JP2016193932A5 - - Google Patents
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- JP2016193932A5 JP2016193932A5 JP2016133918A JP2016133918A JP2016193932A5 JP 2016193932 A5 JP2016193932 A5 JP 2016193932A5 JP 2016133918 A JP2016133918 A JP 2016133918A JP 2016133918 A JP2016133918 A JP 2016133918A JP 2016193932 A5 JP2016193932 A5 JP 2016193932A5
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- 239000003862 glucocorticoid Substances 0.000 claims description 20
- 229960003957 dexamethasone Drugs 0.000 claims description 11
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 11
- 230000000926 neurological effect Effects 0.000 claims description 11
- 230000002411 adverse Effects 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 4
- 206010003591 Ataxia Diseases 0.000 claims description 3
- 206010019233 Headaches Diseases 0.000 claims description 3
- 229960003008 blinatumomab Drugs 0.000 claims description 3
- 231100000869 headache Toxicity 0.000 claims description 3
- 206010048962 Brain oedema Diseases 0.000 claims description 2
- 206010010904 Convulsion Diseases 0.000 claims description 2
- 208000004547 Hallucinations Diseases 0.000 claims description 2
- 208000020764 Sensation disease Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 206010044565 Tremor Diseases 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 208000006752 brain edema Diseases 0.000 claims description 2
- 208000027765 speech disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 208000008035 Back Pain Diseases 0.000 claims 2
- 206010003062 Apraxia Diseases 0.000 claims 1
- 208000007542 Paresis Diseases 0.000 claims 1
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 description 4
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000004209 confusion Diseases 0.000 description 1
- 206010013395 disorientation Diseases 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222910P | 2010-11-10 | 2010-11-10 | |
| US61/412,229 | 2010-11-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538125A Division JP6023717B2 (ja) | 2010-11-10 | 2011-10-27 | Ｃｄ３特異的結合ドメインによって引き起こされる有害作用の予防 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016193932A JP2016193932A (ja) | 2016-11-17 |
| JP2016193932A5 true JP2016193932A5 (https=) | 2017-06-08 |
| JP6189491B2 JP6189491B2 (ja) | 2017-08-30 |
Family
ID=45044532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538125A Active JP6023717B2 (ja) | 2010-11-10 | 2011-10-27 | Ｃｄ３特異的結合ドメインによって引き起こされる有害作用の予防 |
| JP2016133918A Active JP6189491B2 (ja) | 2010-11-10 | 2016-07-06 | Ｃｄ３特異的結合ドメインによって引き起こされる有害作用の予防 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538125A Active JP6023717B2 (ja) | 2010-11-10 | 2011-10-27 | Ｃｄ３特異的結合ドメインによって引き起こされる有害作用の予防 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10130638B2 (https=) |
| EP (3) | EP2637670B2 (https=) |
| JP (2) | JP6023717B2 (https=) |
| KR (1) | KR101891845B1 (https=) |
| CN (2) | CN103533943B (https=) |
| AU (3) | AU2011328393B2 (https=) |
| CA (1) | CA2816668C (https=) |
| CL (1) | CL2013001287A1 (https=) |
| CR (1) | CR20130278A (https=) |
| CY (1) | CY1118894T1 (https=) |
| DK (1) | DK2637670T4 (https=) |
| EA (1) | EA026075B1 (https=) |
| ES (2) | ES2842937T3 (https=) |
| FI (1) | FI2637670T4 (https=) |
| HR (1) | HRP20170814T4 (https=) |
| HU (1) | HUE032782T2 (https=) |
| IL (2) | IL226268B (https=) |
| LT (1) | LT2637670T (https=) |
| MA (1) | MA34726B1 (https=) |
| ME (1) | ME02722B (https=) |
| MY (1) | MY173177A (https=) |
| NZ (1) | NZ610034A (https=) |
| PH (1) | PH12013500940A1 (https=) |
| PL (1) | PL2637670T5 (https=) |
| PT (1) | PT2637670T (https=) |
| RS (1) | RS55995B2 (https=) |
| SG (2) | SG10201508789TA (https=) |
| SI (1) | SI2637670T2 (https=) |
| SM (1) | SMT201700250T1 (https=) |
| TN (1) | TN2013000250A1 (https=) |
| UA (1) | UA113397C2 (https=) |
| WO (1) | WO2012062596A1 (https=) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1874821T3 (pl) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
| EA026075B1 (ru) | 2010-11-10 | 2017-02-28 | Эмджен Рисерч (Мьюник) Гмбх | Предотвращение неблагоприятных эффектов, вызванных cd3-специфическими связывающими доменами |
| KR102345943B1 (ko) * | 2011-04-28 | 2021-12-31 | 암젠 리서치 (뮌헨) 게엠베하 | 잠재적 유해 효과의 위험에 처한 환자에게 cd19xcd3 이중특이적 항체를 투여하기 위한 투여 요법 |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| KR102211837B1 (ko) * | 2013-01-14 | 2021-02-03 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| JO3529B1 (ar) * | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| JP6594855B2 (ja) * | 2013-03-15 | 2019-10-23 | ゼンコア インコーポレイテッド | ヘテロ二量体タンパク質 |
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| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
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| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| ES2744540T3 (es) | 2014-12-05 | 2020-02-25 | Hoffmann La Roche | Anticuerpos anti-CD79b y procedimientos de uso |
| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| DK3310814T5 (da) | 2015-06-16 | 2024-10-07 | Hoffmann La Roche | Humaniserede og affinitetsmodnede antistoffer mod FcRH5 og fremgangsmåder til anvendelse |
| US10501545B2 (en) | 2015-06-16 | 2019-12-10 | Genentech, Inc. | Anti-CLL-1 antibodies and methods of use |
| EP3322735A4 (en) | 2015-07-15 | 2019-03-13 | Zymeworks Inc. | ACTIVE CONJUGATED BIS-SPECIFIC ANTIGEN-BONDING CONSTRUCTS |
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| EA039859B1 (ru) * | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
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| ATE243754T1 (de) | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
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| EA026075B1 (ru) | 2010-11-10 | 2017-02-28 | Эмджен Рисерч (Мьюник) Гмбх | Предотвращение неблагоприятных эффектов, вызванных cd3-специфическими связывающими доменами |
-
2011
- 2011-10-27 EA EA201390621A patent/EA026075B1/ru not_active IP Right Cessation
- 2011-10-27 AU AU2011328393A patent/AU2011328393B2/en active Active
- 2011-10-27 MY MYPI2013001611A patent/MY173177A/en unknown
- 2011-10-27 PL PL11788077.3T patent/PL2637670T5/pl unknown
- 2011-10-27 PT PT117880773T patent/PT2637670T/pt unknown
- 2011-10-27 ES ES17159560T patent/ES2842937T3/es active Active
- 2011-10-27 FI FIEP11788077.3T patent/FI2637670T4/fi active
- 2011-10-27 CN CN201180064622.5A patent/CN103533943B/zh active Active
- 2011-10-27 CA CA2816668A patent/CA2816668C/en active Active
- 2011-10-27 SG SG10201508789TA patent/SG10201508789TA/en unknown
- 2011-10-27 LT LTEP11788077.3T patent/LT2637670T/lt unknown
- 2011-10-27 SG SG2013034731A patent/SG190174A1/en unknown
- 2011-10-27 SM SM20170250T patent/SMT201700250T1/it unknown
- 2011-10-27 JP JP2013538125A patent/JP6023717B2/ja active Active
- 2011-10-27 RS RS20170458A patent/RS55995B2/sr unknown
- 2011-10-27 US US13/884,497 patent/US10130638B2/en active Active
- 2011-10-27 EP EP11788077.3A patent/EP2637670B2/en active Active
- 2011-10-27 WO PCT/EP2011/068862 patent/WO2012062596A1/en not_active Ceased
- 2011-10-27 KR KR1020137014669A patent/KR101891845B1/ko active Active
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