JP2016504284A - 抗ウイルス性アザ糖を含有するヌクレオシド - Google Patents

抗ウイルス性アザ糖を含有するヌクレオシド Download PDF

Info

Publication number
JP2016504284A
JP2016504284A JP2015542870A JP2015542870A JP2016504284A JP 2016504284 A JP2016504284 A JP 2016504284A JP 2015542870 A JP2015542870 A JP 2015542870A JP 2015542870 A JP2015542870 A JP 2015542870A JP 2016504284 A JP2016504284 A JP 2016504284A
Authority
JP
Japan
Prior art keywords
group
alkyl
independently
aryl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015542870A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016504284A5 (https=
Inventor
エス バブ，ヤルラガッダ
エス バブ，ヤルラガッダ
エル コティアン，プラヴィン
エル コティアン，プラヴィン
バンティア，シャンタ
ウー，ミンワン
サティシュ クマル，ヴィー
サティシュ クマル，ヴィー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocryst Pharmaceuticals Inc
Original Assignee
Biocryst Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharmaceuticals Inc filed Critical Biocryst Pharmaceuticals Inc
Publication of JP2016504284A publication Critical patent/JP2016504284A/ja
Publication of JP2016504284A5 publication Critical patent/JP2016504284A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015542870A 2012-11-16 2013-11-18 抗ウイルス性アザ糖を含有するヌクレオシド Pending JP2016504284A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261727468P 2012-11-16 2012-11-16
US61/727,468 2012-11-16
PCT/US2013/070537 WO2014078778A2 (en) 2012-11-16 2013-11-18 Antiviral azasugar-containing nucleosides

Publications (2)

Publication Number Publication Date
JP2016504284A true JP2016504284A (ja) 2016-02-12
JP2016504284A5 JP2016504284A5 (https=) 2017-01-12

Family

ID=50731836

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015542870A Pending JP2016504284A (ja) 2012-11-16 2013-11-18 抗ウイルス性アザ糖を含有するヌクレオシド

Country Status (9)

Country Link
US (2) US20150291596A1 (https=)
EP (2) EP2919785A4 (https=)
JP (1) JP2016504284A (https=)
AU (1) AU2013344422A1 (https=)
CA (1) CA2890905A1 (https=)
HK (1) HK1212235A1 (https=)
IL (1) IL238785A0 (https=)
MX (1) MX2015005949A (https=)
WO (1) WO2014078778A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022270628A1 (ja) * 2021-06-25 2022-12-29 国立大学法人 大分大学 Ｒｓウイルス感染症の処置および／または予防用医薬としてのヘテロシクロアルキル置換ポリヘテロアゾール誘導体
WO2023022216A1 (ja) * 2021-08-20 2023-02-23 塩野義製薬株式会社 ウイルス増殖抑制作用を有するヌクレオシド誘導体及びそれらのプロドラッグ
JP2023537293A (ja) * 2020-07-30 2023-08-31 スーチュワン ユニバーシティ フォロデシンの調製方法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI483950B (zh) 2009-09-21 2015-05-11 Gilead Sciences Inc 用於製備１’－取代碳核苷類似物之方法及中間物
BR122020020745B8 (pt) 2010-07-22 2023-10-31 Gilead Sciences Inc Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende
TWI767201B (zh) 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
WO2016141092A1 (en) 2015-03-04 2016-09-09 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
SI3349758T1 (sl) * 2015-09-16 2022-08-31 Gilead Sciences, Inc. Postopki za zdravljenje okužb z virusom arenaviridae
BR112018012112A2 (pt) 2015-12-16 2018-12-04 Bristol-Myers Squibb Company heteroaril-hidroxipirimidinonas como agonistas do receptor apj
MD3436461T2 (ro) 2016-03-28 2024-05-31 Incyte Corp Compuși pirolotriazină ca inhibitori TAM
CN109923106B (zh) 2016-09-02 2022-09-13 吉利德科学公司 toll样受体调节剂化合物
EP3507288B1 (en) 2016-09-02 2020-08-26 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
US10682368B2 (en) 2017-03-14 2020-06-16 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
CN106834546A (zh) * 2017-03-20 2017-06-13 杭州迪安医学检验中心有限公司 一种基于熔解曲线法单管同时检测多种呼吸道病毒的引物及其应用
AU2018262501B2 (en) 2017-05-01 2020-12-10 Gilead Sciences, Inc. Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
WO2019014247A1 (en) 2017-07-11 2019-01-17 Gilead Sciences, Inc. COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS
CN109053788A (zh) * 2018-09-20 2018-12-21 山东谛爱生物技术有限公司 一种吡唑类化合物的制备方法
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
US11660307B2 (en) 2020-01-27 2023-05-30 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
JP7554841B2 (ja) 2020-03-12 2024-09-20 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノヌクレオシドを調製する方法
WO2021207049A1 (en) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
CA3179226A1 (en) 2020-05-29 2021-12-02 Tomas Cihlar Remdesivir treatment methods
AU2021296841B2 (en) 2020-06-24 2025-01-23 Gilead Sciences, Inc. 1'-cyano nucleoside analogs and uses thereof
SI4204421T1 (sl) 2020-08-27 2024-07-31 Gilead Sciences, Inc., Spojine in postopki za zdravljenje virusnih okužb
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN114588159A (zh) * 2020-12-07 2022-06-07 成都傲科新技术有限责任公司 一种治疗猫冠状病毒感染的化合物及其应用
CN113666941B (zh) * 2021-09-01 2023-03-10 浙江珲达生物科技有限公司 一种2,3-O-异亚丙基-D-核糖酸-γ-内酯的重结晶方法
US12552827B2 (en) * 2022-01-21 2026-02-17 Biocryst Pharmaceuticals, Inc. Synthesis of an antiviral azasugar triphosphate
IL315102A (en) 2022-03-02 2024-10-01 Gilead Sciences Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004547A1 (fr) * 1992-08-26 1994-03-03 Japan Tobacco Inc. Nouveau derive de nicotine
WO2003100009A2 (en) * 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
US6780993B1 (en) * 2003-02-19 2004-08-24 Biocryst Pharmaceuticals, Inc. Preparation of deazaguanine analog
WO2006002231A1 (en) * 2004-06-22 2006-01-05 Biocryst Pharmaceuticals, Inc. Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
JP2008518934A (ja) * 2004-10-29 2008-06-05 バイオクライスト ファーマシューティカルズ， インコーポレイテッド 治療用フロピリミジンおよびチエノピリミジン
JP2010515760A (ja) * 2007-01-12 2010-05-13 バイオクライスト ファーマシューティカルズ， インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
JP2011513195A (ja) * 2007-05-10 2011-04-28 バイオクライスト ファーマシューティカルズ， インコーポレイテッド ウイルス感染およびがんの処置に使用するためのテトラヒドロフロ［３，４−ｄ］ジオキソラン化合物
WO2012051570A1 (en) * 2010-10-15 2012-04-19 Shanta Bantia Methods and compositions for inhibition of polymerase

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US3840556A (en) 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
EP1544294B8 (en) * 2002-07-17 2014-03-19 Riken Nucleosides or nucleotides having novel unnatural bases and use thereof
EP2189466A3 (en) 2002-12-04 2010-09-08 Mitsubishi Gas Chemical Company, Inc. Method of fluorination by microwaves
TWI345568B (en) 2004-04-02 2011-07-21 Mitsubishi Tanabe Pharma Corp Tetrahydronaphthyridine derivatives and a process for preparing the same
DK1891038T3 (da) * 2005-05-13 2009-01-19 Lilly Co Eli Substituerede n-arylpyrrolidiner som selektive androgenreceptormodulatorer
WO2007020193A2 (en) * 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Antiviral phosphoramidates of 4 ' -substituted pronucleotides
WO2007062370A2 (en) * 2005-11-22 2007-05-31 Smithkline Beecham Corporation Calcilytic compounds
KR101461680B1 (ko) 2005-12-02 2014-11-19 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체
WO2007109459A2 (en) 2006-03-21 2007-09-27 Janssen Pharmaceutica, Nv Pyridines and pyridine n-oxides as modulators of thrombin
EP2010523A1 (en) 2006-04-27 2009-01-07 Glaxo Group Limited Spirocompounds useful as modulators for dopamine d3 receptors
EP2313102A2 (en) * 2008-07-03 2011-04-27 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
WO2010033236A2 (en) * 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US8716478B2 (en) 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011132017A1 (en) 2010-04-19 2011-10-27 Glenmark Pharmaceuticals S.A. Pyrido[3,4-d]pyrimidinyl acetamide derivatives as trpa1 modulators
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004547A1 (fr) * 1992-08-26 1994-03-03 Japan Tobacco Inc. Nouveau derive de nicotine
WO2003100009A2 (en) * 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
US6780993B1 (en) * 2003-02-19 2004-08-24 Biocryst Pharmaceuticals, Inc. Preparation of deazaguanine analog
WO2006002231A1 (en) * 2004-06-22 2006-01-05 Biocryst Pharmaceuticals, Inc. Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
JP2008518934A (ja) * 2004-10-29 2008-06-05 バイオクライスト ファーマシューティカルズ， インコーポレイテッド 治療用フロピリミジンおよびチエノピリミジン
JP2010515760A (ja) * 2007-01-12 2010-05-13 バイオクライスト ファーマシューティカルズ， インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
JP2011513195A (ja) * 2007-05-10 2011-04-28 バイオクライスト ファーマシューティカルズ， インコーポレイテッド ウイルス感染およびがんの処置に使用するためのテトラヒドロフロ［３，４−ｄ］ジオキソラン化合物
WO2012051570A1 (en) * 2010-10-15 2012-04-19 Shanta Bantia Methods and compositions for inhibition of polymerase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EVANS, GARY B.: "The Synthesis of N-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 57(9), JPN6017039697, 2004, pages 837 - 854, ISSN: 0003800694 *
LEWANDOWICZ, ANDRZEJ; RINGIA, ERIKA A. TAYLOR; TING, LI-MIN; KIM, KAMI; TYLER, PETER C.; EVANS, GARY: "Energetic Mapping of Transition State Analogue Interactions with Human and Plasmodium falciparum Pur", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280(34), JPN6017039703, 2005, pages 30320 - 30328, ISSN: 0003800697 *
MAYER, ALAIN; LEUMANN, CHRISTIAN J.: "Pyrrolidino DNA with bases corresponding to the 2-oxo deletion mutants of thymine and cytosine: synt", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. (24), JPN6017039698, 2007, pages 4038 - 4049, ISSN: 0003800695 *
MILES, ROBERT W.; TYLER, PETER C.; EVANS, GARY B.; FURNEAUX, RICHARD H.; PARKIN, DAVID W.; SCHRAMM,: "Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases", BIOCHEMISTRY, vol. 38(40), JPN6017039700, 1999, pages 13147 - 13154, ISSN: 0003800696 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023537293A (ja) * 2020-07-30 2023-08-31 スーチュワン ユニバーシティ フォロデシンの調製方法
WO2022270628A1 (ja) * 2021-06-25 2022-12-29 国立大学法人 大分大学 Ｒｓウイルス感染症の処置および／または予防用医薬としてのヘテロシクロアルキル置換ポリヘテロアゾール誘導体
JPWO2022270628A1 (https=) * 2021-06-25 2022-12-29
WO2023022216A1 (ja) * 2021-08-20 2023-02-23 塩野義製薬株式会社 ウイルス増殖抑制作用を有するヌクレオシド誘導体及びそれらのプロドラッグ

Also Published As

Publication number Publication date
AU2013344422A1 (en) 2015-07-02
HK1212235A1 (en) 2016-06-10
MX2015005949A (es) 2015-09-08
EP2919785A2 (en) 2015-09-23
CA2890905A1 (en) 2014-05-22
IL238785A0 (en) 2015-06-30
EP2919785A4 (en) 2016-10-05
WO2014078778A2 (en) 2014-05-22
US20150291596A1 (en) 2015-10-15
EP3251674A2 (en) 2017-12-06
US20170267681A1 (en) 2017-09-21
WO2014078778A3 (en) 2014-10-09
EP3251674A3 (en) 2018-02-21

Similar Documents

Publication Publication Date Title
JP2016504284A (ja) 抗ウイルス性アザ糖を含有するヌクレオシド
JP6559266B2 (ja) ウイルスポリメラーゼを阻害するための組成物および方法
AU2025204785A1 (en) Methods for treating Arenaviridae and Coronaviridae virus infections
AU2024205205A1 (en) Methods for treating SARS CoV-2 infections
KR102002886B1 (ko) 2’-플루오로-6’-메틸렌 탄소환 뉴클레오시드 및 바이러스 감염을 치료하는 방법
TR201906416T4 (tr) Hiv inhibitörü bileşiklerin fosfonat analogları.
US20180298011A1 (en) Pyrazolo[1,5-a]pyrimidines for antiviral treatment
CN102712632A (zh) 黄病毒科病毒的抑制剂
KR20230057419A (ko) 인지질 화합물 및 이의 용도
JP2025503422A (ja) Ｐｄ－ｌ１を標的とするための方法及び組成物
HK1206627B (en) Compositions and methods for inhibiting viral polymerase

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161116

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161116

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170928

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171024

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180522