JP2016505612A5 - - Google Patents
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- JP2016505612A5 JP2016505612A5 JP2015551182A JP2015551182A JP2016505612A5 JP 2016505612 A5 JP2016505612 A5 JP 2016505612A5 JP 2015551182 A JP2015551182 A JP 2015551182A JP 2015551182 A JP2015551182 A JP 2015551182A JP 2016505612 A5 JP2016505612 A5 JP 2016505612A5
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- JP
- Japan
- Prior art keywords
- composition
- peptide
- skin
- seq
- disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 238000000034 method Methods 0.000 claims 13
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 9
- 101150036847 NOX1 gene Proteins 0.000 claims 5
- 230000032683 aging Effects 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000005855 radiation Effects 0.000 claims 5
- 102000004019 NADPH Oxidase 1 Human genes 0.000 claims 4
- 108090000424 NADPH Oxidase 1 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000001965 increasing effect Effects 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000003711 photoprotective effect Effects 0.000 claims 3
- 210000004761 scalp Anatomy 0.000 claims 3
- 230000037380 skin damage Effects 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- XUNKPNYCNUKOAU-VXJRNSOOSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]a Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O XUNKPNYCNUKOAU-VXJRNSOOSA-N 0.000 claims 1
- UAXAYRSMIDOXCU-BJDJZHNGSA-N 2-[[(2r)-2-[[(2s)-2-[[2-[[(2s)-4-amino-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]acetic acid Chemical compound SC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(=O)NCC(O)=O UAXAYRSMIDOXCU-BJDJZHNGSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 102000004400 Aminopeptidases Human genes 0.000 claims 1
- 108090000915 Aminopeptidases Proteins 0.000 claims 1
- 108700031308 Antennapedia Homeodomain Proteins 0.000 claims 1
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 1
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 1
- 108700003968 Human immunodeficiency virus 1 tat peptide (49-57) Proteins 0.000 claims 1
- 208000029578 Muscle disease Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 108010047562 NGR peptide Proteins 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 108010033276 Peptide Fragments Proteins 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 206010051246 Photodermatosis Diseases 0.000 claims 1
- 206010049422 Precancerous skin lesion Diseases 0.000 claims 1
- 206010063493 Premature ageing Diseases 0.000 claims 1
- 208000032038 Premature aging Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 101710149951 Protein Tat Proteins 0.000 claims 1
- 241000187391 Streptomyces hygroscopicus Species 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 201000006083 Xeroderma Pigmentosum Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000003154 papilloma Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 108010043655 penetratin Proteins 0.000 claims 1
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 230000008845 photoaging Effects 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 230000004224 protection Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 230000035882 stress Effects 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
- 230000005748 tumor development Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13150187.6 | 2013-01-03 | ||
| EP13150187.6A EP2752196A1 (en) | 2013-01-03 | 2013-01-03 | Selective nox-1 inhibitor peptides and uses thereof |
| PCT/EP2014/050063 WO2014106649A1 (en) | 2013-01-03 | 2014-01-03 | Selective nox-1 inhibitor peptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505612A JP2016505612A (ja) | 2016-02-25 |
| JP2016505612A5 true JP2016505612A5 (cg-RX-API-DMAC7.html) | 2017-02-09 |
| JP6488237B2 JP6488237B2 (ja) | 2019-03-20 |
Family
ID=47458818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551182A Active JP6488237B2 (ja) | 2013-01-03 | 2014-01-03 | 選択的ｎｏｘ−１インヒビターペプチドおよびそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20170000842A9 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2752196A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6488237B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105007933A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014204309B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015015242B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2894576A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2941268T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE050715T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL239762B (cg-RX-API-DMAC7.html) |
| MA (1) | MA38296B2 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2699726C2 (cg-RX-API-DMAC7.html) |
| TN (1) | TN2015000295A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014106649A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3034500A1 (en) | 2014-12-17 | 2016-06-22 | Genkyotex Sa | Amido thiazole derivatives as NADPH oxidase inhibitors |
| JP6472693B2 (ja) * | 2015-03-24 | 2019-02-20 | 株式会社荏原製作所 | 基板処理装置 |
| US20170110622A1 (en) * | 2015-10-14 | 2017-04-20 | Solarcity Corporation | Apparatus for electroplating of electrodes on photovoltaic structures |
| WO2019023263A1 (en) * | 2017-07-25 | 2019-01-31 | Immune Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR TREATING TUMORS COMPRISING A BCR-ABL1 FUSION GENE |
| EP3628669A1 (en) | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Novel compounds as nadph oxidase inhibitors |
| WO2020070651A1 (en) * | 2018-10-05 | 2020-04-09 | Pfizer Inc. | Boron containing pde4 inhibitors |
| KR20220026538A (ko) | 2019-06-05 | 2022-03-04 | 에모리 유니버시티 | 코로나바이러스 및 피코르나바이러스 감염 치료용 펩티도모방체 |
| KR20210129517A (ko) * | 2020-04-20 | 2021-10-28 | 경북대학교병원 | Nadph 산화효소 1 저해제를 유효성분으로 포함하는 허혈-재관류 손상 예방 또는 치료용 조성물 |
| CN113773394B (zh) * | 2020-06-10 | 2023-10-27 | 山东大学 | 一种融合肽及在制备抗肿瘤制剂中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593966A (en) * | 1989-03-31 | 1997-01-14 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide derivatives of cytochrome b558 and their use as medicaments |
| US5726155A (en) * | 1993-08-02 | 1998-03-10 | The Scripps Research Institute | Regulation of oxidative burst using LMWG-derived peptides and analogs |
| GB2285047B (en) * | 1993-12-21 | 1998-04-15 | Yamanouchi U K Ltd | Polypeptides which inhibit the NADPH oxidase complex |
| EP0750630A4 (en) * | 1994-03-11 | 1998-01-07 | Ariad Pharma Inc | METHOD AND MATERIALS FOR IDENTIFYING INHIBITORS OF MOLECULAR INTERACTIONS, WHICH ARE BROUGHT BY THE SH3 DOMAINS |
| US6184205B1 (en) * | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
| EP0772773B1 (en) * | 1994-07-22 | 2006-04-05 | The University Of North Carolina | Src SH3 BINDING PEPTIDES AND METHODS OF ISOLATING AND USING SAME |
| US6713605B1 (en) * | 1996-04-10 | 2004-03-30 | Kansas State University Research Foundation | Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes |
| US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| JP2005168329A (ja) * | 2003-12-08 | 2005-06-30 | Hokkaido Univ | Ｎａｄｐｈオキシダーゼ活性を阻害するポリペプチド |
| US7582606B2 (en) * | 2005-11-03 | 2009-09-01 | The Board Of Regents Of The University Of Texas System | Nadph oxidase cytosolic cofactor mutant |
| US20100119533A1 (en) * | 2007-03-07 | 2010-05-13 | Cornelius Joseph Clancy | Polynucleotides and Polypeptides Identified by IVIAT Screening and Methods of Use |
| EP2280714A1 (en) * | 2008-03-28 | 2011-02-09 | Nu Skin International, Inc. | Compositions comprising anrnox-inhibitors for the inhibition of reactive oxygen species |
| WO2013074816A2 (en) | 2011-11-15 | 2013-05-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Novel inhibitors of nox1 |
-
2013
- 2013-01-03 EP EP13150187.6A patent/EP2752196A1/en not_active Withdrawn
-
2014
- 2014-01-03 CA CA2894576A patent/CA2894576A1/en not_active Abandoned
- 2014-01-03 US US14/758,991 patent/US20170000842A9/en not_active Abandoned
- 2014-01-03 WO PCT/EP2014/050063 patent/WO2014106649A1/en not_active Ceased
- 2014-01-03 AU AU2014204309A patent/AU2014204309B2/en active Active
- 2014-01-03 BR BR112015015242-2A patent/BR112015015242B1/pt not_active IP Right Cessation
- 2014-01-03 EP EP14700063.2A patent/EP2941268B1/en active Active
- 2014-01-03 CN CN201480003978.1A patent/CN105007933A/zh active Pending
- 2014-01-03 DK DK14700063.2T patent/DK2941268T3/da active
- 2014-01-03 JP JP2015551182A patent/JP6488237B2/ja active Active
- 2014-01-03 RU RU2015132087A patent/RU2699726C2/ru not_active IP Right Cessation
- 2014-01-03 HU HUE14700063A patent/HUE050715T2/hu unknown
- 2014-01-03 MA MA38296A patent/MA38296B2/fr unknown
-
2015
- 2015-06-29 TN TNP2015000295A patent/TN2015000295A1/fr unknown
- 2015-07-02 IL IL239762A patent/IL239762B/en not_active IP Right Cessation
-
2017
- 2017-08-03 US US15/667,737 patent/US10517919B2/en active Active
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