JP2016504284A5 - - Google Patents
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- JP2016504284A5 JP2016504284A5 JP2015542870A JP2015542870A JP2016504284A5 JP 2016504284 A5 JP2016504284 A5 JP 2016504284A5 JP 2015542870 A JP2015542870 A JP 2015542870A JP 2015542870 A JP2015542870 A JP 2015542870A JP 2016504284 A5 JP2016504284 A5 JP 2016504284A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkynyl
- independently
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229910052739 hydrogen Inorganic materials 0.000 claims 99
- 229910052799 carbon Inorganic materials 0.000 claims 95
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 55
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 49
- 150000004820 halides Chemical class 0.000 claims 47
- -1 aminothionyl Chemical group 0.000 claims 44
- 125000003118 aryl group Chemical group 0.000 claims 41
- 125000001072 heteroaryl group Chemical group 0.000 claims 39
- 125000003710 aryl alkyl group Chemical group 0.000 claims 36
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 31
- 150000001540 azides Chemical class 0.000 claims 29
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 29
- 229910052757 nitrogen Inorganic materials 0.000 claims 21
- 125000000304 alkynyl group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 15
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 241000700605 Viruses Species 0.000 claims 13
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 229910052717 sulfur Inorganic materials 0.000 claims 13
- 125000004001 thioalkyl group Chemical group 0.000 claims 12
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 11
- 125000004414 alkyl thio group Chemical group 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 241000712431 Influenza A virus Species 0.000 claims 3
- 241000713196 Influenza B virus Species 0.000 claims 3
- 241001115401 Marburgvirus Species 0.000 claims 3
- 241000710772 Yellow fever virus Species 0.000 claims 3
- 229940051021 yellow-fever virus Drugs 0.000 claims 3
- 241000725619 Dengue virus Species 0.000 claims 2
- 241001115402 Ebolavirus Species 0.000 claims 2
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000712890 Junin mammarenavirus Species 0.000 claims 2
- 241000712079 Measles morbillivirus Species 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 241000713124 Rift Valley fever virus Species 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 241000712908 Tacaribe mammarenavirus Species 0.000 claims 2
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 2
- 241000710886 West Nile virus Species 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 241000712892 Arenaviridae Species 0.000 claims 1
- 241001493160 California encephalitis virus Species 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 241000190708 Guanarito mammarenavirus Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 206010023927 Lassa fever Diseases 0.000 claims 1
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 1
- 241000712898 Machupo mammarenavirus Species 0.000 claims 1
- 241000150452 Orthohantavirus Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000713126 Punta Toro virus Species 0.000 claims 1
- 241000315672 SARS coronavirus Species 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000710951 Western equine encephalitis virus Species 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 *C1=CN=C(*)NC1=* Chemical compound *C1=CN=C(*)NC1=* 0.000 description 155
- DNLJAPGUAPBXHE-RXDXJJGDSA-N CO[C@H]1[C@H](c2c[nH]c3c2ncnc3N)N[C@H](CO)[C@H]1O Chemical compound CO[C@H]1[C@H](c2c[nH]c3c2ncnc3N)N[C@H](CO)[C@H]1O DNLJAPGUAPBXHE-RXDXJJGDSA-N 0.000 description 2
- LLXZUZLCCNNAOM-JKUQZMGJSA-N C[C@@H](C1)N[C@H](CO)[C@H]1O Chemical compound C[C@@H](C1)N[C@H](CO)[C@H]1O LLXZUZLCCNNAOM-JKUQZMGJSA-N 0.000 description 2
- GUFBLOGHOCWZCD-POYBYMJQSA-N Nc1c2[nH]cc([C@@H]3N[C@H](CO)CC3)c2ncn1 Chemical compound Nc1c2[nH]cc([C@@H]3N[C@H](CO)CC3)c2ncn1 GUFBLOGHOCWZCD-POYBYMJQSA-N 0.000 description 2
- RSYWBFOPJYGRMR-GEVIPFJHSA-N Nc1c2[nH]cc([C@@H]3N[C@H](CO)C[C@@H]3F)c2ncn1 Chemical compound Nc1c2[nH]cc([C@@H]3N[C@H](CO)C[C@@H]3F)c2ncn1 RSYWBFOPJYGRMR-GEVIPFJHSA-N 0.000 description 2
- OBIXMCRFEXZXER-ARDNSNSESA-N Nc1c2[nH]cc([C@@H]3N[C@H](CO)C[C@H]3O)c2ncn1 Chemical compound Nc1c2[nH]cc([C@@H]3N[C@H](CO)C[C@H]3O)c2ncn1 OBIXMCRFEXZXER-ARDNSNSESA-N 0.000 description 2
- HTKJHJQGNWKVRD-HQMQMISQSA-N Nc1ncnc2c1NCC2[C@@H](C1(F)F)N[C@H](CO)[C@H]1O Chemical compound Nc1ncnc2c1NCC2[C@@H](C1(F)F)N[C@H](CO)[C@H]1O HTKJHJQGNWKVRD-HQMQMISQSA-N 0.000 description 2
- WSYRZIZYUWPOLP-RGOKHQFPSA-N C#CC(C=C1[C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C(N)NC1=O Chemical compound C#CC(C=C1[C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C(N)NC1=O WSYRZIZYUWPOLP-RGOKHQFPSA-N 0.000 description 1
- DWELXPFRAWEKLB-XAVMHZPKSA-N CC(C(N1)=O)=CC([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C1O Chemical compound CC(C(N1)=O)=CC([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C1O DWELXPFRAWEKLB-XAVMHZPKSA-N 0.000 description 1
- WAPKAXXJFRIDCE-XAVMHZPKSA-N CC(C=C1[C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C(N)NC1=O Chemical compound CC(C=C1[C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C(N)NC1=O WAPKAXXJFRIDCE-XAVMHZPKSA-N 0.000 description 1
- FMIRQNOVTQGDEW-RGOKHQFPSA-N CCC(C=C1[C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C(N)NC1=O Chemical compound CCC(C=C1[C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)=C(N)NC1=O FMIRQNOVTQGDEW-RGOKHQFPSA-N 0.000 description 1
- CHQVICWFDPEJOK-UCROKIRRSA-N NC(C([C@@H]([C@@H]1O)N[C@H](CO)[C@H]1O)=CN1)=NC1=O Chemical compound NC(C([C@@H]([C@@H]1O)N[C@H](CO)[C@H]1O)=CN1)=NC1=O CHQVICWFDPEJOK-UCROKIRRSA-N 0.000 description 1
- CPOLMWXQKHMDTG-JYFAAPFMSA-N NC(N1)=CC=C([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)C1=O Chemical compound NC(N1)=CC=C([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)C1=O CPOLMWXQKHMDTG-JYFAAPFMSA-N 0.000 description 1
- VXCZUOGLGVWRIR-ZUMNNYEFSA-N NC(N1)=NC=C(C([C@@H]2O)N[C@H](CO)[C@H]2O)C1=O Chemical compound NC(N1)=NC=C(C([C@@H]2O)N[C@H](CO)[C@H]2O)C1=O VXCZUOGLGVWRIR-ZUMNNYEFSA-N 0.000 description 1
- ABQFSPSUNQYJRN-HWBGAQDOSA-N NC(NC(C(C([C@@H]1O)N[C@H](CO)[C@H]1O)=C1)=O)=C1F Chemical compound NC(NC(C(C([C@@H]1O)N[C@H](CO)[C@H]1O)=C1)=O)=C1F ABQFSPSUNQYJRN-HWBGAQDOSA-N 0.000 description 1
- OVLGEFNKTPVUHW-NEPJDUFXSA-N Nc1ccc([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)cn1 Chemical compound Nc1ccc([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)cn1 OVLGEFNKTPVUHW-NEPJDUFXSA-N 0.000 description 1
- UMFCMUAQLLZTAO-MIRRECJXSA-N Nc1nc(O)c([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)c(O)n1 Chemical compound Nc1nc(O)c([C@@H]([C@@H]2O)N[C@H](CO)[C@H]2O)c(O)n1 UMFCMUAQLLZTAO-MIRRECJXSA-N 0.000 description 1
- CJCSSIACHRZLAQ-VVXQKDJTSA-N OC[C@H]([C@H](C1)O)NC1C1=CN=CNC1=O Chemical compound OC[C@H]([C@H](C1)O)NC1C1=CN=CNC1=O CJCSSIACHRZLAQ-VVXQKDJTSA-N 0.000 description 1
- FEYBDKGNVYMXKY-FXWAIPRXSA-N OC[C@H]([C@H]([C@H]1O)O)NC1C(C=CC(N1)=O)=C1O Chemical compound OC[C@H]([C@H]([C@H]1O)O)NC1C(C=CC(N1)=O)=C1O FEYBDKGNVYMXKY-FXWAIPRXSA-N 0.000 description 1
- XKRKHLSUXIRKHX-UCROKIRRSA-N OC[C@H]([C@H]([C@H]1O)O)N[C@H]1C(C(N1)=O)=COC1=O Chemical compound OC[C@H]([C@H]([C@H]1O)O)N[C@H]1C(C(N1)=O)=COC1=O XKRKHLSUXIRKHX-UCROKIRRSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261727468P | 2012-11-16 | 2012-11-16 | |
| US61/727,468 | 2012-11-16 | ||
| PCT/US2013/070537 WO2014078778A2 (en) | 2012-11-16 | 2013-11-18 | Antiviral azasugar-containing nucleosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016504284A JP2016504284A (ja) | 2016-02-12 |
| JP2016504284A5 true JP2016504284A5 (https=) | 2017-01-12 |
Family
ID=50731836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542870A Pending JP2016504284A (ja) | 2012-11-16 | 2013-11-18 | 抗ウイルス性アザ糖を含有するヌクレオシド |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150291596A1 (https=) |
| EP (2) | EP3251674A3 (https=) |
| JP (1) | JP2016504284A (https=) |
| AU (1) | AU2013344422A1 (https=) |
| CA (1) | CA2890905A1 (https=) |
| HK (1) | HK1212235A1 (https=) |
| IL (1) | IL238785A0 (https=) |
| MX (1) | MX2015005949A (https=) |
| WO (1) | WO2014078778A2 (https=) |
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| DK3785717T3 (da) | 2015-09-16 | 2022-03-21 | Gilead Sciences Inc | Fremgangsmåder til behandling af coronaviridae-infektioner |
| TW201725203A (zh) | 2015-12-16 | 2017-07-16 | 必治妥美雅史谷比公司 | 作為ａｐｊ受體促效劑之雜芳基羥基嘧啶酮 |
| KR102483020B1 (ko) | 2016-03-28 | 2023-01-04 | 인사이트 코포레이션 | Tam 저해제로서의 피롤로트리아진 화합물 |
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| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
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| CN106834546A (zh) * | 2017-03-20 | 2017-06-13 | 杭州迪安医学检验中心有限公司 | 一种基于熔解曲线法单管同时检测多种呼吸道病毒的引物及其应用 |
| CA3059777C (en) | 2017-05-01 | 2023-02-21 | Gilead Sciences, Inc. | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
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| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ， インコーポレイテッド | ＳＡＲＳ ＣｏＶ－２感染を治療するための方法 |
| KR20220153619A (ko) | 2020-03-12 | 2022-11-18 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 뉴클레오사이드의 제조 방법 |
| CA3172483A1 (en) | 2020-04-06 | 2021-10-14 | Scott Ellis | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| TW202203941A (zh) | 2020-05-29 | 2022-02-01 | 美商基利科學股份有限公司 | 瑞德西韋之治療方法 |
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| CN111704619B (zh) * | 2020-07-30 | 2021-10-19 | 四川大学 | 一种Forodesine的制备方法 |
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| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CN114588159A (zh) * | 2020-12-07 | 2022-06-07 | 成都傲科新技术有限责任公司 | 一种治疗猫冠状病毒感染的化合物及其应用 |
| US20240327392A1 (en) * | 2021-06-25 | 2024-10-03 | Albius Sciences Alpha Private Limited | Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections |
| EP4389750A4 (en) | 2021-08-20 | 2025-10-01 | Shionogi & Co | NUCLEOSIDE DERIVATIVES AND THEIR PRODRUGS HAVING VIRAL GROWTH INHIBITORY ACTION |
| CN113666941B (zh) * | 2021-09-01 | 2023-03-10 | 浙江珲达生物科技有限公司 | 一种2,3-O-异亚丙基-D-核糖酸-γ-内酯的重结晶方法 |
| US12552827B2 (en) * | 2022-01-21 | 2026-02-17 | Biocryst Pharmaceuticals, Inc. | Synthesis of an antiviral azasugar triphosphate |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
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| HRP20120914T1 (hr) * | 2007-05-10 | 2012-12-31 | Biocryst Pharmaceuticals, Inc. | Spojevi tetrahidrofuro[3,4-d]dioksolana, namijenjeni upotrebi u lijeäśenju virusnih infekcija i raka |
| WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| US20110190265A1 (en) * | 2008-09-22 | 2011-08-04 | Schramm Vern L | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| WO2011132017A1 (en) | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceuticals S.A. | Pyrido[3,4-d]pyrimidinyl acetamide derivatives as trpa1 modulators |
| DK2898885T3 (en) * | 2010-10-15 | 2018-02-05 | Biocryst Pharm Inc | PYRROLOPYRIMIDINE DERIVATIVES FOR USE IN TREATMENT OF VIRUS INFECTIONS |
| AR090699A1 (es) * | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
-
2013
- 2013-11-18 JP JP2015542870A patent/JP2016504284A/ja active Pending
- 2013-11-18 AU AU2013344422A patent/AU2013344422A1/en not_active Abandoned
- 2013-11-18 HK HK16100301.6A patent/HK1212235A1/xx unknown
- 2013-11-18 CA CA2890905A patent/CA2890905A1/en not_active Abandoned
- 2013-11-18 EP EP17162146.9A patent/EP3251674A3/en not_active Withdrawn
- 2013-11-18 MX MX2015005949A patent/MX2015005949A/es unknown
- 2013-11-18 WO PCT/US2013/070537 patent/WO2014078778A2/en not_active Ceased
- 2013-11-18 EP EP13855441.5A patent/EP2919785A4/en not_active Withdrawn
- 2013-11-18 US US14/441,762 patent/US20150291596A1/en not_active Abandoned
-
2015
- 2015-05-13 IL IL238785A patent/IL238785A0/en unknown
-
2017
- 2017-03-31 US US15/475,507 patent/US20170267681A1/en not_active Abandoned
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