JP2016505536A5 - - Google Patents
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- Publication number
- JP2016505536A5 JP2016505536A5 JP2015544098A JP2015544098A JP2016505536A5 JP 2016505536 A5 JP2016505536 A5 JP 2016505536A5 JP 2015544098 A JP2015544098 A JP 2015544098A JP 2015544098 A JP2015544098 A JP 2015544098A JP 2016505536 A5 JP2016505536 A5 JP 2016505536A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- halogen
- dialkylamino
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- -1 cyano, hydroxy Chemical group 0.000 claims 15
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims 9
- 125000004103 aminoalkyl group Chemical group 0.000 claims 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 6
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 6
- 125000004995 haloalkylthio group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000003566 oxetanyl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 3
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 3
- 125000000262 haloalkenyl group Chemical group 0.000 claims 3
- 125000000232 haloalkynyl group Chemical group 0.000 claims 3
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 206010061217 Infestation Diseases 0.000 claims 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004956 cyclohexylene group Chemical group 0.000 claims 2
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 claims 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 2
- 125000005368 heteroarylthio group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 208000026803 Animal Parasitic disease Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 244000000054 animal parasite Species 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 244000078703 ectoparasite Species 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000590 parasiticidal effect Effects 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728782P | 2012-11-20 | 2012-11-20 | |
| US61/728,782 | 2012-11-20 | ||
| PCT/US2013/070731 WO2014081697A2 (en) | 2012-11-20 | 2013-11-19 | Anthelmintic compounds and compositions and method of using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505536A JP2016505536A (ja) | 2016-02-25 |
| JP2016505536A5 true JP2016505536A5 (enExample) | 2017-06-08 |
| JP6506694B2 JP6506694B2 (ja) | 2019-04-24 |
Family
ID=49759550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544098A Expired - Fee Related JP6506694B2 (ja) | 2012-11-20 | 2013-11-19 | 駆虫性化合物及び組成物並びにこれらの使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US9249102B2 (enExample) |
| EP (2) | EP2922845B1 (enExample) |
| JP (1) | JP6506694B2 (enExample) |
| KR (1) | KR102151832B1 (enExample) |
| CN (1) | CN104884453B (enExample) |
| AP (1) | AP3965A (enExample) |
| AR (1) | AR093562A1 (enExample) |
| AU (3) | AU2013348175B2 (enExample) |
| BR (1) | BR112015011441A2 (enExample) |
| CA (1) | CA2891926A1 (enExample) |
| CL (1) | CL2015001389A1 (enExample) |
| CY (1) | CY1120549T1 (enExample) |
| DK (1) | DK2922845T3 (enExample) |
| EA (1) | EA030814B1 (enExample) |
| ES (2) | ES2893777T3 (enExample) |
| HR (1) | HRP20181448T1 (enExample) |
| HU (1) | HUE039915T2 (enExample) |
| LT (1) | LT2922845T (enExample) |
| MX (2) | MX366041B (enExample) |
| NZ (3) | NZ716598A (enExample) |
| PL (1) | PL2922845T3 (enExample) |
| PT (1) | PT2922845T (enExample) |
| RS (1) | RS57779B1 (enExample) |
| SG (1) | SG11201503959VA (enExample) |
| SI (1) | SI2922845T1 (enExample) |
| SM (1) | SMT201800443T1 (enExample) |
| WO (1) | WO2014081697A2 (enExample) |
| ZA (1) | ZA201503481B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2745977C2 (ru) | 2010-04-22 | 2021-04-05 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| SG10201913575VA (en) | 2014-04-15 | 2020-02-27 | Vertex Pharma | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
| US10045979B2 (en) * | 2014-05-19 | 2018-08-14 | Merial Inc. | Anthelmintic compounds |
| CN106470683A (zh) * | 2014-07-11 | 2017-03-01 | 英特维特国际股份有限公司 | 针对犬心丝虫的抗蠕虫剂的用途 |
| US10010538B2 (en) | 2014-07-11 | 2018-07-03 | Intervet Inc. | Use of anthelmintic agents against Dirofilaria immitis |
| ES2907461T3 (es) | 2015-01-20 | 2022-04-25 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelmínticos, composiciones y procedimientos de uso de los mismos |
| WO2017049321A1 (en) | 2015-09-17 | 2017-03-23 | Miller Marvin J | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| US11384032B2 (en) | 2016-05-12 | 2022-07-12 | Verdesian Life Sciences, U.S., Llc | Compositions for controlling enzyme-induced urea decomposition |
| HRP20241558T1 (hr) | 2017-03-13 | 2025-03-28 | Lundbeck La Jolla Research Center, Inc. | Dvojni inhibitori magl i faah |
| WO2018183562A1 (en) | 2017-03-28 | 2018-10-04 | Verdesian Life Sciences, U.S., Llc | Triarylmethane compounds for controlling enzyme-induced urea decomposition |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| BR112021018631A2 (pt) * | 2019-03-19 | 2021-11-23 | Boehringer Ingelheim Animal Health Usa Inc | Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| MX2022001940A (es) | 2019-08-14 | 2022-05-10 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2. |
| CN119930610A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US20220187813A1 (en) | 2020-12-10 | 2022-06-16 | Caterpillar Inc. | Hybrid ensemble approach for iot predictive modelling |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
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