JP2016504362A - アルブミンおよびパクリタキセルのナノ粒子組成物 - Google Patents

アルブミンおよびパクリタキセルのナノ粒子組成物 Download PDF

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Publication number
JP2016504362A
JP2016504362A JP2015550675A JP2015550675A JP2016504362A JP 2016504362 A JP2016504362 A JP 2016504362A JP 2015550675 A JP2015550675 A JP 2015550675A JP 2015550675 A JP2015550675 A JP 2015550675A JP 2016504362 A JP2016504362 A JP 2016504362A
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Prior art keywords
composition
albumin
paclitaxel
less
nanoparticles
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Pending
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JP2015550675A
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English (en)
Japanese (ja)
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JP2016504362A5 (OSRAM
Inventor
ニール ピー． デサイ，
ニール ピー． デサイ，
Original Assignee
アブラクシス バイオサイエンス， エルエルシー
アブラクシス バイオサイエンス， エルエルシー
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Application filed by アブラクシス バイオサイエンス， エルエルシー, アブラクシス バイオサイエンス， エルエルシー filed Critical アブラクシス バイオサイエンス， エルエルシー
Publication of JP2016504362A publication Critical patent/JP2016504362A/ja
Publication of JP2016504362A5 publication Critical patent/JP2016504362A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015550675A 2012-12-28 2013-12-19 アルブミンおよびパクリタキセルのナノ粒子組成物 Pending JP2016504362A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261747123P 2012-12-28 2012-12-28
US61/747,123 2012-12-28
US13/794,705 US20140186447A1 (en) 2012-12-28 2013-03-11 Nanoparticle compositions of albumin and paclitaxel
US13/794,705 2013-03-11
PCT/US2013/076630 WO2014105644A1 (en) 2012-12-28 2013-12-19 Nanoparticle compositions of albumin and paclitaxel

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018030637A Division JP2018087241A (ja) 2012-12-28 2018-02-23 アルブミンおよびパクリタキセルのナノ粒子組成物

Publications (2)

Publication Number Publication Date
JP2016504362A true JP2016504362A (ja) 2016-02-12
JP2016504362A5 JP2016504362A5 (OSRAM) 2017-02-02

Family

ID=51017455

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015550675A Pending JP2016504362A (ja) 2012-12-28 2013-12-19 アルブミンおよびパクリタキセルのナノ粒子組成物
JP2018030637A Pending JP2018087241A (ja) 2012-12-28 2018-02-23 アルブミンおよびパクリタキセルのナノ粒子組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018030637A Pending JP2018087241A (ja) 2012-12-28 2018-02-23 アルブミンおよびパクリタキセルのナノ粒子組成物

Country Status (19)

Country Link
US (2) US20140186447A1 (OSRAM)
EP (1) EP2938340A4 (OSRAM)
JP (2) JP2016504362A (OSRAM)
KR (1) KR20150100903A (OSRAM)
CN (1) CN105007912A (OSRAM)
AU (1) AU2013370955B2 (OSRAM)
BR (1) BR112015015319A2 (OSRAM)
CA (1) CA2896288A1 (OSRAM)
CR (1) CR20150386A (OSRAM)
HK (1) HK1216611A1 (OSRAM)
IL (1) IL239593A0 (OSRAM)
MX (1) MX2015008361A (OSRAM)
NI (1) NI201500090A (OSRAM)
NZ (1) NZ630912A (OSRAM)
PH (1) PH12015501486B1 (OSRAM)
RU (1) RU2663687C2 (OSRAM)
SG (1) SG11201505111TA (OSRAM)
WO (1) WO2014105644A1 (OSRAM)
ZA (1) ZA201504762B (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2020536052A (ja) * 2017-10-03 2020-12-10 クリティテック・インコーポレイテッド 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達
JP2022553426A (ja) * 2019-10-28 2022-12-22 アブラクシス バイオサイエンス， エルエルシー アルブミンおよびラパマイシンの医薬組成物
JP2024540366A (ja) * 2021-11-03 2024-10-31 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法
JP7786770B2 (ja) 2021-11-03 2025-12-16 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法

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HUE042678T2 (hu) 2005-08-31 2019-07-29 Abraxis Bioscience Llc Vízben rosszul oldódó gyógyszerhatóanyagok és antimikrobiális szerek
JP5933893B2 (ja) 2006-12-14 2016-06-15 アブラクシス バイオサイエンス， エルエルシー ホルモン受容体状態に基づいてタキサンを含むナノ粒子用いる乳癌治療法
AU2008260447B2 (en) * 2007-06-01 2013-10-10 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
ME03596B (me) 2009-04-15 2020-07-20 Abraxis Bioscience Llc Kompozicije nanočesтica bez priona i postupci povezani sa njima
HRP20160609T1 (hr) 2010-03-26 2016-09-23 Abraxis Bioscience, Llc Postupci liječenja hepatocelularnog karcinoma
KR101894689B1 (ko) 2010-03-29 2018-09-04 아브락시스 바이오사이언스, 엘엘씨 암의 치료 방법
CA2794147A1 (en) 2010-03-29 2011-10-06 Abraxis Bioscience, Llc Use of a composition comprising nanoparticles comprising a taxane and an albumin to improve uptake of chemotherapeutics by tumors and for treating a cancer that is highly fibrotic and/or has a dense stroma
EP2575804A4 (en) 2010-06-04 2013-10-23 Abraxis Bioscience Llc METHOD FOR THE TREATMENT OF PANCREASCRE
KR101970342B1 (ko) 2011-04-28 2019-04-18 아브락시스 바이오사이언스, 엘엘씨 나노입자 조성물의 혈관내 전달 및 그의 용도
WO2012154861A2 (en) 2011-05-09 2012-11-15 Mayo Foundation For Medical Education And Research Cancer treatments
EP3560486A1 (en) 2011-12-14 2019-10-30 Abraxis BioScience, LLC Use of polymeric excipients for lyophilization or freezing of particles
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US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
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EP2968191B1 (en) 2013-03-14 2021-06-16 Abraxis BioScience, LLC Methods of treating bladder cancer
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CA2950926A1 (en) 2014-06-13 2015-12-17 Mayo Foundation For Medical Education And Research Albumin-bound paclitaxel nanoparticle/rituximab complexes for treatment of cd20-expressing lymphomas
WO2015195476A1 (en) 2014-06-16 2015-12-23 Mayo Foundation For Medical Education And Research Treating myelomas
CN104224750A (zh) * 2014-09-17 2014-12-24 四川大学 一种注射用卡巴他赛白蛋白纳米粒制剂及其制备方法
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
PT3229776T (pt) 2014-11-25 2023-08-17 Curadigm Sas Composição farmacêutica combinando pelo menos duas nanopartícuas distintas e um composto farmacêutico, preparaçâo e suas utilizações
JP6789960B2 (ja) 2014-11-25 2020-11-25 キュラディグム・エスアエスＣｕｒａｄｉｇｍ Ｓａｓ 医薬組成物、その調製及び使用
LT3223796T (lt) 2014-11-25 2021-10-25 Curadigm Sas Farmacinės kompozicijos, jų gamyba ir panaudojimo būdai
PL3229843T3 (pl) * 2014-11-25 2020-06-29 Curadigm Sas Kompozycja farmaceutyczna, wytwarzanie i zastosowanie tej kompozycji
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) * 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
EA201792560A1 (ru) 2015-05-28 2018-06-29 Нанобиотикс Наночастицы для применения в качестве терапевтической вакцины
EA036790B1 (ru) 2015-06-29 2020-12-22 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Способ лечения злокачественной пекомы
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體－抗體組合物及其製造及使用方法
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
US11571469B2 (en) 2016-01-07 2023-02-07 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression
EP3413874A4 (en) 2016-02-12 2020-01-22 Mayo Foundation for Medical Education and Research TREATMENTS FOR BLOOD CANCER
EP3432928A4 (en) 2016-03-21 2019-11-20 Mayo Foundation for Medical Education and Research PROCESS FOR IMPROVING THE THERAPEUTIC INDEX FOR CHEMOTHERAPEUTIC
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JP2019526579A (ja) 2016-09-01 2019-09-19 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｔ細胞癌を標的とする為の方法及び組成物
RU2019110071A (ru) 2016-09-06 2020-10-08 Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч Способы лечения злокачественных новообразований, экспрессирующих pd-l1
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536052A (ja) * 2017-10-03 2020-12-10 クリティテック・インコーポレイテッド 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達
JP2022553426A (ja) * 2019-10-28 2022-12-22 アブラクシス バイオサイエンス， エルエルシー アルブミンおよびラパマイシンの医薬組成物
JP2024540366A (ja) * 2021-11-03 2024-10-31 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法
JP7786770B2 (ja) 2021-11-03 2025-12-16 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法

Also Published As

Publication number Publication date
CA2896288A1 (en) 2014-07-03
SG11201505111TA (en) 2015-07-30
RU2015131141A (ru) 2017-02-03
HK1216611A1 (zh) 2016-11-25
EP2938340A4 (en) 2016-08-03
KR20150100903A (ko) 2015-09-02
EP2938340A1 (en) 2015-11-04
AU2013370955A1 (en) 2015-07-16
CN105007912A (zh) 2015-10-28
WO2014105644A1 (en) 2014-07-03
NI201500090A (es) 2015-12-22
IL239593A0 (en) 2015-08-31
US20140186447A1 (en) 2014-07-03
AU2013370955B2 (en) 2018-12-06
PH12015501486A1 (en) 2015-09-21
NZ630912A (en) 2017-05-26
BR112015015319A2 (pt) 2017-07-11
JP2018087241A (ja) 2018-06-07
MX2015008361A (es) 2016-03-11
PH12015501486B1 (en) 2020-12-16
US20190192477A1 (en) 2019-06-27
RU2663687C2 (ru) 2018-08-08
ZA201504762B (en) 2016-10-26
CR20150386A (es) 2015-10-07

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