AU2012355736A2 (en) | 2014-09-18 |
| NZ626334A (en) | 2016-04-29 |
| RU2623880C2 (ru) | 2017-06-29 |
| CN104114713A (zh) | 2014-10-22 |
| CA2860097C (en) | 2020-07-07 |
| US9250245B2 (en) | 2016-02-02 |
| BR112014015603A8 (pt) | 2017-07-04 |
| AU2012355736A1 (en) | 2014-07-17 |
| US20130165330A1 (en) | 2013-06-27 |
| RU2014124974A (ru) | 2016-02-20 |
| EP2794908A1 (en) | 2014-10-29 |
| BR112014015603B1 (pt) | 2020-04-28 |
| EP2794908A4 (en) | 2015-05-06 |
| WO2013095896A1 (en) | 2013-06-27 |
| KR102046194B1 (ko) | 2019-11-18 |
| US20130345089A1 (en) | 2013-12-26 |
| KR20140103350A (ko) | 2014-08-26 |
| SG11201403460SA (en) | 2014-07-30 |
| JP6148682B2 (ja) | 2017-06-14 |
| US8568991B2 (en) | 2013-10-29 |
| CA2860097A1 (en) | 2013-06-27 |
| AU2012355736B2 (en) | 2017-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104114713B (zh) | 染料的光敏化化学漂白 | |
| JP6499960B2 (ja) | 生体試料中のｄｎａ、ｒｎａ及びタンパク質を検出する方法 | |
| CN105143885B (zh) | 染料的光敏化化学漂白 | |
| US10677802B2 (en) | Chemical bleaching of dyes using radical photoinitiators | |
| US10101322B2 (en) | Photoactivated chemical bleaching of dyes using borates | |
| US9708349B2 (en) | Borates for photoactivated chemical bleaching | |
| EP3256857B1 (en) | Photoactivated chemical bleaching of dyes using borates | |
| NZ626334B2 (en) | Photoactivated chemical bleaching of dyes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210818 Address after: Massachusetts, USA Patentee after: Globegroup life technology consulting America Co.,Ltd. Address before: New York State, USA Patentee before: General Electric Co. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220110 Address after: Germany Wetzlar Patentee after: LEICA MICROSYSTEMS CMS GmbH Address before: Massachusetts Patentee before: Globegroup life technology consulting America Co.,Ltd. |
|
| TR01 | Transfer of patent right |