JP2016505616A - GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{CompositionforpreventingortreatingallergicdermatitiscomprisingGPCR19agonistasanactiveingredient} - Google Patents
GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{CompositionforpreventingortreatingallergicdermatitiscomprisingGPCR19agonistasanactiveingredient} Download PDFInfo
- Publication number
- JP2016505616A JP2016505616A JP2015551631A JP2015551631A JP2016505616A JP 2016505616 A JP2016505616 A JP 2016505616A JP 2015551631 A JP2015551631 A JP 2015551631A JP 2015551631 A JP2015551631 A JP 2015551631A JP 2016505616 A JP2016505616 A JP 2016505616A
- Authority
- JP
- Japan
- Prior art keywords
- allergic
- allergic skin
- skin disease
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 77
- 201000008937 atopic dermatitis Diseases 0.000 title claims abstract description 59
- 208000017520 skin disease Diseases 0.000 title claims abstract description 51
- 230000000172 allergic effect Effects 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 238000011282 treatment Methods 0.000 title claims abstract description 34
- 239000000556 agonist Substances 0.000 title claims abstract description 28
- 206010012434 Dermatitis allergic Diseases 0.000 title claims abstract description 24
- 239000004480 active ingredient Substances 0.000 title claims abstract description 23
- 230000002265 prevention Effects 0.000 title claims abstract description 16
- 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 title abstract 2
- 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 title abstract 2
- 239000004615 ingredient Substances 0.000 title description 16
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title 1
- 238000013329 compounding Methods 0.000 title 1
- 229940045946 sodium taurodeoxycholate Drugs 0.000 claims abstract description 44
- YXHRQQJFKOHLAP-FVCKGWAHSA-M sodium;2-[[(4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 YXHRQQJFKOHLAP-FVCKGWAHSA-M 0.000 claims abstract description 44
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 26
- 238000002360 preparation method Methods 0.000 claims abstract description 26
- 239000002537 cosmetic Substances 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- 239000002674 ointment Substances 0.000 claims abstract description 13
- 108090000695 Cytokines Proteins 0.000 claims abstract description 11
- 102000004127 Cytokines Human genes 0.000 claims abstract description 11
- 238000002347 injection Methods 0.000 claims abstract description 10
- 239000007924 injection Substances 0.000 claims abstract description 10
- 230000007423 decrease Effects 0.000 claims abstract description 6
- 230000006872 improvement Effects 0.000 claims abstract description 5
- 101000829779 Homo sapiens Probable G-protein coupled receptor 19 Proteins 0.000 claims description 41
- 102100023417 Probable G-protein coupled receptor 19 Human genes 0.000 claims description 41
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 35
- 239000000243 solution Substances 0.000 claims description 16
- 239000002552 dosage form Substances 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000006071 cream Substances 0.000 claims description 11
- -1 astringent Substances 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 10
- 239000006210 lotion Substances 0.000 claims description 9
- 208000003251 Pruritus Diseases 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 5
- 206010012442 Dermatitis contact Diseases 0.000 claims description 4
- 208000024780 Urticaria Diseases 0.000 claims description 4
- 208000010247 contact dermatitis Diseases 0.000 claims description 4
- 239000000686 essence Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 4
- 239000000344 soap Substances 0.000 claims description 4
- 238000003287 bathing Methods 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- 239000002453 shampoo Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 13
- 210000002966 serum Anatomy 0.000 abstract description 12
- 150000003431 steroids Chemical class 0.000 abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 210000003979 eosinophil Anatomy 0.000 abstract description 7
- 210000000440 neutrophil Anatomy 0.000 abstract description 7
- 210000003630 histaminocyte Anatomy 0.000 abstract description 6
- 230000003449 preventive effect Effects 0.000 abstract description 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract description 2
- 102000018358 immunoglobulin Human genes 0.000 abstract description 2
- 230000001506 immunosuppresive effect Effects 0.000 abstract description 2
- 230000008595 infiltration Effects 0.000 abstract description 2
- 238000001764 infiltration Methods 0.000 abstract description 2
- 210000004927 skin cell Anatomy 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 67
- 210000003491 skin Anatomy 0.000 description 23
- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 13
- 210000004207 dermis Anatomy 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 201000004624 Dermatitis Diseases 0.000 description 10
- 229940112971 protopic Drugs 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 206010003645 Atopy Diseases 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 239000000454 talc Substances 0.000 description 6
- 229910052623 talc Inorganic materials 0.000 description 6
- 235000012222 talc Nutrition 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- 238000010186 staining Methods 0.000 description 5
- 108010010803 Gelatin Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 229940125715 antihistaminic agent Drugs 0.000 description 4
- 239000000739 antihistaminic agent Substances 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 229940014259 gelatin Drugs 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000003018 immunosuppressive agent Substances 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 229940087412 maxidex Drugs 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 241000416162 Astragalus gummifer Species 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 108010074328 Interferon-gamma Proteins 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 229920001615 Tragacanth Polymers 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- PLCQGRYPOISRTQ-FCJDYXGNSA-L dexamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-FCJDYXGNSA-L 0.000 description 3
- 239000008298 dragée Substances 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000000829 suppository Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000010487 tragacanth Nutrition 0.000 description 3
- 239000000196 tragacanth Substances 0.000 description 3
- 229940116362 tragacanth Drugs 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical group C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- 208000035874 Excoriation Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 102100037850 Interferon gamma Human genes 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010039085 Rhinitis allergic Diseases 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- FMVKYSCWHDVMGO-UHFFFAOYSA-N [3-[(2-methylphenyl)carbamoyl]naphthalen-2-yl] 2-chloroacetate Chemical compound CC1=CC=CC=C1NC(=O)C1=CC2=CC=CC=C2C=C1OC(=O)CCl FMVKYSCWHDVMGO-UHFFFAOYSA-N 0.000 description 2
- 201000010105 allergic rhinitis Diseases 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 229940121354 immunomodulator Drugs 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 229940125721 immunosuppressive agent Drugs 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000003791 organic solvent mixture Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- KASDHRXLYQOAKZ-XDSKOBMDSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-XDSKOBMDSA-N 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000007940 sugar coated tablet Substances 0.000 description 2
- 229960001967 tacrolimus Drugs 0.000 description 2
- 229950003937 tolonium Drugs 0.000 description 2
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 206010001343 Adrenal cortical hypofunctions Diseases 0.000 description 1
- 206010001367 Adrenal insufficiency Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000012657 Atopic disease Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 240000006890 Erythroxylum coca Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 241001516614 Exema Species 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020112 Hirsutism Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 208000037014 Rare skin disease Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 229940081735 acetylcellulose Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 208000017515 adrenocortical insufficiency Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229940040563 agaric acid Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 201000009961 allergic asthma Diseases 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 229940046731 calcineurin inhibitors Drugs 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 235000008957 cocaer Nutrition 0.000 description 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000002554 disease preventive effect Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 229940020485 elidel Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000005639 glycero group Chemical group 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229940045996 isethionic acid Drugs 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N lauric acid triglyceride Natural products CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000012931 lyophilized formulation Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229960005330 pimecrolimus Drugs 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 229940069575 rompun Drugs 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
また、本発明において、"改善"とは、症状の軽減、予防又は治療を含むことを意味する。
また、本発明において、"有効成分"とは、単独で活性をあらわすか、又はその自体は活性がない担体(carrier)と共に活性を現す成分を意味する。
前記本発明の医薬組成物は、薬学的に有効な量で投与する。
実施例 1: 資料の製造
下記試験サンプルの製造するために、タウロデオキシコール酸ナトリウム(Sodium taurodeoxycholate)粉末を2.5%又は5%になるようにポリエチレン・グリコール400溶液(10 % in distilled water)とエタノール原液(Absolute ethanol)を7:3で混合した溶液に溶かした後、0.4μmフィルタで濾過し、試験サンプルを製造した。
タウロデオキシコール酸ナトリウム(Sodium taurodeoxycholate)組成物のアトピー性皮膚炎の治療効果を確認するために、アトピー動物モデルの一つであるマウスなどの皮膚炎誘発試験を実施した。本実験では6週となった雄Balb/CマウスとハプテンであるDNCB(2,4-dinitro-1-chloro-benzene、Sigma)を使用し、各群あたり5匹ずつ試験を実施した。前記動物モデルは、血液内のIgE量を測定し、薬物のIgE水準の抑制効果を持つため、より直接的なアトピー性皮膚炎の治療効果を確認できる動物モデルである。DNCBをアセトンに2.5%の濃度で溶解した溶液 200μlを除毛したマウスの背に塗布し、感作させ、3日が経った後、アセトンに1%の濃度で溶解したDNCB溶液 200μlを追加塗布し、10日目にアセトンに0.2%の濃度でDNCBを溶解した溶液を追加塗布し、アトピー性皮膚炎を誘発させた。
アトピー性皮膚炎に対するタウロデオキシコール酸ナトリウム(Sodium taurodeoxycholate)の治療効能を精査するため、アトピー性皮膚炎を発生させた動物モデルBalb/Cマウスにタウロデオキシコール酸ナトリウム(Sodium taurodeoxycholate)を実験例 1に従ってDNCB塗布を始めた後、15日目に最終的にアトピー性皮膚炎発生部位の外観観察及び官能評価を施行し、皮膚炎の好転可否を検査した。官能評価は、DNCB塗布を始めた後、15日目で2文間掻く回数(Itch)、紅斑及び出血(erythema、hemorrhage)、浮腫(edema)、擦過傷及び爛れ(excoriation、erosion)、鱗屑及び乾燥(scaling、dryness)の重症度に従い、各々0点(none)から3点(severe)まで点数を付与し、総点15点を満点に計算し、すべてのグループとすべての個体に対して実行した。3人が盲検で各々評価した後、各マウス個体の平均値を算出した。
実験例 2の評価を終えた直後、各群に属するマウスに、ゾテピン 250 mg/5cc(Virbar社)と2%ロムプン(Rompun)溶液(Bayer Korea社)を8:2(v/v)で混合した後、これを食塩水で10倍希釈し、注射麻酔した後、心臓から採血した。血清を分離して酵素免疫分析法(Mouse IgE ELISA、BD)で血清内IgE濃度を測定し、ELISA kit(eBioscience)を使用し、TH1サイトカイン(IFN-γ、IL-2)とTH2サイトカイン(IL-4)の血清内濃度を測定した。
実験例 2及び実験例 3の実験のための試料を準備した直後、各群に属するマウス個体の組織病理学的な検査のために、皮膚組織を生検した。マウスの背皮膚組織を切断し、10%のホルマリン溶液内で24時間固定した後、蒸留水で洗浄した。固定した皮膚組織をパラフィンブロックで作った後、7 μmの厚さで切断し、ヘマトキシリン-エオシン(H&E)染色した(図 5a 参照)。図 5bと5cを参照すると、マウスの各グループで得た皮膚組織をH&E染色した結果、DNCBだけを処理したグループのマウス皮膚はDNCBを処理しなかったshamグループの上皮(26.07±1.02 μm)及び真皮(384.7±11.36 μm)に比べて上皮(epidermis、320.2±21.63 μm)及び真皮(dermis、930.2±34.17 μm)が厚くなった。これと対照的にDNCBでアトピー性皮膚炎を誘発し、2.5%と5%のタウロデオキシコール酸ナトリウム(Sodium taurodeoxycholate、105.3±7.00μm、75.0±8.38μm)、プロトピック(123.1±14.78μm)又はマキシデックス(51.72±7.13μm)を処理したグループの皮膚上皮がDNCBだけを処理したグループと比べて厚さが顕著に減少した(p <0.05)。さらに、DNCBでアトピー性皮膚炎を誘発し、2.5%と5%のタウロデオキシコール酸ナトリウム(Sodium taurodeoxycholate、616.0±21.05μm、521.7±18.27μm)又はプロトピック(572.6±20.16μm)を処理したグループの皮膚真皮がDNCBだけを処理したグループと比べて厚さが正常に近く回復した(p<0.05)。しかし、マキシデックス(310.3±15.28μm)を処理したグループの皮膚真皮の厚さは、DNCBを処理しなかったshamグループの真皮の厚さと比べて有意に薄くなった(p<0.05)。
タウロデオキシコール酸ナトリウム 10mg
スクロース 100mg
タルク 10mg
前記成分を粉末化し、混合した後、気密性の袋に充填し、散剤を製造する。
タウロデオキシコール酸ナトリウム 10mg
澱粉 100mg
スクロース 100mg
ステアリン酸マグネシウム 2mg
通常の錠剤の製造方法によって前記成分を混合した後、これを打錠し、錠剤を製造する。
タウロデオキシコール酸ナトリウム 10mg
結晶性セルロース 3mg
ラクトース 15mg
ステアリン酸マグネシウム 1mg
通常のカプセル剤の製造方法に従い、前記成分を混合した後、ゼラチンカプセルに充填し、カプセル剤を製造する。
タウロデオキシコール酸ナトリウム 10mg
大豆抽出物 50mg
ブドウ糖 200mg
澱粉 500mg
前記成分を混合した後、30%のエタノール100mLを添加し、60℃で乾燥させ、顆粒を形成した後、気密性の袋に充填し、顆粒剤を製造する。
タウロデオキシコール酸ナトリウム 10mg
乳糖 1,500mg
グリセリン 1,500mg
澱粉 980mg
前記成分を混合した後、通常の丸剤の製造方法に従い、1丸あたり4gになるように製造する。
タウロデオキシコール酸ナトリウム 10mg
マンニット 180mg
注射用滅菌蒸留水 2,970mg
Na2HPO4・12H2O 30mg
通常の注射剤の製造方法に従い、1アンプルあたり(2mL)になるように前記成分を混合し、製造する。
タウロデオキシコール酸ナトリウム 10mg
異性化糖 10,000mg
マンニット 5,000mg
精製水の適量
通常の液剤の製造方法に従い、精製水に前記成分を溶解させ、適切な香りを加えた後、瓶に充填し、滅菌させ、製造する。
水 330 mLとNaOH 175 gを混合し、完全に溶解させた後、タウロデオキシコール酸ナトリウム10mgを約30分間少しずつ添加しながら混合した。前記混合物を乾燥できるまで暗所かつ風がよく通じる所で乾燥させた。
タウロデオキシコール酸ナトリウム10mgを約60℃程度なるようにした後、天日塩を入れ、飽和溶液を作り、水を蒸発させた。前記溶液を室温で冷却した後、急速冷凍させ、凍結乾燥させた。前記凍結乾燥された固形剤を粉末化し、沐浴剤を製造した。
製造例 10. クレンジングローション製造
製造例 11. スキン製造
製造例 12. セラム製造
製造例 13. ローション製造
製造例 14. エッセンス製造
製造例 15. クリーム製造
製造例 16. パック製造
製造例 17. マッサージジクリーム製造
製造例 18. メーキャップベース製造
製造例 19. パウダパクト製造
製造例 20. ツーウェイケーキ製造
Claims (12)
- Gたんぱく質結合型受容体19(G protein-Coupled Receptor19、GPCR19)作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 前記Gたんぱく質結合型受容体19(GPCR19)作用剤は、タウロデオキシコール酸ナトリウム(HY2191、Sodium taurodeoxycholate)又はその誘導体であることを特徴とする第1項記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 前記GPCR19作用剤は、血中IgE含量及び血中TH2サイトカインレベルを減少させ、血中TH1サイトカインレベルを増加させることを特徴とする第1項記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 前記医薬組成物は、経口用製剤、注射用製剤又は外用剤の形態として剤形化されることを特徴とする第1項記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 経口用製剤は、精製、顆粒剤、丸剤、散剤、カプセル剤及び液剤で構成されるグループから選択される剤形であることを特徴とする第4項記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 外用剤は、クリーム、ゼル、軟膏、乳化液、懸濁液、噴霧剤及び経皮伝達性パッチ剤で構成されるグループから選択されることを特徴とする第4記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 前記外用剤は、1日あたり 0.1乃至50 mgの量で塗布されることを特徴とする第4項記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- 前記アレルギー性皮膚疾患は、アレルギー性皮膚炎(allergic dermatitis)、アトピー性皮膚炎(atopic dermatitis)、接触性皮膚炎(contact dermatitis)、蕁麻疹(hives)及び掻痒症(pruritus)から成るグループから選択されることを特徴とする第1項乃至第7項のいずれの一つ記載のアレルギー性皮膚疾患の予防又は治療用の医薬組成物。
- Gたんぱく質結合型受容体19(G protein-Coupled Receptor19、GPCR19)作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は改善用化粧料組成物.
- 前記Gたんぱく質結合型受容体19(GPCR19)作用剤は、タウロデオキシコール酸ナトリウム(HY2191、Sodium taurodeoxycholate)又はこれの誘導体であることを特徴とする第9項記載のアレルギー性皮膚疾患の予防又は改善用化粧料組成物。
- 前記化粧料組成物は、アレルギー性皮膚疾患用の石鹸、クレンジングフォーム、クレンジングクリーム、クレンジングウォーター、沐浴剤、スキンローション、スキン軟化剤、スキントナー、ローション、クリーム、エッセンス、アストリンゼント、乳液、ゼル、リップスティック、噴霧剤、シャンプ、リンス、トリートメント、バーディークレンザー、パック、マッサージ剤、フェースパウダー、コンパクト、ファウンデーション、ツーウェイケーキ及びメーキャップベースから成るグループ選択されるいずれの一つ以上の剤形から製造されることを特徴とする第9項記載のアレルギー性皮膚疾患の予防又は改善用化粧料組成物。
- 前記アレルギー性皮膚疾患は、アレルギー性皮膚炎(allergic dermatitis)、アトピー性皮膚炎(atopic dermatitis)、接触性皮膚炎(contact dermatitis)、蕁麻疹(hives)及び掻痒症(pruritus)から成るグループから選択されることを特徴とする第9至第11項のいずれの一つ記載のアレルギー性皮膚疾患の予防又は改善用化粧料組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020130100813A KR101548955B1 (ko) | 2013-08-26 | 2013-08-26 | Gpcr19 작용제를 유효성분으로 함유하는 아토피 예방 또는 치료용 조성물 |
KR10-2013-0100813 | 2013-08-26 | ||
PCT/KR2014/001819 WO2015030328A1 (ko) | 2013-08-26 | 2014-03-05 | Gpcr19 작용제를 유효성분으로 함유하는 알러지성 피부질환의 예방 또는 치료용 조성물 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017020559A Division JP6542275B2 (ja) | 2013-08-26 | 2017-02-07 | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{Composition for preventing or treating allergic dermatitis comprising GPCR19 agonist as an active ingredient} |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016505616A true JP2016505616A (ja) | 2016-02-25 |
JP6105751B2 JP6105751B2 (ja) | 2017-03-29 |
Family
ID=52586843
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015551631A Active JP6105751B2 (ja) | 2013-08-26 | 2014-03-05 | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{CompositionforpreventingortreatingallergicdermatitiscomprisingGPCR19agonistasanactiveingredient} |
JP2017020559A Active JP6542275B2 (ja) | 2013-08-26 | 2017-02-07 | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{Composition for preventing or treating allergic dermatitis comprising GPCR19 agonist as an active ingredient} |
JP2019017330A Active JP6663052B2 (ja) | 2013-08-26 | 2019-02-01 | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{Composition for preventing or treating allergic dermatitis comprising GPCR19 agonist as an active ingredient} |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017020559A Active JP6542275B2 (ja) | 2013-08-26 | 2017-02-07 | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{Composition for preventing or treating allergic dermatitis comprising GPCR19 agonist as an active ingredient} |
JP2019017330A Active JP6663052B2 (ja) | 2013-08-26 | 2019-02-01 | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{Composition for preventing or treating allergic dermatitis comprising GPCR19 agonist as an active ingredient} |
Country Status (7)
Country | Link |
---|---|
US (1) | US9629854B2 (ja) |
EP (1) | EP2910247B1 (ja) |
JP (3) | JP6105751B2 (ja) |
KR (1) | KR101548955B1 (ja) |
CN (1) | CN104853759B (ja) |
ES (1) | ES2678944T3 (ja) |
WO (1) | WO2015030328A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021511323A (ja) * | 2018-01-19 | 2021-05-06 | アイビバ バイオファーマ インコーポレイテッド | 多標的阻害剤の懸濁組成物 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101743960B1 (ko) | 2015-07-06 | 2017-06-08 | 서울대학교산학협력단 | G단백질 결합형 수용체19 작용제를 유효성분으로 함유하는 알츠하이머 질환 또는 치매를 예방, 치료 또는 지연하기 위한 약학적 조성물 |
US20230366875A1 (en) * | 2020-09-18 | 2023-11-16 | Seoul National University R&Db Foundation | Gpcr19-p2xn receptor complex and use thereof |
KR20230043774A (ko) | 2021-09-24 | 2023-03-31 | (주)샤페론 | 염증복합체 억제제를 유효성분으로 하는 아토피 피부염 예방, 개선 또는 치료용 약학 조성물 |
KR20240072368A (ko) | 2022-11-15 | 2024-05-24 | 서울대학교산학협력단 | 아토피 피부염을 치료하기 위한 치료 예측용 바이오마커 및 동반 진단용 조성물 |
WO2024105449A1 (en) * | 2022-11-15 | 2024-05-23 | Shaperon Inc. | Biomarkers for predicting the treatment efficacy of gpcr19 agonists in the treatment of atopic dermatitis and methods for treating subjects with such biomarkers |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2166427A1 (en) * | 1995-01-04 | 1996-07-05 | Josef Olaf Widauer | Use of bile acids for preparing medicaments for the treatment of skin diseases |
JPH10114665A (ja) * | 1996-10-15 | 1998-05-06 | Dokutaazu Kosumeteikusu:Kk | 津液改善剤及びそれを含有する経口投与用組成物 |
JPH10120579A (ja) * | 1996-10-18 | 1998-05-12 | Dokutaazu Kosumeteikusu:Kk | 津液改善用皮膚外用剤 |
JP2007106730A (ja) * | 2005-10-17 | 2007-04-26 | Mitsubishi Pharma Corp | Rantes誘導阻害薬 |
JP2009543823A (ja) * | 2006-07-17 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | 免疫調節剤として使用するための胆汁酸アミドのスルホニルアミノカルボニル誘導体 |
JP2010523627A (ja) * | 2007-04-13 | 2010-07-15 | ノバルティス アーゲー | Gpbar1アゴニストとしてのピリダジン誘導体、ピリジン誘導体およびピラン誘導体 |
US20100267684A1 (en) * | 2007-05-14 | 2010-10-21 | Seoul National University Industry Foundation | Use of biological surfactant as anti-inflammatory agent and tissue preservative solution |
JP2011511752A (ja) * | 2007-01-19 | 2011-04-14 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Tgr5調節剤としての23−置換胆汁酸およびその使用方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8417895D0 (en) * | 1984-07-13 | 1984-08-15 | Marples B A | Pharmaceutical anti-fungal composition |
JP3714443B2 (ja) | 1997-07-22 | 2005-11-09 | タカラバイオ株式会社 | アトピー性皮膚炎の検出方法 |
AU2001272759A1 (en) * | 2000-07-19 | 2002-01-30 | Kyowa Hakko Kogyo Co. Ltd. | Preventives or remedies for atopic dermatitis |
EP1814911A2 (en) * | 2004-11-04 | 2007-08-08 | New England Medical Center Hospitals, Inc. | G protein coupled receptor agonists and antagonists and methods of use |
KR101452864B1 (ko) * | 2011-11-17 | 2014-11-04 | 서울대학교산학협력단 | Gpcr19 경로의 활성화에 의한 골수 유래 면역 조절 세포 및 면역 조절 b 림프구의 체내외 증폭 |
-
2013
- 2013-08-26 KR KR1020130100813A patent/KR101548955B1/ko active IP Right Grant
-
2014
- 2014-03-05 EP EP14841209.1A patent/EP2910247B1/en active Active
- 2014-03-05 WO PCT/KR2014/001819 patent/WO2015030328A1/ko active Application Filing
- 2014-03-05 ES ES14841209.1T patent/ES2678944T3/es active Active
- 2014-03-05 US US14/440,875 patent/US9629854B2/en active Active
- 2014-03-05 JP JP2015551631A patent/JP6105751B2/ja active Active
- 2014-03-05 CN CN201480002520.4A patent/CN104853759B/zh active Active
-
2017
- 2017-02-07 JP JP2017020559A patent/JP6542275B2/ja active Active
-
2019
- 2019-02-01 JP JP2019017330A patent/JP6663052B2/ja active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2166427A1 (en) * | 1995-01-04 | 1996-07-05 | Josef Olaf Widauer | Use of bile acids for preparing medicaments for the treatment of skin diseases |
JPH10114665A (ja) * | 1996-10-15 | 1998-05-06 | Dokutaazu Kosumeteikusu:Kk | 津液改善剤及びそれを含有する経口投与用組成物 |
JPH10120579A (ja) * | 1996-10-18 | 1998-05-12 | Dokutaazu Kosumeteikusu:Kk | 津液改善用皮膚外用剤 |
JP2007106730A (ja) * | 2005-10-17 | 2007-04-26 | Mitsubishi Pharma Corp | Rantes誘導阻害薬 |
JP2009543823A (ja) * | 2006-07-17 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | 免疫調節剤として使用するための胆汁酸アミドのスルホニルアミノカルボニル誘導体 |
JP2011511752A (ja) * | 2007-01-19 | 2011-04-14 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Tgr5調節剤としての23−置換胆汁酸およびその使用方法 |
JP2010523627A (ja) * | 2007-04-13 | 2010-07-15 | ノバルティス アーゲー | Gpbar1アゴニストとしてのピリダジン誘導体、ピリジン誘導体およびピラン誘導体 |
US20100267684A1 (en) * | 2007-05-14 | 2010-10-21 | Seoul National University Industry Foundation | Use of biological surfactant as anti-inflammatory agent and tissue preservative solution |
Non-Patent Citations (1)
Title |
---|
J.MED.CHEM., vol. 51, JPN6016022095, 2008, pages 1831 - 1841, ISSN: 0003499581 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021511323A (ja) * | 2018-01-19 | 2021-05-06 | アイビバ バイオファーマ インコーポレイテッド | 多標的阻害剤の懸濁組成物 |
Also Published As
Publication number | Publication date |
---|---|
CN104853759B (zh) | 2018-05-29 |
KR20150029043A (ko) | 2015-03-18 |
KR101548955B1 (ko) | 2015-09-02 |
EP2910247A1 (en) | 2015-08-26 |
CN104853759A (zh) | 2015-08-19 |
WO2015030328A1 (ko) | 2015-03-05 |
US9629854B2 (en) | 2017-04-25 |
ES2678944T3 (es) | 2018-08-21 |
JP2019112405A (ja) | 2019-07-11 |
JP2017114879A (ja) | 2017-06-29 |
EP2910247A4 (en) | 2016-04-13 |
US20150290219A1 (en) | 2015-10-15 |
JP6663052B2 (ja) | 2020-03-11 |
EP2910247B1 (en) | 2018-04-18 |
JP6542275B2 (ja) | 2019-07-10 |
JP6105751B2 (ja) | 2017-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6663052B2 (ja) | GPCR19作用剤を有効成分として含有するアレルギー性皮膚疾患の予防又は治療用の組成物{Composition for preventing or treating allergic dermatitis comprising GPCR19 agonist as an active ingredient} | |
JP2021176888A (ja) | パープルコーン抽出物を含む皮膚疾患の予防または治療用薬剤学的組成物 | |
US9855283B2 (en) | Composition comprising GPCR19 agonist as an active ingredient for preventing or treating allergic dermatitis | |
KR101998402B1 (ko) | Gpcr19 작용제를 유효성분으로 함유하는 아토피 예방 또는 치료용 조성물 | |
AU2014315877B2 (en) | Composition containing monoacetyldiacylglycerol compound as active ingredient for preventing or treating atopic dermatitis | |
JP2023529202A (ja) | ペンタペプチドを有効成分として含むアレルギー性疾患又はかゆみの予防、改善又は治療用組成物 | |
JP2023089077A (ja) | N-アセチル又はn-アシルアミノ酸を含むアトピー又は痒み症治療用組成物 | |
TWI746701B (zh) | 用於治療異位性皮膚炎的方法和組成物 | |
KR20240008375A (ko) | 건선을 치료하기 위한 약제의 제조에서의 망고스틴 과일 껍질 추출물의 용도 | |
KR101470087B1 (ko) | 면역억제제 및 트랜스글루타미나제 2 억제제를 포함하는 아토피 피부염의 예방, 치료 또는 개선용 조성물 | |
CN114173790A (zh) | 一种包含6-重氮-5-氧代-l-正亮氨酸的用于治疗炎症皮肤疾病的药物组合物 | |
KR101491927B1 (ko) | 컬러감자 외피 추출물을 유효성분으로 함유하는 아토피 예방 또는 치료용 조성물 | |
JPH06239757A (ja) | 抗アレルギー剤 | |
KR102412656B1 (ko) | 차매자스민을 유효성분으로 함유하는 아토피성 피부염 예방 또는 치료용 조성물 | |
KR20230043774A (ko) | 염증복합체 억제제를 유효성분으로 하는 아토피 피부염 예방, 개선 또는 치료용 약학 조성물 | |
EP4403164A1 (en) | Gel composition for prevention or treatment of atopic dermatitis | |
KR20130115727A (ko) | 퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물 | |
CN116782908A (zh) | 含半乳糖的预防、改善或治疗超敏反应免疫疾病的组合物 | |
KR20240075720A (ko) | 피부 장벽 강화 및 가려움 개선용 조성물 | |
KR20220128792A (ko) | 용머리 꽃 씨앗 추출물을 유효 성분으로 포함하는 아토피 피부염 개선용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151208 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160614 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160912 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20161108 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170207 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170221 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170302 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6105751 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |